Milburn, US
Andrew Milburn, Los Angeles, CA US
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20130308051 | METHOD, SYSTEM, AND NON-TRANSITORY MACHINE-READABLE MEDIUM FOR CONTROLLING A DISPLAY IN A FIRST MEDIUM BY ANALYSIS OF CONTEMPORANEOUSLY ACCESSIBLE CONTENT SOURCES - A display in a first medium is controlled in response to commands generated by analyzing a second, contemporaneously available medium such as a video accompanied by a soundtrack having components in first and second domain. A transform is applied to signals in the first domain to generate signals in the second domain. The second domain signals are ordered according to a rule and used to produce a command signal or signals to produce time varying commands to vary at least one parameter of the video signal. | 11-21-2013 |
20130308621 | DIRECTED WI-FI NETWORK IN A VENUE INTEGRATING COMMUNICATIONS OF A CENTRAL CONCERT CONTROLLER WITH PORTABLE INTERACTIVE DEVICES - Communications between a central concert controller and portable interactive devices of audience members in a venue are integrated through a Wi-Fi network providing coverage of the venue. A multi-megabit traffic exchange without loss of data is achieved. Both omnidirectional and highly directional radios utilize a single frequency in order to provide a signal to areas that are not in a line of sight of a single Wi-Fi source. Each directional radio includes a backhaul transceiver. Users are sent images such as streaming videos by a video jockey, and may upload content to the central system. A server within the system controls interactions of user devices. Each user device may be assigned a unique ID number. | 11-21-2013 |
20130310083 | METHOD AND APPARATUS FOR MANAGING BANDWIDTH BY MANAGING SELECTED INTERNET ACCESS BY DEVICES IN A WI-FI LINKED AUDIENCE - A central controller associated with a performance interacts with portable interactive devices such as smartphones in a venue to provide a shared user experience. The controller may be linked to portable interactive devices by a Wi-Fi link in the venue. Additionally, the controller may need to interface with the outside world via the Internet to add information to the experience. In order to prevent excessive bandwidth demands on the Internet connection, a URL filter is coupled to block all requests for connection to the Internet except those required for running the interactive system or device and transferring information. The filter permits access to a limited number of specific URLs for selected social networks, e.g., Facebook®. Permitted data is throttled to a low data rate so that it is acquired over time. It is unnecessary to gather the data in real time. Consequently, bandwidth requirements are minimized. | 11-21-2013 |
20130311566 | METHOD AND APPARATUS FOR CREATING RULE-BASED INTERACTION OF PORTABLE CLIENT DEVICES AT A LIVE EVENT - A system creates an enhanced experience at a concert or other event. A central server provides commands through which information is sent or gathered or both between portable interactive devices of audience members and a central server. A shared experience such as a common display sent to all users is created. A system “app” is installed in the portable interactive device. Rules are implemented in a processor to enable a game to be played by audience members in which a processor enables interaction of users with the server and in which the processor processes user inputs according to rules of the game. | 11-21-2013 |
20130311581 | TRANSMISSION OF COMMAND EXECUTION MESSAGES FOR PROVIDING A SHARED EXPERIENCE TO BOTH INTERNAL, AT-VENUE PARTICIPANTS, AND EXTERNAL, NETWORKED PARTICIPANTS - Command execution messages are transmitted to both internal, at-venue participants and external, networked participants. An event server sends messages to local, at-venue users. In order to avoid overloading the event server, transmissions to remote users are directed to a staging server that is not required to be at the venue. Cloud capability may be utilized. The event server may send a message to the staging server. The staging server will subsequently send the message to all registered remote participants. Incoming messages from remote participants are processed by the staging server to determine if the messages need to be sent to the event server. If so, compression and other techniques to reduce the size of messages relayed to the event server are used. | 11-21-2013 |
20130325928 | CONCERT SERVER INCORPORATING FRONT-END AND BACK-END FUNCTIONS TO COOPERATE WITH AN APP TO PROVIDE SYNCHRONIZED MESSAGING TO MULTIPLE CLIENTS - In a communications system, a controller communicates to multiple client devices, each subject to a different latency, in an application in which the multiple client devices need to react substantially simultaneously to a command from a server. A controller front-end in a server provides an abstract environment for the acceptance, initiation, and processing of messages. The framework provides a scaffold which handles reception of messages and makes them available to the specific application business logic as events to be processed. A back-end enables synchronized command execution, abstracted database table definition, creation of generalized table access, selective message transmission, and the like. By providing the back-end and front-end foundation framework, the present subject matter provides the foundational components in the system so that development of mobile applications is simplified. | 12-05-2013 |
20140019520 | METHOD AND SYSTEM FOR SYNCHRONIZED DISTRIBUTED DISPLAY OVER MULTIPLE CLIENT DEVICES - Portable interactive devices of audience members are remotely operated to substantially “simultaneously” respond to a signal from an origin, e.g., a central server, despite variation in latencies among the devices in order to produce a shared experience. The audience members are reached through varying communication links. Latencies vary among portable interactive devices and among carriers. A firing time for the portable interactive devices is selected to occur at a time in the future. An execution time at which a respective portable interactive device is commanded to operate is a function of the firing time minus the latency control signal reaches clients in a venue in an audience or at a remote location simultaneously despite the varying latencies. | 01-16-2014 |
Andrew Morton Milburn, New Paltz, NY US
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20090077170 | System, Architecture and Method for Real-Time Collaborative Viewing and Modifying of Multimedia - A system, architecture and method for real-time viewing and collaborative modification of data is disclosed. The platform utilizes pointers to quickly and efficiently render data at a user location. A mechanism for viewing and disseminating modifications in real-time is disclosed. | 03-19-2009 |
Claire Milburn, Thousand Oaks, CA US
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20090018116 | Therapeutic Compounds - Compounds of formula I or pharmaceutically acceptable salts thereof: | 01-15-2009 |
20090181968 | Novel 3-Bicyclocarbonylaminopyridine-2-Carboxamides or 3-Bicyclocarbonylaminopyrazine-2-Carboxamides - The present invention relates to compounds of formula (I) [Chemical formula should be inserted here. Please see paper copy] as well as pharmaceutically acceptable salts and pharmaceutical compositions including the compounds are prepared or thereof: wherein, A | 07-16-2009 |
Cody E. Milburn, Brookland, AR US
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20140312757 | BOLSTER FOR A SAFETY CABINET - A cabinet including a receptacle having a floor, a front wall, a rear wall, and a pair of opposed sidewalls extending upwardly from the floor. A plurality of bolsters is attached to the floor, each bolster including a lower panel defining at least a first aperture having a longitudinal center axis, and a first and a second sidewall, each extending from the lower panel toward the floor, the first sidewall defining an acute angle with the lower panel and defining a first aperture disposed vertically above a corresponding first aperture of the lower panel. A leg is rotatably received within the first aperture so that rotation of the leg results in the leg moving axially with respect to the lower panel. | 10-23-2014 |
Daniel S. Milburn, Cary, NC US
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20110289046 | Systems and Methods for Archiving Business Objects - The invention relates to systems and methods for archiving business objects, particularly unstructured information from email and journaling agents and file systems. The systems and methods include a remotely installed archiving agent on a target server connected via VPN to a source system at a client location. The target servers are located at a remote Tier IV, SAS70 certified data center that is staffed by operators monitoring the archive process. The systems and methods include the movement of data from individual target servers to individual SQL servers to a data warehouse which provides support for a web portal. This web portal allows for enhanced search capabilities across different file types of archived business objects. | 11-24-2011 |
David E. Milburn, Highland, MI US
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20130076902 | ROBOTICALLY OPERATED VEHICLE CHARGING STATION - A robotic charging station for charging a battery of an electric vehicle includes a base plate, a riser coupled with the base plate and extending substantially transverse to the base plate, and a robotic arm. The robotic arm extends from the riser and supports an end effector. The end effector includes a plurality of electrical contacts configured to couple with a receptacle disposed on the electric vehicle. The robotic arm is configured to move the end effector in three degrees of motion. | 03-28-2013 |
David W. Milburn, Middlebury, CT US
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20160050964 | ALL NATURAL JUICE BEVERAGE - A juice beverage includes 96.00% to 94.00% watermelon juice, 5.00% to 3.00% lime juice, and 2.50% to 0.50% beet juice. A method for making a juice beverage includes extracting watermelon juice from watermelons, extracting whole beet juice from whole beets, and adding the extracted whole beet juice to the extracted watermelon juice in a specified percentage by volume. | 02-25-2016 |
Greg Milburn, Fort Collins, CO US
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20090257481 | IDENTIFICATION OF BOARD CONNECTIONS FOR DIFFERENTIAL RECEIVERS - Embodiments of the invention include testing arrangements for detecting proper DC-coupled board connections on the input legs of a differential receiver. The testing implementation includes a first test receiver AC-coupled to the connection between the first input/output (I/O) pad and the differential receiver positive input and/or a second test receiver coupled to the connection between the second I/O pad and the differential receiver negative input. The test receiver protects the test receiver input from DC voltages applied to the differential receiver via the differential receiver input. Also, the test receiver includes a high-pass filter arrangement that generates data capable of detecting whether the I/O pad connected to the test receiver has a proper DC-coupled connection or an improper connection when presented with a stimulus pulse. The test receiver is less susceptible to noise because than conventional arrangements that use a low-pass RC filter. | 10-15-2009 |
James Milburn, Irvine, CA US
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20130092012 | BRAIDING MECHANISM AND METHODS OF USE - A device and method for forming a tubular braid comprising a plurality of filaments. The braiding machine comprises a disc with a mandrel extending from the center in a perpendicular direction and a plurality of catch mechanisms arranged circumferentially around the edge of the disc. A plurality of filaments are temporarily affixed to the mandrel, each filament extending from the mandrel toward the edge of the disc and engaging the edge of the disc at a discrete point of engagement. The plurality of catch mechanisms are attached to actuators adapted to move the catch mechanisms in a generally radial direction relative to the edge of the disc to allow the catch mechanism to engage a subset of the filaments and move the engaged filaments beyond the circumferential edge of the disc. | 04-18-2013 |
James A. Milburn, Irvine, CA US
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20130092013 | BRAIDING MECHANISM AND METHODS OF USE - Devices and methods for forming a tubular braid comprising a plurality of filaments. The braiding machine includes a circular array of filament guiding members defining a plane; a mandrel defining an axis and adapted to carry one or more filaments extending from the mandrel to the circular array; a plurality of filaments extending from the mandrel in a radial array; a plurality of actuator mechanisms disposed operably about the disc; and a rotating mechanism adapted to rotate one or more filaments. The actuator mechanisms and rotating mechanism are configured to move each of the one or more filaments about the mandrel axis in a path comprising a series of arcs and radial movements. The braiding machine may alternately first and second annular members, a mandrel, first and second plurality of tubular wire guides, and a plurality of wires extending from the mandrel. | 04-18-2013 |
20130233160 | BRAIDING MECHANISM AND METHODS OF USE - A tubular braid and mechanisms for forming the braid are described. The mechanism for braiding includes a disc, a mandrel, a plurality of catch mechanisms, and a plurality of actuators. The disc defines a plane and a circumferential edge. The mandrel extends from a center of the disc and is adapted to hold a plurality of filaments extending radially from the mandrel toward the circumferential edge of the disc. The plurality of catch mechanisms are positioned circumferentially around the edge of the disc and are adapted to engage a filament. The plurality of actuators are configured to move relative to one another and are adapted to move the plurality of catch mechanisms in a substantially radial direction relative to the circumferential edge of the disc. | 09-12-2013 |
20130239790 | BRAIDING MECHANISM AND METHODS OF USE - Devices and methods for forming a tubular braid comprising a plurality of filaments. The method for braiding includes the step of loading a plurality of filaments on a mandrel and extending the filaments radially from the mandrel, the plurality of filaments have a first subset and a second subset. Tension is applied to the plurality of filaments using a weight attached to each filament. The first subset of the plurality of filaments is engaged, moved circumferentially relative to the second subset, and then released. The second subset of filaments is then engaged and moved circumferentially relative to the first subset of filaments, such that a tubular braid of filaments is formed. | 09-19-2013 |
20140318354 | BRAIDING MECHANISM AND METHODS OF USE - A braiding machine and methods of braiding are described. The braiding machine includes first and second annular members having inclined surfaces, the second annular member being concentric with the first annular member. The inclined surfaces are inclined at a non-zero angle formed between an axis of the outer ring and a horizontal axis that lies perpendicular to the longitudinal axis of the mandrel. Each of the annular members has a plurality of tubular guide wires slideably mounted thereon and a plurality of wires extend from the mandrel through each of the tubular wire guides. One of the first and second annular members rotates circumferentially relative to the other. The first plurality of tubular wire guides slides radially inward so as to align with the second annular member, and the second plurality of tubular wire guides slides radially outward so as to align with the first annular member. | 10-30-2014 |
20140318355 | BRAIDING MECHANISM AND METHODS OF USE - Mechanisms and methods for forming a tubular braid are described. The mechanism for braiding includes a disc, a mandrel, a plurality of catch mechanisms, a plurality of actuators, and a computer program. The disc defines a plane and a circumferential edge. The mandrel extends from a center of the disc and is adapted to hold a plurality of filaments extending radially from the mandrel toward the circumferential edge of the disc. The plurality of catch mechanisms are positioned circumferentially around the edge of the disc and are adapted to engage a filament. The plurality of actuators are configured to move relative to one another and are adapted to move the plurality of catch mechanisms in a substantially radial direction relative to the circumferential edge of the disc. | 10-30-2014 |
John Milburn, Georgetown, TX US
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20090096469 | Determining Key Resistance Values - A system for determining a correct resistor key value for a vehicle equipped with a theft deterrent system includes a test key having two electrical contacts positioned to engage respective contacts of a vehicle theft deterrent system when the test key is inserted into a vehicle ignition key receptacle, and a scanner connected to the electrical contacts of the test key. The scanner includes a controller configured to sequentially apply a series of discrete, fixed electrical resistance values across the key contacts while the key is inserted in the receptacle, to determine which resistance value corresponds to a resistance value required to activate the ignition. | 04-16-2009 |
John Milburn, Palo Alto, CA US
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20140344458 | Device and method for distributing load of server based on cloud computing - A load distribution device that distributes load of a target server is provided. The load distribution device includes a load detection unit that monitors a load amount of the target server and determines whether the load amount exceeds a predetermined critical value, a server driving unit that drives a replication server when the load amount exceeds the critical value, and a server control unit that distributes part of load to the replication server when the replication server has started to be driven. The replication server is implemented by a cloud computing technique. | 11-20-2014 |
Jonathan Terrill Milburn, Kingsport, TN US
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20140113094 | COPOLYESTERS CONTAINING NEOPENTYL GLYCOL AND 2,2,4,4-TETRAALKYL 1,3-CYCLOBUTANEDIOL - There is provided an article comprising a copolyester containing residues of neopentyl glycol, 2,2,4,4-tetraalkyl 1,3-cyclobutanediol such as 2,2,4,4-tetramethyl 1,3-cyclobutanediol, tin atoms, aluminum atoms, an alkali or alkaline earth metal atoms such as lithium atoms, optionally phosphorus atoms, and having an It.V. of at least 0.55 dL/g, and Tg of at least 90° C. Such higher It.V. copolyesters can now be made having high Tg, good thermal stability, and higher insertion of 2,2,4,4-tetraalkyl 1,3-cyclobutanediol. | 04-24-2014 |
Joshua Milburn, Oakland, CA US
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20150287263 | SOLAR LIGHTING WITH PAY-AS-YOU GO TECHNOLOGY - Disclosed are systems, devices and methods for providing solar lighting and power to a customer by using pay-as-you-go (PAYG) technology. The PAYG technology allows a customer to make incremental payments for a solar energy system that includes a lighting unit. The payments can be made through a smartphone. A cable is used to connect an audio jack of the smartphone and a PV power jack of the lighting unit. Analog AC signals including data about activation, payment, usage and status are transmitted over the cable between the service provider and lighting unit, through a smartphone. The power jack of the lighting unit is also used to connect to a solar panel of a charging unit and a battery of the lighting unit. | 10-08-2015 |
Kenneth Milburn, Wolverine Lake, MI US
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20100088909 | VEHICLE DRIVE AXIS ALIGNMENT DEVICE - An alignment device measures an angular offset between a vehicle body axis and a vehicle drive axis. The device includes an arm having a mounting portion for mounting to a vehicle such that the arm is aligned with the vehicle body axis. A wheel support member is coupled to the arm for rotation relative to the arm. A wheel is rotatably supported by the wheel support member and configured to roll on a ground surface, such that the wheel and the wheel support member are configured to self-align with the vehicle drive axis when the arm is mounted to the vehicle and the vehicle is driven on the ground surface. An indicator displays the angular offset between the wheel support member and the arm, which is indicative of the angular offset between the vehicle body axis and the vehicle drive axis. A method of carrying out a measurement with the device is also disclosed. | 04-15-2010 |
20120265395 | TIRE PRESSURE MONITORING SYSTEMS AND METHODS - A system for determining if a tire of a vehicle is improperly inflated. The system includes a radar, a wheel speed sensor, and a controller. The radar is configured to emit a signal generally parallel to a surface the vehicle is traveling on, to detect a reflection of the signal off of an object positioned perpendicular to the vehicle, and to output an indication of a speed of the vehicle. The wheel speed sensor is configured to sense a speed of a wheel of the vehicle. The controller is coupled to the radar and the wheel speed sensor, and is configured to receive the indication of the speed of the vehicle from the radar, to calculate a speed of the vehicle based on the sensed speed of the wheel, and to determine a tire of the wheel is improperly inflated when the speed of the vehicle calculated using the wheel speed sensor varies by more than a predetermined amount from the speed of the vehicle determined using the radar signal. | 10-18-2012 |
Lawrence E. Milburn, Bel Air, MD US
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20090015410 | WIRELESS ASSET MONITORING AND SECURITY SYSTEM - An asset monitoring and security system includes at least one asset assigned a unique identifier and operable wirelessly transmit an identification signal embodying the identifier. A data store maintains a list of the assets and privileges associated with the assets for authorized users of the assets. A control unit is adapted to receive identification signals from the assets and monitor positions of the assets within a defined area. The control unit communicates with the data store and is further operable to initiate an alarm event when privileges associated with a given asset for authorized users of the asset are exceeded. Each of the assets includes a lock-out mechanism that impedes use of the asset when the lock-out mechanism is activated. The control unit activates the lock-out mechanism of a given asset when the privileges associated with the asset for authorized users of the asset are exceeded. | 01-15-2009 |
Mark Milburn, Missoula, MT US
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20100237307 | Modular solar fence system - Exemplary embodiments include a solar and non-solar fence slat designs for use in a modular fence system. The fence slat comprises an elongated slat body having a front side wall, a back side wall, bottom side wall, top side wall, right side wall and left side wall. The slat first and second fasteners coupled to right and left sides of the elongated slat body and being configured to couple or interlock with adjacent slats. The slat also includes at least one chain-link interface coupler coupled to the back side wall to connect to at least one horizontal cross-bar of a chain-link fence. In an embodiment, the fence slat has a solar panel integrated therewith. | 09-23-2010 |
Martin Thomas Milburn, Harrodsburg, KY US
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20100289185 | GROOVE IMPRINTING DEVICE FOR INJECTION MOLDED PARTS - The invention provides a mold insert system that includes an insert for insertion into an injection mold apparatus and an actuator. The insert includes a movable imprint plate with a predetermined pattern of protrusions configured to form grooves in an article molded by the mold apparatus. The insert also includes a stationary piece with a pattern of slots configured to correspond to the predetermined pattern of protrusions in the imprint plate. The actuator moves the imprint plate from a first position in which the protrusions on the imprint plate do not extend beyond the slots in the stationary piece to a second position in which the protrusions on the imprint plate extend temporarily beyond the slots in the stationary piece. An injection mold apparatus including the mold insert system, as well as a method of making a molded article including the mold insert system are also provided. | 11-18-2010 |
Matthew Milburn, Boulder Creek, CA US
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20090028781 | CATALYTIC REACTOR METHOD FOR GENERATING HIGH PURITY WATER VAPOR - A catalytic reactor apparatus produces high purity water vapor by reacting hydrogen and oxygen together within a catalytic reaction chamber. The reactants and an inert gas, such as argon gas or nitrogen, are supplied to the catalytic reaction chamber in a controlled fashion by a gas panel. The cylindrical catalytic reaction chamber is preferably constructed of titanium or stainless steel. The catalytic reaction chamber is filled with high purity ceramic pellets of a nonreactive material coated with a catalyst, such a noble metal catalyst. Screens at each end of the reaction chamber prevent the catalyst pellets from being transported outside reaction chamber. The interior of the reaction chamber has two perpendicular baffle plates traversing the length to increase contact area with the catalytic pellets for electrical charge and thermal transport during the reaction. The temperature of the reaction chamber is maintained below 350 C during operation. | 01-29-2009 |
Matthew L. Milburn, Felton, CA US
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20090114295 | GAS-PANEL ASSEMBLY - A gas-panel manifold for use in a gas-panel assembly is disclosed. A manifold in the assembly provides a plurality of support surfaces, each designed for supporting a gas-component thereon, and internal passageways disposed within the manifold body for connecting gas components, with such carried on the manifold, for gas flow through the manifold in a generally downstream direction. The adjacent support surfaces in the manifold are in different planes, representing different heights above the support. | 05-07-2009 |
Michael Milburn, Cary, NC US
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20090069301 | Acridine and Quinoline Derivatives as Sirtuin Modulators - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, chemotherapeutic induced neuropathy, neuropathy associated with an ischemic event, polyglutamine diseases, ocular diseases and/or disorders, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 03-12-2009 |
20090143376 | Fused Heterocyclic Compounds and Their Use as Sirtuin Modulators - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, chemotherapeutic induced neuropathy, neuropathy associated with an ischemic event, polyglutamine diseases, ocular diseases and/or disorders, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 06-04-2009 |
20090155826 | Biomarkers for pre-diabetes, cardiovascular diseases, and other metabolic-syndrome related disorders and methods using the same - Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. | 06-18-2009 |
20090163476 | N-Phenyl Benzamide Derivatives as Sirtuin Modulators - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 06-25-2009 |
20110300571 | Determination of the Liver Toxicity of an Agent - The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropionate, 4-imidazoleacetate, tyramine, anthranilate, 2′-deoxycytidine, N-acetyl aspartate (NAA), beta-hydroxy-hexanoate, and sarcosine (N-methylglycine) The methods of using the biomarkers include exposing a first hepatocyte culture to a test agent and comparing the levels of the one or more biomarkers obtained in the first hepatocyte culture to the levels of the one or more biomarkers obtained in a second hepatocyte culture without the test agent, where differential levels of the one or more biomarkers in the first hepatocyte culture as compared to the levels in the second hepatocyte culture is indicative of the test agent being a hepatotoxicant. | 12-08-2011 |
20120122981 | Biomarkers Related to Insulin Resistance and Methods using the Same - Biomarkers relating to glucose disposal rate, insulin resistance, and/or insulin resistance-related disorders are provided. Methods based on the same biomarkers are also provided. | 05-17-2012 |
20120208215 | Biomarkers for Pre-Diabetes, Cardiovascular Diseases, and Other Metabolic-Syndrome Related Disorders and Methods Using the Same - Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. | 08-16-2012 |
20130338031 | Biomarkers for Pre-Diabetes, Cardiovascular Diseases, and Other Metabolic-Syndrome Related Disorders and Methods Using the Same - Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. | 12-19-2013 |
20140212872 | Identity Elucidation of Unknown Metabolites - A method of elucidating the identity of an unknown metabolite comprising measuring amounts of known and unknown metabolites in subjects; associating the unknown metabolite with a specific gene from a gene association study; determining a protein associated with the specific gene and analyzing information for the protein; associating the unknown metabolite with concentrations and/or ratios of other metabolites in subjects; obtaining chemical structural data for the unknown metabolite; and using the information obtained to elucidate the identity of the unknown metabolite. | 07-31-2014 |
20150175645 | NICOTINAMIDE RIBOSIDE AND ANALOGUES THEREOF - Provided herein are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 06-25-2015 |
Michael V. Milburn, Emeryville, CA US
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20100210036 | PPAR ACTIVE COMPOUNDS - Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile. | 08-19-2010 |
Michael V. Milburn, Cary, NC US
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20140303228 | Biomarkers for Amyotrophic Lateral Sclerosis and Methods Using the Same - The disclosure provides biomarkers of amyotrophic lateral sclerosis (ALS). The disclosure also provides various methods of using the biomarkers, including methods for diagnosis of ALS, methods of determining predisposition to ALS, methods of monitoring progression/regression of ALS, methods of assessing efficacy of compositions for treating ALS, methods of screening compositions for activity in modulating biomarkers of ALS, methods of treating ALS, as well as other methods based on biomarkers of ALS. | 10-09-2014 |
Mike Milburn, Cary, NC US
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20100279337 | Biomarkers Related To Metabolic Age and Methods Using The Same - Biomarkers relating to metabolic age are provided, as well as methods for using such biomarkers as biomarkers for determining metabolic age. In addition, methods for modulating the metabolic age of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for metabolic age. | 11-04-2010 |
20160116461 | Biomarkers Related To Metabolic Age and Methods Using The Same - Biomarkers relating to metabolic age are provided, as well as methods for using such biomarkers as biomarkers for determining metabolic age. In addition, methods for modulating the metabolic age of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for metabolic age. | 04-28-2016 |
Robert Milburn, Thousand Oaks, CA US
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20150299182 | CRYSTALLINE FORMS OF (1S)-1-[5-(AMINO)-1,2,4-THIADIAZOL-3-YL]ETHANE-1,2-DIOL - The present invention relates to crystalline polymorph forms of (1S)-1-[5-({3-[(2-methylpyridin-3-yl)oxy]-5-(pyridin-2-ylsulfanyl)pyridin-2-yl}amino)-1,2,4-thiadiazol-3-yl]ethane-1,2-diol, to pharmaceutical compositions comprising such crystalline polymorph forms, and to processes for preparing them. The invention further relates to methods of treatment of diabetes related disorders comprising administering such solid-state forms or compositions thereof to a subject, and to use of such crystalline polymorph forms in the manufacture of medicaments. | 10-22-2015 |
Robert R. Milburn, Thousand Oaks, CA US
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20150141655 | METHOD FOR THE PREPARATION OF THIADIAZOLES - The present invention relates to processes for preparing protected glyceraldehydes, such as (hydroxy)methanesulfonates. In addition, the invention relates to thiadiazoles, particularly 3-diooxolanyl-thiadiazoles. | 05-21-2015 |
Robert Ronald Milburn, Belmont, CA US
Patent application number | Description | Published |
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20160122356 | METHODS FOR THE PREPARATION OF RIBOSIDES - Provided are methods of preparing compounds and pharmaceutical compositions for treating Filoviridae virus infections The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections. | 05-05-2016 |
Rowland James Milburn, Naperville, IL US
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20130341966 | CAB SUSPENSION SYSTEM FOR AN OFF-ROAD VEHICLE - A suspension system for a cab of an off-road vehicle includes a superstructure configured to receive a cab frame. The superstructure forms a framework, the corners of which receive suspension assemblies and dampers. The suspension assemblies include one or more springs or resilient elements to resist suspension motion, and the dampers provide dampening of the motion. Lateral and longitudinal suspension motions are resisted by links between the corners of the superstructure. An anti-roll bar reduces roll. The entire suspension system may be pre-assembled and then joined to the vehicle chassis frame. The cab frame may then be placed on the suspension system. Parts of the suspension system may interface with and be housed by roll-over protective structures. | 12-26-2013 |
Ted Milburn, Bradenton, FL US
Patent application number | Description | Published |
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20140241533 | Smart Notification Appliances - Smart notification appliances used in a mass notification system (MNS) have integrated software and distributed hardware for real time information to in-building, immediate vicinity and distributed recipients during emergency situations. Programmable control configurations in the smart notification appliances provide flexible installations. A distributed architecture system provides distributed intelligence in the smart notification appliances for maximum survivability and robust operation of the MNS. Audio messages are stored in each smart notification appliance with a one-to-one relationship to a speaker circuit. This configuration provides any circuit with either a live page or a plurality of preconfigured messages, in effect a multi-channel system limited only by the number of stored messages and controllable by software. Similarly, programmable light strobe intensity, flash rate and color may be controlled through the smart notification appliances. Both light intensity and sound loudness may also be adjusted based upon ambient light and background noise conditions. | 08-28-2014 |
20150271781 | Mass Notification Systems - A mass notification system is disclosed. The system can include a communication network. The system can also include a number of network devices communicably coupled to the communication network, where at least two of the network devices are configured to generate a communication substantially simultaneously. The system can further include a server communicably coupled to the communication network and configured to control the plurality of network devices, where the server instructs the at least two of the plurality of network devices to generate the communication. The system can also include a first client communicably coupled to the communication network and comprising a user interface, where the first client is configured to communicate, via the user interface, with the server and the plurality of network devices. | 09-24-2015 |
Thaddeus Scott Milburn, Fort Worth, TX US
Patent application number | Description | Published |
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20130204255 | Saw Blade Stability and Collet System Mechanism - A surgical system for cutting tissue of a patient includes an outer housing and a reciprocating assembly structurally configured to carry a cutting tool in a reciprocating motion. An actuator knob is manually accessible to the user and may be fixed axially to the outer housing. The reciprocating assembly may reciprocate relative to the actuator knob. The actuator knob may be configured for rotational movement between a lock position and an unlock position. The system may also include a locking mechanism configured to retain a cutting tool within the reciprocating assembly. The locking mechanism may be responsive to movement of the actuator knob to maintain the tool within the output shaft when the actuator knob is in the lock position and permit removal of the tool when the actuator knob is in the unlock position. Surgical cutting tools, such as blades include thickness enhancing features. | 08-08-2013 |
20150032112 | Saw Blade Stability And Collet System Mechanism - A surgical system for cutting tissue of a patient includes an outer housing and a reciprocating assembly structurally configured to carry a cutting tool in a reciprocating motion. An actuator knob is manually accessible to the user and may be fixed axially to the outer housing. The reciprocating assembly may reciprocate relative to the actuator knob. The actuator knob may be configured for rotational movement between a lock position and an unlock position. The system may also include a locking mechanism configured to retain a cutting tool within the reciprocating assembly. The locking mechanism may be responsive to movement of the actuator knob to maintain the tool within the output shaft when the actuator knob is in the lock position and permit removal of the tool when the actuator knob is in the unlock position. Surgical cutting tools, such as blades include thickness enhancing features. | 01-29-2015 |