Müller, Berlin
Andre Müller, Berlin DE
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20110250137 | RADIOISOTOPE-LABELED LYSINE AND ORNITHINE DERIVATIVES, THEIR USE AND PROCESSES FOR THEIR PREPARATION - The invention relates to the compounds suitable for radiolabeling with a chelator free radioisotope and radiolabeled compounds of the general Formula I. | 10-13-2011 |
20130034497 | IODINE-LABELED HOMOGLUTAMIC ACID AND GLUTAMIC ACID DERIVATIVES - This invention relates to derivatives of Iodine-labeled homoglutamic acids and glutamic acids and their analogues suitable for labeling or already labeled by Iodine, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging or radiotherapy. | 02-07-2013 |
20130071327 | HOMOGLUTAMIC ACID DERIVATIVES - This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with | 03-21-2013 |
Christian Müller, Berlin DE
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20090169537 | GLUTADON - The present invention relates to a pharmaceutical combination product for cancer therapy. The combination product comprises the two active ingredients glutaminase and 6-diazo-5-oxo-L-norleucine (DON). The invention further relates to the use of such a combination product for the treatment of cancers. | 07-02-2009 |
Dan Robin Müller, Berlin DE
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20110097313 | Method for the Identification and Separation of Non-regulatory T-cells from a Mixture of Regulatory T-cells - The present invention relates to a method of identifying and separating non-regulatory T-cells (conventional T-cells) from a mixture comprising regulatory T-cells by using of the CD154 molecule (CD40 ligand) through depletion of CD154+ T-cells from the mixture or in combination with additional positive selection of Treg using markers that are specific for regulatory T-cells, such as for example, CD25, GITR, CTLA4 or markers which are specific for activated regulatory T-cells, such as, for example, CD137, “latent TGF-beta (LAP)”, GARP (LRRC32), CD121a/b, thereby generating a cell composition of activated Treg cells. The invention relates also to a kit comprising an antibody for detecting CD154 and at least one additional antibody for detecting markers for activated or non-activated regulatory T-cells. The antibodies can be coupled to a fluorescent dye or magnetic microparticles. | 04-28-2011 |
Dan Robin Müller, Berlin DE
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20110097313 | Method for the Identification and Separation of Non-regulatory T-cells from a Mixture of Regulatory T-cells - The present invention relates to a method of identifying and separating non-regulatory T-cells (conventional T-cells) from a mixture comprising regulatory T-cells by using of the CD154 molecule (CD40 ligand) through depletion of CD154+ T-cells from the mixture or in combination with additional positive selection of Treg using markers that are specific for regulatory T-cells, such as for example, CD25, GITR, CTLA4 or markers which are specific for activated regulatory T-cells, such as, for example, CD137, “latent TGF-beta (LAP)”, GARP (LRRC32), CD121a/b, thereby generating a cell composition of activated Treg cells. The invention relates also to a kit comprising an antibody for detecting CD154 and at least one additional antibody for detecting markers for activated or non-activated regulatory T-cells. The antibodies can be coupled to a fluorescent dye or magnetic microparticles. | 04-28-2011 |
Dominik N. Müller, Berlin DE
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20120122972 | NOVEL EICOSANOID DERIVATIVES - The present invention provides compounds (n-3 PUFA derivatives) of formula (I) that modulate conditions associated with cardiac damage, especially cardiac arrhythmias. | 05-17-2012 |
Joerg Müller, Berlin DE
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20120310036 | BLOOD PUMP - A blood pump has a hollow body in which an impeller with a spiral blading produces an axial propulsion of blood along the impeller, as well as an at least partly actively stabilized magnetic bearing device and a hydrodynamic bearing device for the impeller. The impeller may be set into a rotation about a rotation axis of the impeller with a motor stator located outside the hollow body. The hollow body has an inlet for the flow of blood into the hollow body in an inflow direction which is essentially parallel to the rotation axis, and an outlet for the outflow of the blood out of the hollow body in an outflow direction which is offset to the rotation axis of the impeller to produce a non-zero outflow angle (α) between the inflow direction and the outflow direction. A total artificial heart can be formed from two such blood pumps. | 12-06-2012 |
Katrin Müller, Berlin DE
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20090214380 | LOW-MIGRATION COPPER ALLOY - The present invention relates to a copper alloy, in particular for components which carry media or drinking water, in particular fittings, valves or compression joints and also an advantageous use of the copper alloy and components for lines carrying media or drinking water. It is an object of the present invention to provide a copper alloy which has good corrosion resistance, good castability and mechanical workability and also good mechanical properties and displays good migration values, particularly in respect of the migration of lead and nickel ions into drinking water. The copper alloy provided for this purpose by the present invention comprises from 2% by weight to 4.5% by weight of silicon, from 1 to 15% by weight of zinc and from 0.05% by weight to 2% by weight of manganese. Furthermore, from 0.05 to 0.4% by weight of aluminium and from 0.05 to 2% by weight of tin can optionally be present. As balance, the copper alloy contains copper and unavoidable impurities. | 08-27-2009 |
20130198095 | Method and Device for Automatically Evaluating a Delivery System - A method for automatically evaluating a delivery system with respect to the energy efficiency and emissions efficiency thereof, may include: determining a service level for the delivery system according to an energy intensity and an evaluation relevance of the particular delivery system, detecting energy data and emissions data of the delivery system corresponding to the determined service level of the delivery system, and calculating at least one indicator based on the detected energy data and emissions data and/or based on data for the energy management and environmental management of the delivery system for evaluating the delivery system with respect to the energy efficiency and emissions efficiency thereof. | 08-01-2013 |
Katrin Müller, Berlin DE
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20090214380 | LOW-MIGRATION COPPER ALLOY - The present invention relates to a copper alloy, in particular for components which carry media or drinking water, in particular fittings, valves or compression joints and also an advantageous use of the copper alloy and components for lines carrying media or drinking water. It is an object of the present invention to provide a copper alloy which has good corrosion resistance, good castability and mechanical workability and also good mechanical properties and displays good migration values, particularly in respect of the migration of lead and nickel ions into drinking water. The copper alloy provided for this purpose by the present invention comprises from 2% by weight to 4.5% by weight of silicon, from 1 to 15% by weight of zinc and from 0.05% by weight to 2% by weight of manganese. Furthermore, from 0.05 to 0.4% by weight of aluminium and from 0.05 to 2% by weight of tin can optionally be present. As balance, the copper alloy contains copper and unavoidable impurities. | 08-27-2009 |
20130198095 | Method and Device for Automatically Evaluating a Delivery System - A method for automatically evaluating a delivery system with respect to the energy efficiency and emissions efficiency thereof, may include: determining a service level for the delivery system according to an energy intensity and an evaluation relevance of the particular delivery system, detecting energy data and emissions data of the delivery system corresponding to the determined service level of the delivery system, and calculating at least one indicator based on the detected energy data and emissions data and/or based on data for the energy management and environmental management of the delivery system for evaluating the delivery system with respect to the energy efficiency and emissions efficiency thereof. | 08-01-2013 |
Klaus-Robert Müller, Berlin DE
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20080201278 | Method and Apparatus for Automatic Online Detection and Classification of Anomalous Objects in a Data Stream - The invention is concerned with a method for automatic online detection and classification of anomalous objects in a data stream, especially comprising datasets and/or signals, wherein a) the detection of at least one incoming data stream containing normal and anomalous objects, b) automatic construction of a geometric representation of normality the incoming objects of the data stream at a time t | 08-21-2008 |
20080255767 | Method and Device For Detection of Splice Form and Alternative Splice Forms in Dna or Rna Sequences - The invention relates to a method and a device for detection of splice sites in DNA or RNA sequences comprising three steps: a) examining a training set of sequences comprising DNA or RNA sequences with known splice sites by an automated, discriminative training device for detecting splicing patterns, especially in a predetermined window around the known splice sites; b) scanning a sequence comprising DNA or RNA sequences containing unknown splice sites for the occurrence of the splicing patterns detected in step a); and c) calculation of a cumulative splice score in dependence of a maximization of the margin between the true splice forms and all wrong splice forms in the sequence. The invention also relates to a method and a device for detection of splice forms and alternative splice forms in DNA or RNA sequences. | 10-16-2008 |
20090024555 | Method and Apparatus for Automatic Comparison of Data Sequences - The invention is concerned with a method and an apparatus for automatic comparison of at least two data sequences characterized in—an evaluation of a local relationship between any pair of subsequences in two or more sequences; —an evaluation of a global relationship by means of aggregation of the evaluations of said local relationships. | 01-22-2009 |
20100060300 | SENSOR SYSTEM AND METHODS FOR THE CAPACITIVE MEASUREMENT OF ELECTROMAGNETIC SIGNALS HAVING A BIOLOGICAL ORIGIN - The invention relates to a sensor system and several method for the capacitive measurement of electromagnetic signals having a biological origin. Such a sensor system comprises a capacitive electrode device ( | 03-11-2010 |
Klaus-Robert Müller, Berlin DE
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20100060300 | SENSOR SYSTEM AND METHODS FOR THE CAPACITIVE MEASUREMENT OF ELECTROMAGNETIC SIGNALS HAVING A BIOLOGICAL ORIGIN - The invention relates to a sensor system and several method for the capacitive measurement of electromagnetic signals having a biological origin. Such a sensor system comprises a capacitive electrode device ( | 03-11-2010 |
20110246578 | Method and system for analyzing messages - The invention relates to a method and system for analyzing messages transmitted in a communication network. An embodiment of the method comprises the steps of: determining an information-related citation index indicating how often information comprised in a message has been forwarded in consecutive messages to other users of the communication network, and providing an analysis result based on the information-related citation index. | 10-06-2011 |
Manfred Müller, Berlin DE
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20100285693 | OVERVOLTAGE PROTECTION MAGAZINE - A connecting strip ( | 11-11-2010 |
Rainer Helmut Müller, Berlin DE
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20090297565 | METHOD AND DEVICE FOR PRODUCING VERY FINE PARTICLES AND COATING SUCH PARTICLES - Disclosed are methods and devices for producing very fine particles which are then coated with protective polymers in another step of the process. The particles are produced using a method in which a liquid flow comprising a particle-free liquid 1 that contains the active substance in a dissolved form is combined with a second liquid flow comprising a liquid 2 in a high-energy zone or no sooner than two seconds before reaching the high-energy zone. Said two liquids can be mixed with each other while the active substance dissolved in liquid 1 is insoluble or more difficult to dissolve in liquid 2 than in liquid 1 and settles in the form of particles in the high-energy zone or within a maximum of 2 seconds before reaching the high-energy zone when the two liquids are mixed. The obtained particles are introduced into an aqueous outer phase which contains the coating materials in a dissolved form and are then subjected to a drying step such that said materials settle on the particles as a closed coating. The coated particles are protected from damaging influences and are provided with modified release kinetics compared to uncoated particles. | 12-03-2009 |
Rainer Helmut Müller, Berlin DE
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20090297565 | METHOD AND DEVICE FOR PRODUCING VERY FINE PARTICLES AND COATING SUCH PARTICLES - Disclosed are methods and devices for producing very fine particles which are then coated with protective polymers in another step of the process. The particles are produced using a method in which a liquid flow comprising a particle-free liquid 1 that contains the active substance in a dissolved form is combined with a second liquid flow comprising a liquid 2 in a high-energy zone or no sooner than two seconds before reaching the high-energy zone. Said two liquids can be mixed with each other while the active substance dissolved in liquid 1 is insoluble or more difficult to dissolve in liquid 2 than in liquid 1 and settles in the form of particles in the high-energy zone or within a maximum of 2 seconds before reaching the high-energy zone when the two liquids are mixed. The obtained particles are introduced into an aqueous outer phase which contains the coating materials in a dissolved form and are then subjected to a drying step such that said materials settle on the particles as a closed coating. The coated particles are protected from damaging influences and are provided with modified release kinetics compared to uncoated particles. | 12-03-2009 |
Ralf Müller, Berlin DE
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20080303468 | CORRECTION METHOD FOR MICROPROCESSOR-CONTROLLED DIGITAL REGULATION - In a correction method for a microprocessor-controlled digital regulation of a drive motor, wherein the measurement arrangement used for the regulation of the motor is simplified. recognizing that the real value surveying cannot always be implemented periodically by the microprocessor at the requested point in time, making sporadic measurement errors of a simplified measurement arrangement ineffectual, in accordance with the method individual measurement values with a sudden change are read out and correction values are used instead of these for the regulation. | 12-11-2008 |
20110069301 | METHOD AND DEVICE FOR SINTERING AN OBJECT WHILE DETERMINING THE GEOMETRIC SURFACE PROFILE OF THE OBJECT - The invention relates to a method and a device for sintering objects by means of time-resolved detection of two- or three-dimensional surface profiles and, optionally, by means of temperature measurement in a high temperature furnace on the basis of optical measurement methods. During sintering, each surface point on an object can be measured for its position and, optionally, its temperature, and a change can be determined by successive measurements. The measured change additionally permits control of the sintering regime. | 03-24-2011 |
Torsten Müller, Berlin DE
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20090008254 | Microfluidic System and Corresponding Control Method - The invention relates to a microfluidic system containing a carrier current channel ( | 01-08-2009 |
20090148937 | MICRO-FLUIDIC SYSTEM COMPRISING AN EXPANDED CHANNEL - The invention relates to a micro-fluidic system including a fluid medium channel that holds a fluid medium containing particles in suspension. According to the invention, the fluid medium channel has an expanded section with an enlarged cross-section along part of its length, in order to reduce the flow speed to allow the analysis of the particles. | 06-11-2009 |
20090300807 | Method for providing a probe for a probe-microscopic analysis of a test sample in a probe microscope and arrangement with a probe microscope - The present invention relates to a method for providing a measuring probe ( | 12-03-2009 |
20100140111 | METHOD AND ARRANGEMENT FOR ELECTRICALLY CONTACTING AN OBJECT SURROUNDED BY A MEMBRANE, USING AN ELECTRODE - Method and arrangement for making electrical contact with a membrane-enveloped object using an electrode | 06-10-2010 |
20100155246 | ELECTRIC FIELD CAGE AND ASSOCIATED OPERATING METHOD - The invention relates to an electric field cage ( | 06-24-2010 |
20100263096 | MEASURING PROBE DEVICE FOR A PROBE MICROSCOPE, MEASURING CELL AND SCANNING PROBE MICROSCOPE - The invention relates to a measuring probe device for a probe microscope, in particular a scanning probe microscope, with a measuring probe holder and a measuring probe arranged on the measuring probe holder, which is set up for a probe microscopic investigation of a sample, wherein on the measuring probe holder, a measuring probe chamber is formed, which receives the measuring probe at least partially and is open on a side away from the measuring probe holder, and is configured to receive a liquid surrounding the measuring probe. The invention also relates to a measuring cell for receiving a liquid sample for a probe microscope, a scanning probe microscope with a measuring probe device and a scanning probe microscope with a measuring cell. | 10-14-2010 |
20100263098 | METHOD AND APPARATUS FOR THE COMBINED ANALYSIS OF A SAMPLE WITH OBJECTS TO BE ANALYZED - The invention relates to a method for the combined analysis of a sample with objects to be analysed, in particular a sample with biological objects, in which measurement results for one or more of the objects to be analysed in the sample are obtained by analysing the one or more objects to be analysed by an imaging method of measurement, probe-microscopic measurement results are obtained for the one or more objects to be analysed by analysing the one or more objects to be analysed by a probe-microscopic method of measurement, and the measurement results and the probe-microscopic measurement results are assigned to one another, after optional prior intermediate processing. Furthermore, the invention relates to an apparatus for carrying out combined analysis of a sample with objects to be investigated, in particular a sample with biological objects. | 10-14-2010 |
20110083961 | MICROFLUIDIC SYSTEM AND CORRESPONDING OPERATING METHOD - The invention relates to an operating method for a microfluidic system, including the following steps: feeding of a carrier flow with particles ( | 04-14-2011 |
20120305398 | METHODS AND DEVICES FOR SEPARATING PARTICLES IN A LIQUID FLOW - Methods and devices for the separation of particles ( | 12-06-2012 |