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Miller, NH

Bethany B. Miller, Orford, NH US

Patent application numberDescriptionPublished
20130052646POSITIVE AND NEGATIVE SELECTABLE MARKERS FOR USE IN THERMOPHILIC ORGANISMS - The present invention relates to the field of molecular biology and genetic tool development in thermophilic bacteria. In particular, it relates to the use of positive and/or negative selection markers that can be used to efficiently select modified strains of interest. By providing such capabilities, the disclosed invention facilitates the recycling of genetic markers in thermophilic bacterial host cells. The present invention also allows the creation of unmarked strains. The genetic tools disclosed in the present invention are prerequisites for making targeted higher order mutations in a single thermophilic strain background.02-28-2013

Christopher A. Miller, Mont Vernon, NH US

Patent application numberDescriptionPublished
20130230062END-PUMPED ALIGNMENT AND TEMPERATURE INSENSITIVE LASER TARGET DESIGNATOR AND MARKER - A compact, lightweight, laser target designator uses a TIR bounce geometry to place an end-pumped gain element functionally in the center of the resonator path, thereby allowing the resonator path to be terminated by a pair of crossed Porro prisms, so that the designator produces a high quality beam that is insensitive to alignment and temperature, and is low in manufacturing cost. Some embodiments fold the Porro legs of the resonator path back toward the gain element for compactness. Embodiments use a single gain element as both an oscillator gain element with TIR and as an output amplifier gain element without TIR. Various embodiments use block optical elements in a planar layout on a standard support medium such as aluminum to facilitate automated manufacturing.09-05-2013

Glen P. Miller, Lee, NH US

Patent application numberDescriptionPublished
20110130593SOLUBLE, PERSISTENT NONACENE DERIVATIVES - The present invention is directed towards a new class of semi-conducting nonacene derivatives. These compounds are all soluble species and they all possess superior resistance to oxidation as compared to their counterparts that lack the substitution patterns disclosed herein.06-02-2011
20110130594CLASS OF SOLUBLE, PHOTOOXIDATIVELY RESISTANT ACENE DERIVATIVES - The present invention is directed towards a new class of semi-conducting acene derivatives. These compounds are all soluble species and they all possess superior resistance to photooxidation as compared to their counterparts that lack the substitution patterns disclosed herein.06-02-2011

Jeffrey B. Miller, Salem, NH US

Patent application numberDescriptionPublished
20150340526NANOWIRE DEVICE WITH ALUMINA PASSIVATION LAYER AND METHODS OF MAKING SAME - In one aspect, the present disclosure relates to a device including a silicon substrate, wherein at least a portion of the substrate surface can be a silicon nanowire array; and a layer of alumina covering the silicon nanowire array. In some embodiments, the device can be a solar cell. In some embodiments, the device can be a p-n junction. In some embodiments, the p-n junction can be located below the bottom surface the nanowire array.11-26-2015

Michael B. Miller, Hanover, NH US

Patent application numberDescriptionPublished
20130085263METHOD FOR NON-COVALENT IMMOBILIZATION OF INFECTIOUS PRION PROTEIN - The present invention is method for non-covalently immobilizing an infectious prion protein using a magnetic substrate.04-04-2013

Michael F. Miller, Hollis, NH US

Patent application numberDescriptionPublished
20090068759REUSABLE DETECTION SURFACES AND METHODS OF USING SAME - The technology provided herein generally relates to reusable detection surfaces and methods for reusing a detection surface after using the detection surface in an assay for an analyte.03-12-2009
20090194181Fluidic System with Improved Flow Characteristics - The invention relates to a fluidic system that includes a body structure having a chamber disposed therein. The fluidic system includes at least one fluid input at a first end of the chamber and at least one fluid output at a second end of the chamber. The fluidic system also includes a sensor device (e.g., an acoustic device) having a surface defining a portion of a surface of the chamber. The fluidic system also includes a first surface at the first end of the chamber oriented at an oblique or arcuate (e.g., curved) angle relative to the surface of the sensor device to direct fluid through the chamber.08-06-2009
20090269248METHOD AND APPARATUS FOR ANALYTE PROCESSING - A system for processing analytes in samples includes an instrument and a cartridge. The cartridge includes fluid inputs, input and output valve assemblies, processing devices, fluid reservoirs, and channels for carrying samples from the fluid inputs to the fluid reservoirs. The valve assemblies include valves adapted to form a sealed fluid chamber in response to force applied by a movable head assembly of the instrument. Each fluid reservoir is adapted to mate and align with an air displacement pump interface member. A valve assembly includes a recess wall surrounding a recess and a valve assembly wall surrounding both the recess and the recess wall. The recess wall and the valve assembly walls are adapted to mate with and seal against a flexible sheet covering the recess, the recess wall, and the valve assembly wall. The cartridge and instrument include complementary features for finely and coarsely aligning instrument assemblies with portions of the cartridge.10-29-2009
20140037504Electrically Responsive Device - In some aspects, an electrically responsive device can include a composite structure having spatially modulated structural properties that includes a substrate material having a surface and defining a plane; an electrically responsive material layer formed over at least a portion of the surface of the substrate material; an electrode material over portions of the electrically responsive material; and a stiffening material disposed along the electrode material, where the stiffening material has a thickness that varies and has regions of increased thickness that correspond with the regions of the composite structure along which the electrode material is disposed. The spatially modulated structural properties can include the regions of the composite structure along which the electrode material is disposed having the increased material stiffness, exclusive of the electrode material, relative to regions of the composite structure that do not include the electrode material.02-06-2014

Patent applications by Michael F. Miller, Hollis, NH US

Michael Francis Miller, Hollis, NH US

Patent application numberDescriptionPublished
20150031047Methods and Systems For the Rapid Characterization of Functional Biological Molecules - In one non-limiting aspect, the invention provides a method for detecting the quality of a biological molecule comprising forming a first mixture of ingredients comprising: (i) a first binding agent that specifically binds to a tag, wherein the first binding agent is attached to a solid support; (ii) a decoy comprising a first portion comprising the tag attached to a second portion comprising an anchor; (iii) a sensor attached to a second binding agent that specifically binds to the anchor; and (iv) a sample suspected of containing a high quality biological molecule comprising a tag, wherein the tag of the high quality biological molecule is accessible; allowing interaction of the ingredients such that the sensor provides an output signal01-29-2015

Michael I. Miller, Jackson, NH US

Patent application numberDescriptionPublished
20100149177GENERATION OF NORMALIZED 2D IMAGERY AND ID SYSTEMS VIA 2D TO 3D LIFTING OF MULTIFEATURED OBJECTS - A method of generating a normalized image of a target head from at least one source 2D image of the head. The method involves estimating a 3D shape of the target head and projecting the estimated 3D target head shape lit by normalized lighting into an image plane corresponding to a normalized pose. The estimation of the 3D shape of the target involves searching a library of 3D avatar models, and may include matching unlabeled feature points in the source image to feature points in the models, and the use of a head's plane of symmetry. Normalizing source imagery before providing it as input to traditional 2D identification systems enhances such systems' accuracy and allows systems to operate effectively with oblique poses and non-standard source lighting conditions.06-17-2010
20100284595AUTOMATED IMAGE ANALYSIS FOR MAGNETIC RESONANCE IMAGING - A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner configured to generate a plurality of signals for forming at least one magnetic resonance image of a soft tissue region from a subject under observation, wherein the at least one magnetic resonance image provides at least one integrating feature to facilitate automatic segmentation; a signal processing system in communication with the magnetic resonance imaging scanner to receive the plurality of signals; and a data storage unit in communication with the signal processing system, wherein the data storage unit contains at least one template corresponding to the soft tissue region, wherein the signal processing system is adapted to process the plurality of signals received from the magnetic resonance imaging scanner to automatically perform segmentation for the soft tissue region of the subject under observation by utilizing the at least one template and the at least one integrating feature.11-11-2010
20150015253AUTOMATED IMAGE ANALYSIS FOR MAGNETIC RESONANCE IMAGING - A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner configured to generate a plurality of signals for forming at least one magnetic resonance image of a soft tissue region from a subject under observation, wherein the at least one magnetic resonance image provides at least one integrating feature to facilitate automatic segmentation; a signal processing system in communication with the magnetic resonance imaging scanner to receive the plurality of signals; and a data storage unit in communication with the signal processing system, wherein the data storage unit contains at least one template corresponding to the soft tissue region, wherein the signal processing system is adapted to process the plurality of signals received from the magnetic resonance imaging scanner to automatically perform segmentation for the soft tissue region of the subject under observation by utilizing the at least one template and the at least one integrating feature.01-15-2015

Patent applications by Michael I. Miller, Jackson, NH US

Owen F. Miller, Alstead, NH US

Patent application numberDescriptionPublished
20110033698Liner-Free Label and Systems - The invention relates to a liner-free label activator, adapted to be joined to another piece of equipment, such as a thermal printer. The activator has a housing including a reservoir for containing a solvent and a pump connected to the reservoir. The activator also has an applicator connected to the pump for applying solvent to a liner-free label passing thereby, an activator control system to connect to a control system of the printer, and structure for connecting the housing to the printer.02-10-2011

Owen Frederick Miller, Alstead, NH US

Patent application numberDescriptionPublished
20150284127Liner-Free Label and Systems - The invention relates to a liner-free label activator, adapted to be joined to another piece of equipment, such as a thermal printer. The activator has a housing including a reservoir for containing a solvent and a pump connected to the reservoir. The activator also has an applicator connected to the pump for applying solvent to a liner-free label passing thereby, an activator control system to connect to a control system of the printer, and structure for connecting the housing to the printer.10-08-2015

Paul Nelson Miller, Derry, NH US

Patent application numberDescriptionPublished
20130064080SYSTEMS AND METHODS FOR INTELLIGENT NETWORK EDGE TRAFFIC AND SIGNALING MANAGEMENT - Systems and methods for intelligent network edge traffic and signaling management are disclosed. According to an aspect, a method for controlling network edge traffic may include receiving network traffic flow information from a network element. The method may also include determining a control command for a network edge element based on the network traffic flow information. Further, the method may include communicating the control command to a network for control of network traffic at an edge.03-14-2013

Peter James Miller, Manchester, NH US

Patent application numberDescriptionPublished
20100019745Multiple switch node power converter control scheme that avoids switching sub-harmonics - A method of and system for modulating buck and boost modulation ramps of a multiple switch node power converter without overlap. As the pulse width or duty cycle of the signal to a modulated complementary switching pair approaches a pre-established reference pulse width or duty cycle, plural fixed-width or fixed duty cycle pulses are generated and introduced to a nonmodulated complementary switching pair. A controller detects proximity to the pulse width or duty cycle limit and, correspondingly, initiates prematurely a pseudo-buck-boost mode in the power converter by generating fixed-width or fixed duty cycle pulses to the nonmodulated complementary switching pair while the duty cycles or pulse widths to the modulated complementary switching pair are still controlled by the appropriate modulation ramp. The net effect is that the power converter reaches its optimal operating point without overlap and eliminates any sub-harmonic switching.01-28-2010
20100097123Keep-alive for power stage with multiple switch nodes - A keep alive circuit for recharging bootstrap capacitors in multiple totem-pole switching power stages using N-channel field effect transistor or NPN bipolar junction transistor switching devices during 100% or substantially 100% duty cycle operation of one of the totem pole pairs.04-22-2010

Steven G. Miller, Milton, NH US

Patent application numberDescriptionPublished
20090222001Fluid-Assisted Electrosurgical Devices, Methods and Systems - The invention provides a bipolar electrosurgical device to treat tissue in a presence of radio frequency energy and a fluid provided from the device. In one embodiment, the device comprises a first electrode and a second electrode at the end of a malleable shaft assembly to be hand shapeable by a user of the device, and at least one fluid outlet. The malleable shaft assembly comprises a first shaft and a second shaft, a length of the first shaft and a length of the second shaft in an outer member comprising a polymer, and at least a portion of the first shaft and at least a portion of the second shaft being malleable.09-03-2009
20110125146Cartridge Assembly For Electrosurgical Devices, Electrosurgical Unit And Methods Of Use Thereof - The invention provides a cartridge assembly to couple a tissue treatment device with an electrosurgical unit, with the cartridge assembly operable with a power delivery apparatus and a fluid delivery apparatus of the electrosurgical unit. The invention also provides an electrosurgical unit comprising a power delivery apparatus and a fluid delivery apparatus operable with the cartridge assembly and a system thereof.05-26-2011
20110178515Electrosurgical Devices, Electrosurgical Unit and Methods of Use Thereof - A cartridge assembly to couple an electrosurgical device to treat tissue with an electrosurgical unit includes a cartridge member to operate with a power delivery apparatus of the electrosurgical unit and a fluid delivery apparatus of the electrosurgical unit. An electrosurgical unit includes a power delivery apparatus and a fluid delivery apparatus arranged to operate with a cartridge member to be located in a cartridge receptacle of the electrosurgical unit. An electrosurgical device includes a first electrode spaced alongside the second electrode, with each electrode having a blade shaped member. Each blade shaped member has opposing sides bounded by edges, with the edges having a medial edge and a lateral edge. At least one fluid outlet is adjacent each blade shaped member, and each fluid outlet is in fluid communication with a fluid passage. The device can be operated as either a bipolar device or a monopolar device and includes a switch to inhibit capacitive coupling to one of the electrodes when the other electrode is used in monopolar fashion.07-21-2011
20110295249Fluid-Assisted Electrosurgical Devices, and Methods of Manufacture Thereof - This invention provides a fluid-assisted electrosurgical device to treat tissue in a presence of radio frequency energy and a fluid provided from the device. The device comprises a handle, a rigid shaft member distal to the handle, and at least one electrode distal to the shaft member. The shaft member comprises a shaft member first body and a shaft member second body joined together along a length of the shaft member. The shaft member further comprises a plurality of longitudinally oriented shaft member passages, with each of the passages having a length defined by the shaft member first body and the shaft member second body.12-01-2011
20140026395FLUID-ASSISTED ELECTROSURGICAL DEVICES, AND METHODS OF MANUFACTURE THEREOF - A method of producing an electrosurgical device is disclosed. Opposing longitudinal clamshells are formed, and each clamshell includes a face having a generally planar major portion. Longitudinal grooves are formed in a clamshell, and an electrical conductor in a disposed in a groove. The faces are aligned to form an electrical passage including the electrical conductor in the groove and a spaced-apart fluid passage with another groove. The clamshells are welded together to form a shaft member such that the electrical passage and the fluid passage are fluid tight along a major longitudinal portion of the shaft. Electrodes are attached to the distal end of the shaft and are in electrical communication with the electrical conductor.01-30-2014
20150157386ELECTROSURGICAL DEVICES, ELECTROSURGICAL UNIT AND METHODS OF USE THEREOF - A cartridge assembly to couple an electrosurgical device to treat tissue with an electro surgical unit includes a cartridge member to operate with a power delivery apparatus of the electro surgical unit and a fluid delivery apparatus of the electro surgical unit. An electrosurgical unit includes a power delivery apparatus and a fluid delivery apparatus arranged to operate with a cartridge member to be located in a cartridge receptacle of the electrosurgical unit. An electrosurgical device includes a first electrode spaced alongside the second electrode, with each electrode having a blade shaped member. Each blade shaped member has opposing sides bounded by edges, with the edges having a medial edge and a lateral edge. At least one fluid outlet is adjacent each blade shaped member, and each fluid outlet is in fluid communication with a fluid passage. The device can be operated as either a bipolar device or a monopolar device and includes a switch to inhibit capacitive coupling to one of the electrodes when the other electrode is used in monopolar fashion.06-11-2015

Patent applications by Steven G. Miller, Milton, NH US

Wilburn M. Miller, Wilton, NH US

Patent application numberDescriptionPublished
20090033345System and method for characterizing a load at the end of a cable - Apparatus within power sourcing equipment and a method for determining whether a load within a powered device coupled to the power sourcing equipment via a cable is within an acceptable resistance range. If the load is within the acceptable resistance range, a voltage source is coupled to the load. In one embodiment one recharge interval is employed during which a capacitor is charged based, at least in part, on the voltage drop across the load and one discharge interval is employed during which a capacitor is discharged based, at least in part, on the voltage drop across the load. In a second embodiment, first and second recharge and discharge intervals are employed and prior to initiation of the recharge and discharge intervals, settling time periods are provided.02-05-2009
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