Patent application number | Description | Published |
20120230999 | BISPECIFIC NANOBODIES AS A THERAPEUTIC FOR ALZHEIMER'S DISEASE - The present invention provides for the treatment of Alzheimer's disease. More specifically, a recombinant bispecific antibody fragment that simultaneously blocks beta-secretase activity while also promoting alpha-secretase activity, comprising a first portion and a second portion, wherein the first portion blocks beta secretase activity and the second portion promotes alpha-secretase activity. | 09-13-2012 |
20130287800 | IMMUNIZATION WITH AMYLOID-BETA OLIGOMERS - The present invention provides methods of immunization against Alzheimer's Disease and compositions for use in such methods. | 10-31-2013 |
20140044733 | ANTIBODY BASED REAGENT THAT SPECIFICALLY RECOGNIZES TOXIC OLIGOMERIC FORM OF BETA-AMYLOID - The invention relates to antibodies, antibody fragments and binding agents that specifically recognizes oligomeric Aβ that is resistant to denaturation by SDS but does not bind monomeric, fibrillar or other oligomeric forms of Aβ that are generated in vitro. | 02-13-2014 |
20150056638 | NANOSCALE PROCESS TO GENERATE REAGENTS SELECTIVE FOR INDIVIDUAL PROTEIN VARIANTS - The present invention provides devices and methods to separate and concentrate target protein species at a microliter scale and to generate reagents to those variants with exquisite selectivity for specific protein isoforms using only picograms of target material. | 02-26-2015 |
20150266947 | ANTIBODY BASED REAGENTS THAT SPECIFICALLY RECOGNIZE TOXIC OLIGOMERIC FORMS OF TAU - The invention relates to antibodies, antibody fragments and binding agents that specifically recognize oligomeric tau but do not bind to monomelic tau, fibrillar tau or non-disease associated forms of tau. | 09-24-2015 |