Patent application number | Description | Published |
20090002383 | MEMORY FOR PROVIDING A GRAPHIC CONTENT - A memory device comprises a memory array and a processing device. The memory array is configured to store a graphic data set. The processing device is configured to initiate outputting of data of the graphic data set from the memory array and to combine the outputted data in response to a read request for providing a graphic content. | 01-01-2009 |
20090006785 | APPARATUS, METHOD AND SYSTEM FOR COMPARING SAMPLE DATA WITH COMPARISON DATA - An apparatus, method and system for comparing sample data with comparison date is disclosed. One embodiment provides a plurality of storage locations, an interface coupled to a plurality of storage locations for an exchange of data between the plurality of storage locations and external circuitry coupled to the interface, and a data comparator for comparing comparison data stored in the plurality of storage locations and sample data. | 01-01-2009 |
20090024806 | STORAGE DEVICE, STORAGE CONTROLLER, SYSTEM, METHOD OF STORING DATA, METHOD OF READING DATA AND FILE SYSTEM - A storage device comprises a storage location, an interface coupled to the storage location, and a data conversion circuit coupled to the storage location and to the interface. The interface is configured for an exchange of data between the storage device and external circuitry coupled to the interface. The data conversion circuit is configured for converting data from a first data format to a second data format. The data conversion circuit is configured to convert at least one of data read from the storage location before they are transferred to the interface, and data received via the interface before they are written to the storage location. | 01-22-2009 |
20090125984 | SYSTEM AND METHOD FOR ESTABLISHING DATA CONNECTIONS BETWEEN ELECTRONIC DEVICES - A system and method is disclosed, including establishing of data connections between electronic devices. One embodiment provides a method for establishing a data connection between a first and a second electronic device, wherein establishing the data connection is authorized by executing at least one action with at least one physical tool. | 05-14-2009 |
20100077139 | MULTI-PORT DRAM ARCHITECTURE - Embodiments of the invention provide a memory device that may be accessed by a plurality of controllers or processor cores via respective ports of the memory device. Each controller may be coupled to a respective port of the memory device via a data bus. Each port of the memory device may be associated a predefined section of memory, thereby giving each controller access to a distinct section of memory without interference from other controllers. A common command/address bus may couple the plurality of controllers to the memory device. Each controller may assert an active signal on a memory access control bus to gain access to the command/address bus to initiate a memory access. | 03-25-2010 |
20100077157 | MULTI MASTER DRAM ARCHITECTURE - Embodiments of the invention provide a memory device that may be accessed by a plurality of controllers or processor cores via respective ports of the memory device. Each controller may be coupled to a respective port of the memory device via a data bus. Each port of the memory device may be associated a predefined section of memory, thereby giving each controller access to a distinct section of memory without interference from other controllers. A common command/address bus may couple the plurality of controllers to the memory device. Each controller may assert an active signal on a memory access control bus to gain access to the command/address bus to initiate a memory access. In some embodiments, the memory device may be a package comprising a plurality of stacked memory dies. | 03-25-2010 |
20110066926 | PHASE SHIFT ADJUSTING METHOD AND CIRCUIT - Method and system of adjusting a first phase shift between a first data signal and a clock signal at a sending device. First and second test signals representing first and second test data, respectively, are transmitted to a receiving device. The test signals have respective phase shifts relative to the clock signal. An error detection code is calculated from first and second received data carried by the transmitted signals. The error detection code is transmitted from the receiving device to the sending device. An estimated first received data is calculated from the error detection code, wherein the estimated first received data are calculated under the assumption that the second received data are identical to the second test data. The first phase shift is adjusted on the basis of a comparison of the estimated first received data and the first test data. | 03-17-2011 |
Patent application number | Description | Published |
20080314120 | Method and Device for Determining Hydraulic Leakage Rate in Liquid-Conveying Sections, in Particular, Injection Valves of Internal Combustion Engines - A method and device for determining the hydraulic leakage rate of liquid-conveying parts, in particular injection valves for internal combustion engines, place the liquid-conveying part into a test body, and the liquid-conveying part is charged with a test liquid under a particular pressure, and a carrier gas stream is provided in a flow duct of the test body, and a vapor mixture behind the liquid-conveying part is conducted to an analyzer, and a measurement and analysis are carried out, using the analyzer, of the hydraulic leakage rate of the liquid-conveying part via the concentration of test liquid in the vapor mixture, the carrier gas stream being brought in via a nozzle element close to the leakage point of the liquid-conveying part, and/or a heating of the vapor mixture being provided behind the liquid-conveying part for complete conversion into the gas phase. The testing device is particularly suitable for leakage measurement in fuel injection valves used in fuel injection systems of mixture-compressing externally ignited internal combustion engines. | 12-25-2008 |
20090033448 | Device Having a Shape Memory Element - Conventional devices have a valve needle and a shape memory element which, by the application of a controllable magnetic field, executes a control stroke travel that operates the actuator, and having a coil that excites the magnetic field which is situated in a magnet housing which, at its end face, is bordered with respect to an actuating axis by a front wall in each case, the front walls having a through opening radially within the coil. It is a disadvantage that the magnetic field excited around the coil is conducted unfavorably, so that at most a slight magnetic field develops in the shape memory element. The shape memory element has a magnetic field flowing through it, in the direction of its longitudinal extension, if at all. Since the shape memory element has a high magnetic resistance and is developed to be very long in the axial direction, only a very weak magnetic field can be induced in the shape memory element. In response to the magnetic field that is weak at most, the shape memory element can generate only a very slight lift of the valve needle. In the device according to the present invention, a strong magnetic field is conducted through the shape memory elements, and in this way, a large control stroke travel is achieved. The shape memory element(s) is/are positioned generally only in the through opening(s). | 02-05-2009 |
20100006068 | FUEL INJECTOR - A fuel injector for fuel injection systems of internal combustion engines is described. The fuel injector includes an electromagnetic actuating element having a magnetic coil, a core and a valve jacket as the outer magnetic circuit component and a movable valve-closure member which interacts with a valve-seat surface assigned to a valve-seat member. The core and a connecting tube in an inner opening of a thin-walled valve sleeve and the valve jacket on the outer circumference of the valve sleeve are firmly connected to the valve sleeve by pressing them therein/thereon. The fixed press connection between two of these metallic components of the fuel injector is characterized in that at least one of the component partners has a structure including grooves in its press area and/or the particular press area has an inlet rounding in at least one transition to an adjacent component section. | 01-14-2010 |
20110177286 | COMPONENT COMPOSITE AND METHOD FOR MANUFACTURING A COMPONENT COMPOSITE - A component composite, in particular for motor vehicle applications, include a first component having a first contact surface and at least one second component having a second contact surface, which presses against the first contact surface, the first contact surface having a surface structure, which is produced using electromagnetic radiation. The surface structure has a microstructure overlaid by a nanostructure. | 07-21-2011 |
20120000994 | DEVICE FOR INJECTING FUEL - A device for injecting pressurized fuel includes an electrodynamic actuator having a movably situated coil, an outwardly opening needle which opens and closes a cross section on a valve seat, a connecting device which connects the needle to the movably situated coil, a pressure chamber which is situated at the needle upstream from the valve seat and contains pressurized fuel, a low-pressure chamber from which, fuel is dischargeable, and a gap seal which is provided at an outer peripheral region of the needle, the gap seal ( | 01-05-2012 |
20120012679 | DEVICE FOR INJECTING FUEL - A device for injecting fuel includes an electrodynamic drive having a movably situated coil, an inwardly opening needle which opens and closes injection holes on a valve seat, a connecting element which connects the needle to the movably situated coil, and a pressure chamber which is situated at the needle upstream from the valve seat and contains pressurized fuel. | 01-19-2012 |
20120043400 | ATOMIZER FOR LIQUIDS, METHOD FOR THE MANUFACTURE THEREOF, AND USE THEREOF - An atomizer is described for liquids, in particular for delivering water in a shower, having an outlet on a liquid supply line for spraying liquids at a low flow rate, the outlet having at least two nozzles for generating liquid jets and for atomizing. The present atomizer is based on the object of optimizing a washing device for delivering water, in particular in a shower, and providing a cost-effective embodiment of a shower head. The atomizer is characterized in that at least one atomizer attachment is provided, which includes at least one atomizer plate, which is convexly curved in the jet direction, and is inserted into the outlet, and at least one slot or multiple slots positioned in parallel directions to one another are introduced into the atomizer plate. The atomizer plate, which is convexly curved in the jet direction, is bent in a shell shape and/or channel shape. | 02-23-2012 |
20120207974 | COMPONENT COMPOSITE AND METHOD FOR MANUFACTURING A COMPONENT COMPOSITE - A component composite, in particular for motor vehicle applications, including a first component having a first contact surface, the first contact surface having a surface structure which has a microstructure overlaid by a nanostructure, and including at least one second component having a second contact surface. A medium, in particular an adhesive layer, is situated for integral connection between the two contact surfaces of the two components. | 08-16-2012 |
20120325939 | POLE BODY FOR SOLENOID VALVES PRODUCED BY MULTI-COMPONENT MIM - An injector having a valve opening, a cylindrical pipe, a valve opening, a valve needle situated inside the pipe in the radial direction and guided to allow axial displacement; a solenoid coil situated outside the pipe in the radial direction; a solenoid core disposed inside the pipe in the radial direction; and a magnetic armature situated inside the pipe, opposite the solenoid core in the radial direction, the magnetic armature being disposed on the valve needle. The pipe is a magnetic first material in a first pipe region and a third pipe region, the first region facing the valve opening in the axial direction, and the third pipe region facing away from the valve opening in the axial direction. The pipe is a non-magnetic second material in a second pipe region, the second pipe region being between the first pipe region and the third pipe region in the axial direction. | 12-27-2012 |
20130055988 | COMPONENT OF A FUEL INJECTION SYSTEM AND FUEL INJECTION SYSTEM - A component of a fuel injection system, designed in particular as a fuel distributor or a fuel injector, includes a base body on which at least one electric line is provided. The electric line is applied to the base body by plasma coating. In addition, a fuel injection system, used in particular for motor vehicles, includes a fuel distributor and multiple fuel injectors mounted on the fuel distributor. | 03-07-2013 |
20130068198 | FUEL DISTRIBUTOR - A fuel distributor, which is used, in particular, for fuel injection systems of mixture-compressing, internal combustion engines having externally supplied ignition, includes a distributor pipe, a first holder and at least one second holder. The distributor pipe has a longitudinal axis. In this connection, the first holder and the second holder are situated at the distributor pipe so as to be axially set apart from one another with respect to the longitudinal axis. The distributor pipe is designed to allow axial length compensation. It is also possible for at least one holder to be designed to allow axial length compensation. | 03-21-2013 |
20130248744 | METHOD FOR MANUFACTURING A SOLENOID VALVE - A method is described for manufacturing a solenoid valve, in particular a fuel injector, the solenoid valve having a valve needle which is movably guided in the axial direction, a magnet core and an armature which is situated axially diametrically opposed to the magnet core, the armature being situated on the valve needle, the armature having a first base material and a first reinforcing element and the magnet core having a second base material and a second reinforcing element. The method has one method step. The first reinforcing element is applied to the first base material and/or the second reinforcing element is applied to the second base material during the method step with the aid of molten bath spraying or with the aid of cold gas spraying. | 09-26-2013 |
20130306762 | FUEL INJECTION VALVE - A fuel injector for fuel-injection systems of internal combustion engines includes an electromagnetic actuating element having a solenoid coil, a fixed core, an outer magnetic circuit component, and a movable armature for actuating a valve-closure element, which cooperates with a valve-seat surface provided on a valve-seat element. The injector is characterized by its extremely small outer dimensions. The flexibility in the installation of fuel injectors of varying valve lengths, which is made possible very simply due to the special modular design, is significantly increased in this manner. An optimized dimensioning of the electromagnetic circuit allows for a DFR (dynamic flow range) greater than 17, the DFR being defined as the quotient of q | 11-21-2013 |
20140008468 | FUEL INJECTOR - A fuel injector for fuel injection systems of internal combustion engines. The valve includes an electromagnetic actuating element which has a solenoid, a solid core, an external magnetic circuit component, and a movable armature for activating a valve closing member which cooperates with a valve seat surface provided on a valve seat member. The valve has extremely small outer dimensions. By optimizing the dimensions of the electromagnetic circuit, the outer diameter of the external magnetic circuit component in the peripheral area of the solenoid is 10.5 mm01-09-2014 | |
20140028297 | ENCODER ELEMENT AND METHOD FOR PRODUCTION THEREOF - A method for producing an encoder element having a base body and a magnetic plastics element includes providing the base body and mixing a plastics base material with a magnetic or magnetizable filler to form an injection-molding material. The method also includes spraying the injection-molding material onto the base body so that a material-bonding, direct connection is produced between the base body and the sprayed-on plastics element. The method also includes magnetizing the sprayed-on plastics element. | 01-30-2014 |
20140123945 | FUEL DISTRIBUTOR - A fuel distributor which is used particularly for fuel injection systems of mixture-compressing, spark ignition internal combustion engines, includes a first half shell and a second half shell. A fuel chamber is embodied between the half shells. A plurality of cups is embodied on the first half shell and/or on the second half shell. The first half shell and the second half shell are connected to each other in a continuous material manner. Such a fuel distributor is especially suitable for medium pressure, particularly between 5 MPa and 7 MPa. | 05-08-2014 |
20140305409 | Fuel System - A fuel system comprises a first reservoir for a first fuel in liquid phase that has a first vapor pressure, and a second reservoir for a second fuel in liquid phase that has a second vapor pressure. The second vapor pressure is higher than the first vapor pressure. The fuel system further includes a mixing device for mixing the first fuel in liquid phase with the second fuel in liquid phase, and an injector which is hydraulically connected to the mixing device and is configured so that as, or immediately after, the mixture passes through an outlet opening of the injector, the second fuel changes from the liquid phase to a gaseous phase. | 10-16-2014 |
20140346383 | METHOD FOR MANUFACTURING A MAGNETIC SEPARATION FOR A SOLENOID VALVE - A method for manufacturing a solenoid valve or a fuel injector, including a sleeve, a valve needle situated inside the sleeve in a radial direction and guided so as to slide, a solenoid coil situated outside of the sleeve in a radial direction, a magnetic core situated inside the sleeve in a radial direction, and a magnet armature situated inside the sleeve in a radial direction, axially opposite to the magnetic core; the magnet armature being situated on the valve needle, the sleeve having a low wall thickness in a thin-walled region situated between the magnet armature and the solenoid coil, the thin-walled region strengthened by a reinforcing element for absorbing radial forces; and a method step, during which, the reinforcing element is deposited onto the sleeve, in the thin-walled region, in a radial direction, outside of the sleeve, using a molten bath or cold gas spraying method. | 11-27-2014 |
20150136878 | DEVICE FOR INJECTING FUEL - A device for injecting fuel includes an electrodynamic drive having a movably situated coil, an inwardly opening needle which opens and closes injection holes on a valve seat, a connecting element which connects the needle to the movably situated coil, and a pressure chamber which is situated at the needle upstream from the valve seat and contains pressurized fuel. | 05-21-2015 |
20150285164 | Fuel System for an Internal Combustion Engine which can be Operated with at least Two Fuel Types - A fuel system for an internal combustion engine is configured to operate with at least two fuel types, and includes an electrically driven high-pressure fuel pump for at least one of the two fuel types. The high-pressure fuel pump is connected on an outlet side to a high-pressure line which is common to the two fuel types. | 10-08-2015 |
Patent application number | Description | Published |
20090023673 | LIPID CONTAINING FORMULATIONS - Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described. | 01-22-2009 |
20090239814 | Carbohydrate Conjugates as Delivery Agents for Oligonucleotides - The present invention provides iRNA agents comprising at least one subunit of the formula (I): | 09-24-2009 |
20110250138 | SINGLE-STRANDED AND DOUBLE-STRANDED OLIGONUCLEOTIDES COMPRISING A METAL-CHELATING LIGAND - The invention provides modified oligonucleotides of formula (I), comprising at least one metal chelator which provides a powerful tool for study of the pharmacokinetics of siRNA and its correlation with in vivo activity. The chelated metals provide luminescent properties enable detection of the oligonucleotides through the use of time-resolved fluorescent quenching based on energy transfer from the metal ion to a nonfluorescent quencher which can be used as non-isotopic labels of oligonucleotides for diagnostics and evaluation of cellular uptake. | 10-13-2011 |
20120046478 | LIPID CONTAINING FORMULATIONS - Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described. | 02-23-2012 |
20140113957 | Compositions and Methods for Inhibition of Expression of Apolipoprotein C-III (APOC3) Genes - The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3. | 04-24-2014 |
20150247143 | COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF - The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria. | 09-03-2015 |
20160108401 | COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF - The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria. | 04-21-2016 |
Patent application number | Description | Published |
20110218334 | PHOSPHOROTHIOATE OLIGONUCLEOTIDES AND NON-NUCLEOSIDIC PHOSPHOROTHIOATES AS DELIVERY AGENTS FOR iRNA AGENTS - The invention relates to use of single-stranded phosphorothioate oligonucleotides or non-nucleosidic phosphrothiaote as vehicles or carriers to modulate the biodistribution of iRNA agents. | 09-08-2011 |
20110223665 | ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND - One aspect of the present invention relates to a double stranded nucleic acid useful as an siRNA, that has a sense strand and an antisense strand relative to a target nucleic acid, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the antisense strand. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one nucleoside comprising a non-natural nucleobase. Another aspect of the invention relates to a method of gene silencing, comprising administering to a mammal in need thereof a therapeutically effective amount of a double-stranded oligonucleotides containing a sense strand and an antisense strand, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the antisense strand. | 09-15-2011 |
20110311583 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - (A1) Translate this text The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ?-aminoalkyls, ?-(substituted)aminoalkyls, ?-phosphoalkyls, ?-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(0)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ?-aminoalkyl, ?-(substituted)aminoalky, ?-phosphoalkyl or ?-thiophosphoalkyl. | 12-22-2011 |
20120027803 | BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS - The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid. | 02-02-2012 |
20120136042 | CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES - The present invention provides iRNA agents comprising at least one subunit of the formula (I): | 05-31-2012 |
20130017223 | METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS - A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties. | 01-17-2013 |
20130178512 | CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES - The present invention provides iRNA agents comprising at least one subunit of the formula (I): | 07-11-2013 |
20130195920 | BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS - The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid. | 08-01-2013 |
20130196434 | ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND - One aspect of the present invention relates to a double stranded nucleic acid useful as an siRNA, that has a sense strand and an antisense strand relative to a target nucleic acid, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the antisense strand. Another aspect of the present invention relates to a single-stranded oligonucleotide comprising at least one nucleoside comprising a non-natural nucleobase. Another aspect of the invention relates to a method of gene silencing, comprising administering to a mammal in need thereof a therapeutically effective amount of a double-stranded oligonucleotides containing a sense strand and an antisense strand, where the sense strand contains one or more modified nucleobases, or one or more mismatch base pairings with the antisense strand. | 08-01-2013 |
20130317080 | MODIFIED iRNA AGENTS - The present invention provides effective motifs for RNA agents conjugated to at least one ligand, which are advantageous for the in vivo delivery of iRNA duplex agents. Additionally, the present invention provides methods of making these compositions, as well as methods of introducing these iRNA duplex agents into cells using these compositions, e.g., for the treatment of various disease conditions. | 11-28-2013 |
20140121393 | LIPID CONTAINING FORMULATIONS - Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described. | 05-01-2014 |
20140200257 | PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY - The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery. | 07-17-2014 |
20140288158 | MODIFIED RNAi AGENTS - One aspect of the present invention relates to double-stranded RNAi (dsRNA) duplex agent capable of inhibiting the expression of a target gene. The dsRNA duplex comprises one or more motifs of three identical modifications on three consecutive nucleotides in one or both strand, particularly at or near the cleavage site of the strand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions. | 09-25-2014 |
20140308304 | LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS - The present invention relates to novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid. | 10-16-2014 |
20140315835 | RNAI AGENTS, COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING TRANSTHYRETIN (TTR) ASSOCIATED DISEASES - The present invention provides RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene and methods of using such RNAi agents for treating or preventing TTR-associated diseases. | 10-23-2014 |
20150119444 | Carbohydrate Conjugates as Delivery Agents for Oligonucleotides - The present invention provides iRNA agents comprising at least one subunit of the formula (I): | 04-30-2015 |
20150119445 | Carbohydrate Conjugates as Delivery Agents for Oligonucleotides - The present invention provides iRNA agents comprising at least one subunit of the formula (I): | 04-30-2015 |
20150265708 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure | 09-24-2015 |
20150273068 | BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS - The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid. | 10-01-2015 |
20150306039 | IMPROVED NUCLEIC ACID LIPID PARTICLE FORMULATIONS - The present invention relates to lipid nanoparticles containing a biodegradable cationic lipid which provide improved delivery of active pharmaceutical ingredients, such as siRNA. | 10-29-2015 |
20160051691 | CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES - The present invention provides iRNA agents comprising at least one subunit of the formula (I): | 02-25-2016 |