Patent application number | Description | Published |
20100100814 | REGISTRY FOR TRADING PARTNERS USING DOCUMENTS FOR COMMERCE IN TRADING PARTNER NETWORKS - A market making node in a network routes machine readable documents to connect businesses with customers, suppliers and trading partners. The self defining electronic documents, such as XML based documents, can be easily understood amongst the partners. Definitions of these electronic business documents, called business interface definitions, are posted on the Internet, or otherwise communicated to members of the network. The business interface definitions tell potential trading partners the services the company offers and the documents to use when communicating with such services. Thus, a typical business interface definition allows a customer to place an order by submitting a purchase order or a supplier checks availability by downloading an inventory status report. Also, the registration at a market maker node of a specification of the input and output documents, coupled with interpretation information in a common business library, enables participants in a trading partner network to execute the transaction in a way which closely parallels the way in which paper based businesses operate. | 04-22-2010 |
20130159845 | REGISTRY FOR TRADING PARTNERS USING DOCUMENTS FOR COMMERCE IN TRADING PARTNER NETWORKS - A market making node in a network routes machine readable documents to connect businesses with customers, suppliers and trading partners. The self defining electronic documents, such as XML based documents, can be easily understood amongst the partners. Definitions of these electronic business documents, called business interface definitions, are posted on the Internet, or otherwise communicated to members of the network. The business interface definitions tell potential trading partners the services the company offers and the documents to use when communicating with such services. Thus, a typical business interface definition allows a customer to place an order by submitting a purchase order or a supplier checks availability by downloading an inventory status report. Also, the registration at a market maker node of a specification of the input and output documents, coupled with interpretation information in a common business library, enables participants in a trading partner network to execute the transaction in a way which closely parallels the way in which paper based businesses operate. | 06-20-2013 |
Patent application number | Description | Published |
20080267313 | Dual Demodulation Mode AM Radio - Apparatuses and methods for receiving an amplitude modulated signal in one of two modes depending on the quality of the received signal. In a first mode, the amplitude modulated signal is converted directly to a baseband signal. In a second mode, the amplitude modulated signal is converted to an intermediate frequency signal. The present invention advantageously combines direct conversion and image-rejection heterodyne receiver topologies with a relatively large degree of component reuse and relatively few additional components. | 10-30-2008 |
20080305760 | Envelope Detector for AM Radio - A receiver for receiving an amplitude modulated (AM) signal may include a first and a second detector for detecting the maximum and minimum envelope values, respectively, of the received AM signal and an equalizer for periodically equalizing the maximum and minimum envelope values. A method for receiving an AM signal may include unidirectionally increasing a first output signal up to the maximum envelope value, unidirectionally decreasing a second output signal down to the minimum envelope value, and periodically equalizing the first and the second output signals. | 12-11-2008 |
20090046809 | Sampling Demodulator for Amplitude Shift Keying (ASK) Radio Receiver - A method, algorithm, circuits, and/or systems for amplitude shift keying (ASK) modulation are disclosed. In one embodiment, a sampling demodulator includes a comparator configured to compare an ASK modulated input to a predetermined voltage level and provide a comparison result, a pulse stretcher with a sampler configured to sample the comparison result a plurality of times for each of a plurality of cycles of the ASK modulated input to generate a bit stream and digital logic configured to determine a value for each data bit in the ASK modulated input from the bit stream, and a digital filter configured to filter an output of the digital logic, thereby providing a demodulated signal. | 02-19-2009 |
20090247100 | Dual Threshold Demodulation in an Amplitude Modulation Radio Receiver - A method, algorithm, circuits, and/or systems for demodulation in an amplitude modulated (AM) radio receiver are disclosed. In one embodiment, a radio receiver can include an amplifier configured to receive a radio frequency (RF) input signal and a gain control signal, and provide an amplified signal, an automatic gain control (AGC) circuit configured to receive a high threshold comparator output and provide the gain control signal, a mixer configured to combine the amplified signal and a local oscillation signal and provide a mixed output, a high threshold comparator configured to compare the mixed output with a reference level and provide the high threshold comparator output, and a low threshold comparator configured to compare the mixed output with the reference level and provide an output of the radio receiver. | 10-01-2009 |
Patent application number | Description | Published |
20090192262 | Hydrophobic Thermoplastic Polyurethane - The present invention discloses a semicrystalline, thermoplastic polyurethane which is comprised of the reaction product of (1) a hydrophobic polyol, (2) a polyisocyanate, and (3) a linear chain extender containing 5 carbon atoms or 7 to 12 carbon atoms; wherein the hydrophobic polyol has a number average molecular weight which is within the range of about 1,000 to about 4,000; wherein the semicrystalline, thermoplastic polyurethane has a weight average molecular weight which is within the range of 50,000 to 1,000,000; and wherein the semicrystalline, thermoplastic polyurethane has a melting point which is within the range of 80° C. to 150° C. This hydrophobic thermoplastic polyurethane offers a unique array of characteristics that are highly desirable for utilization in manufacturing a variety of products. For instance, it can be used in overmolding soft grips onto consumer products, in adhesives, and in protective coatings. | 07-30-2009 |
20100056682 | Soft Thermoplastic Elastomer Composition - The present invention relates to a soft, semicrystalline, thermoplastic elastomer composition which is comprised of (I) a hydrophobic thermoplastic block copolymer which is comprised of (I) the reaction product of (1) a hydrophobic polyol or polyamine, (2) a polyisocyanate or an aromatic dicarboxylic acid, and (3) a chain extender containing 2 to 20 carbon atoms, or the reaction product of (1) a hydrophobic polyol or polyamine, and (2) a carboxyl terminated telechelic polyamide sequence; wherein the hydrophobic polyol or polyamine has a number average molecular weight in the range of from 1,000 to 4,000 Daltons; wherein the hydrophobic thermoplastic block copolymer has a weight average molecular weight in the range of 50,000 to 1,000,000 Daltons; and (II) from 1 to 80 weight percent of a mineral oil, wherein the soft, semicrystalline, thermoplastic elastomer composition has a Shore A hardness which is within the range of 20 to 80. | 03-04-2010 |
20100243154 | Cured In Place Pipe Liner With Styrene Barrier - A liner for repairing damaged pipes, such as underground sewer or gas pipes is disclosed. The liner comprises a TPU coating on fibrous mat of non-woven fabric. The TPU coating contains a barrier layer to retard the migration of styrene from the liner to the media used to force the liner against the damaged pipe and to activate the thermoset resin. The thermoset resin converts the liner from a flexible state to a rigid state as the liner is cured in place inside the pipe. | 09-30-2010 |
20110092648 | Electrostatic Dissipative TPU and Compositions Thereof - The present invention relates to an electrostatic dissipative thermoplastic polyurethane composition made by reacting (a) at least one polyester polyol intermediate with (b) at least one diisocyanate and (c) at least one chain extender. The polyester polyol intermediate, may be derived from at least one dialkylene glycol and at least one dicarboxylic acid, or an ester or anhydride thereof. The invention further provides for methods of making said thermoplastic polyurethane composition, polymer blends containing said thermoplastic and polymer articles made from said thermoplastic. | 04-21-2011 |
20110112270 | Low Melting Polyurethane Elastomers - The present invention relates generally to polyurethane elastomer compositions; and more preferably to thermo-plastic polyurethane elastomer compositions. In one embodiment, the polyurethane elastomer compositions of the present invention have low melting points while still behaving in an elastomeric manner. In one embodiment, the polyurethane elastomer compositions of the present invention are prepared from the reaction of a polyol component, a polyisocyanate component, and a diol chain extender. In another embodiment, the polyurethane elastomer compositions of the present invention are prepared from the reaction of a polyester polyol component, a methylene diphenyl diisocyanate (MDI) component, and a linear diol chain extender having either 5 carbons or 7 or more carbons between the OH groups of the diol. | 05-12-2011 |
20110135899 | Films And Articles Made With Thermoplastic Block Copolymers - The present invention relates to printing blankets, pipe liners, conveyor belts, inflatable articles, collapsible containers, protective clothing, and other types of coated fabrics that are manufactured with a thermoplastic block copolymer (TBC). This TBC can be a thermoplastic polyurethane (TPU), a copolyester (COPE), a copolyamide (COPA) or a polyurethaneurea (TPUU). The subject invention more specifically discloses a printing blanket or printing sleeve and a cured in place liner for a passageway or pipe. The TBC is (I) the reaction product of (1) a hydrophobic polyol or polyamine, (2) a polyisocyanate or an aromatic dicarboxylic acid, and (3) a linear chain extender containing 2 to 20 carbon atoms, or (II) the reaction product of (1) a hydrophobic polyol or polyamine, and (2) a carboxylic terminated telechelic polyamide sequence. | 06-09-2011 |
20110168043 | Thermoplastic Polyurethane For Printing Blankets - The present invention provides an offset printing blanket or sleeve including one or more layers that are made with a soft thermoplastic polyurethane composition that provides excellent compression set and excellent resistance to apolar solvents, such as naphthenic mineral spirits. The subject invention more specifically reveals a printing blanket comprising: a base layer; a compressible layer, and a printing surface layer, wherein the compressible layer and/or the printing surface layer is comprised of a thermoplastic polyurethane composition, wherein the thermoplastic polyurethane composition made by reacting (a) at least one polyester polyol intermediate with (b) at least one diisocyanate and (c) at least one chain extender; wherein the polyester polyol intermediate comprises an intermediate derived from at least one dialkylene glycol and at least one dicarboxylic acid or an ester or anhydride thereof. It is particularly beneficial to utilize the thermoplastic polyurethane composition in the printing surface layer. | 07-14-2011 |
20110312237 | High Moisture Vapor Transmissive Polyurethanes - The present invention relates generally to polyurethane compositions; and more preferably to thermoplastic polyurethane compositions. In one embodiment, the polyurethane compositions of the present invention have high moisture vapor transmission rates and are suitable for film applications (e.g., breathable films). In one embodiment, the polyurethane compositions of the present invention are prepared from the reaction of a mixed polyol component, a polyisocyanate component, a chain extender, and optionally at least one suitable catalyst, wherein the mixed polyol component is formed by a combination of one or more poly(ethylene oxide) polyols and one or more copolymer polyols, where the resulting mixed polyol component comprises from about 3 to about 30 weight percent of a copolymer polyol and about 70 to 97 weight percent of poly(ethylene oxide) polyol. | 12-22-2011 |
20120018080 | Cured In Place Pipe Liner - A liner for repairing damaged pipes, such as underground sewer or gas pipes is disclosed. The liner comprises a TPU coating on a fibrous mat of non-woven fabric. The TPU coating is a high heat resistance polyester TPU which allows an epoxy resin/amine to be saturated in the non-woven fabric and the cure initiated by the use of steam or hot water. The cured epoxy resin converts the liner from a flexible state to a rigid state as the liner is cured in place inside the pipe. The TPU containing liner may also be used with thermoset resins other than epoxy resins, such as polyester resins and vinyl ester resins. | 01-26-2012 |
20140255792 | Polyurethane Based Electrolyte Systems For Electrochemical Cells - The invention relates to a polymer gel electrolyte system for use in an electrochemical cell having positive and negative electrodes, said electrolyte system comprising: (A) a poly(dialkylene ester) thermoplastic polyurethane composition; (B) an alkali metal salt; and (C) an aprotic organic solvent. The invention also provides an electrochemical cell comprising a positive electrode, a negative electrode, and (I) a polymer electrolyte disposed between said positive and negative electrodes, wherein the polymer electrolyte comprises (A) the poly(dialkylene ester) thermoplastic polyurethane composition; (B) an alkali metal salt; and (C) an aprotic organic solvent. | 09-11-2014 |
20140315010 | SOFT TOUCH LAMINATES CONSTRUCTED WITH IMPROVED FIRE RETARDANT PROPERTIES FOR TRANSPORTATION - Soft touch fire retardant laminates with PVC middle layers, foamed or unfoamed, and multiblock copolymer or polyurethane or silicone top layers which meet FAA requirements are disclosed. | 10-23-2014 |
Patent application number | Description | Published |
20140258346 | Associating an Online File Folder with a Uniform Resource Locator - Systems and method of the present invention provide for one or more server computers configured to register a domain name; receive a request to: generate a file folder linked to an online storage account owned by a user; and map a URL, comprising a sub domain concatenated to the registered domain name, to the file folder. The server(s) may be further configured to determine whether an alias for the URL, comprising the subdomain, is located in a DNS record for the domain name. The server(s) may automatically generate the file folder and map the URL to the file folder. Any HTTP requests comprising the URL received by the server(s) may be resolved to the file folder. | 09-11-2014 |
20140258349 | Systems for Associating an Online File Folder with a Uniform Resource Locator - Systems and method of the present invention provide for one or more server computers configured to register a domain name; receive a request to: generate a file folder linked to an online storage account owned by a user; and map a URL, comprising a sub domain concatenated to the registered domain name, to the file folder. The server(s) may be further configured to determine whether an alias for the URL, comprising the subdomain, is located in a DNS record for the domain name. The server(s) may automatically generate the file folder and map the URL to the file folder. Any HTTP requests comprising the URL received by the server(s) may be resolved to the file folder. | 09-11-2014 |
20140310044 | Transmitting an Electronic Message to Calendar Event Invitees - Systems and method of the present invention provide for one or more server computers configured to identify, within a database, an invitee the invitee's attendance status for an electronic calendar event; generate a control panel comprising a selectable list of a plurality of attendance statuses, including the attendance status of the at least one invitee; transmit the control panel to a client computer; receive a selection of the attendance status of the at least one invitee and a message content for the electronic message; and transmit the electronic message to the at least one invitee. | 10-16-2014 |
20140310045 | Generating and Displaying a Calendar Event Recurrence Preview - Systems and method of the present invention provide for one or more server computers configured to receive a start date and a recurrence interval for an electronic calendar event; generate a recurrence preview calendar comprising a graphical representation of a plurality of dates arranged to represent days and weeks within at least one month; highlight, within the recurrence preview calendar, the start date and at least one of the plurality of dates after the start date occurring at the recurrence interval; and transmit the recurrence preview calendar to a client computer. | 10-16-2014 |
Patent application number | Description | Published |
20120244529 | MULTIPLEX ANALYSIS OF CELLS, PARTICLES, AND OTHER ANALYTES - In general, the invention features multiplexed devices, systems, methods, and kits for analysis of cells, particles, and other analytes on a porous membrane. Preferred devices detect, identify and quantify low levels of microorganisms in complex biological samples, such as blood. An exemplary device includes a housing having a fluid inlet that is in fluid communication with a plurality of channels, e.g., having substantially the same fluidic resistance. Each of the plurality of channels is in fluid communication with a reservoir containing reagents for analyzing cells, particles, or other analytes bound to particles, one or more substantially planar, porous membranes through which the cells or particles do not pass, and one or more outlets, wherein liquid flowing away from the inlet is divided between the plurality of channels and flows through the one or more membranes towards the outlet, and wherein the reservoir is disposed upstream of the one or more membranes. | 09-27-2012 |
20140186832 | SELECTIVE ULTRASONIC LYSIS OF BLOOD AND OTHER BIOLOGICAL FLUIDS AND TISSUES - The present invention features methods for selective lysis of endogenous cells in a biological sample. In preferred embodiments, the methods of the invention comprise contacting the biological sample with lysis solution, and subjecting the mixture to ultrasound, thereby selectively lysing the endogenous cells in the biological sample. The invention also features a lysis solution comprising Saponin and Proteinase. | 07-03-2014 |
Patent application number | Description | Published |
20140178875 | Devices, Compositions and Methods Pertaining To Microscopic Analysis Of Microorganisms and Other Analytes of Interest - This invention pertains to devices, compositions and methods that can be used for the rapid determination of microorganisms, cells and other analytes of interest (e.g. a nucleic acid target) as well as associated properties of said microorganisms, cells and analytes. For example, said devices, compositions and/or methods can be applied to the determination of a trait of a microorganism present in a sample. Said devices, compositions and methods utilize matrix-forming prolonged-dissolution hydrophilic polymer to encapsulate hybridization probes and optionally other assay reagents within two or more reagent zones and/or matrix zones disposed on the surface of a substrate. Each reagent zone and/or matrix zone can be designed as a separate assay. Thus, a plurality of assays can be performed on a single substrate. In some embodiments, devices can be supplied in a form ready for a customer to rapidly perform one or a plurality of assays. | 06-26-2014 |
20150275280 | Devices, Compositions and Methods Pertaining To Microscopic Analysis Of Microorganisms and Other Analytes of Interest - This invention pertains to devices, compositions and methods that can be used for the rapid determination of microorganisms, cells and other analytes of interest (e.g. a nucleic acid target) as well as associated properties of said microorganisms, cells and analytes. For example, said devices, compositions and/or methods can be applied to the determination of a trait of a microorganism present in a sample. Said devices, compositions and methods utilize matrix-forming prolonged-dissolution hydrophilic polymer to encapsulate hybridization probes and optionally other assay reagents within two or more reagent zones and/or matrix zones disposed on the surface of a substrate. Each reagent zone and/or matrix zone can be designed as a separate assay. Thus, a plurality of assays can be performed on a single substrate. In some embodiments, devices can be supplied in a form ready for a customer to rapidly perform one or a plurality of assays. | 10-01-2015 |
Patent application number | Description | Published |
20090023645 | AIB1, a novel steroid receptor co-activator - The invention features a substantially pure DNA which includes a sequence encoding a novel steroid receptor co-activator which is overexpressed in breast cancer cells, diagnostic assays for steroid hormone-responsive cancers, and screening assays to identify compounds which inhibit an interaction of the co-activator with the steroid hormone. | 01-22-2009 |
20090035766 | Methods for Analyzing High Dimension Data for Classifying, Diagnosing, Prognosticating, and/or Predicting Diseases and Other Biological States - A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on the outcome of the supervised pattern recognition method, choosing multiple data points from the data, wherein the choice is based on the relative ranking of the individual data points, and using the multiple data points to determine if an unknown set of experimental data indicates a diseased condition, a predilection for a diseased condition, or a prognosis about a diseased condition. | 02-05-2009 |
20100312486 | METHODS FOR ANALYZING HIGH DIMENSIONAL DATA FOR CLASSIFYING, DIAGNOSING, PROGNOSTICATING, AND/OR PREDICTING DISEASES AND OTHER BIOLOGICAL STATES - A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on the outcome of the supervised pattern recognition method, choosing multiple data points from the data, wherein the choice is based on the relative ranking of the individual data points, and using the multiple data points to determine if an unknown set of experimental data indicates a diseased condition, a predilection for a diseased condition, or a prognosis about a diseased condition. | 12-09-2010 |
20120046878 | METHODS FOR ANALYZING HIGH DIMENSIONAL DATA FOR CLASSIFYING, DIAGNOSING, PROGNOSTICATING, AND/OR PREDICTING DISEASES AND OTHER BIOLOGICAL STATES - A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on the outcome of the supervised pattern recognition method, choosing multiple data points from the data, wherein the choice is based on the relative ranking of the individual data points, and using the multiple data points to determine if an unknown set of experimental data indicates a diseased condition, a predilection for a diseased condition, or a prognosis about a diseased condition. | 02-23-2012 |
20140221234 | Methods for Analyzing High Dimensional Data for Classifying, Diagnosing, Prognosticating, and/or Predicting Diseases and Other Biological States - A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from the data, wherein the ranking is dependent on the outcome of the supervised pattern recognition method, choosing multiple data points from the data, wherein the choice is based on the relative ranking of the individual data points, and using the multiple data points to determine if an unknown set of experimental data indicates a diseased condition, a predilection for a diseased condition, or a prognosis about a diseased condition. | 08-07-2014 |
Patent application number | Description | Published |
20130000738 | METHOD AND SYSTEM FOR TRANSFERRING AND/OR CONCENTRATING A SAMPLE - A method of controlling the concentration of a sample flowing through a microchannel is provided. The method includes flowing a sample carrier fluid from a sample carrier channel and into an upstream portion of a microchannel such that the sample carrier fluid flows from the upstream portion and toward a downstream portion of the microchannel, and flowing a sheathing fluid from a sheathing fluid channel and into the upstream portion of the microchannel such that the sheathing fluid flows from the upstream portion and toward the downstream portion of the microchannel, and generally parallel to the sample carrier fluid. The method further includes detecting a concentration of a sample in the sample carrier fluid in the downstream portion of the microchannel, and adjusting a flow rate of at least one of the sample carrier fluid and the sheathing fluid based upon the detected concentration of the sample. | 01-03-2013 |
20130295686 | INTERCALATION METHODS AND DEVICES - The invention provides devices and methods for improving labeling of nucleic acids including intercalation of nucleic acids using for example mono intercalators such as mono cyanine intercalators. | 11-07-2013 |
20130309780 | DEVICE FOR STRETCHING A POLYMER IN A FLUID SAMPLE - The invention provides structures and methods that allow polymers of any length, including nucleic acids, to be stretched into a long, linear conformation for further analysis. | 11-21-2013 |
20140234985 | DEVICE FOR STRETCHING A POLYMER IN A FLUID SAMPLE - The invention provides structures and methods that allow polymers of any length, including nucleic acids, to be stretched into a long, linear conformation for further analysis. | 08-21-2014 |
Patent application number | Description | Published |
20080299566 | Methylation of Gene Promoters as a Predictor of Effectiveness of Therapy - The present invention provides methods for identifying, diagnosing, evaluating or monitoring a disease state in a subject comprising identifying the methylation status of a panel of genes in the subject. The present invention also relates to identifying, diagnosing, evaluating or monitoring the responsiveness of a subject to a therapeutic regimen, with the methods comprising determining the methylation status of a panel of genes in the subject. | 12-04-2008 |
20090111120 | METHYLATION OF GENES AS A PREDICTOR OF POLYP FORMATION AND RECURRENCE - The present invention provides methods for identifying or assessing probabilities for developing an abnormal condition in subject and for the recurrence of the abnormal condition in the subject after receiving treatment. The method comprises determining the methylation status of at least one gene in the subject and comparing this methylation status to normal methylation status. Differences between the methylation status of the one or more genes is indicative of the subject developing an abnormal condition or for the recurrence of the abnormal conditions after receiving treatment. | 04-30-2009 |
20100183511 | SMALL PEPTIDES SPECIFICALLY BIND TO COLORECTAL CANCERS - Cancers are extremely heterogeneous in terms of the frequency and types of mutations present in different malignant tumors. Thus, it is likely that uniform clinical treatment is not optimal for all patients, and that the development of individualized therapeutic regimens may be beneficial. Multiple, unique small peptides bind to cell lines derived from different colon adenocarcinomas. Within two hours of contact, the colorectal cancer cells are able to transfer a | 07-22-2010 |
20100285466 | ESOPHAGEAL CANCER MARKERS - The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression. Characteristic expression of the markers indicates the presence of cancer or the predisposition to cancer. A panel of eleven markers are particularly good at identifying cancer and the predisposition to cancer. | 11-11-2010 |
20130209359 | Small Peptides Specifically Bind to Colorectal Cancers - Cancers are extremely heterogeneous in terms of the frequency and types of mutations present in different malignant tumors. Thus, it is likely that uniform clinical treatment is not optimal for all patients, and that the development of individualized therapeutic regimens may be beneficial. Multiple, unique small peptides bind to cell lines derived from different colon adenocarcinomas. Within two hours of contact, the colorectal cancer cells are able to transfer a | 08-15-2013 |
20140031246 | CIRCULATING MICRORNAS ARE BIOMARKERS OF VARIOUS DISEASES - The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to diagnose and monitor various diseases such as cancer. | 01-30-2014 |
20140031258 | SERUM-BASED MIRNA MICROARRAY AND ITS USE IN DIAGNOSIS AND TREATMENT OF BARRETT'S ESOPHAGUS (BE) AND ESOPHAGEAL ADENOCARCINOMA (EAC) - Robust and reliable molecular diagnostic screening tools for early detection of esophageal and gastrointestinal tract cancers and pre-cancerous lesions, such as Barrett's Esophagus, and esophageal adenocarcinoma are provided. Included in the invention is an array of miRNA probes specific for identifying, diagnosing and prognosticating esophageal and gastrointestinal tract cancers and pre-cancerous lesions in subjects from blood or serum samples. A biochip comprising the array as well as methods for its use are also provided. | 01-30-2014 |
20140206565 | Esophageal Cancer Markers - The present invention is directed to methods for diagnosing cancer in a subject. Morphologically normal epithelial cells of the esophagus are assayed for marker expression. Characteristic expression of the markers indicates the presence of cancer or the predisposition to cancer. A panel of eleven markers are particularly good at identifying cancer and the predisposition to cancer. | 07-24-2014 |
20150133330 | METHODS AND COMPOSITIONS USEFUL FOR DIAGNOSING INFLAMMATORY BOWEL DISEASE-ASSOCIATED NEOPLASIA - The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of microRNAs to diagnose and monitor various diseases such as cancer. In particular embodiments, microRNA expression levels can serve as diagnostic biomarkers in inflammatory bowel disease-associated neoplasia (IBDN). More specifically, in certain embodiments, the present invention can be used to differentiate or distinguish IBDN from sporadic colorectal cancer (S-CRC), IBD-Dysplasia, IBD and/or normal. | 05-14-2015 |
20150292029 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING GASTRIC CANCER - The present invention relates to the field of gastric cancer. More specifically, the present invention provides methods and compositions for diagnosing and treating gastric cancer. In a specific embodiment, a method for diagnosing gastric cancer or a likelihood thereof in a patient comprises the steps of (a) providing a sample from the patient; (b) measuring the methylation levels of one or more biomarkers in the sample collected from the patient; and (c) predicting gastric cancer in the patient if the biomarkers are hypermethylated. In a more specific embodiment, the one or more biomarkers comprises tight junction protein claudin-1 1 (CLD-N11), the transcription factor BarH-like homeobox (BARX1), basonuclin1 (BNC1), Coagulation factor C homolog (COCH), filamin C gamma (FLNC), cytoglobin B (CYGB), glutamine-fructose-6-phospahe-transaminase-2 (GFPT2), heat-shock-70 kDa protein-6 (HSPA6), snail homolog 1(SNAL1), skin calmodulin-related factor (SCARF), and tumor protein p53 binding protein 2 (TP53BP2). | 10-15-2015 |