Mascarello
Alessandra Mascarello, Florianopolis BR
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20150191445 | ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF - The present invention relates to acyl-hydrazone compounds, in particular 3,4,5-trimethoxyphenyl-hydrazide derivatives, as well as the oxadiazole analogs thereof and other similar compounds, and to the pharmaceutical use of the same for the treatment of various diseases associated with cell proliferation, such as leukemias, including acute lymphoblastic leukemia (ALL), tumours and inflammation. Acyl-hydrazones have been obtained having activity similar to that of the compound used as a standard in experiments (colchicine). The greater selectivity of the compounds according to the invention is an important feature, associated with fewer side effects than the pharmaceuticals used at present in clinical treatments. The synthetised acyl-hydrazones, more particularly the compounds 02 and 07, exhibited important antileukemic activity, which suggests 02 and 07 as candidates to pharmaceutical prototypes, or to pharmaceuticals for the treatment of leukemias, in particular acute lymphoblastic leukemia (ALL), tumours and other proliferative diseases, such as inflammation. The action mechanism of the most active compounds was determined by using DNA microarrays and subsequent tests indicated by the chip, besides selectivity studies in healthy human lymphocytes. | 07-09-2015 |
Francesco Mascarello, Allschwil CH
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20120077992 | DEVICE FOR CARRYING OUT CHEMICAL REACTIONS UNDER HOMOGENOUS AND HETEROGENOUS CONDITIONS - The present invention relates to a device for treatment of material transported through the device comprising at least one porous element consisting of solid, for example metallic, structure which allows cross-flow of the material through the porous element. The invention also relates to various types of uses of the device. A device in accordance with the invention is particularly useful to carry out chemical reactions under homogenous and heterogeneous conditions. Such a device hereinafter also referred as reactor may comprises a tube ( | 03-29-2012 |
20120080113 | DEVICE FOR PROCESSING AND CONDITIONING OF MATERIAL TRANSPORTED THROUGH THE DEVICE - The present invention relates to a device for treatment of material transported through the device comprising at least one porous element consisting of solid, for example metallic, structure which allows cross-flow of the material through the porous element. A device in accordance with the invention is particularly useful as mixer or heat exchanger or to carry out chemical reactions under homogenous and heterogeneous conditions. Such a device hereinafter also referred as reactor may comprises a tube ( | 04-05-2012 |
Francesco Mascarello, Padova IT
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20150328217 | A CFTR CORRECTOR FOR THE TREATMENT OF GENETIC DISORDERS AFFECTING STRIATED MUSCLE - The present invention relates to the use of CFTR correctors in the treatment of genetic disorders affecting striated muscle selected from sarcoglycanopathies, Brody's disease (BD) and the recessive forms of Cathecolaminergic Polymorphic Ventricular Tachycardia (CPVT). | 11-19-2015 |
Ledimara Mascarello, Joinville BR
Patent application number | Description | Published |
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20120152815 | WATER FILTER SUPPORT - A device for supporting and fixing a water filter in connection with an oven having a chassis that includes: a housing for receiving the water filter that attaches to the bottom surface with a chassis of the oven; a protective plate that attached to the front wall of the housing; and a cover plate that hides the protective plate and the water filter to keep the set built-in. | 06-21-2012 |