Mcdonagh
Charlotte Mcdonagh, Bothell, WA US
Patent application number | Description | Published |
---|---|---|
20080305044 | Engineered Antibodies and Immunoconjugates - Antibody drug conjugates with predetermined sites and stoichiometries of drug attachment are provided. Also provided are methods of using antibody drug conjugates. | 12-11-2008 |
Charlotte Mcdonagh, Seattle, WA US
Patent application number | Description | Published |
---|---|---|
20090148942 | HUMANIZED ANTI-CD70 BINDING AGENTS AND USES THEREOF - Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions. | 06-11-2009 |
20140178936 | Humanized Anti-CD70 Binding Agents and Uses Thereof - Disclosed are CD70 binding agents, such as humanized anti-CD70 antibodies and fragments and derivatives, that exert a cytotoxic, cytostatic or immunomodulatory on CD70 expressing cells, as well as pharmaceutical compositions and kits comprising the antibody, fragment or derivative. Also disclosed are methods for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the CD70 binding agents or pharmaceutical compositions. | 06-26-2014 |
Daniel M. Mcdonagh, Seattle, WA US
Patent application number | Description | Published |
---|---|---|
20150041048 | Method and Apparatus for Fabricating Contoured Laminate Structures - Apparatus for forming composite plies on a contoured tool includes a forming head for forming the composite plies on the tool. The forming head is mounted on a manipulator and includes a compliant nosepiece adapted to conform to the contoured tool. | 02-12-2015 |
Daniel M.q Mcdonagh, Seattle, WA US
Patent application number | Description | Published |
---|---|---|
20150013162 | Apparatus and Method for Moving a Structure in a Manufacturing Environment - A mobile fixture configured to move a structure in a manufacturing environment may include a motorized base configured to move on a surface and a support system connected to the motorized base, the support system being configured to support the structure, the support system being configured to position the structure along at least one of an X-axis, a Y-axis, and a Z-axis, the support system being configured to position the structure about the Z-axis, and the support system being configured to provide free rotation of the structure about at least one of the X-axis and the Y-axis. | 01-15-2015 |
Dennis G. Mcdonagh, Olean, NY US
Patent application number | Description | Published |
---|---|---|
20090056493 | Steering column manufacturing machine and method of manufacturing a steering column - A method of manufacturing a steering column assembly having a first jacket and a second jacket with a bushing between the first and second jackets. The method utilizes a manufacturing machine having a loadable member, a fixed member, and a thermal fixture. The method comprises the steps of: assembling the first jacket to the second jacket with the bushing located radially between the first and second jackets to interlock the first and second jackets and prevent axial movement between the first and second jackets; connecting the first jacket to the loadable member of the manufacturing machine; connecting the second jacket to a fixed member of the manufacturing machine; loading the loadable member to apply an axial force to the first jacket; heating the thermal fixture of the manufacturing machine; and melting the bushing until the first jacket moves axially relative to the second jacket. | 03-05-2009 |
20120067160 | STEERING COLUMN MANUFACTURING MACHINE AND METHOD OF MANUFACTURING A STEERING COLUMN - A steering column assembly is provided. The assembly includes an outer jacket, an inner jacket telescopingly disposed within the outer jacket for movement along a longitudinal axis with a cavity defined between the inner and outer jackets. A bushing is radially disposed about the inner jacket within the cavity between the inner and outer jackets. The bushing includes at least one tab engaging the inner jacket to interconnect the bushing to the inner jacket and includes at least one radially projecting pad engaging the outer jacket to frictionally interconnect the bushing to the outer jacket for interlocking the inner and outer jackets. | 03-22-2012 |
Emma Louise Mcdonagh, Smailholme GB
Patent application number | Description | Published |
---|---|---|
20100173855 | Dermatological Formulations - Aqueous preparations of substantially equimolor amounts of a zinc salt and clindamycin phosphate form a polymer useful in the topical treatment of acne and rosacea, with very low systemic levels of clindamycin. | 07-08-2010 |
Greg Mcdonagh, Providence, UT US
Patent application number | Description | Published |
---|---|---|
20090249725 | Wall forming system and method thereof - A tie system and method for forming a wall from a hardenable pourable building material. In one embodiment, the tie system includes multiple ties configured to be directly interconnected into a vertically extending tie stack such that multiple tie stacks can be positioned over a footing in a spaced apart arrangement. The multiple tie stacks are configured to extend substantially perpendicular between substantially parallel panel structures. Each tie stack includes a base tie and one or more wall ties, each of which directly attach to each other in a vertically stacked arrangement. | 10-08-2009 |
Joanne Mcdonagh, Lawrenceville, GA US
Patent application number | Description | Published |
---|---|---|
20120042467 | REUSABLE CLEANING CLOTH - A reusable cleaning article comprising a base layer of microfiber cloth and a top layer of polyester material. The layer of polyester material is secured to the base layer of microfiber cloth. The reusable cleaning article also comprises a layer of foam. The layer of foam is secured between the base microfiber layer and the top polyester layer. | 02-23-2012 |
Lisa Mcdonagh, Dublin IE
Patent application number | Description | Published |
---|---|---|
20130174981 | CYANOACRYLATE ADHESIVE WITH IMPROVED WATER RESISTANCE - The present invention relates generally to cyanoacrylate adhesives and, more particularly, to a one-part adhesive, comprising one or more 2-cyanoacrylate esters, one or more bis-silanes and optionally one or more monosilanes and to the use of said adhesive as an instant adhesive with improved water resistance. | 07-11-2013 |
Louis Mcdonagh, Kaiserslautern DE
Patent application number | Description | Published |
---|---|---|
20130329762 | ENHANCED OPTICAL PUMPING OF MATERIALS EXHIBITING POLARIZATION-DEPENDENT ABSORPTION - An optically pumped laser oscillator or amplifier includes a laser head having a gain medium exhibiting polarization-dependent absorption along two crystallographic axes and a pump source producing a pump beam. The medium's absorption coefficients along both said crystallographic axes are equal or the difference between the absorption coefficients relative to the lowest absorption coefficients R=Abs(α | 12-12-2013 |
20150016479 | LASER APPARATUS WITH BEAM TRANSLATION - A laser-resonator is terminated between an outcoupling mirror and a semiconductor saturable absorbing mirror (SESAM). A beam-translator including two spaced-apart mirrors is located in the laser resonator in a beam-path of laser radiation circulating in the laser-resonator. The two spaced apart mirrors are selectively rotatable as a pair about two axes perpendicular to each other for selectively translating an incidence point of the laser radiation on the SESAM. | 01-15-2015 |
Louis Mcdonagh, Bordeaux FR
Patent application number | Description | Published |
---|---|---|
20110222565 | DEVICE FOR EXTENDING THE SERVICE LIFE OF A NON-LINEAR OPTICAL SYSTEM SUBJECTED TO THE RADIATION OF AN INTENSE LASER BEAM AND NON-LINEAR OPTICAL SOURCE INCLUDING SAID DEVICE - A device for extending the lifetime of a frequency-converting non-linear optical system ( | 09-15-2011 |
Matthew Mcdonagh, Victoria AU
Patent application number | Description | Published |
---|---|---|
20100136172 | PROCESS FOR THE PREPARATION OF ANGIOGENIN - The invention provides a process for the preparation of an angiogenin-enriched fraction from a milk product, the process comprising contacting the milk product with a cation exchange resin and eluting the angiogenin-enriched fraction from the cation exchange resin with a mobile phase. The invention also provides angiogenin-enriched fractions produced by process and food products, neutraceuticals and pharmaceutical comprising such angiogenin. | 06-03-2010 |
20110123514 | ANGIOGENIN-ENRICHED MILK FRACTIONS - The invention provides methods for enriching a milk extract for angiogenin, such methods involving separation by size, charge or immunoaffinity. The invention also provides the angiogenin enriched extract produced by the methods and provides them in pharmaceutical and neutraceutical compositions and foods for treating a variety of diseases or disorders that can be treated by angiogenin. | 05-26-2011 |
20110151016 | USE OF ANGIOGENIN OR ANGIOGENIN AGONISTS FOR TREATING DISEASES AND DISORDERS - The invention provides a method of treating a disorder characterised by elevated or dysregulated myostatin, disorders where the interaction between follistatin and angiogenin can be used to improve function in tissues, neurological diseases or disorders, spinal injuries or diseases, bone diseases or disorders, diseases involving glucose homeostasis, wound healing, neuro-protection, nervous system functional support or managing metabolic diseases, the method comprising administering an effective amount of angiogenin or an angiogenin agonist. Compositions and neutraceuticals comprising angiogenin are also provided. | 06-23-2011 |
20110262422 | ORALLY ADMINISTRABLE DOSAGE FORMS COMPRISING ANGIOGENIN AND USES THEREOF - The invention provides a method of treatment of any disorder in which administration of angiogenin is beneficial wherein the angiogenin is administered orally. Particularly, the oral angiogenin does not require a carrier or excipient or for the protein to be encapsulated or subjected to any other mechanism to improve its oral bioavailability. | 10-27-2011 |
Matthew Mcdonagh, Williamstown AU
Patent application number | Description | Published |
---|---|---|
20120309092 | Angiogenin Expression in Plants - The present invention relates to plant-produced angiogenins, to related plant cells, plant calli, plants, seeds and other plant parts and products derived therefrom and to uses of plant-produced angiogenins. The present invention also relates to expression of angiogenin genes in plants and to related nucleic acids, constructs and methods. | 12-06-2012 |
20120328591 | METHODS FOR IMPROVING ORAL DELIVERY - The invention provides a method of improving the oral delivery of a therapeutic agent, comprising the step of linking the therapeutic agent to a carrier protein comprising angiogenin, fusion proteins or conjugates comprising angiogenin and a therapeutic agent and their use in medicine. | 12-27-2012 |
20120331575 | TRANSGENIC NON-HUMAN ANIMALS - The invention provides a non-human transgenic animal comprising a transgene encoding angiogenin and food products comprising or obtained from the non-human transgenic animal and uses thereof. | 12-27-2012 |
20130039889 | RECOMBINANT MICROORGANISMS - The invention relates to a recombinant microorganism comprising a transgene encoding angiogenin and optionally follistatin, a food product, beverage product or animal feed produced from or comprising said microorganism and uses thereof. | 02-14-2013 |
20130243728 | RECOMBINANT MICROORGANISMS - The invention relates to a recombinant microorganism comprising a transgene encoding angiogenin and optionally follistatin, a food product, beverage product or animal feed produced from or comprising said microorganism and uses thereof. | 09-19-2013 |
Maurice Mcdonagh US
Patent application number | Description | Published |
---|---|---|
20150275546 | CLEANING DEVICE FOR DOOR HANDLES AND PUSH PLATES - A cleaning device for door handles and door push plates comprising a housing ( | 10-01-2015 |
Maurice Mcdonagh, Dublin IE
Patent application number | Description | Published |
---|---|---|
20150275546 | CLEANING DEVICE FOR DOOR HANDLES AND PUSH PLATES - A cleaning device for door handles and door push plates comprising a housing ( | 10-01-2015 |
Padraig Mcdonagh, Ballymote IE
Patent application number | Description | Published |
---|---|---|
20090145296 | Angled slot foam dispenser - The present invention provides a piston pump for liquid in which a sump is defined in a chamber into which sump liquid in the chamber flows due to gravity. A passageway leads from an outlet of the sump out of the chamber to a dispensing outlet. The dispensing outlet is at a height below the height of the sump outlet and fluid to exit the sump flows from the sump outlet upwardly in a first portion of the passageway to a height above the sump outlet then downwardly to the dispensing outlet. The chamber and its sump is defined between a piston chamber-forming member defining the chamber to be downwardly opening and a piston forming element axially slidable in the chamber. | 06-11-2009 |
Patrick Mcdonagh, Churchtown IE
Patent application number | Description | Published |
---|---|---|
20150135245 | USE OF SIMULTANEOUSLY RECEIVED VIDEOS BY A SYSTEM TO GENERATE A QUALITY OF EXPERIENCE VALUE - A first instance of a reference video is stored. A primary video and a second instance of the reference video are simultaneously received. At least one quality of experience value that infers a perceptual quality of the primary video as received by a system is generated by comparing the first instance of the reference video to the second instance of the reference video on a pixel-by-pixel, frame-by-frame, basis and determining whether each pixel and each frame contained in the first instance of the reference video are contained in the second instance of the reference video. | 05-14-2015 |
20150135246 | USE OF SIMULTANEOUSLY RECEIVED VIDEOS BY A SYSTEM TO GENERATE A QUALITY OF EXPERIENCE VALUE - A first instance of a reference video is stored. A primary video and a second instance of the reference video are simultaneously received. At least one quality of experience value that infers a perceptual quality of the primary video as received by a system is generated by comparing the first instance of the reference video to the second instance of the reference video on a pixel-by-pixel, frame-by-frame, basis and determining whether each pixel and each frame contained in the first instance of the reference video are contained in the second instance of the reference video. | 05-14-2015 |
20150189394 | DECODING MEDIA STREAMS WITHIN THRESHOLDS - A computer-implemented method, computer program product, and computing system is provided for decoding media streams. In an implementation, a method may include selecting a time window for monitoring discontinuities in a plurality of packets in a media transmission stream having a first time and a second time. The first time may indicate a beginning of the time window and the second time may indicate an end of the time window. The method may also include determining the number of discontinuities in the plurality of packets at the first time at a network node. The method may also include determining the number of discontinuities in the plurality of packets at the second time at the network node. The method may also include determining the number of discontinuities in the plurality of packets within the time window. The method may also include comparing the number of discontinuities within the time widow to a plurality of predefined discontinuities threshold values. The method may also include decoding one or more of the plurality of packets in the media stream based upon, at least in part, the comparison of the number of discontinuities within the time widow to the plurality of predefined discontinuities threshold values. | 07-02-2015 |
Patrick J. Mcdonagh, Tara IE
Patent application number | Description | Published |
---|---|---|
20100120008 | SYSTEM AND METHOD FOR INTERACTIVE LEARNING ON TELEVISION - A system and method for providing interactive learning applications on a television and managing the learning process is disclosed. The learning management technology utilizes internet, television, and learning management systems to allow a student to interactively access learning content. The functionality of the learning management system may be accessed on a television via a host server. The interactive application further allows parents and teachers to monitor student performance, change the learning content, control workflow, and send messages and reminders to the student. The interactive application further allows restriction of television viewing based on learning results or until an assignment has been completed. The learning content may be copied or downloaded onto a computer readable medium (e.g., a memory stick) from a central location (e.g., a Kiosk). The learning content may then be copied or uploaded to a television set-top box for execution by the television set-top box. The viewer may interact with the learning application via a remote control or other input device (e.g., a keyboard) coupled to the television set-top box. | 05-13-2010 |
Patrick W. Mcdonagh, Dublin IE
Patent application number | Description | Published |
---|---|---|
20140267787 | SYSTEM AND METHOD FOR MONITORING VIDEO PERFORMANCE - A computer-implemented method, computer program product, and computing system for receiving one or more transmitted frame identifiers that are mathematical representations of one or more transmitted video frames included within a multi-frame video. One or more video frames included within the multi-frame video are received, thus defining one or more received video frames. A mathematical representation of each of the one or more received video frames is generated, thus defining one or more received frame identifiers. The one or more received frame identifiers are compared to the one or more transmitted frame identifiers to determine a level of similarity between the one or more received video frames and the one or more transmitted video frames. | 09-18-2014 |
Patrick W. Mcdonagh, Churchtown IE
Patent application number | Description | Published |
---|---|---|
20150082366 | MANAGING QUALITY OF EXPERIENCE FOR MEDIA TRANSMISSIONS - A computer-implemented method, computer program product, and computing system is provided for quality of experience for media transmissions. In an implementation, a method may include defining a lower media stream discontinuity threshold. The method may also include evaluating a media stream discontinuity rate associated with a portion of a media stream. When the media stream discontinuity rate associated with the portion of the media stream is greater than the lower media stream discontinuity threshold, the method may further include determining a quality of experience associated with the portion of the media stream based upon, at least in part, a payload associated with the portion of the media stream. | 03-19-2015 |
Stephen T Mcdonagh, Derby GB
Patent application number | Description | Published |
---|---|---|
20090185769 | Bearing arrangement - An outer ring for a rolling element bearing has three mounting pads on its outer surface. The inner surface of the ring is arranged to be non-circular, with its effective radius being at a minimum at the three points midway between adjacent pairs of mounting pads. This provides a preload on the rolling elements of the bearing in use, preventing skidding, but because the ring is not supported between the pads it can still flex under loads. The ring may be oriented in use so that transient loads are directed through one of the mounting pads. | 07-23-2009 |
Stephen Terence Mcdonagh, Derby GB
Patent application number | Description | Published |
---|---|---|
20160069186 | LIQUID-CAPTURING SHAFT - There is provided a liquid-capturing shaft ( | 03-10-2016 |
Susan Jane Mcdonagh, Inverness GB
Patent application number | Description | Published |
---|---|---|
20100304383 | BIOMARKERS FOR PRENATAL DIAGNOSIS OF CONGENITAL CYTOMEGALOVIRUS - The invention provides compositions and methods useful for early detection of congenital CMV infection, predicting the likelihood and severity of congenital CMV disease, and monitoring the efficacy of therapeutic approaches. Compositions of the present invention include biomarkers that are differentially expressed in CMV-infected mothers and fetuses compared to uninfected individuals. | 12-02-2010 |
20140141406 | BIOMARKERS FOR PRENATAL DIAGNOSIS OF CONGENITAL CYTOMEGALOVIRUS - The invention provides compositions and methods useful for early detection of congenital CMV infection, predicting the likelihood and severity of congenital CMV disease, and monitoring the efficacy of therapeutic approaches. Compositions of the present invention include biomarkers that are differentially expressed in CMV-infected mothers and fetuses compared to uninfected individuals. | 05-22-2014 |