Patent application number | Description | Published |
20130068043 | APPARATUS AND METHODS FOR PREPARATION AND ANALYSIS OF DRIED SAMPLES OF A BIOLOGICAL FLUID - Described is a device for collecting a fluid sample, such as a biological fluid sample. The device includes a planar collection substrate having an absorbent material. The planar collection substrate includes an impermeable region and a sample collection region. The impermeable region is impermeable to the fluid sample and is embedded in the planar collection substrate in a spatial pattern. The sample collection region is in an area excluded from the spatial pattern and has a shape and a size defined by the spatial pattern. The sample collection region is configured to receive a known volume of the fluid sample. In an alternative form, the device includes a sample collection element disposed in an impermeable planar holder and, in another alternative form, the device includes an absorbent material disposed inside an impermeable tube wall. | 03-21-2013 |
20130327129 | SPECTROSCOPIC SAMPLE INSPECTION FOR AUTOMATED CHROMATOGRAPHY - A method and a system for generating an extraction sample from a dried sample spot. The method includes acquiring a spectroscopic image of an analyte in the spot. The spectroscopic image includes information on a spatial distribution of the analyte. A region of the spot to be extracted is determined from the spectroscopic image and an extraction sample is generated from the determined region. In other embodiments, the method and system are based on acquiring a spectroscopic measurement of an analyte in the dried sample spot, determining a quantity of the analyte in the spot based on the spectroscopic measurement and determining a volume of an extraction solvent for creating an extraction sample from the spot. The determined volume is based on the determined quantity of the analyte and a detection characteristic of an analytical measurement system. In other embodiments, the method is applied to solid samples. | 12-12-2013 |
20140208836 | ANALYSIS OF DRIED BLOOD SPOT SAMPLES IN A MICROFLUIDIC SYSTEM WITH DILUTION OF EXTRACTED SAMPLES - An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column. | 07-31-2014 |
20140220278 | Porous Material And Devices For Performing Separations, Filtrations, And Catalysis And EK Pumps, And Mthods Of Making And Using The Same - Embodiments of the present invention are directed to a porous monolith polymeric composition having utility in catalysis, chromatography, filtration, and electro-kinetic pumps, devices incorporating such composition and methods or making and using such monoliths. The monoliths are characterized by a substantially homogeneous skeletal core with little shrinkage, few voids and few channels. | 08-07-2014 |
20140366656 | SOLID PHASE EXTRACTION DEVICE FOR DRIED SAMPLE CARDS - Described is a device for solid phase extraction of a dried sample of a biological fluid. The device includes a support structure such as a plate or support block that has a first side to receive a dried sample card. The support structure also has a second side that is opposite the first side and a number of apertures that extend between the first and second sides. The device also includes a plurality of wells each containing a sample preparation material and having an inlet end that communicates with a respective aperture at the second side of the support structure. Each dried sample on the dried sample card is aligned with one of the apertures. Extraction samples in each well pass through the sample preparation material, such as a chromatographic sorbent, in the well to remove one or more constituents of the extraction sample. | 12-18-2014 |
20140373644 | DRIED SAMPLE CARRIER HAVING DISSOLVABLE SAMPLE REGIONS - Described are sample carriers and methods of extracting a fluid sample from a dried sample on a sample carrier. The sample carrier has a first carrier portion that receives a fluid sample, and includes a material that adsorbs the fluid sample and dissolves upon application of a solvent. A second carrier portion is attached to the first carrier portion and includes a material that is indissolvable in the solvent. The first carrier portion having a dried sample is dissolved into a solution upon application of the solvent. The solution can be analyzed to determine constituents in the extracted sample. The sample carrier can conveniently be in the form of a card or a dipstick. In alternative embodiments, a carrier portion that includes the dried sample is indissolvable in the solvent but is released from another carrier portion through application of a solvent to an intervening dissolvable carrier portion. | 12-25-2014 |
20150047441 | SAMPLE CARRIER FOR DRIED BIOLOGICAL SAMPLES - Described is a biological sample carrier based on a rigid hydrophilic object fabricated from a non-absorbing inert porous material. A biological fluid sample applied to the surface of the object is absorbed into the pores and constituents of the biological fluid sample remain in the pores after drying. Unlike a disc punched from a conventional dried blood spot (DBS) card, the object is easily handled. In contrast to DBS cards containing glass fiber structures that interact with basic analytes and other DBS card having adsorbing fibers that tend to separate blood constituents as the sample spreads through the fibers, the biological sample carrier is substantially inert to drug analytes. | 02-19-2015 |
20150266019 | APPARATUS AND METHOD FOR ANALYTE EXTRACTION - Described is a matrix spot processing device comprising a tubular apparatus. An absorbent media is located either separate from, or attached to, the tubular apparatus. A sample is spotted on the absorbent media. A reservoir is in the tubular apparatus. A first region of the reservoir is constructed and arranged to have an extraction solvent. A second region of the reservoir, which may or may not be the same as the first region, is constructed and arranged to receive an extract generated from an interaction between the extraction solvent and the spotted sample at the absorbent media. | 09-24-2015 |