Mercedes
Mercedes Alonso Cascon, Madrid ES
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20080275088 | Use of Collismycin and Derivatives Thereof as Oxidative Stress Inhibitors - The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease. | 11-06-2008 |
20090124686 | GSK-3 INHIBITORS - The invention relates to urea derivatives of formula (I) as inhibitors of glycogen synthase kinase 3β, GSK-3, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which GSK-3 is involved, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. | 05-14-2009 |
20090192204 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES AS GSK-3 INHIBITORS - The present invention relates to the use of N-(2-thiazolyl)-amide derivatives of formula (I) for the treatment and/or prophylaxis of a disease in which glycogen synthase kinase 3 (GSK-3) is involved, especially neurodegenerative diseases, such as Alzheimer's disease, or non-insulin dependent diabetes mellitus. | 07-30-2009 |
20090221647 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES AS GSK-3 INHIBITORS - The present invention relates to the use of N-(2-thiazolyl)-amide derivatives of formula (I), for the treatment and/or prophylaxis of a disease in which glycogen synthase kinase 3 (GSK-3) is involved, especially neurodegenerative diseases, such as Alzheimer's disease, or non-insulin dependent diabetes mellitus. | 09-03-2009 |
20100048635 | USE OF COLLISMYCIN AND DERIVATIVES THEREOF AS OXIDATIVE STRESS INHIBITORS - The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease. | 02-25-2010 |
Mercedes Alonso Cascon, Tres Cantos (madrid) ES
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20100240692 | [1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES - The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition, their use as a medicament, especially for treating a treatment neurodegenerative or haematological disease or condition, and a pharmaceutical composition comprising the compounds. | 09-23-2010 |
20140011835 | [1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES - The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or prophylaxis of a neurodegenerative or hematological disease or condition, their use as a medicament, especially for treating a neurodegenerative or hematological disease or condition, and a pharmaceutical composition comprising the compounds. | 01-09-2014 |
Mercedes Alonso Cascón, Tres Cantos (madrid) ES
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20110213000 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES - The invention relates to the use of a compound of formula (I): | 09-01-2011 |
20110306631 | TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER - The present invention relates to a new family of triple substituted phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition or cancer, their use as a medicament, especially for treating a neurodegenerative or haematological disease or condition or cancer, and a pharmaceutical composition comprising the compounds. | 12-15-2011 |
Mercedes Alonso Cascón, Tres Cantos ES
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20140005195 | BIPYRIDINE SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES OR CONDITIONS | 01-02-2014 |
Mercedes Alvarez Domingo, Barcelona ES
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20090124647 | Indole Derivatives as Antitumoral Compounds - Antitumoural compounds of general formula (I); wherein Ar is an heterocyclic group of formula (a) and R | 05-14-2009 |
20100048596 | Indole Derivatives as Antitumoral Compounds - Antitumoural compounds of general formula (I); wherein Ar is an heterocyclic group of formula (a) and R | 02-25-2010 |
Mercedes Alvarez Domingo, Sant Joan Despi ES
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20110060125 | INDOLESULFONYL PROTECTING GROUPS FOR PROTECTION OF GUANIDINO AND AMINO GROUPS - The invention relates to indolesulfonyl halogenides which are useful for the protection of organic compounds comprising at least one guanidino moiety and/or at least one amino group. The invention further relates to a process for their preparation and their use as protecting reagents. The invention also relates to the process for the protecting reaction and to the protected compounds thereof. | 03-10-2011 |
Mercedes Alvaro Rodriguez, Valencia ES
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20080203359 | Electroluminescent Hybrid Material Comprising a Microporous or Mesoporous Solid Containing Covalently-Bonded Organic Compounds Which Confer Electroluminescent Properties to Same - The invention relates to an electroluminescent organic-inorganic hybrid material which is characterised in that it comprises: at least one microporous or mesoporous solid having a structure that is selected from among the structures of zeolites, porous oxides, molecular sieves, silicoaluminophosphates and aluminosilicates; and at least one organic compound which confers electroluminescent properties thereto. The invention is also characterised in that the organic compound is a polycyclic aromatic hydrocarbon, at least part of which is joined to the structure of the microporous or mesoporous solid using covalent bonds. The invention also relates to the method of obtaining said material and to the use thereof. | 08-28-2008 |
Mercedes Armand Ugón, Balears ES
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20100022769 | NOVEL POLYNITROGENATED SYSTEMS AS ANTI-HIV AGENTS - The present invention describes the synthesis of the compounds of formulae (1), (2) and (3) in which m and n, which may be identical or different, may have the values 0, 2, 3, 4, 5 and 6; Z and Y, which may be identical or different, represent a nitrogenated cyclic system bonded by nitrogen or by one of the ring carbons or an NR | 01-28-2010 |
Mercedes Armand Ugón, Balears ES
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20100022769 | NOVEL POLYNITROGENATED SYSTEMS AS ANTI-HIV AGENTS - The present invention describes the synthesis of the compounds of formulae (1), (2) and (3) in which m and n, which may be identical or different, may have the values 0, 2, 3, 4, 5 and 6; Z and Y, which may be identical or different, represent a nitrogenated cyclic system bonded by nitrogen or by one of the ring carbons or an NR | 01-28-2010 |
Mercedes Ballesteros Perdices, Madrid ES
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20100151550 | METHOD FOR RECOVERING ENERGY FROM THE ORGANIC FRACTION OF SOLID URBAN WASTE AND ASSOCIATED FACILITY - The invention relates to a method for recovering energy from the organic fraction of urban solid waste comprising the following steps: a) the organic fraction is pre treated with mineral acids, preferably sulfuric acid, during which the fraction is heated by an outer thermal jacket with no steam injection or steam explosion, thereby producing a first slurry containing an insoluble solid susceptible to enzymatic attack by cellulases; b) a step comprising enzymatic hydrolysis using cellulases and simultaneous fermentation, using an ethanologenic microorganism, of the first slurry in order to obtain a second slurry containing diluted ethanol; and c) distillation of the second slurry such as to obtain wet ethanol, a recyclable liquid effluent and a solid. | 06-17-2010 |
Mercedes Cabrerizo, Miami, FL US
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20160015994 | Hardware/Software Integrated Design for a 3D Tremor Detector Using TMS in Parkinson's Disease and Related Disorders - Systems that integrate Transcranial Stimulation Biofeedback (TSB) Detector functions and Transcranial Magnetic Stimulation (TMS) functions, as well as methods of manufacturing such systems and methods of performing TSB detection and TMS using such systems, are provided. A system can include a hardware component and a software component in operable communication with the hardware component. The hardware component can include or be in operable communication with a TMS machine, and the software component can be configured to receive waveforms from the TSB Detector hardware. | 01-21-2016 |
Mercedes Cocera Núñez, Barcelona ES
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20120321683 | Liposome-Encapsulated Bicelles and Use Thereof in Diluted Systems - The aim of the invention is to preserve the morphology of bicelles in high-water-content environments. For this purpose, the invention relates to a liposome comprising, in its internal aqueous medium, at least one bicelle. The bicelles concentration in said aqueous means is between 5 and 25% dry weight in relation to the end liposome. The invention also relates to the use of said liposomes for the encapsulation of active principles, as well as to the use thereof as a medicament or to produce a cosmetic product. The invention further relates to the method for obtaining said liposomes. | 12-20-2012 |
Mercedes Cocera Núñez, Barcelona ES
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20120321683 | Liposome-Encapsulated Bicelles and Use Thereof in Diluted Systems - The aim of the invention is to preserve the morphology of bicelles in high-water-content environments. For this purpose, the invention relates to a liposome comprising, in its internal aqueous medium, at least one bicelle. The bicelles concentration in said aqueous means is between 5 and 25% dry weight in relation to the end liposome. The invention also relates to the use of said liposomes for the encapsulation of active principles, as well as to the use thereof as a medicament or to produce a cosmetic product. The invention further relates to the method for obtaining said liposomes. | 12-20-2012 |
Mercedes Crego Calama, Geldrop-Mierlo NL
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20100176822 | NANOWIRE SENSOR - An analyte sensing device is disclosed. In one aspect, the device includes at least one sensing module on a substrate. The sensing module has at least one nanowire including a bottom, an intermediate part and a top, the bottom being closer to the substrate than the top. The module has a surrounding electrode surrounding the bottom and at least part of the intermediate part of each nanowire in height direction and being electrically isolated from the nanowire. There is a gap between each nanowire and the corresponding surrounding electrode allowing penetration of an analyte to be detected between the nanowire and the surrounding electrode. A measurement circuitry is electrically connected to each nanowire and the surrounding electrode for detecting a change in an electrical property as a result of the penetration of the analyte into the gap. | 07-15-2010 |
20100264333 | Gas Sensing Device - The present invention relates to a gas sensing device comprising a nanoparticle layer ( | 10-21-2010 |
20110192720 | MICROFABRICATED LIQUID-JUNCTION REFERENCE ELECTRODE - Micromachined reference electrodes for use in miniaturized electrochemical sensors, and methods for fabricating such reference electrodes and electrochemical sensors, for example, as a part of a microfluidic system, are disclosed. Electrochemical measurements allow for inexpensive detection of a wide variety of (bio-)chemical compounds in solution. The reference electrode is one of the main parts of an electrochemical cell. The reference electrode, from which no current is drawn, has a stable, constant potential. | 08-11-2011 |
20110205543 | Gas Sensor, Method for Optically Measuring the Presence of a Gas Using the Gas Sensor, and Gas Sensing System - The present disclosure relates to a gas sensor including a first layer and a second layer superimposed on each other along an interface between the two layers. The first layer includes an array of nanoparticles along the interface, the nanoparticles provided so as to allow, upon illumination with electromagnetic radiation, long range diffractive coupling of surface plasmon resonances resulting in a surface lattice resonance condition. The second layer includes a material that, when exposed to at least one predetermined gas, detectably affects the surface lattice resonance condition. The material of the second layer preferably has a porosity of at least 10%. | 08-25-2011 |
20120075634 | Sensor, Method for Detecting The Presence and/or Concentration of an Analyte Using the Sensor, and Use of the Method - Methods and sensors for detecting the presence and/or concentration of an analyte are disclosed. In one aspect, a sensing element for use in a sensor is disclosed. The sensing element comprises a resonant cavity device configured to emit optical radiation at an initial power level, a sensing layer exhibiting an initial refractive index, and a detector. The sensing layer is configured to absorb or adsorb an analyte and, in response to absorbing or adsorbing the analyte, exhibit a modified refractive index that differs from the initial refractive index. The resonant cavity device is further configured to, in response to the sensing layer absorbing or adsorbing the analyte, emit optical radiation at a modified power level based on the modified refractive index. The detector is configured to detect the modified power level. | 03-29-2012 |
20120077019 | HUMIDITY BARRIER - A humidity barrier comprises a mixed matrix membrane, wherein the mixed matrix membrane comprises a polymer matrix with at least a hydrophobic surface, in which polymer matrix porous hydrophilic filler particles are dispersed. The hydrophobic surface may be formed either by hydrophobic polymer material itself or a hydrophobic coating may be provided on top of non-hydrophobic polymer material. | 03-29-2012 |
20120151997 | METHOD OF MAKING AN ELECTRICALLY CONDUCTIVE STRUCTURE, METHOD OF MAKING A GAS SENSOR, GAS SENSOR OBTAINED WITH THE METHOD AND USE OF THE GAS SENSOR FOR SENSING A GAS - A method of making an electrically conductive structure in a surface portion of a dielectric material is disclosed. In one aspect, the method includes creating vacancies at at least part of an exposed surface of the dielectric material by removing atoms from a plurality of molecules of the dielectric material. | 06-21-2012 |
20120181185 | CONFIGURATION, A SENSING ELEMENT WITH SUCH CONFIGURATION, ELECTROCHEMICAL SENSOR COMPRISING SUCH SENSING ELEMENT AND METHOD FOR ELECTROCHEMICAL SENSING USING SUCH ELECTROCHEMICAL SENSOR - A configuration is disclosed. In one aspect, the configuration includes a substantially planar electrode layer, in a first plane. The configuration further includes a substantially planar two-dimensional electron gas (2DEG) layer electrically connected in series with the electrode layer. The 2DEG layer is provided in a second plane substantially parallel with the first plane and located at a predetermined distance, in a direction orthogonal to the first plane, from the first plane. The 2DEG layer and the electrode layer are patterned such that the electrode layer overlays a part of the 2DEG layer, wherein the predetermined distance between the first plane and the second plane is selected to be sufficiently small for allowing electrostatic interaction between the electrode layer and the 2DEG layer. | 07-19-2012 |
20120247978 | ELECTROCHEMICAL ETHYLENE SENSOR AND METHOD FOR MONITORING ETHYLENE - An electrochemical ethylene sensor and method for ethylene sensing are disclosed. In one aspect, an electrochemical ethylene sensor includes a working electrode and a counter electrode on an electrically insulating substrate. An ionic liquid layer covers the working electrode and counter electrode. In one method, a voltage is applied to the working electrode which is equal to or lower than the voltage required for the onset of oxidation of the material of the working electrode, for example, in the range spanning 700 mV before the onset of oxidation of the material of the working electrode. | 10-04-2012 |
20130111977 | Chemical Sensor - The application describes methods and apparatus for chemical sensing, e.g. gas sensing, which have high sensitivity but low power operation. A sensor is described having a flexible membrane comprising a III/N heterojunction structure configured so as to form a two dimensional electron gas within said structure. A sensing material is disposed on at least part of the flexible membrane, the sensing material being sensitive to one or more target chemicals so as to undergo a change in physical properties in the presence of said one or more target chemicals. The sensing material is coupled to said heterojunction structure such that said change in physical properties of the sensing material imparts a change in stress within the heterojunction structure which modulates the resistivity of the two dimensional electron gas. | 05-09-2013 |
20130334061 | SENSOR FOR SENSING THE PRESENCE OF AT LEAST ONE FLUIDUM - A Sensor for sensing the presence of at least one fluidum in a space adjoining the sensor is disclosed. In one aspect, the sensor has a two-dimensional electron gas (2DEG) layer stack, a gate electrode overlaying at least part of the 2DEG layer stack for electrostatically controlling electron density of a 2DEG in the 2DEG layer stack and a source and a drain electrode contacting the 2DEG layer stack for electrically contacting the 2DEG, wherein a detection opening is provided in between the gate electrode and the 2DEG layer stack and wherein the detection opening communicates with the space through a detection opening inlet such that molecules of the fluidum can move from the adjoining space through the detection opening inlet into the detection opening where they can measurably alter a electric characteristic of the 2DEG. | 12-19-2013 |
20140012114 | Monitoring of Fluid Content - This application describes methods and apparatus for monitoring of fluid content that are suitable for in-situ, real time and/or continuous monitoring, especially of bodily fluids and in particular the content of sweat. The application also describes fabrication of such an apparatus. The apparatus comprises a multilayer structure comprising at least two electrode layers for detection of fluid content separated by at least one insulating layer. The multilayer structure defines at least one flow channel which provides a flow path for continuous flow of fluid in use, and the electrode layers form part of the sidewall of the flow channel(s). The flow channel(s) may run in a direction substantially perpendicular to the layers. The electrode layers may employ electrochemical detection and may comprise a reference electrode and an ion-sensitive electrode. The apparatus may be fabricated using various printing or deposition techniques. | 01-09-2014 |
20140175516 | TWO-DIMENSIONAL ELECTRON GAS SENSOR AND METHODS FOR MAKING AND USING THE SENSOR - The disclosed technology generally relates to a sensor and methods for making and using the same, and more particularly relates to a sensor configured to sense the presence of at least one fluidum. In one aspect, a sensor for sensing a fluidum in a space adjoining the sensor comprises a two-dimensional electron gas (2DEG) layer stack. The sensor additionally comprises a gate lying adjacent to at least part of the 2DEG layer stack and configured to electrostatically control the electron density of a two-dimensional electron gas (2DEG) in the 2DEG layer stack. The sensor further comprises a source electrode contacting the 2DEG layer stack for electrically contacting the 2DEG. The 2DEG layer stack of the sensor comprises a contact surface contacting the space and provided to contact molecules of the fluidum which is desired to be detected, and the gate of the sensor comprises a doped semiconductor bottom layer of the 2DEG layer stack in electrical contact with at least one gate electrode, where the doped semiconductor bottom layer being located at a side of the 2DEG layer stack opposing the contact surface. | 06-26-2014 |
Mercedes Crego Calama, Geldrop-Mierio NL
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20120272721 | DEVICE COMPRISING A GAS SENSOR SENSITIVE TO THE PRESENCE OF A SPECIFIC GAS, METHOD OF MANUFACTURING A GAS SENSOR SENSITIVE TO THE PRESENCE OF A SPECIFIC GAS FOR USE IN THE DEVICE AND USE OF THE DEVICE - A device including a gas sensor sensitive to the presence of a specific gas is disclosed. In one aspect, the gas sensor includes a first segment made of a dielectric material and a second segment made of a semiconducting material. The first segment has a first surface exposed to an environment of the gas sensor and is located between the environment and the second segment. The first segment has a first thickness and the second segment has a second thickness. The first thickness is selected such that upon diffusion of a gas molecule of the specific gas into the first segment, a dipole of the molecule of the specific gas detectably influences a bending of an energy-band structure of the semiconducting material of the second segment. The second thickness is in the order of, or smaller than, the Debye length of the semiconducting material. | 11-01-2012 |
Mercedes Diaz Lagos, Madrid ES
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20130111637 | MODIFICATION OF ATOMIC FORCE MICROSCOPY TIPS BY DEPOSITION OF NANOPARTICLES WITH AN AGGREGATE SOURCE | 05-02-2013 |
Mercedes Ferreras, Copenhagen DK
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20110052639 | ALLERGEN MUTANTS - Novel recombinant allergens with multiple mutations and reduced IgE binding affinity are disclosed. The allergens are mutants of naturally occurring allergens. The overall α-carbon backbone tertiary structure is essentially preserved. Also disclosed is a method for preparing such recombinant allergens as well as uses thereof. | 03-03-2011 |
Mercedes Ferros Presa, Zamudio (vizcaya) ES
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20100213748 | HEADREST SYSTEM, SEAT WITH A HEADREST SYSTEM, AND VEHICLE INCLUDING SAME - The invention relates to a headrest system comprising: | 08-26-2010 |
Mercedes Frances Pedraz, San Sebastian (guipuzcoa) ES
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20100223662 | PROGRAMMABLE ELECTRONIC ACCESS CONTROL SYSTEM - The invention relates to a programmable electronic access control system including: an updating unit which operates in conjunction with a central control unit and is provided with management software for global control of installation access. Access elements are associated with the entrance/exit routes, and a credential is associated with each system user. In addition, each updating unit includes means for the bi-directional transfer of data in relation to user credentials, and the central control unit. The updating unit transfers only the information concerning a particular user and the installation closure plan to the user credentials, while receiving information stored on the user credential relating to past events associated therewith, which have been transferred to each of the access elements. | 09-02-2010 |
Mercedes Herranz Gracia, Forchheim DE
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20150311759 | ASYNCHRONOUS MACHINE WITH OPTIMIZED DISTRIBUTION OF ELECTRICAL LOSSES BETWEEN STATOR AND ROTOR - The invention relates to an asynchronous machine ( | 10-29-2015 |
Mercedes Hortal Ramos, Paterna ES
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20130143988 | MODIFIED PHYLLOSILICATE - Polymer nanocomposites including: a) a polylactic polymer; and b) a modified phyllosilicate composition including a modifying agent which includes hexadecyl trimethyl ammonium cations which are intercalated between the layers of the phyllosilicate, and preparation processes therefor, as well as the modified phyllosilicate composition. The polymer nanocomposites are particularly useful for packaging, particularly food and drink packaging. | 06-06-2013 |
20130177723 | POLYMER NANOCOMPOSITE COMPRISING POLYLACTIC ACID REINFORCED WITH THE MODIFIED PHYLLOSILICATE - Polymer nanocomposite having: a) a polylactic polymer; and b) a modified phyllosilicate composition having a modifying agent which includes hexadecyl trimethyl ammonium cations which are intercalated between the layers of the phyllosilicate; and preparation process of such a polymer nanocomposite. The polymer nanocomposite is particularly useful for packaging, particularly food and drink packaging. | 07-11-2013 |
Mercedes Labiano Ros, Zaragoza ES
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20080251106 | Process of cleaning a hard surface with zwitterionic copolymer - The present invention relates to a process of cleaning a hard surface with a composition comprising a specific water-soluble or water-dispersible copolymer, said process comprises the steps of applying said composition onto said surface in diluted form and leaving said diluted composition to dry on said surface without rinsing said surface. | 10-16-2008 |
20090075858 | PROCESS FOR TREATING INCLINED HARD SURFACE - The present invention relates to a process of treating a hard surface with a composition comprising polyalkoxylate trisiloxane. More specifically, it relates to a process of treating an inclined or vertical hard surface, wherein a composition comprising polyalkoxylate trisiloxane is applied onto said hard surface. | 03-19-2009 |
20090084402 | PROCESS FOR TREATING HARD SURFACE - The present invention relates to a process of treating a hard surface with a composition comprising polyalkoxylate trisiloxane. More specifically, it relates to a process of treating an horizontal hard surface, wherein a composition comprising polyalkoxylate trisiloxane is applied onto said hard surface. | 04-02-2009 |
20120012495 | PROCESS OF TREATING HARD SURFACE - The present invention relates to a process of treating a hard surface with a composition comprising polyalkoxylate trisiloxane. More specifically, it relates to a process of treating an horizontal hard surface, wherein a composition comprising polyalkoxylate trisiloxane is applied onto said hard surface. | 01-19-2012 |
Mercedes Lobera, Bolton, MA US
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20090163537 | Thienopyridinone Compounds and Methods of Treatment - The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included. | 06-25-2009 |
20100184749 | BENZOTHIADIAZINE COMPOUNDS AND THEIR USE - Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein. | 07-22-2010 |
20100197723 | BICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME - Disclosed herein are compounds that may be modulators of 5-HT receptors, and methods of making and using same. | 08-05-2010 |
20100317649 | S1P Receptor Modulating Compounds and Use Thereof - The present invention relates to compounds that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. In certain embodiments, the compounds of the invention relate to aryl oxoimidazolidinyls. | 12-16-2010 |
20110059945 | S1P Receptor Modulating Compounds and Use Thereof - The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions. | 03-10-2011 |
20110195953 | COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS - The invention generally relates to thienopyridinone 5-HT | 08-11-2011 |
20110212940 | S1P Receptor Modulating Compounds and Use Thereof - The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions. | 09-01-2011 |
20120088793 | Bicyclic Compounds and Methods of Making and Using Same - Disclosed herein are compounds that may be modulators of 5-HT receptors, and methods of making and using same. | 04-12-2012 |
Mercedes Lopez, Santiago CL
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20140371159 | IN VITRO METHOD FOR MODIFYING THE DEPLETION PROFILE OF TREG CELLS PRESENT IN A TOTAL SPLENOCYTE POPULATION OF A BIOLOGICAL SAMPLE BY MEANS OF THE ISOLATION, CULTURING AND EXPOSURE THEREOF TO AN ATP AND POLYMIXIN B MEDIUM - In vitro method to modify the deplexion profile of Treg Cells present in a total splenocyte population of a biological sample comprising isolating, cultivating and submitting the splenocyte at a ATP medium and polymyx B, where the splenocytes at concentrations of Polymyxin B in the range 0.1 μg/ml to 100 μg/ml, and combined use of Polymyxin B and ATP to prepare a medicament useful in the treatment tumor or cancer mammals, where cancer is melamine. | 12-18-2014 |
Mercedes Mapua, San Mateo, CA US
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20140189476 | IMAGE MANIPULATION FOR WEB CONTENT - A web page or group of pages can be automatically generated based on images selected by a user. The images are analyzed for color and groups of colors for the page background and image framing are determined. Images are analyzed to determine the shapes of the images and the images are placed within appropriate shapes on a page on the web. Click-through rate can be estimated for images and this click-through rate used during the web page generation. Important sections are evaluated in the images and cropping may occur for the images on a page. Text and video can be part of the web page. Software applications can be accessed from the web page as well. The online web pages can be tailored for presentation on a mobile device. | 07-03-2014 |
Mercedes Marín De Mateo, Sant Cugat Del Valles (barcelona) ES
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20120077222 | Method and Device for Determining the Microbiological Contamination in an Environment - The method comprises providing at least one sampling plate and at least one supporting member in said environment with the supporting member being suitable for detachably receiving the sampling plate; and removing the plate from the supporting member after a period of time such that the microbiological contamination in said environment can be determined by analyzing said sampling plate. A device is provided for carrying out said method comprising the supporting member carrying one or more sampling plates, attaching means for detachably fixing the sampling plates therein and releasing means for removing of the sampling plate from the supporting member. | 03-29-2012 |
Mercedes Maroto-Valer, Nottingham GB
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20130287673 | CAPTURE OF CARBON DIOXIDE - A method for capturing carbon dioxide comprising the steps of extracting mineral ions from a mineral source material to a mineral solution by reaction with a first ammonium salt; reacting the mineral solution with a CO | 10-31-2013 |
Mercedes Martinez Perez, Barcelona ES
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20130273156 | ORAL PHARMACEUTICAL TABLET FOR CONTROLLED RELEASE OF MESALAZINE AND PROCESS FOR OBTAINING IT - The invention provides an oral pharmaceutical tablet for controlled release of mesalazine or a pharmaceutically acceptable salt thereof as active ingredient with a core and a gastro-resistant outer coating, wherein the core comprises mesalazine and a hydrophilic matrix consisting of a mixture of hydroxypropylmethyl cellulose (HPMC) having a different viscosity and the gastro-resistant outer coating comprises a pH-dependent release polymer, with the pharmaceutically acceptable excipients. The invention also refers to the process for obtaining said oral pharmaceutical tablet and to said oral pharmaceutical tablet of controlled release of mesalazine for treating ulcerative colitis. | 10-17-2013 |
Mercedes Rodrugues Vieytes, Lugo ES
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20110065138 | Quantitative Method For Detecting Yessotoxins In Fishery Products On Based On The Activation That The Toxin Produces In Cellular Phosphodiesterases And Therapeutic Use Of This Activation - The present invention relates to a quantitative method for detecting yessotoxins in fishery products based on the activation the toxin produces on cellular phosphodiesterases and the therapeutic use of this activation. The cellular target of yessotoxin (YTX) and its analogs is the activation of phosphodiesterases (PDEs). The PDEs-YTX bond produces a measurable signal. The bond can be quantified by means of an affinity biosensor or by fluorescence. The biosensor detects biomolecular interactions and allows determining the presence of YTX due to its interaction with PDEs. The variations in the degradation rate of the fluorescent derivative anthraniloyl-cAMP are determined by means of plate fluorescence. The rate at which the PDEs degrade this molecule increases in the presence of YTX. YTX inhibits immunological activation of mastocytes in rats and induces a cytotoxic effect in human hepatocarcinoma cells, which implies two therapeutic uses of YTXs as an antiallergic and antitumor compound. | 03-17-2011 |
Mercedes Salvador-Silva, Rochester, NY US
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20110077270 | Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure - A composition for treating or controlling an ocular disease or condition comprises a dissociated glucocorticoid receptor agonist (“DIGRA”), which disease or condition has an etiology, or results, in inflammation. The composition can optionally include an anti-inflammatory agent, an anti-infective agent, or both. The composition can be formulated for topical application, injection, or implantation in an affected eye to treat or control the ocular inflammatory disease or condition. | 03-31-2011 |
20120065228 | COMPOSITIONS AND METHODS FOR TREATING, CONTROLLING, REDUCING, OR AMELIORATING OCULAR INFLAMMATORY WITH LOWER RISK OF INCREASED INTRAOCULAR PRESSURE - A composition for treating, controlling, reducing, or ameliorating inflammatory pain comprises a dissociated glucocorticoid receptor agonist (“DIGRA”), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can comprise an additional anti-inflammatory agent and can be formulated for topical application, injection, or implantation. It may be used in a method of managing ocular inflammation and/or pain such that it has lower risk of eliciting increased intraocular pressure seen with glucocorticoids. | 03-15-2012 |
Mercedes Santinelli Ramos, Cuajimalpa De Morelos MX
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20150290063 | CHIROPRACTIC TABLE - Chiropractic table that allows conservation of the natural curves of the spine of a patient using thereof, comprising a continuous curved surface having a concave section at its central portion on the convex side of said curved surface defining first and second convex sections, wherein the ends of the curved surface are in contact with the ends of a frame composed of a plurality of longitudinal straight bar pairs, parallel to each other and which are transversely joined by a plurality of main transverse bars to said longitudinal straight bars, wherein further the first convex section has a greater height than the second convex section with respect to the plane defined by the plurality of longitudinal straight bars and the plurality of main transverse bars. | 10-15-2015 |
Mercedes Sanz Millan, Pamplona (navarra) ES
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20140271210 | CONNECTION SYSTEM FOR CONNECTING COMPONENT SECTIONS OF WIND TURBINE BLADES - The present invention relates to a connection system for connecting component sections of wind turbine blades, according to which one or more intermediate parts ( | 09-18-2014 |
Mercedes Soria-Li, Mountain View, CA US
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20150205298 | AUTONOMOUS DATA MACHINES AND SYSTEMS - Autonomous data machines and systems may be provided, which may be deployed in an environment. The machines may roam within the environment and collect data with aid of one or more sensors. The data may be sent to a control center, which may optionally receive information from additional data sources, such as other on-site sensors, existing static data, or real-time social data. The control center may send instructions to the machines to perform one or more reaction based on the received information. The autonomous data machines may be capable of reacting autonomously to one or more detected condition. In some instances, the autonomous data machines may be employed for security or surveillance. | 07-23-2015 |
Mercedes Soto Rodriguez, Madrid ES
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20130051800 | SYSTEM FOR INTEGRATION OF CHANNELS WITH QUANTUM INFORMATION IN COMMUNICATION NETWORKS - System for integration of channels with quantum information in communication networks. The network includes fibre-optic segments and conventional equipment, whilst a quantum key distribution (QKD) system has devices for the exchange of information by a quantum channel. The system includes at least one filter for each one of the exchange devices and at least one unit for managing conventional and quantum channels that reduces the noise in quantum channels and has at least the following functions: attenuation of insertion power of conventional channels in the network; different polarizations in the various conventional and quantum channels; and changes of wavelength assignment in not only conventional but also quantum channels. | 02-28-2013 |
20130347112 | METHOD FOR A FINE OPTICAL LINE MONITORING IN COMMUNICATION LINES THROUGH QKD SYSTEMS - Two ends of a QKD system are connected through a private quantum channel using a protocol based on the principles of quantum physics and a conventional channel, both channels being introduced through the same medium using multiplexing techniques, wherein a possible intrusion in the communication is detected by checking the variability of the distribution of exchanged photons between both ends of said private quantum channel and in case of detecting an intrusion due to the risk identified on the communication channel the system launches an alarm. To avoid other attacks another conventional channel different from the quantum channel is further used in order to check the error rate in the exchanges. | 12-26-2013 |
Mercedes Unzeta López, Barcelona ES
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20130012522 | NEW DERIVATIVES OF PROPARGYLAMINE HAVING NEUROPROTECTIVE CAPACITY FOR THE TREATMENT OF ALZHEIMER'S AND PARKINSON'S DISEASES - The present invention relates to a compound of formula (I) wherein: R | 01-10-2013 |
Mercedes Vazquez-Anon, Chesterfield, MO US
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20110021461 | COMBINATIONS TO IMPROVE ANIMAL HEALTH AND PERFORMANCE - The present invention provides combinations of dietary supplements and methods of using of these combinations to improve the health and production performance of animals. In particular, the combinations of the invention comprise antioxidants, trace minerals, organic acids, essential amino acids, and mixtures thereof. | 01-27-2011 |
20110172269 | ANTIOXIDANT COMBINATIONS FOR USE IN FEED RATIONS TO INCREASE MILK PRODUCTION AND MILK FAT - The present invention provides a combination of antioxidants that effectively stabilize different types of fats utilized in a ruminant diet. When included in a ruminant feed ration or water source, the antioxidant combination typically increases nutrient digestion, such as fiber and protein, improves rumen fermentation, improves microbial growth, improves microbial efficiency, increases milk production and/or milk fat, improves antioxidant status of the ruminant, and attenuates the negative effects of some fats in the ruminant animal. | 07-14-2011 |
Mercedes Vicioso Sanchez, Madrid ES
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20100041897 | Process for preparing a crystalline form of candesartan cilexetil - A process for preparing a crystalline form of candesartan cilexetil referred to as Form I, which has a content of Form II lower than 1% (w/w), is described. The process includes a seeding stage with a crystalline product, which mainly includes Form I, and a digestion stage. The invention also relates to the crystalline form, the pharmaceutical compositions containing it and its use for the preparation of a medicament for the treatment of hypertension. Candesartan cilexetil Form I has shown good stability under accelerated stability conditions, when the content of Form II is lower than 1% w/w. | 02-18-2010 |
Mercedes Villarroya Sánchez, Madrid ES
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20100305157 | DERIVATIVES OF DICARBOXYLIC AMINO ACIDS AND THEIR APPLICATION IN THE TREATMENT OF NEURODEGENERATIVE DISEASES - Products of a general formula (I) and their use in the manufacture of medicines useful for the treatment of neurodegenerative diseases such as Alzheimer's disease or, in general, any disease or pathology produced by alterations of biological functions that can be treated or therapeutically modified by these products. | 12-02-2010 |
Mercedes Villarroya Sánchez, Madrid ES
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20100305157 | DERIVATIVES OF DICARBOXYLIC AMINO ACIDS AND THEIR APPLICATION IN THE TREATMENT OF NEURODEGENERATIVE DISEASES - Products of a general formula (I) and their use in the manufacture of medicines useful for the treatment of neurodegenerative diseases such as Alzheimer's disease or, in general, any disease or pathology produced by alterations of biological functions that can be treated or therapeutically modified by these products. | 12-02-2010 |
Mercedes Zurita Castillo, Madrid ES
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20110123497 | GRAFT COMPOSITION FOR NEURAL TISSUE REGENERATION, METHOD OF PRODUCTION AND USES THEREOF - The present invention provides a biocompatible, biodegradable graft composition for regeneration of neural tissue, comprising the following components: a) a gel scaffold formed from an isolated platelet containing fluid and an activating agent comprising calcium chloride, with or without thrombin, b) a nerve growth factor selected from BDNF, NGF, retinoic acid and combinations thereof, and c) a culture of at least 50,000 progenitor stem cells; the method of production and the uses thereof. | 05-26-2011 |