Patent application number | Description | Published |
20090143002 | COMPUTER SYSTEM AIRFLOW OPTIMIZATION AND CONFIGURATION DEVICE - The air flow optimization apparatus includes a first member configured to attach to openings of an air vent on a server enclosure, such that the attachment of the first member to the air vent prevents air leakage. Further, the air flow optimization apparatus includes a second member configured to mount on top of a fan module connector within the server enclosure. A method for installing the air flow optimization apparatus includes inserting the first member into the openings of the air vent in a server enclosure, such that the first member includes attaching fins configured to be inserted into outer ends of the openings of the air vent. Further, the method for installing the air flow optimization apparatus also includes mounting the second member on top of a fan module connector, such that the second member includes engaging portions configured to engage with the fan module connector. | 06-04-2009 |
20140013809 | SECURITY APPARATUS WITH BLOCKING ELEMENT - A security apparatus for securing a portable device includes a shell configured to surround at least a portion of the portable device, an attachment device coupled to the shell, and a blocking element defining a clearance aperture. The blocking element is movably coupled to the shell for movement between a first position, in which the portable device is removable from the shell, and a second position, in which the portable device is secured within the shell. The attachment device extends through the clearance aperture of the blocking element when the blocking element is in the second position. | 01-16-2014 |
20140015812 | TABLET STYLUS WITH PRESENTATION INTERACTION FUNCTIONALITY - A handheld apparatus includes a body including a laser portion having a laser lens, a stylus portion having a conductive tip, and a connection portion coupled to the laser portion and the stylus portion. The connection portion has a charging port. The laser portion and the stylus portion are movable relative to each other between a first position, in which at least one of the laser portion and the stylus portion covers the charging port of the connection portion, and a second position, in which the charging port of the connection portion is exposed. The handheld apparatus also includes a power source positioned within the body and coupled to the charging port, and a laser module positioned within the laser portion. The laser module is operable to output a directed laser through the laser lens. | 01-16-2014 |
20150041341 | CASE FOR A PORTABLE ELECTRONIC DEVICE - A case for a portable electronic device and a keyboard includes a first cover portion, an engagement member secured to the first cover portion and configured to support the portable electronic device, a second cover portion configured to support the keyboard, and a spine portion connecting the first cover portion to the second cover portion. The spine portion allows movement of the first cover portion relative to the second cover portion so that the case is positionable in a closed position and in an operating position. The case also includes a rigid spine component coupled to the second cover portion adjacent the spine portion. The rigid spine component includes a groove configured to receive a portion of at least one of the engagement member and the portable electronic device when the case is in the operating position. | 02-12-2015 |
20150114880 | RETAIL PACKAGING SYSTEM - A retail packaging system includes an electronic device case and a packaging box for enclosing and displaying the electronic device case. The packaging box includes a bottom cover and a top cover pivotally coupled to the bottom cover. A pedestal is positioned at least partially within the bottom cover and supports the electronic device case, and a hinge is coupled to the pedestal and the top cover such that the pedestal lifts the electronic device case relative to the bottom cover as the packaging box is opened into a display position. | 04-30-2015 |
20150116926 | PORTABLE ELECTRONIC DEVICE CASE, FOLIO, AND DOCK - A docking system for a portable electronic device includes a dock having a housing and a lock mechanism supported by the housing. The housing is configured to couple to the portable electronic device. The lock mechanism is operable to secure the portable electronic device to the housing. The docking system also includes a wireless key operable to communicate with the dock and an actuator coupled to the lock mechanism. The actuator is operable to disengage the lock mechanism to release the portable electronic device from the housing when the wireless key communicates with the dock. | 04-30-2015 |
20150116927 | PORTABLE ELECTRONIC DEVICE CASE, FOLIO, AND DOCK - A system for use with a portable electronic device includes a case having a body configured to receive the portable electronic device, a first attachment structure formed on the body, and a second attachment structure formed on the body. The system also includes a folio having a cover and an attachment member. The attachment member is engageable with the first attachment structure of the case to selectively attach the case to the folio. The system further includes a dock having a housing and a lock mechanism supported by the housing. The lock mechanism is engageable with the second attachment structure of the case to selectively attach the case to the dock. | 04-30-2015 |
20150151879 | SYSTEM FOR COUPLING ACCESSORY DEVICES TO A PORTABLE ELECTRONIC DEVICE - A system for coupling accessory devices to a portable electronic device includes a casing that receives the portable electronic device. The casing has a front opening through which a display screen of a portable electronic device is accessible to a user, and a rear opening. The system further includes a plate element that is inserted into the casing and is positioned adjacent the rear opening such that a portion of the plate element is exposed by the rear opening. The system further includes an accessory device coupled to the plate element. The accessory device has an inner portion and an outer portion, such that when the accessory device is coupled to the plate element, at least part of the plate element is between the inner portion and the outer portion. | 06-04-2015 |
20150177362 | PROXIMITY TAGS FOR VEHICLES - An object tracking system includes a wireless device having a first antenna, a first transceiver coupled to the first antenna, and a sensor coupled to the first transceiver and configured to monitor a parameter of the vehicle. The parameter is related to an operational state of the vehicle. The object tracking system also includes a mobile communication device having a second antenna, a second transceiver coupled to the second antenna and configured to communicate with the wireless device, and a processor coupled to the second transceiver. The processor is operable to generate a first list of objects when the vehicle is in a first operational state, generate a second list of wireless when the vehicle is in a second operational state, and compare the second list of objects to the first list of objects. | 06-25-2015 |
Patent application number | Description | Published |
20110087592 | SYSTEMS AND METHODS FOR FACILITATING TRANSACTIONS - Pursuant to some embodiments, a payment account including multiple subaccounts is provided where each subaccount can be used only for payment for a designated category of products. Pursuant to some embodiments, purchases using the subaccounts can be automatically combined in a single transaction to redeem multiple categories of products, with each subaccount providing funds for the redemption of a single product category. In some embodiments, the payment account may include a subaccount that contains value that is unrestricted and available for general spending or to automatically provide supplementary funds for the redemption of products from subaccounts with product category restrictions. The value contained within each subaccount may be immediately available funds, access to credit provided by an entity who has agreed to extend credit to the account holder for purchasing products in a designated category or a combination of these types of value. Alternatively, in some embodiments, the value may include benefits provided by a health care plan whose redemption is limited to specific categories of products and services as provided by the plan. | 04-14-2011 |
20110099028 | SYSTEMS AND METHODS FOR VERIFYING MEDICAL PROGRAM ELIGIBILITY AND PAYMENT DATA - Systems, methods and means for facilitating verification transactions in connection with a discount medical program are provided which include a verification host, configured to maintain rules and logic relating to price and member verification, a rate verification subsystem configured to maintain rules and logic for receiving price information from a plurality of discount medical plan sponsors including the prices for services from each medical service provider participating in the program and for processing requests for price verification received from medical services providers, and a member verification subsystem configured to maintain rules and logic for issuing a payment card to individuals with said card representing membership in a discount medical program, for receiving member information from medical plan sponsors including the current membership status of each member, for processing requests for member verification received from medical services providers, and for processing payment transactions associated with the member payment card. | 04-28-2011 |
20120059701 | SYSTEMS AND METHODS FORFACILITATING A REWARDS PROGRAM INVOLVING MULTIPLE PAYMENTS ACCOUNTS - Systems and methods are provided for linking multiple payment card accounts to a single rewards program account which include associating, in a program management computer system, a first program identifier with the single rewards program account, associating, in the program management computer system, the first program identifier with a first payment card account, associating, in the program management computer system, the first program identifier to at least a second payment card account; and storing, in the program management computer system, at least a first set of reward program rules associated with the single reward program account, the first set of reward program rules specifying at least one of a reward conversion ratio and a promotion rule. Payment transactions conducted using the first and at least second payment card accounts earning a reward amount are associated with the single rewards program account and the first set of reward program rules are applied to the payment transactions. | 03-08-2012 |
20150242980 | Processes to Enable Individuals to Opt Out (or be Opted Out) of Various Facial Recognition and other Schemes and Enable Businesses and other Entities to Comply with Such Decisions - Falling costs of imaging technologies, processing, data storage, and networking have led to an explosion in the use of facial recognition technologies previously used almost exclusively by governments at border checkpoints and around other high value and sensitive locations. Increasingly, private companies are using these technologies, usually paired with other technologies and data for commercial purposes. This widespread and growing use of facial recognition has profound implications for personal privacy. While government use of facial recognition technology is generally unrestricted in public places and commercial use is largely unregulated, more stringent controls are likely to be imposed upon uses of facial recognition. The disclosure provides a multifaceted method of administering a system whereby individuals can request or demand (depending on the legal framework) to opt out of facial recognition collection, processing, correlation, storage, and dissemination. | 08-27-2015 |
20150245200 | Processes for Protecting Privacy Through Mobile Device Signature-Hopping - This disclosure allows greater privacy for mobile device users while maintaining functionality through a process of signature-hopping. Mobile devices have persistent identifiers or signatures which are used in providing device functionality (routing calls to the correct number, returning web queries to the originating device, and connection continuity in local area networks such as WiFi®. These persistent identifiers or signatures can also be collected by unintended recipients or used by intended recipients to correlate, track, or otherwise discover information about the user of the device in extremely intrusive ways. Regularly changing these signatures can mitigate privacy problems for mobile device users, and the disclosure here shows how functionality may be maintained through these changes. | 08-27-2015 |
Patent application number | Description | Published |
20100010901 | POINT-OF-SALE TRANSACTION MANAGEMENT - A point-of-sale system comprises a webserver that receives lists of products and services offered at retail points of sale, and that can sort them into items that are qualified, conditionally qualified, and non-qualified to be purchased by a cardholder using a flexible spending account payment card. The qualified items are permissible to be purchased by all cardholders, but purchases of conditionally qualified items are only permissible when the cardholder has registered a particular qualifying characteristic. For example, a health condition for which a doctor has prescribed the retail item for purchase. The demographics of the cardholders are available for affinity programs, promotional offers, discounts, and rebates. Such are proffered at the point of sale during transaction authorization to be considered by the cardholder or to be automatically exercised. Purchases in excess of the funds then available in the cardholders' flexible spending accounts can be deducted from other registered accounts or payrolls. | 01-14-2010 |
20100010909 | BENEFIT ORDERING AND COMPLIANCE SERVER - A benefits ordering system provides flexible spending account debit cards to employees and allows their employer to enroll in a Plan that ensures compliance with ERISA regulations. The system applies compliance rules during a data collection and plan definition stages of ordering, and produces an ERISA-compliant Plan and documentation as legally required. A directed questioning and answering wizard guides companies and participants through the placing of orders for products. The particular sequence of questions is dependent on the products being ordered, and the parameters drive variations in the plans. Rules and parameters are built into libraries used by the system, and it is these that direct the information collection flow. Each type of Plan is constructed from previously composed paragraphs that are threaded together to encapsulate the parameters and include the required components. Plans can be modified, if new compliance rules must be met, based on changing parameters. | 01-14-2010 |
20140143728 | ERGONOMIC THUMB INTERFACE FOR MOBILE PHONE, SMART PHONE, OR TABLET - An ergonomic graphical user interface in a mobile device allows a user to use the mobile device effectively with one hand. The ergonomic user interface organizes icons representing related application programs into common arcs. Such arcs serve as a convenient gateway to apps of a specific context category and thus enhance the ability to comfortably use the mobile device using only one hand. The advantages are achieved by basing the interface design on ease of interaction with the touch screen using the natural range of motion of the human thumb. Related application programs may share data, information and resources. A sever may interact with the related applications to provide additional services and analytical information based on the shared data. | 05-22-2014 |
20140157256 | OWNER/USER-DRIVEN CONTROLLED DISTRIBUTION OF SOFTWARE FOR MOBILE DEVICES AND PERSONAL COMPUTER THROUGH A PRIVILEGED PORTAL - A business process links several interrelated technological processes that allow a user or an owner to control the scope of applications or programs downloaded to a device by linking 1) an application or program rating system to 2) custom filters that screen out applications or programs not meeting the criteria defined by the user or owner to 3) a lock-down feature which warns, discloses, or impedes downloads or installation of applications not meeting the filter criteria to 4) an application or program removal system that removes or alerts users or owners of the presence of disables applications or programs that are either no longer consistent with user or owner expressed preferences because of a change of those preferences or a re-rating of or change in the application or program. | 06-05-2014 |
Patent application number | Description | Published |
20100081350 | Smooth surface ceramic composites - A method of making a smooth surfaced, fiber reinforced ceramic matrix composite includes the steps of providing a fiber preform, the preform having a surface containing voids; placing fibers into the voids; coating the preform fibers and the void fibers with a coating material to create a weak interface; and infiltrating the coated fibers with a matrix material to infill the voids and preform, and form strongly bonded networks within the voids. Alternatively, the resulting smooth surfaced, fiber reinforced ceramic matrix composite may include, in addition to the first coating material on the preform fibers and the void fibers and the matrix material within the coated fibers and the preform to infill the voids and preform, a second coating material on the preform fibers and the void fibers, creating a second coating of substantially uniform thickness on the fibers and forming strongly bonded networks within the voids. | 04-01-2010 |
20100329880 | HYBRID COMPOSITE FOR EROSION RESISTANT HELICOPTER BLADES - A protective hybrid composite for a rotor blade is based on the use of tape cast ceramic layers densified by pre-ceramic polymer infiltration methods and laminated together with polymer matrix composite prepregs, with or without an embedded metallic mesh, to form a conforming helicopter blade cladding that is laminated to the blade surface for added erosion protection. The hybrid composite is fabricated to net shape and laminated to the blade using either an adhesive or a polymer composite prepreg inner layer. Installation is accomplished by a standard composite fabrication method of vacuum bagging the blade while the system is laminated to its surface. Repair methods based on removal of ceramic tiles is facilitated by incorporation of a metallic mesh element laminated beneath the ceramic tiles that can be used to heat the tile and decrease its adhesion strength. | 12-30-2010 |
20110180145 | Tailorable Stiffness Shape Morphing Flow-Path - An apparatus and method for an improved morphing flow path. A flexible structure has a plurality of sections which include a first section and a second section. An actuator system is connected to the flexible structure and includes a number of actuators. The actuator system is capable of changing a configuration of the flexible structure. A controller is connected to the actuator system. The controller is capable of changing a position of a number of actuators within the actuator system. | 07-28-2011 |
20140014263 | HYBRID COMPOSITE FOR EROSION RESISTANT HELICOPTER BLADES - A protective hybrid composite for a rotor blade is based on the use of tape cast ceramic layers densified by pre-ceramic polymer infiltration methods and laminated together with polymer matrix composite prepregs, with or without an embedded metallic mesh, to form a conforming helicopter blade cladding that is laminated to the blade surface for added erosion protection. The hybrid composite is fabricated to net shape and laminated to the blade using either an adhesive or a polymer composite prepreg inner layer. Installation is accomplished by a standard composite fabrication method of vacuum bagging the blade while the system is laminated to its surface. Repair methods based on removal of ceramic tiles is facilitated by incorporation of a metallic mesh element laminated beneath the ceramic tiles that can be used to heat the tile and decrease its adhesion strength. | 01-16-2014 |
20140065292 | USE OF MONAZITE OR XENOTIME SOLUTION PRECURSORS TO INCREASE THE DENSITY AND SHEAR STRENGTH OF OXIDE COMPOSITES - Aqueous precursor solutions are described that comprise at least one monazite-based material precursor, at least one xenotime-based material precursor or a combination thereof; and a plurality of fine suspended particles of an oxide material. Contemplated oxide composites, as described herein, comprise a plurality of fibers surrounded by at least one monazite or xenotime-based material, wherein the oxide composite has nearly a fully dense matrix. Contemplated embodiments disclosed herein provides a method for producing an oxide composite with nearly fully dense matrix and with all fibers surrounded by a monazite- or xenotime-based material that prevents embrittlement at temperatures at least as high as 1200° C. Oxide composites are described that contain a plurality of fibers, a matrix containing at least one or more oxide materials, and at least one monazite-based material, xenotime-based material or combination thereof, wherein the monazite-based or xenotime-based material is formed from the aqueous precursor solutions disclosed herein. Contemplated methods of production include: a) providing a composite comprising oxide-reinforcing fibers and a porous matrix of oxide materials, and b) infiltrating the porosity in the matrix with a solution that contains precursors for at least one monazite-based material, at least one xenotime-based material or a combination thereof; and c) heat treating the composite to convert the precursors to monazite, xenotime, or combinations thereof. | 03-06-2014 |
20150226071 | INTEGRAL TEXTILE STRUCTURE FOR 3-D CMC TURBINE AIRFOILS - An integral textile structure for 3-D CMC turbine airfoils includes top and bottom walls made from an angle-interlock weave, each of the walls comprising warp and weft fiber tows. The top and bottom walls are merged on a first side parallel to the warp fiber tows into a single wall along a portion of their widths, with the weft fiber tows making up the single wall interlocked through the wall's thickness such that delamination of the wall is inhibited. The single wall suitably forms the trailing edge of an airfoil; the top and bottom walls are preferably joined along a second side opposite the first side and parallel to the radial fiber tows by a continuously curved section in which the weave structure remains continuous with the weave structure in the top and bottom walls, the continuously curved section being the leading edge of the airfoil. | 08-13-2015 |
Patent application number | Description | Published |
20120321192 | DIGITAL IMAGE COMMUNICATION - A system for enhancing group communication includes a computer server for receiving a first digital from a remote client. The server analyzes the first image to determine one or more first image attributes and communicates the image to one or more recipients. Communication information including image attributes, email addresses, and names of the recipients is stored. When a second image is received the server analyzes it to determine its attributes and forms second image communication information relevant to the second image. The second communication information includes data from the first image communication information, its image attributes, and one or more separate second image recipients. | 12-20-2012 |
20120321221 | DIGITAL IMAGE COMMUNICATION - A server analyzes a received digital image to determine and store one or more first image attributes. The image is transmitted to at least one recipient and pertinent information is recorded, including one or more image attributes and the one or more first image recipients. A second image is received and analyzed in a similar fashion as the first. Second image communication information is generated that is relevant to the second image based on a comparison with the first image communication information and the one or more first image attributes. | 12-20-2012 |
20140250188 | DIGITAL IMAGE COMMUNICATION - A system for enhancing group communication includes a computer server for receiving a first digital from a remote client. The server analyzes the first image to determine one or more first image attributes and communicates the image to one or more recipients. Communication information including image attributes, email addresses, and names of the recipients is stored. When a second image is received the server analyzes it to determine its attributes and forms second image communication information relevant to the second image. The second communication information includes data from the first image communication information, its image attributes, and one or more separate second image recipients. | 09-04-2014 |
20150066907 | SEAMLESS PAGINATION - A search engine determines a number of pages to present to a user based on one or more of a variety of factors. The search engine may send the search results to a client machine, which may present a subset of the results along with a pagination control in a scrollable interface. The pagination control may present the number of pages determined by the search engine. The search engine may also determine a number of search results to present prior to the presentation of non-scrollable user interface (UI) elements based on the same or different factors. After the amount of scrolling exceeds a threshold, a non-scrollable UI element may be displayed. Additional thresholds may exist, such that additional non-scrollable UI elements are added as the user continues to scroll. | 03-05-2015 |
20150088921 | SEARCH GUIDANCE - A user may submit a search query to a search engine, which may process the search query and generate a set of results. Previous actions of the user or of other users may be used to identify recommended search queries. The recommended search queries may be presented to the user along with the search results for the query. The location of the recommended search queries may be fixed, set by the user, or determined on a query-by-query basis. A user interface element operable to cause the presentation of one or more recommended search queries may be presented after a delay. After an additional or independent delay, the recommended search queries may be presented automatically. The delays may be fixed, set by the user, or determined on a query-by-query basis. | 03-26-2015 |
Patent application number | Description | Published |
20090053224 | LOX AND LOXL2 INHIBITORS AND USES THEREOF - The present application relates to anti-LOX and anti-LOXL | 02-26-2009 |
20090104201 | METHODS AND COMPOSITIONS FOR TREATMENT AND DIAGNOSIS OF FIBROSIS, TUMOR INVASION, ANGIOGENESIS, AND METASTASIS - The present disclosure provides innovative methodology and related compositions and kits for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX and an inhibitor of a LOXL, or a synergistic combination of an inhibitor of LOX or LOXL combined with other therapeutic agents. Also provided are innovative methods for selecting agents that prevent or inhibit tumor invasion, angiogenesis and metastasis, by contacting cells that are in an epithelial-mesenchymal transition (EMT) state with a candidate agent and detecting a change in the EMT state of the cells. Methods and related compositions and kits for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using molecules or agents that specifically recognize processed forms of LOX or LOXL are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL. Such diseases or conditions include pathological cardiovascular conditions and diseases such as hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, and restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease. | 04-23-2009 |
20100203062 | Methods and Compositions for Treatment of Neovascularization - Disclosed herein are methods and compositions for treatment of neovascularization, in particular, ocular neovascularization and resultant fibrotic damage. Compositions comprise inhibitors of the activity of one or more lysyl oxidase-type enzymes, and the methods include methods for making the inhibitors and methods for administration of the inhibitors to a subject in need thereof. | 08-12-2010 |
20130095101 | METHODS AND COMPOSITIONS FOR TREATMENT AND DIAGNOSIS OF FIBROSIS, TUMOR INVASION, ANGIOGENESIS, AND METASTASIS - Provided are methodology, compositions and kits to prevent and treat diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, using processed lysyl oxidase or lysyl oxidase-like protein inhibitors, LOX inhibitors and LOXL inhibitors, or synergistic combinations of such inhibitors with therapeutic agents. Provided are methods for selecting tumor invasion, angiogenesis and metastasis inhibiting agents, by contacting cells in EMT states with candidate agents and detecting changes in such states; and methods, compositions, and kits for diagnosing or monitoring diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, using molecules or agents specifically recognizing processed LOX or LOXL. Provided are methods, compositions, medical devices, systems and kits for preventing or treating diseases and conditions associated with fibrosis, including pathological cardiovascular conditions and diseases, e.g., hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease, with LOX or LOXL inhibitors. | 04-18-2013 |
20130324705 | LOX AND LOXL2 INHIBITORS AND USES THEREOF - The present application relates to anti-LOX and anti-LOXL2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof. Anti-LOX and anti-LOXL2 antibodies can be used to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state. | 12-05-2013 |
20140079707 | LOX AND LOXL2 INHIBITORS AND USES THEREOF - The present application relates to anti-LOX and anti-LOXL2 antibodies and their use in purification, diagnostic and therapeutic methods. Antibodies include monoclonal antibodies, humanized antibodies and functional fragments thereof. Anti-LOX and anti-LOXL2 antibodies can be used to identify and treat conditions such as a fibrotic condition, angiogenesis, or to prevent a transition from an epithelial cell state to a mesenchymal cell state. | 03-20-2014 |
20140128284 | METHODS AND COMPOSITIONS FOR TREATMENT AND DIAGNOSIS OF FIBROSIS, TUMOR INVASION, ANGIOGENESIS, AND METASTASIS - Provided are methodology, compositions and kits to prevent and treat diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, using processed lysyl oxidase or lysyl oxidase-like protein inhibitors, LOX inhibitors and LOXL inhibitors, or synergistic combinations of such inhibitors with therapeutic agents. Provided are methods for selecting tumor invasion, angiogenesis and metastasis inhibiting agents, by contacting cells in EMT states with candidate agents and detecting changes in such states; and methods, compositions, and kits for diagnosing or monitoring diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, using molecules or agents specifically recognizing processed LOX or LOXL. Provided are methods, compositions, medical devices, systems and kits for preventing or treating diseases and conditions associated with fibrosis, including pathological cardiovascular conditions and diseases, e.g., hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease, with LOX or LOXL inhibitors. | 05-08-2014 |
20140349309 | METHODS AND COMPOSITIONS FOR TREATMENT AND DIAGNOSIS OF FIBROSIS, TUMOR INVASION, ANGIOGENESIS, AND METASTASIS - The present disclosure provides innovative methodology and related compositions and kits for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX and an inhibitor of a LOXL, or a synergistic combination of an inhibitor of LOX or LOXL combined with other therapeutic agents. Also provided are innovative methods for selecting agents that prevent or inhibit tumor invasion, angiogenesis and metastasis, by contacting cells that are in an epithelial-mesenchymal transition (EMT) state with a candidate agent and detecting a change in the EMT state of the cells. Methods and related compositions and kits for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using molecules or agents that specifically recognize processed forms of LOX or LOXL are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL. Such diseases or conditions include pathological cardiovascular conditions and diseases such as hypertension, hypertensive heart disease, myocardial infarction, atherosclerosis, and restenosis, liver fibrosis, kidney fibrosis, lung fibrosis, dermal scaring, keloid formation, and Alzheimer's disease. | 11-27-2014 |
Patent application number | Description | Published |
20090195448 | Position Computation in a Positioning System Using Synchronization Time Bias - In general, this disclosure is directed to techniques for computing a positioning solution for a mobile unit based on signals received from the satellite navigation system and the wireless communication system. The techniques allow for, and resolve, a synchronization bias that constrains a system time for the satellite navigation system and a system time for the wireless communication system relative to each other. The mobile unit may utilize the defined constraint to compute a position solution in environments where additional independent measurements would otherwise be required. The mobile unit may incorporate Receiver Autonomous Integrity Monitoring (RAIM) functionality to validate the position and time solutions derived from each of received signals. According to the techniques described herein, the mobile unit may be able to utilize the defined synchronization bias to apply RAIM or similar techniques in environments where such techniques would otherwise be indeterminate. | 08-06-2009 |
20090233620 | Methods and Apparatuses Supporting Multiple Positioning Protocol Versions in Wireless Communication Networks - Methods and apparatuses are provided for supporting multiple positioning protocol versions within wireless communication networks. | 09-17-2009 |
20100013701 | Methods And Apparatuses For Requesting /Providing Assistance Data Associated With Various Satellite Positioning Systems In Wireless Communication Networks - Methods and apparatuses are provided for use by devices within in wireless communication network to request and/or provide assistance data and/or other like data associated with various Satellite Positioning Systems (SPSs). | 01-21-2010 |
20100135365 | METHOD AND APPARATUS FOR MULTIPATH MITIGATION - An apparatus and method for short multipath mitigation. In one aspect the method comprises subtracting a first stronger path from a correlation function to obtain a first residual signal, wherein one component of the first residual signal is a weaker path; applying reconstruction on the first residual signal to obtain a first reconstructed weaker path; subtracting the first reconstructed weaker path from the correlation function to obtain a second residual signal; and applying reconstruction on the second residual signal to obtain a second stronger path. In one aspect, the apparatus includes an antenna for receiving a composite receive RF signal, a receiver front-end for converting the composite receive RF signal into a composite receive digital signal; and a processor for performing signal correlation on the composite receive digital signal to obtain a correlation function and for processing the correlation function to obtain a desired signal. In one aspect, the short multipath is identified by computing a Left Edge Height Ratio Indicator (LEHRI). | 06-03-2010 |
20100141470 | SYSTEMS, METHODS, AND COMPUTER PROGRAM PRODUCTS FOR REFRESHING DATA - A method performs an update for a first device that consumes information with a known expiration time. The first device operates within a network that accommodates other devices also consuming the information. The method includes setting a time for the first device to refresh the information, the time to refresh being based on a pseudorandom time offset. The method also includes sending a refresh request to a resource for the data during the set time. | 06-10-2010 |
20110291885 | ALMANAC MAINTENANCE FOR MOBILE STATION POSITIONING - An almanac data management system at a location remote from a cell phone ( | 12-01-2011 |
20130035113 | METHODS AND APPARATUSES SUPPORTING MULTIPLE POSITIONING PROTOCOL VERSIONS IN WIRELESS COMMUNICATION NETWORKS - Methods and apparatuses are provided for supporting multiple positioning protocol versions within wireless communication networks. | 02-07-2013 |
20140135040 | Techniques for generating environment and reference data reports for particular environments on behalf of mobile devices - Various methods, apparatuses and/or articles of manufacture are provided which may be implemented using one or more fixed electronic devices to generate a reference data report corresponding to a particular environment. Various methods, apparatuses and/or articles of manufacture are provided which may be implemented using one or more mobile electronic devices to generate an environment report corresponding to a particular environment. | 05-15-2014 |
20140221005 | TERRESTRIAL POSITIONING SYSTEM CALIBRATION - Embodiments disclosed aggregate a plurality of crowdsourced measurement sets for antennas received from a plurality of Mobile Stations (MS) with a Base Station Almanac (BSA), based on a measurement location estimate and a measurement location uncertainty estimate associated with each measurement set. A map comprising a plurality of map layers may be obtained, where each map layer associates locations in the BSA with spatially variable Forward Link Calibration (FLC) values for the antenna derived from the updated BSA data, wherein each spatially variable FLC value is associated with a corresponding location in the updated BSA data. Map layers, which may also include multipath map and/or received signal strength layers, may be provided to MS′ as location assistance data. | 08-07-2014 |
20140295881 | DETERMINATION OF DIFFERENTIAL FORWARD LINK CALIBRATION IN LTE NETWORKS FOR POSITIONING - Techniques are provided which may be implemented using various methods and/or apparatuses to determine time difference of arrival of signals from two base stations as received at a mobile device, to use the time difference of arrival to determine differential forward link calibration for at least two base stations, and also to determine location using the differential forward link calibration for at least two base stations, determined using the time difference of arrival of signals from at least two base stations as received by a mobile device. | 10-02-2014 |
20140302871 | METHODS AND APPARATUSES FOR REQUESTING/PROVIDING ASSISTANCE DATA ASSOCIATED WITH VARIOUS SATELLITE POSITIONING SYSTEMS IN WIRELESS COMMUNICATION NETWORKS - Systems and methods for requesting and providing assistance data for a satellite positioning system are described herein. A method as described herein includes receiving, at a base station over a wireless communication link, a first message from a mobile station, wherein the first message comprises a first field identifying requested assistance data associated with a first Satellite Positioning System (SPS) and a second field identifying a requested format of the requested assistance data, and wherein the requested assistance data are available in a plurality of formats that includes the requested format; and transmitting a second message from the base station to the mobile station over the wireless communication link, wherein the second message includes the requested assistance data in the requested format. | 10-09-2014 |
20150195674 | METHOD FOR ESTIMATING DELAY DIFFERENCE BETWEEN RECEIVE PROCESSING CHAINS OF A DEVICE USING CROWD SOURCING - Systems, methods, and devices are described for estimating delay difference between two receive chains of a mobile device. The mobile device receives a first signal from a base station using a first receive chain, and receives a second signal using a second receive chain from a common, remote timing source for the base station and the mobile device. In addition, the mobile device obtains a transmit delay parameter associated with the base station and estimates, based at least in part on the transmit delay parameter, an offset value corresponding to a difference between amount of time for the first signal to pass through the first receive chain of the mobile device and amount of time for the second signal to pass through the second receive chain of the mobile device. The mobile device may store the offset value for subsequent use in estimating its position. | 07-09-2015 |
Patent application number | Description | Published |
20100142793 | Facilitating Computer-Aided Detection, Comparison and/or Display of Medical Images - The present invention is methods for processing medical images so as to remove certain effects of the physical characteristics of the object being imaged and/or of the apparatus used to form the images. The invention further provides for the formation of a standardized image from the processed image and for the use of the standardized image or the processed image in the training of computer-aided detection/diagnosis algorithms. These algorithms may then be used to detect abnormalities in other standardized or processed images derived from any of a variety of image acquisition systems. | 06-10-2010 |
20100246913 | COMPUTER-AIDED DETECTION OF ANATOMICAL ABNORMALITIES IN X-RAY TOMOSYNTHESIS IMAGES - Methods, systems, and related computer program products for computer-aided detection (CAD) of anatomical abnormalities in a breast volume based on a plurality of two-dimensional x-ray tomosynthesis projection images thereof is described. Each projection image is processed according to at least one predetermined feature extraction algorithm to generate at least one projection feature array corresponding thereto. For each of the at least one predetermined features extracted, the plurality of corresponding projection feature arrays is backprojected according to a predetermined tomosynthesis reconstruction algorithm to form a plurality of two-dimensional tomosynthesis reconstructed feature arrays. Each pixel in the three-dimensional breast geometry is then individually classified as being either a pixel of interest, or not a pixel of interest, based upon the at least one tomosynthesis reconstructed feature array value corresponding to that pixel. CAD detections for the breast volume are then generated based on the identified pixels of interest. | 09-30-2010 |
20110019887 | Displaying And Navigating Computer-Aided Detection Results On A Review Workstation - Display and navigation for multiple computer-aided detection (CAD) detections is described. A medical image is displayed to a viewer, and a request is received to instantiate CAD-assisted viewing. A timewise presentation sequence for the CAD detections is automatically computed according to a predetermined sequencing criterion. For each CAD detection, an expanded presentation window is displayed for its associated location in the medical image, the expanded presentation windows being displayed according to the timewise presentation sequence. Also described is a navigational tool comprising a plot of an operating curve onto which a computed feature associated with the CAD algorithm can be mapped, the operating curve characterizing an application of the CAD algorithm to a reference database of mammographic cases having known diagnoses. The navigational tool further comprises a plurality of CAD pointer icons spatially distributed therealong according to mappings of the computed feature for the CAD detections onto the operating curve. | 01-27-2011 |
20110103675 | Integrating Auxiliary Detection And Voting Algorithms Into Clinical CAD Workflow - Methods, systems, and related computer program products for computer-aided detection (CAD) of anatomical abnormalities in medical images are described. A preexisting CAD environment includes a review workstation and a primary CAD processor programmed with a primary CAD algorithm. Installed into the preexisting CAD environment is an auxiliary processing system programmed to receive a first CAD report from the primary CAD processor, apply an auxiliary CAD algorithm that is independent of the primary CAD algorithm to the underlying medical image, apply a voting algorithm to the primary and auxiliary CAD findings, and generate a second CAD report that includes the voting results. The second CAD report is configured to result in a rendering by the review workstation that is highly similar to a rendering that would result from the first CAD report except that the voted CAD findings are substituted in place of the primary CAD findings. | 05-05-2011 |
20110109650 | Displaying Computer-Aided Detection Information With Associated Breast Tomosynthesis Image Information - Methods, systems, and related computer program products for processing and displaying computer-aided detection (CAD) information associated with medical breast x-ray images, such as breast x-ray tomosynthesis volumes, are described. An interactive graphical user interface for displaying a tomosynthesis data volume is described that includes a display of a two-dimensional composited image having slabbed sub-images spatially localized to marked CAD findings. Also described is a graphical navigation tool for optimized CAD-assisted viewing of the data volume, comprising a plurality of CAD indicator icons running near and along a slice ruler, each CAD indicator icon spanning a contiguous segment of the slice ruler and corresponding in depthwise position and extent to a subset of image slices spanned by the associated CAD finding, each CAD indicator icon including at least one single-slice highlighting mark indicating a respective image slice containing viewable image information corresponding to the associated CAD finding. | 05-12-2011 |
20110110576 | Selective Display Of Computer-Aided Detection Findings With Associated Breast X-Ray Mammogram and/or Tomosynthesis Image Information - Methods, systems, and related computer program products for processing and displaying computer-aided detection (CAD) information associated with medical breast x-ray images, such as breast x-ray tomosynthesis volumes and conventional x-ray mammograms, are described. For one preferred embodiment, CAD findings for several cases (or several individual data volumes) are selectively designated for marking such that a predetermined number of CAD findings per case (or per data volume) are marked for display across all of the cases (or data volumes). In another preferred embodiment, localized breast fibroglandular tissue density information is used together with certainty-of-finding information as a basis for selecting which candidate CAD findings to designate as marked CAD findings, with increased certainty-of-finding being required to mark CAD findings in regions of higher fibroglandular tissue density. In another preferred embodiment, CAD findings located within regions of excessively dense fibroglandular tissue are withheld altogether, and associated warnings are displayed. | 05-12-2011 |
20110128289 | Facilitating Temporal Comparison of Medical Images - Methods, systems, and computer program products for facilitating temporal comparison of medical images is provided, with one exemplary application being for breast mammograms. In one embodiment, prior and subsequent mammographic images of a breast acquired using at least partially different mammogram acquisition systems are displayed for simultaneous viewing on a same mammogram display at an identical tissue distance per unit display distance without requiring a scale-adjusting viewer input. Also described are other embodiments for optimally scaling, windowing and/or otherwise advantageously processing and/or displaying prior and subsequent mammographic image sets in manners that facilitate temporal comparison therebetween. | 06-02-2011 |
20110194157 | User Selectable and User Definable Scanning Protocols In Mammographic Film Scanning System With Stack Film Feeder - A system and method for processing mammographic data are described. The system includes a user input/output system adapted and configured to receive from a user a user-defined scanning protocol that identifies the laterality and view type for each mammographic film in a film case to be scanned. A storage system stores the user-defined scanning protocol for subsequent use in scanning film cases. A scanning system scans film cases and generates digitized versions of each mammographic film. A processor then assigns laterality and view types to the digitized versions of the mammographic film according to the user-defined scanning protocol. The system also receives user alterations to stored scanning protocols. The system can also re-assign a case scanned according to one scanning protocol to another scanning protocol in response to a user's instruction to do so. The system processes the digitized versions according to at least one computer aided detection (CAD) algorithm for detecting anatomical abnormalities therein. | 08-11-2011 |
20120063566 | METHODS AND SYSTEMS FOR DYNAMICALLY MODIFYING ACQUISITION PARAMETER DURING IMAGE ACQUISITION - Systems and methods for automatically and dynamically modifying an image acquisition parameter for use in tomosynthesis breast imaging. A selected image acquisition parameter is modified in response to a measured characteristic of an imaged object such as a breast, and thus tailored to provide the highest quality image for the particular object. For example, image quality in a breast tomosynthesis system can be improved by dynamically varying motion and other acquisition parameters of the tomosynthesis system in response to physical characteristics of the breast to be imaged (determined during image acquisition), such as the breast thickness, density or composition. Dynamically varying acquisition or processing methods helps to customize the system for each particular patient, thereby improving image quality and identification and assessment of potential pathologies and abnormalities, and lower radiation dose, and thus a reduced the risk of long-term adverse health effects due to lifetime accumulated radiation dose. | 03-15-2012 |
20120063567 | METHODS AND SYSTEMS FOR DETECTING POSSIBLE ERROR IN PATIENT POSITION - Systems and methods for automatically and dynamically modifying an image acquisition parameter for use in tomosynthesis breast imaging. A selected image acquisition parameter is modified in response to a measured characteristic of an imaged object such as a breast, and thus tailored to provide the highest quality image for the particular object. For example, image quality in a breast tomosynthesis system can be improved by dynamically varying motion and other acquisition parameters of the tomosynthesis system in response to physical characteristics of the breast to be imaged (determined during image acquisition), such as the breast thickness, density or composition. Dynamically varying acquisition or processing methods helps to customize the system for each particular patient, thereby improving image quality and identification and assessment of potential pathologies and abnormalities, and lower radiation dose, and thus a reduced the risk of long-term adverse health effects due to lifetime accumulated radiation dose. | 03-15-2012 |
20120133600 | USER INTERFACE FOR MEDICAL IMAGE REVIEW WORKSTATION - Methods, systems and computer program products for controlling display of different types of medical images and providing touchscreen interfaces for display on a mobile communication device and associated with different image types, e.g., different imaging modalities or different view modes. Detection of a multi-finger tap on the screen of the mobile communication device while viewing a first touchscreen interface for an image type invokes a second or auxiliary touchscreen interface for that image type having a subset of interface elements of the first touchscreen interface. | 05-31-2012 |
20120133601 | USER INTERFACE FOR MEDICAL IMAGE REVIEW WORKSTATION - Methods, systems and computer program products for controlling display of different types of medical images and providing touchscreen interfaces for display on a mobile communication device and associated with different image types, e.g., different imaging modalities or different view modes. Detection of a multi-finger tap on the screen of the mobile communication device while viewing a first touchscreen interface for an image type invokes a second or auxiliary touchscreen interface for that image type having a subset of interface elements of the first touchscreen interface. | 05-31-2012 |
20120210272 | Displaying And Navigating Computer-Aided Detection Results On A Review Workstation - Display and navigation for multiple computer-aided detection (CAD) detections is described. A medical image is displayed to a viewer, and a request is received to instantiate CAD-assisted viewing. A timewise presentation sequence for the CAD detections is automatically computed according to a predetermined sequencing criterion. For each CAD detection, an expanded presentation window is displayed for its associated location in the medical image, the expanded presentation windows being displayed according to the timewise presentation sequence. Also described is a navigational tool comprising a plot of an operating curve onto which a computed feature associated with the CAD algorithm can be mapped, the operating curve characterizing an application of the CAD algorithm to a reference database of mammographic cases having known diagnoses. The navigational tool further comprises a plurality of CAD pointer icons spatially distributed therealong according to mappings of the computed feature for the CAD detections onto the operating curve. | 08-16-2012 |
20120256920 | System and Method for Fusing Computer Assisted Detection in a Multi-Modality, Multi-Dimensional Breast Imaging Environment - A multi-modality cancer screening and diagnosis system fuses CAD information obtained by imaging an immobilized patient using multiple different image acquisition systems to provide a single fused CAD data set. Combining the CAD results of multiple modalities into a single, rich, data set allows the strengths of each imaging modality to be leveraged to improve the sensitivity and specificity of breast cancer diagnosis. The CAD results may be used, together with fused image data, to train a CAD algorithm which may be used to directly process a fused multi-mode image data set. | 10-11-2012 |
20140033126 | Displaying Computer-Aided Detection Information With Associated Breast Tomosynthesis Image Information - Methods, systems, and related computer program products for processing and displaying computer-aided detection (CAD) information associated with medical breast x-ray images, such as breast x-ray tomosynthesis volumes, are described. An interactive graphical user interface for displaying a tomosynthesis data volume is described that includes a display of a two-dimensional composited image having slabbed sub-images spatially localized to marked CAD findings. Also described is a graphical navigation tool for optimized CAD-assisted viewing of the data volume, comprising a plurality of CAD indicator icons running near and along a slice ruler, each CAD indicator icon spanning a contiguous segment of the slice ruler and corresponding in depthwise position and extent to a subset of image slices spanned by the associated CAD finding, each CAD indicator icon including at least one single-slice highlighting mark indicating a respective image slice containing viewable image information corresponding to the associated CAD finding. | 01-30-2014 |
20140089837 | DISPLAYING AND NAVIGATING COMPUTER-AIDED DETECTION RESULTS ON A REVIEW WORKSTATION - Display and navigation for multiple computer-aided detection (CAD) detections is described. A medical image is displayed to a viewer, and a request is received to instantiate CAD-assisted viewing. A timewise presentation sequence for the CAD detections is automatically computed according to a predetermined sequencing criterion. For each CAD detection, an expanded presentation window is displayed for its associated location in the medical image, the expanded presentation windows being displayed according to the timewise presentation sequence. Also described is a navigational tool comprising a plot of an operating curve onto which a computed feature associated with the CAD algorithm can be mapped, the operating curve characterizing an application of the CAD algorithm to a reference database of mammographic cases having known diagnoses. The navigational tool further comprises a plurality of CAD pointer icons spatially distributed therealong according to mappings of the computed feature for the CAD detections onto the operating curve. | 03-27-2014 |
20140341337 | METHODS AND SYSTEMS FOR DYNAMICALLY MODIFYING ACQUISITION PARAMETER DURING IMAGE ACQUISITION - Systems and methods for automatically and dynamically modifying an image acquisition parameter for use in tomosynthesis breast imaging. A selected image acquisition parameter is modified in response to a measured characteristic of an imaged object such as a breast, and thus tailored to provide the highest quality image for the particular object. For example, image quality in a breast tomosynthesis system can be improved by dynamically varying motion and other acquisition parameters of the tomosynthesis system in response to physical characteristics of the breast to be imaged (determined during image acquisition), such as the breast thickness, density or composition. Dynamically varying acquisition or processing methods helps to customize the system for each particular patient, thereby improving image quality and identification and assessment of potential pathologies and abnormalities, and lower radiation dose, and thus a reduced the risk of long-term adverse health effects due to lifetime accumulated radiation dose. | 11-20-2014 |
20150052471 | SYSTEM AND METHOD FOR NAVIGATING A TOMOSYNTHESIS STACK USING SYNTHESIZED IMAGE DATA - A system and method for displaying and navigating breast tissue is configured for or includes obtaining a plurality of 2D and/or 3D images of a patient's breast; generating a synthesized 2D image of the breast from the obtained images; displaying the synthesized 2D image; receiving a user command, or otherwise detecting through a user interface, a user selection or other indication of an object or region in the synthesized 2D image; and displaying at least a portion of one or more images from the plurality, including a source image and/or most similar representation of the user selected or indicated object or region. | 02-19-2015 |
20150148670 | METHODS AND SYSTEMS FOR DYNAMICALLY MODIFYING ACQUISITION PARAMETER DURING IMAGE ACQUISITION - Systems and methods for automatically and dynamically modifying an image acquisition parameter for use in tomosynthesis breast imaging. A selected image acquisition parameter is modified in response to a measured characteristic of an imaged object such as a breast, and thus tailored to provide the highest quality image for the particular object. For example, image quality in a breast tomosynthesis system can be improved by dynamically varying motion and other acquisition parameters of the tomosynthesis system in response to physical characteristics of the breast to be imaged (determined during image acquisition), such as the breast thickness, density or composition. Dynamically varying acquisition or processing methods helps to customize the system for each particular patient, thereby improving image quality and identification and assessment of potential pathologies and abnormalities, and lower radiation dose, and thus a reduced the risk of long-term adverse health effects due to lifetime accumulated radiation dose. | 05-28-2015 |
Patent application number | Description | Published |
20110003384 | COMPOSITIONS AND METHODS OF USE FOR MGD-CSF IN DISEASE TREATMENT - Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss. | 01-06-2011 |
20120258071 | Compositions and Methods of Use for MGD-CSF in Disease Treatment - Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss. | 10-11-2012 |