Patent application number | Description | Published |
20110159485 | Lysis Buffers for Extracting Nucleic Acids - The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be used in downstream applications such as genotyping, detection, quantification, and identification of the source of the biological material. | 06-30-2011 |
20120045767 | MAGNETIC BEADS HAVING SURFACE GLYCOCONJUGATES AND USE THEREOF - Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification. | 02-23-2012 |
20130157277 | DEVICE FOR CAPTURE AND LYSIS OF MICROORGANISMS FROM LIQUIDS AND METHODS OF USE THEREOF - Devices and methods for detecting microbial contaminants, such as bacteria and fungi, in fluids such as drinking water, pharmaceutical solutions and tissue culture media are provided. More particularly, provided are filtration devices for capture and processing of microorganisms from fluids, and improved methods for recovery, lysis and detection of microorganisms based on a combination of physical disruption with small beads and lysis solutions. | 06-20-2013 |
20140005061 | COMPOSITIONS AND METHODS FOR DETECTION OF MULTIPLE MICROORGANISMS | 01-02-2014 |
20140039176 | METHODS AND KITS FOR EXTRACTION OF DNA - Methods and materials are disclosed for use in recovering a biopolymer from a solution. In particular, the invention provides methods for extraction and isolation of nucleic acids from biological materials. The nucleic acids can be separated by forming a stable complex with soluble polysaccharide polymers and magnetic particles, in the presence of detergents and solvent. When the particles are magnetically separated out of the solution, the nucleic acids are separated with them. The nucleic acids can subsequently be released and separated from the particles. The nucleic acid preparation is useful for achieving efficient and accurate results in downstream molecular techniques such as quantification, identification of the source of the nucleic acids, and genotyping. | 02-06-2014 |
20140272940 | METHODS FOR DETECTION OF MULTIPLE TARGET NUCLEIC ACIDS - The present disclosure, in some embodiments, relates to compositions and methods for detection of multiple target nucleic acid sequences by a single nucleic acid amplification based assay (e.g. PCR). Compositions comprising two or more primers are described for multiple target nucleic acid detection. Methods for differential detection of microorganisms (including strains/serovars/subtypes thereof) and cell types comprise a single step method to detect a signature of target nucleic acid sequences comprising: two, three or more target nucleic acids that are uniquely present in a microorganism/strain/serovar/subtype and/or cell and absent in other closely related organisms/cells. Embodiments relate to methods of diagnosis of diseases or conditions that can be detected by detecting the presence of two or more nucleic acid target markers. | 09-18-2014 |
20150197743 | MAGNETIC BEADS HAVING SURFACE GLYCOCONJUGATES AND USE THEREOF - Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification. | 07-16-2015 |
20150307869 | DEVICE FOR CAPTURE AND LYSIS OF MICROORGANISMS FROM LIQUIDS AND METHODS OF USE THEREOF - Devices and methods for detecting microbial contaminants, such as bacteria and fungi, in fluids such as drinking water, pharmaceutical solutions and tissue culture media are provided. More particularly, provided are filtration devices for capture and processing of microorganisms from fluids, and improved methods for recovery, lysis and detection of microorganisms based on a combination of physical disruption with small beads and lysis solutions. | 10-29-2015 |