Mccartan
Damian Mccartan, Dublin IE
Patent application number | Description | Published |
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20150031626 | ADAM22 FOR USE AS A PROGNOSTIC VARIABLE, AND TARGET FOR THERAPY, OF A METASTATIC BREAST CANCER DISEASE - A method of diagnosing metastatic potential of a breast cancer in an individual with breast cancer is described. The method comprises a step of assaying a breast cancer tumour sample from the patient for expression of ADAM22, wherein expression of ADAM22 correlates with increased potential for metastasis compared with a patient who is ADAM22 negative. The invention also describes an agent for use in the treatment of metastatic breast cancer in a patient, in which the agent is selected from LGI1 protein (SEQ ID NO:1) and an LGI1 peptide mimic capable of mimicking the ADAM22 binding activity of LGI1 by binding to the LGI1 binding domain of ADAM22 (SEQ ID NO: 4) and which is capable of inhibiting migration of endocrine resistant breast cancer cells. | 01-29-2015 |
Darmian Mccartan, Dublin IE
Patent application number | Description | Published |
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20110097806 | METHOD OF ASSESSING CANCER STATUS IN A BREAST CANCER PATIENT - A method of assessing recurrence status in a breast cancer patient comprises a step of assaying a biological sample from the patient for a level of a biomarker selected from S100β or HOX-C1I, wherein positive detection of one or both of the biomarkers is indicative of a positive recurrence status. Suitably, the method is a method of prognosis of poor disease free survival in a breast cancer patient, wherein positive detection of one or both of the biomarkers is indicative of poor disease survival. The method may also be a method of diagnosis of recurrence, wherein positive detection of circulating S100β is a diagnostic variable of recurrence. The method of diagnosis is carried out on a patient who is undergoing first line therapy and/or a patient who has had surgery to remove a primary breast tumour. | 04-28-2011 |
Thomas Mccartan, Nashville, TN US
Patent application number | Description | Published |
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20140214544 | CUSTOMIZED ADVERTISEMENT SCHEDULING - There is disclosed a computerized system and method for scheduling advertising Events which utilizes a set of configurable instructions regarding booking an order which iterates through a series of broadening, configurable criteria and also implements a configurable scoring system for the purpose of comparing multiple Events to determine if one Event is more valuable than the other. | 07-31-2014 |