Patent application number | Description | Published |
20090192178 | mGluR1 ANTAGONISTS AS THERAPEUTIC AGENTS - In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J | 07-30-2009 |
20110236400 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS - Disclosed are novel gamma secretase inhibitors of the formula. Also disclosed are methods of inhibiting gamma-secretase, methods of treating neurodegenerative diseases, and methods of treating Alzheimer's Disease. Also disclosed are processes for preparing alkenes in one reaction step using a mixture of an aldehyde (or ketone) and an alkyl substituted with two electron withdrawing groups, and reacting the mixture with: (a) a sulfonyl halide (e.g., a sulfonyl chloride) and a basic tertiary amine, or, (b) a sulfonyl anhydride and a basic amine, or (c) an aryl-C(O)-halide and a basic tertiary amine, or (d) an aryl-C(O)—O—C(O)-aryl and a basic tertiary amine, or (e) an heteroaryl-C(O)-halide and a basic tertiary amine, or (f) a heteroaryl-C(O)—O—C(O)-heteroaryl and a basic tertiary amine. | 09-29-2011 |
20120264736 | BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS - This invention discloses novel gamma secretase inhibitors of the formula: | 10-18-2012 |
Patent application number | Description | Published |
20090217544 | HOT STICK WITH MEASURING CALIPERS - There is a hot stick with measuring calipers. The hot stick has a hot stick stock and a hot stick driving bar. Movement of the hot stick driving bar controls the movement of fixed and movable jaw portions of internal and external caliper measurement jaws. In operation a dimension measuring element displays a distance between the fixed and movable jaw portions of the internal and external caliper measuring jaws. A hand grip allows an operator to move the hot stick driving bar relative to the hot stick driving bar. The hot stick stock and the hot stick driving bar both at least partially made of a dielectric material to allow measurements of at least one component of electrical power transmission equipment. The measurements may then be used to modify the electrical power transmission equipment. | 09-03-2009 |
20110019902 | PHOTOGRAMMETRIC METHODS AND APPARATUS FOR MEASUREMENT OF ELECTRICAL EQUIPMENT - A method is disclosed comprising: imaging a feature of a component of an electrical power transmission system for example in combination with a reference component or feature of known dimensions, the reference component or feature comprising a reference, to produce one or more images; analyzing the one or more images with a photogrammetry algorithm to measure the feature of the component; and placing a protector at least partially over the component, the protector being selected to fit the component based on the measurement of the feature. In some embodiments the method may further comprise making the protector based on the measurement of the feature. A method is also disclosed comprising: remotely placing a reference object into a position that is inside a safe Limit of Approach and in the vicinity of a feature of a component of an energized live electrical power transmission system, the reference object comprising a reference; imaging a combination of the reference and the feature of the component to produce one or more images; and analyzing the one or more images with a photogrammetry algorithm to measure the feature of the component. | 01-27-2011 |
20110083783 | CONDUCTOR COVER APPLICATOR - An applicator is disclosed for applying a tubular conductor cover to a cable, the conductor cover being split longitudinally to define a first longitudinal edge and a second longitudinal edge, the applicator comprising: a head having a separator shaped to contact, in operation of the applicator, an interior surface of the conductor cover to spread open the first longitudinal edge and the second longitudinal edge along a portion of the conductor cover to allow the portion of the conductor cover to be applied to a cable. A method is also disclosed of applying tubular conductor cover to a cable, the conductor cover being split longitudinally to define a first longitudinal edge and a second longitudinal edge, the method comprising: spreading open the first longitudinal edge and the second longitudinal edge of a portion of the conductor cover with a separator on a head, the separator contacting an interior surface of the conductor cover; and applying a length of conductor cover to the cable through the head. | 04-14-2011 |
20110192627 | APPARATUS AND METHOD FOR PROTECTING A COMPONENT OF AN ELECTRICAL POWER TRANSMISSION SYSTEM - An apparatus and method are disclosed for protecting a component of an electrical power transmission system. The apparatus comprises: a dielectric cover having opposed portions that define a component enclosing space when in a closed position; the dielectric cover having an open position in which enclosing edges of the opposed portions are spaced to allow entry of the component between the enclosing edges into the dielectric cover; and a spreader, connected to the opposed portions for moving the opposed portions into the closed position, and having a tool connector for operation of the spreader by a tool. The spreader may be configured to exert positive control in use to hold the opposed portions in position over a range of positions between the closed position and an open position. | 08-11-2011 |
20120151742 | FASTENER APPLICATOR TOOL AND METHOD - An applicator tool is disclosed for applying a fastener between cooperating surfaces of a dielectric protector placed at least partially over a component of an electrical power transmission system, the applicator tool made at least in part of dielectric material and comprising: a structural frame element; a fastener mount connected to the structural frame element and moveable relative to the structural frame element between a first position and a second position to at least partially define a fastener drive path; and an actuator connected to drive the fastener mount from the first position to the second position to apply in use a fastener, mounted on the fastener mount, through cooperating surfaces positioned on the fastener drive path. A tool is also disclosed for holding together in alignment two mating surfaces with pre-drilled holes and applying a fastener to penetrate the holes and secure the mating surfaces together. | 06-21-2012 |
20120284997 | TOOL AND METHOD FOR HANDLING A PART - A tool and method for handling a part within an electrical power transmission system is disclosed, the part having a flange with a hole through the flange. A first jaw and a second jaw are connected to pivot relative to one another and have respective ends that converge upon closure, for example to hold the flange between the respective ends. The first jaw may have a tooth extended at the respective end of the first jaw for fitting within the hole in the flange to hold the flange between the respective ends when the tool is in a closed position. The tool may be a hot stick adapter, or may include a hot stick made at least in part of dielectric material. An actuator may be connected to operate one or both of the first jaw and the second jaw from a user end of the hot stick. | 11-15-2012 |
20130239482 | APPARATUS AND METHOD FOR REMOTELY BLOCKING A CAVITY OF AN ENERGIZED ELECTRICAL TRANSMISSION SYSTEM - An apparatus and method for remotely blocking a cavity of a component of an energized electrical transmission system. A protector has a blocking part for blocking the cavity of the component. The protector has a hotstick connector. A dielectric hotstick has an engagement part such as a hook at a remote end of the dielectric hotstick. The hook may be removably connected to the external point of attachment for remote installation of the blocking part blocking the cavity within a component, such as a piece of equipment or support structure. The blocking part may be remotely installed blocking the cavity using a dielectric hotstick operated by a user who is in a position outside a safe Limit of Approach. The blocking part may comprise a compressible material such as rubber or memory foam. | 09-19-2013 |
20150068798 | ELECTRICAL POWER TRANSMISSION PROTECTORS WITH COMPONENT GRIPPERS, AND RELATED METHODS - A dielectric cover for protecting a component of an electrical power transmission system, the dielectric cover comprising: an enclosing part having enclosing portions that are configured for relative movement to each other to enclose the component; and a gripping part having gripping portions that are configured for relative movement to each other to grip the component, the movement of the gripping portions being independent of the relative movement of the enclosing part. | 03-12-2015 |
20150130200 | HOT STICK ADAPTER, COMBINATION, AND METHOD - An adapter for a dielectric hot stick, the hot stick having a hook, the hook being movable along an axis of travel that includes a retracted position where the hook is within an axial passage in the hot stick, and an extended position where the hook is extended past a work end of the hot stick, the adapter comprising: a frame with a hot stick seat shaped to be mounted on the work end of the hot stick, the frame defining a lever passage positioned to at least partially align with the axial passage in use; and a lever assembly pivotally connected to the frame, the lever assembly having a first end with a connector for the hook and being at least partially within the lever passage, and the lever assembly having a second end defining or connected to a tool part to move the tool part relative to the frame to carry out a function when the hook moves along the axis of travel. | 05-14-2015 |
20160035464 | BARRIER WALLS AND METHODS OF USE IN ELECTRICAL POWER TRANSMISSION SYSTEMS - A method of protecting an exposed switch mounted on a structural frame in an electrical power transmission system, the switch having one or more insulators extended from the structural frame, first and second conductor connectors supported on the one or more insulators, and a blade connected to pivot to close and open an electrical path between the first and second conductor connectors, the method including mounting a barrier wall adjacent the switch and on the structural frame. | 02-04-2016 |
Patent application number | Description | Published |
20100261195 | RAPID ANTEMORTEM DETECTION OF INFECTIOUS AGENTS - Methods for detection of the presence or absence of PrP | 10-14-2010 |
20110140001 | HIGH THROUGHPUT FIBER OPTICAL ASSEMBLY FOR FLUORESCENCE SPECTROMETRY - System for high-throughput detection of the presence of an analyte of interest in a sample, said system comprising a multi-well plate sample container; an automated means for successively transporting samples from the multi-well plate sample container to a transparent capillary contained within a sample holder; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the capillary, and wherein the radiation induces a signal which is emitted from the sample; and, at least one linear array comprising: a proximal end disposed in proximity to the sample holder and a single end port distal from the proximal end; a plurality of optical fibers extending from the proximal end to the end port and having a first end and a second end, wherein the first ends of the individual optical fibers are arranged substantially parallel and adjacent to one another, and wherein the second ends of the optical fibers form a non-linearly arranged bundle, and wherein the plurality of optical fibers transmits the fluorescent signal from the proximal end to the end port; and an end port assembly optically coupled to the end port, the end port assembly comprising a single photo-detector, wherein the photo-detector detects the fluorescent signal and converts the fluorescent signal into an electrical signal. | 06-16-2011 |
20120112069 | FIBER OPTICAL ASSSEMBLY FOR FLUORESCENCE SPECTROMETRY - System is provided for detecting the presence of an analyte of interest in a sample, said system comprising an elongated, transparent container for a sample; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the sample, and wherein the radiation induces a signal which is emitted from the sample; and, at least two linear arrays disposed about the sample holder, each linear array comprising a plurality of optical fibers having a first end and a second end, wherein the first ends of the fibers are disposed along the length of the container and in proximity thereto; the second ends of the fibers of each array are bundled together to form a single end port. | 05-10-2012 |
20160098825 | FEATURE EXTRACTION METHOD AND SYSTEM FOR ADDITIVE MANUFACTURING - The present invention provides a feature extraction system that extracts geometrical features of a part using in-process data acquired during an additive manufacturing process. The geometric features are extracted by applying a number of image processing operations to images taken of a powder bed during the additive manufacturing process. In this way, both internal and external geometries of the part can be characterized. In some embodiments, geometric feature extraction can be used in conjunction with other part characterizing operations, such as for example, thermal characterization processes. | 04-07-2016 |
Patent application number | Description | Published |
20080278040 | Air bypass system for biosafety cabinets - A biosafety cabinet has an air bypass system. The air bypass system reduces air noise and static pressure in the biosafety cabinet, and continues a supply of air to the blower, when the view screen or door is fully closed by providing an alternate path for the air entering the cabinet. The air bypass system further includes an armrest provided on the door sill. The armrest may have perforations on the front and rear surfaces of the armrest to allow the air to travel under the armrest, through an air inlet. The air bypass system additionally blocks germicidal light generated inside the biosafety cabinet from escaping when the view screen or door is fully closed. | 11-13-2008 |
20080278041 | Cable port for biosafety cabinet - A biosafety cabinet includes at least one cable port disposed in a wall of the cabinet that allows small tubing and/or cables to enter the cabinet through the walls. The cable port eliminates problems associated with running the tubing and/or cables through an open door at the front of the cabinet. The cable ports enable the user to fully close the view screen door, while maintaining the ability to connect various tubes and/or cables to devices in the interior work area of the cabinet. The biosafety cabinet further includes a double wall configuration with negative pressure air space between the two walls. Air and byproducts or contaminants attempting to escape from the cabinet into the room or enter the cabinet from the outside environment is captured in the negative pressure area between the walls and transported directly to an air filter. | 11-13-2008 |
20080278042 | Biosafety cabinets with air filters accessible through the work chamber - A biosafety cabinet includes one or more air filters below the work surface and a system for holding, sealing, replacing and disposing the air filters through the work access opening of the biosafety cabinet. The air filters under the work surface of the biosafety cabinet capture particulates entering the cabinet from the exterior environment and the particulates within the cabinet's work chamber. Instead of a mechanical clamp, the perimeter of the air filters are sealed using a gasket and a tape, eliminating the accumulation of the contaminants around mechanical clamps. The air filters may be accessed through the work access opening of the biosafety cabinet, packaged for disposal and removed from the biosafety cabinet without being exposed to the exterior environment. A filter cover with an adhesive surface is used to cover and lift the used, contaminated air filter within the biosafety cabinet. | 11-13-2008 |
Patent application number | Description | Published |
20090142640 | CARBON-TITANIUM OXIDE ELECTROCATALYST SUPPORTS FOR OXYGEN REDUCTION IN PEM FUEL CELLS - A high surface area support material is formed of an intimate mixture of carbon clusters and titanium oxide clusters. A catalytic metal, such as platinum, is deposited on the support particles and the catalyzed material us as an electrocatalyst in an electrochemical cell such as a PEM fuel cell. The composite material is prepared by thermal decomposition and oxidation of an intimate mixture of a precursor carbon polymer, a titanium alkoxide and a surfactant that serves as a molecular template for the mixed precursors. | 06-04-2009 |
20090312181 | MESOPOROUS ELECTRICALLY CONDUCTIVE METAL OXIDE CATALYST SUPPORTS - A catalyst support material comprising TiO | 12-17-2009 |
20100160153 | MAKING ELECTROCATALYST SUPPORTS FOR FUEL CELLS - Titanium oxide (usually titanium dioxide) catalyst support particles are doped for electronic conductivity and formed with surface area-enhancing pores for use, for example, in electro-catalyzed electrodes on proton exchange membrane electrodes in hydrogen/oxygen fuel cells. Suitable compounds of titanium and a dopant are dispersed with pore-forming particles in a liquid medium. The compounds are deposited as a precipitate or sol on the pore-forming particles and heated to transform the deposit into crystals of dopant-containing titanium dioxide. If the heating has not decomposed the pore-forming particles, they are chemically removed from the, now pore-enhanced, the titanium dioxide particles | 06-24-2010 |
20110081600 | CARBON-TITANIUM OXIDE ELECTROCATALYST SUPPORTS FOR OXYGEN REDUCTION IN PEM FUEL CELLS - A high surface area support material is formed of an intimate mixture of carbon clusters and titanium oxide clusters. A catalytic metal, such as platinum, is deposited on the support particles and the catalyzed material used as an electrocatalyst in an electrochemical cell such as a PEM fuel cell. The composite material is prepared by thermal decomposition and oxidation of an intimate mixture of a precursor carbon polymer, a titanium alkoxide and a surfactant that serves as a molecular template for the mixed precursors. | 04-07-2011 |
Patent application number | Description | Published |
20100029500 | OLIGONUCLEOTIDE ARRAYS TO MONITOR GENE EXPRESSION AND METHODS FOR MAKING AND USING SAME - The present invention provides an oligonucleotide array capable of identifying genes and related pathways involved with the induction of a particular phenotype by a cell line, e.g., the genes and related pathways involved with the induction of transgene expression by the cell line. The invention is particularly useful when there is little or no information about the genome of the cell line being studied, because it provides methods for identifying consensus sequences for known and previously undiscovered genes, and for designing oligonucleotide probes to the identified consensus sequences. Additionally, when the array is to be used to determine optimal conditions for expression of a transgene by the cell line, the invention teaches methods of including oligonucleotide probes to transgene sequences in the array. The invention also provides methods of using the array to identify genes and related pathways involved with the induction of a particular cell line phenotype. The invention also provides novel polynucleotides of undiscovered genes (i.e., a gene that had not been sequenced and/or shown to be expressed by CHO cells) and novel polynucleotides involved with the induction of a particular cell phenotype, e.g., increased survival when grown under stressful culture conditions, increased transgene expression, decreased production of an antigen, etc. These novel polynucleotides are termed novel CHO sequences and differential CHO sequences, respectively. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides methods of using the polynucleotides of the invention. | 02-04-2010 |
20110038863 | METHODS AND COMPOSITIONS FOR IMPROVING RECOMBINANT PROTEIN PRODUCTION - Nucleic acid molecules modified to enhance recombinant protein, e.g., antibody, expression and/or reduce or eliminate mis-spliced and/or intron read-through (IRT) by-products are disclosed. The invention also provides methods for producing proteins devoid of mis-spliced and/or intron read-through by-products by the use of such vectors in host cells under cell culture conditions suitable for recombinant protein expression. | 02-17-2011 |