Patent application number | Description | Published |
20080214932 | Method and surgical navigation system for creating a recess to receive an acetabulum - To facilitate assistance of the operating surgeon when determining the disposition of a receiving cavity in the case of a method and a navigation system for creating a cavity to receive an acetabulum in a navigated pelvic bone with the aid of a navigated tool, it is proposed that the tear-drop point on the pelvic bone is located by means of a navigated scanning instrument, from the position data and the plane of the pelvic inlet of said pelvic bone there is determined a tear-drop plane, which lies perpendicular to said plane of the pelvic inlet and extends parallel to a line connecting the two anterior superior iliac spines and through the scanned tear-drop point, that a reference point is determined at a defined height above the tear-drop plane and in a defined position in the anterior-posterior direction and at a defined spacing from the outer surface of the pelvic bone in the lateral-medial direction, and that the tool is worked into the pelvic bone in a desired direction relative to the reference point until a predetermined disposition of the tool relative to the reference point is reached. | 09-04-2008 |
20110040180 | Method and device for determining the position of a tangential plane on three extreme points of a body - In order to improve the computation of the position of the tangential plane in a method for determining the position of a tangential plane which rests tangentially on three non-collinear extreme points of structures of a body, in which one determines the position of the three extreme points approximately by using three starting points disposed in the locality of the structures and computes the tangential plane as being a plane passing through these three starting points, it is proposed that one investigates the structure of the body in the vicinity of the three extreme points using a navigated ultrasonic head which emits ultrasonic radiation in an investigation plane and displays the ultrasonic image of each investigated structure on a display screen, in that one overlays a line of intersection of the investigation plane and the tangential plane on the ultrasonic image in the display screen, in that, for each structure, one selects as an improved extreme point that point of the structure which is located in the investigation plane at the greatest or the least spacing from the line of intersection, and in that one computes an improved tangential plane as being a plane which passes through these three improved extreme points. A device for carrying out this method is disclosed in the patent. | 02-17-2011 |
Patent application number | Description | Published |
20090118257 | 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES - Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, and stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 4-(p-quinolyl)-2-hydroxybutanamide derivatives. Methods and compounds useful in treating other disorders such as amyotrophic lateral sclerosis (ALS), Huntington's disease, Parkinson's disease, and pervasive developmental disorders such as autism are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed. | 05-07-2009 |
20110124679 | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES - Methods of treating or suppressing oxidative stress diseases including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases and diseases of aging are disclosed, as well as compounds useful in the methods of the invention, such as 2-substituted-p-quinone derivatives as disclosed herein. | 05-26-2011 |
20120122934 | 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES - Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, and stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 4-(p-quinolyl)-2-hydroxybutanamide derivatives. Methods and compounds useful in treating other disorders such as amyotrophic lateral sclerosis (ALS), Huntington's disease, Parkinson's disease, and pervasive developmental disorders such as autism are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed. | 05-17-2012 |
20130289034 | 4-(p-QUINONYL)-2-HYDROXYBUTANAMIDE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES - Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, and stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 4-(p-quinolyl)-2-hydroxybutanamide derivatives. Methods and compounds useful in treating other disorders such as amyotrophic lateral sclerosis (ALS), Huntington's disease, Parkinson's disease, and pervasive developmental disorders such as autism are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed. | 10-31-2013 |
20140243424 | CATECHOL DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES - Methods of treating or suppressing oxidative stress disorders affecting normal electron flow in the cells, including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases, diseases of aging and diseases caused by reactive oxygen species are disclosed, as well as compounds useful in the methods of the invention, such as such as catechol or ortho-quinone derivatives of Formula (I). | 08-28-2014 |
20140249332 | METHODS FOR SELECTIVE OXIDATION OF ALPHA TOCOTRIENOL IN THE PRESENCE OF NON-ALPHA TOCOTRIENOLS - A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-tocotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs the non-alpha tocotrienol chromans. | 09-04-2014 |
20140329860 | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES - Methods of treating or suppressing oxidative stress diseases including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases and diseases of aging are disclosed, as well as compounds useful in the methods of the invention, such as 2-substituted-p-quinone derivatives as disclosed herein. | 11-06-2014 |