Patent application number | Description | Published |
20080221642 | Treatment of Consumption Disorders with Biostimulation - Nerves that carry taste sensations to the brain are stimulated in order to diminish (or, depending on the application, augment) the pleasure ordinarily associated with consumption behavior to be modified. | 09-11-2008 |
20080272023 | Surgical Pack and Tray - A surgical pack includes a platform having a plurality of recesses configured to function as a surgical tray. A plurality of surgical instruments are contained in a corresponding recess of the platform. The recess may have the shape of the surgical instrument that it is designed to receive. The recess may also include safety mechanisms to protect the tips of certain instruments and to lower the risk of injury caused by them. A packaging or covering holds the platform and the plurality of surgical instruments in a substantially sterile condition. | 11-06-2008 |
20080281254 | Independent Surgical Center - A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used independently. In some embodiments, instruments communicate status information to each other, and adjust operating parameters based on the communications. | 11-13-2008 |
20080281301 | Personal Surgical Center - A personal surgical center embodied as a general purpose computer (e.g. laptop) with wireless technology for monitoring the operation of an independent surgical center and/or handheld instruments. The computer tracks procedures in the operating room and instruments used during those procedures, and accounts for billing, supply management, and payment options. The monitoring of the instruments used during the surgery is conducted by the personal surgical center while actual control of the settings of those instruments is via the independent surgical center or via controls included in the instruments themselves. The monitored information is stored in a log file which is then transmitted to a hospital server for generating reports, inventory control, billing, and the like. Other information generated during the procedure (e.g. doctor notes) is also stored in the log file. The personal surgical center may also access the hospital server or local data storage device for retrieving a surgeon's specific surgery parameters, obtaining patient files, and the like. | 11-13-2008 |
20080305320 | NANOSCALE SURFACE ACTIVATION OF SILICONE VIA LASER PROCESSING - The invention provides a method of activating a silicone polymer surface using a laser, particularly an excimer laser, so that the silicone is more reactive. A silicone article containing an activated surface is also provided, and can be used to make silicone implants that can be securely fixed to tissue. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. | 12-11-2008 |
20090143734 | STERILE SURGICAL TRAY - A sterile surgical tray includes structure for receiving a plurality of surgical instruments, a pump fluid reservoir within the tray, a pump contained within the sterile tray and connected to the pump fluid reservoir, and a motor contained within the sterile tray and connected to the pump. Sterile surgical tray | 06-04-2009 |
20090192493 | IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR REFILLING THE DEVICES - In various embodiments, a needle is employed in refilling drug-delivery devices. | 07-30-2009 |
20090240215 | APPARATUS AND METHODS FOR DELIVERING THERAPEUTIC AGENTS - In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient. | 09-24-2009 |
20090306585 | IMPLANTABLE PUMPS AND CANNULAS THEREFOR - In various embodiments, an implantable pump includes a cannula. The pump (e.g., the cannula thereof) may include, for example, flow sensors, pressure sensors, filters, and/or other components. | 12-10-2009 |
20090306594 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include a drug reservoir, a cannula fluidly coupled to the reservoir, a pumping mechanism for forcing liquid from the reservoir through the cannula, control circuitry for operating the pumping mechanism, and a power source comprising primary and auxiliary batteries in a stacked configuration, only the main battery being operatively coupled to the control circuitry during normal operation, the control circuitry operatively coupling the back-up battery upon detection of an electrical fault. The pump may further include a hermetic enclosure containing the control circuitry and the power source. | 12-10-2009 |
20090306595 | IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR FILLING THE DEVICES - In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device. | 12-10-2009 |
20090311133 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of method of manufacturing an implantable pump, including providing an upper layer comprising a dome structure for housing a drug chamber and a cannula in fluid communication with the drug chamber, providing a middle deflection layer adjacent the drug chamber, providing a bottom layer comprising electrolysis electrodes, and bonding the upper layer, middle deflection layer, and bottom layer to form the pump. | 12-17-2009 |
20090312742 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula. | 12-17-2009 |
20100004639 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon. | 01-07-2010 |
20100157620 | ENHANCED VISUALIZATION ILLUMINATION SYSTEM - A first light source producing a first light beam with a first intensity and a second light source producing a second light beam with a second intensity. A light filter device receives the first light beam and transmits a filtered portion of the first light beam. A first angling device reflects the filtered portion of the first light beam in a first angled direction and a second angling device reflects the second light beam in a second angled direction. A mirror receives and in turn reflects the filtered portion of the first light beam reflected by the first angling device and the second light beam reflected by the second angling device to form a converged light beam with a third intensity. | 06-24-2010 |
20100174415 | STERILE SURGICAL TRAY - A sterile surgical tray includes structure for receiving a plurality of surgical instruments. The sterile surgical tray also may include electrical input and output connectors attached to tray. | 07-08-2010 |
20100197826 | Wound Closing Compounds With Additives - According to one embodiment of the present invention, there is provided a polyacrylamide or derivative thereof, such as poly-N-isopropyl acrylamide (pNIPAM) for use in the closure of wounds. Also provided is a composition comprising a polyacrylamide or derivative thereof in an amount effective for closing a wound, at least in part, and one or more pharmaceutically acceptable carriers. The a polyacrylamide or derivative thereof may be used in the composition according to the invention in various concentrations and may be combined with other therapeutic compounds. In another embodiment, a method for treating a wound with the compounds and compositions described herein is provided. The method comprises administering to a mammal a polyacrylamide or derivative thereof in an amount effective to close at least a part of a wound. | 08-05-2010 |
20100228123 | MULTI-FUNCTION OPTICAL PROBE SYSTEM FOR MEDICAL AND VETERINARY APPLICATIONS - A device includes a handpiece having a probe tip disposed at an end thereof, and, connected to the handpiece such that, at the probe tip, a functionality of each is provided, a plurality of optical coherence tomography (OCT) probes. | 09-09-2010 |
20100228124 | MEDICAL AND VETERINARY IMAGING AND DIAGNOSTIC PROCEDURES UTILIZING OPTICAL PROBE SYSTEMS - An imaging method includes providing a handpiece having a probe tip insertable into human or animal tissue disposed at an end thereof, and, an optical coherence tomography (OCT) probe connected to the handpiece such that a functionality of the OCT probe is provided at the probe tip. The probe tip is disposed adjacent to or into human or animal tissue. Imaging of the tissue, measuring at least one of a feature size or a quantifiable characteristic of a structure in the tissue for biometry analysis, and/or performing a diagnostic procedure on the tissue or a device implanted in the tissue is performed with the OCT probe. | 09-09-2010 |
20100228132 | SYSTEMS FOR CONTROLLING OPTICAL PROBE FUNCTIONS DURING MEDICAL AND VETERINARY PROCEDURES - A device includes a handpiece having a probe tip disposed at an end thereof, and, an optical coherence tomography (OCT) probe connected to the handpiece such that, at the probe tip, a functionality of the OCT probe is provided. A sensor responsive to movement and/or handling of the handpiece for controlling the functionality of the OCT probe is disposed within or on the handpiece. | 09-09-2010 |
20100228238 | MULTI-FUNCTION OPTICAL PROBE SYSTEM FOR MEDICAL AND VETERINARY APPLICATIONS - A device includes a handpiece having a probe tip disposed at an end thereof, and, connected to the handpiece such that, at the probe tip, a functionality of each is provided, a plurality of probes. The probes may include an optical coherence tomography (OCT) probe, an endoillumination probe, a laser therapy probe, an ultrasound imaging probe, an electrocautery probe, an RF ablation probe, a cryosurgical probe, an irrigator, and/or a mechanical probe. | 09-09-2010 |
20100268013 | METHODS AND APPARATUS FOR INTRAOCULAR BRACHYTHERAPY - A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed. | 10-21-2010 |
20110059146 | Antimicrobial Materials - The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to the substrate. In one embodiment, for example, there is provided a quaternary amine-containing polymeric coating comprising propylene and ethylene repeat units. | 03-10-2011 |
20110190690 | INDEPENDENT SURGICAL CENTER - A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used independently. In some embodiments, instruments communicate status information to each other, and adjust operating parameters based on the communications. | 08-04-2011 |
20110275987 | PISTON-DRIVEN DRUG PUMP DEVICES - In piston-pump drug-delivery devices, changes in friction between the piston and vial in which it moves may be reduced and/or compensated for by suitable surface coatings and/or feedback control. | 11-10-2011 |
20110276340 | PERSONAL SURGICAL CENTER - A personal surgical center embodied as a general purpose computer (e.g. laptop) with wireless technology for monitoring the operation of an independent surgical center and/or handheld instruments. The computer tracks procedures in the operating room and instruments used during those procedures, and accounts for billing, supply management, and payment options. The monitoring of the instruments used during the surgery is conducted by the personal surgical center while actual control of the settings of those instruments is via the independent surgical center or via controls included in the instruments themselves. The monitored information is stored in a log file which is then transmitted to a hospital server for generating reports, inventory control, billing, and the like. Other information generated during the procedure (e.g. doctor notes) is also stored in the log file. The personal surgical center may also access the hospital server or local data storage device for retrieving a surgeon's specific surgery parameters, obtaining patient files, and the like. | 11-10-2011 |
20110279821 | OPTICAL COHERENCE TOMOGRAPHY WITH MULTIPLE SAMPLE ARMS - A multiplexed OCT imaging system includes a plurality of sample arms, an imaging engine, and an optical controller. The sample arms are optically coupled to the imaging engine via the optical controller; the optical controller multiplexes optical signals from the sample arms to permit some of the sample arms to operate sequentially or simultaneously. | 11-17-2011 |
20110282160 | SELF CONTAINED ILLUMINATED INFUSION CANNULA SYSTEMS AND METHODS AND DEVICES - A cannula is described having a housing, a first lumen, a second lumen, and a port capable of fluid communication with the first lumen. The second lumen configured to receive fluid from the first lumen and to direct the fluid to a surgical site. A light emitting diode light source is positionable within the housing and configured to direct light through the second lumen to the surgical site. | 11-17-2011 |
20110282161 | ENHANCED VISUALIZATION ILLUMINATION SYSTEM - A first light source producing a first light beam with a first intensity and a second light source producing a second light beam with a second intensity. A light filter device receives the first light beam and transmits a filtered portion of the first light beam. A first angling device reflects the filtered portion of the first light beam in a first angled direction and a second angling device reflects the second light beam in a second angled direction. A mirror receives and in turn reflects the filtered portion of the first light beam reflected by the first angling device and the second light beam reflected by the second angling device to form a converged light beam with a third intensity. | 11-17-2011 |
20110282190 | COMBINED ENDOSCOPIC SURGICAL TOOLS - A probe assembly includes a forward-imaging optical coherence tomography (OCT) probe having a field of view and an instrument, adjacent to the probe, for performing manipulations at least within the OCT field of view. | 11-17-2011 |
20110282191 | OPTICAL COHERENCE TOMOGRAPHY FOR NEURAL-SIGNAL APPLICATIONS - An electrode carrier includes multiple electrodes, each electrode having a contact located at a different position along a distal end of the carrier, and multiple optical fibers, each associated with one of the electrodes and having an end face proximate to the contact of the associated electrode. Each optical fiber end face may capture optical information from tissue adjacent to the associated contact. The electrode carrier may be used for interfacing with an OCT system and a neural signal system. | 11-17-2011 |
20110282331 | OPTICAL COHERENCE TOMOGRAPHY WITH MULTIPLE IMAGING INSTRUMENTS - A combination includes an OCT system, an optical instrument, optics defining an optical path from the optical instrument to a target, and secondary optics for coupling the OCT system to the optical path. This combination permits simultaneous operation of the OCT system and the optical instrument. | 11-17-2011 |
20120009159 | BIOCOMPATIBLE SUBSTRATE FOR FACILITATING INTERCONNECTIONS BETWEEN STEM CELLS AND TARGET TISSUES AND METHODS FOR IMPLANTING SAME - Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue. | 01-12-2012 |
20120041427 | ELECTROLYTICALLY DRIVEN DRUG PUMP DEVICES - Electrolytically driven drug pump devices may be configured so as to ensure sustained contact of the electrolysis electrodes with the electrolyte, thereby improving the reliability and/or pump capacity of the devices. | 02-16-2012 |
20120172668 | ADJUSTABLE CANNULA SYSTEMS AND DEVICES - Various adjustable cannula systems are provided. The systems can include an adjustable cannula capable of expansion and/or contraction having an elongate body with a distal end and a proximal end. The adjustable cannula can be coupled to an upper housing and a lower housing such that rotation of the upper housing results in expansion or contraction of the adjustable cannula. The adjustable cannula can also have a proximal end having a lumen larger than a distal end lumen. A plurality of flanges can be formed in the elongate body by a plurality of slits that span a majority of a length of the cannula, including along or proximate to its proximal end and distal end. | 07-05-2012 |
20120215282 | Wide-Field Retinal Prosthesis - A wide-filed retinal prosthesis enables an increased field of vision with a relatively small scleral incision. The retinal prosthesis includes a flexible substrate comprising a central member and at least one wing, with an array of electrodes disposed therein that are configured to stimulate the central and peripheral nerves of the retina. | 08-23-2012 |
20120234433 | INSTRUMENT AND METHODS FOR FILLING AN IMPLANTED DRUG PUMP - A tool for refilling an implantable pump having at least one reservoir. The tool includes a plurality of independent fluid channels; a fluid reservoir in fluid communication with a first one of the fluid channels; at least one pump fluidly coupled to the fluid channels, the at least one pump and the independent fluid channels differing from each other in number, wherein (i) a pump is configured to apply positive pressure to the first fluid channel so as to drive fluid from the fluid reservoir therethrough, and (ii) a pump is configured to apply negative pressure to the second fluid channel; and a connector for removably connecting the fluid channels to the at least one reservoir. | 09-20-2012 |
20120277733 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include a first expandable diaphragm and a second flexible diaphragm, and first and second chambers each for containing a fluid, wherein the first expandable diaphragm separates the first and second chambers and provides a fluid barrier therebetween, and the second chamber is formed between the first expandable diaphragm and the second flexible diaphragms. The pump may further include electrolysis electrodes within the first chamber for causing generation of a gas therein and to thereby expand the expandable diaphragm so that fluid is forced from the second chamber into a cannula. | 11-01-2012 |
20120289883 | Implantable Intraocular Pressure Drain - An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical valve, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures. | 11-15-2012 |
20120296423 | FILLING AND IMPLANTING ACCOMMODATIVE INTRAOCULAR LENSES - Advances in filling apparatus, handheld tools, surgical techniques and intraoperative biometry for implanting and adjusting an accommodative liquid lens are disclosed. The lens may be attached to or retained within a handheld surgical tool, which can be fluidly connectable to a filling console to fill the lens with a liquid. In various embodiments, a filling console facilitates aspirating liquid out of the lens in order to ensure the absence of residual bubbles and filling of the lens with fluid during surgery, as well as during post-operative adjustments to the lens. Actuated by the surgeon, the filling console can aspirate fluid from the lens and inject fluid into the lens following insertion thereof. | 11-22-2012 |
20120303118 | ACCOMMODATING INTRAOCULAR LENS - Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens. | 11-29-2012 |
20120323218 | DRUG-DELIVERY PUMPS AND METHODS OF MANUFACTURE - Embodiments of an implantable electrolytic pump include an electrolysis chamber, a drug chamber and an osmosis chamber, the osmosis chamber having a first portion in contact with the drug chamber and a second portion exposed to facilitate contact with a surrounding fluid. The pump further includes a cannula for conducting liquid from the drug chamber and electrolysis electrodes within the electrolysis chamber for causing generation of a gas therein, the electrolysis and drug chambers being in contact such that gas electrolysis within electrolysis chamber forces fluid from the drug chamber into the cannula, contact between the drug chamber and the osmosis chamber permitting fluid admitted into the osmotic chamber from the surrounding fluid to offset volume loss from the drug chamber and prevent buildup of vacuum pressure thereon. | 12-20-2012 |
20120325704 | STERILE SURGICAL TRAY - A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section. | 12-27-2012 |
20120330101 | Scanning Endoscopic Imaging Probes and Related Methods - An imaging probe may utilize one or more suitably shaped lens structure to deflect light off-axis, allowing for the acquisition of B-scans by rotary or reciprocating motion of the lens. In some embodiments, a rotary joint is integrated into the probe to couple the lens structure(s) to, for example, an external imaging console. | 12-27-2012 |
20120330102 | Scanning Endoscopic Imaging Probes and Related Methods - An imaging probe may utilize a suitably shaped lens structure to deflect light off-axis, allowing for the acquisition of B-scans by rotary or reciprocating motion of the lens. | 12-27-2012 |
20130000119 | MEMS DEVICE AND METHOD FOR DELIVERY OF THERAPEUTIC AGENTS - Embodiments of an implantable device for delivering a therapeutic agent to a patient include a reservoir configured to contain a liquid comprising the therapeutic agent, and a cannula in fluid communication with the reservoir. The cannula is shaped to facilitate insertion thereof into a patient's eyeball. | 01-03-2013 |
20130018412 | SURGICAL IMPLANTATION INSTRUMENT - Surgical introducers aid surgeons in the implantation of medical devices. The introducer provides support and an even distribution of force for ease of insertion and prevention of damage to the medical device while protecting the tissue into which the device is implanted. A representative embodiment includes or consists of a locking device, a pair of forceps, a specially configured and/or angled head with a seat for the device to be implanted, and a gripping area. | 01-17-2013 |
20130102962 | IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR FILLING THE DEVICES - In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device. | 04-25-2013 |
20130116665 | IMPLANTABLE DRUG PUMPS AND REFILL DEVICES THEREFOR - Implanted drug pump devices can be refilled with a refill needle inserted through a fill port in the drug reservoir of the drug pump device. Proper needle insertion may be verified visually or using electrical, magnetic, optical, acoustic, or other suitable sensing mechanisms. | 05-09-2013 |
20130143326 | ULTRATHIN PARYLENE-C SEMIPERMEABLE MEMBRANES FOR BIOMEDICAL APPLICATIONS - Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there. | 06-06-2013 |
20130144399 | 3-DIMENSIONAL PARYLENE SCAFFOLD CAGE - Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The application further provides an implantable cage-like apparatus for culturing cells comprising the parylene membrane. | 06-06-2013 |
20130149351 | POLYMER SCAFFOLDS AND THEIR USE IN THE TREATMENT OF VISION LOSS - The present invention provides for scaffolds for growing RPE cells, comprising two or more biodegradable polymers. The present invention also provides for methods for creating a scaffold for growing RPE cells. Additionally, the present invention provides for RGD peptide linked polymer scaffolds for supporting the growth of RPE cells. The present invention provides methods of culturing RPE cells using the scaffolds produced herein. The present invention also provides methods of treating vision loss through the administration of RPE cell attached RGD peptide linked polymer scaffolds produced herein. The present invention further provides kits for treating vision loss. | 06-13-2013 |
20130150960 | ACCOMMODATING INTRAOCULAR LENS - Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable to air. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens. | 06-13-2013 |
20140030437 | ANTIMICROBIAL MATERIALS - The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to the substrate. in one embodiment, for example, there is provided a quaternary amine-containing polymeric coating comprising propylene and ethylene repeat units. | 01-30-2014 |
20140045264 | METHOD OF CRYOPRESERVATION OF STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS ON POLYMERIC SUBSTRATE - Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease. | 02-13-2014 |
20140050386 | SYSTEMS AND METHODS FOR IN VITRO AND IN VIVO IMAGING OF CELLS ON A SUBSTRATE - Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy. | 02-20-2014 |
20140058506 | 3-COIL WIRELESS POWER TRANSFER SYSTEM FOR EYE IMPLANTS - A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil. | 02-27-2014 |
20140238890 | STERILE SURGICAL TRAY - A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section. | 08-28-2014 |
20140243712 | THROMBOLYSIS IN RETINAL VESSELS WITH ULTRASOUND - Systems and methods are described providing for the use of ultrasound energy to effect the dislodging of one or more blood clots inside blood vessels. Such clots can include those inside retinal vessels, especially in patients with central retinal vein occlusion. Embodiments of the present disclosure may be used for any retinal arterial or venous occlusion. In exemplary embodiments, a small probe can be inserted into the eye of a patient and placed over the retinal vessels. Acoustic streaming created by the probe can be directed to an area or region including targeted blood vessels, resulting in increased flow in one or more retinal veins and facilitating or effecting mechanical dislodging of one or more blood clots in the targets blood vessels. Exemplary embodiments can utilize ultrasonic energy produced at a frequency of approximately 44 MHz to 46 MHz with pulse repetition frequencies of approximately 100 Hz to 100 kHz. | 08-28-2014 |
20140271901 | Management of Tractional Membranes - Methods and compositions are provided here to manage tractional membranes, as well as other diseases and disorders of the eye. Compositions comprising microbubbles associated with enzymes or vitreolytic agents, are provided. The method of the present invention involves administration of the microbubble and an enzyme or vitreolytic agent to a subject in need thereof, followed by application of ultrasound. | 09-18-2014 |
20140308208 | CAGED COMPOUND DELIVERY AND RELATED COMPOSITIONS, METHODS AND SYSTEMS - Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength absorber, the long wavelength being a wavelength greater than or equal to 750 nm; and irradiating the biological environment to excite the long wavelength absorber with light at a wavelength in a range from 900-1100 nm, thus decaging the compound. | 10-16-2014 |
20140323813 | INDEPENDENT SURGICAL CENTER - A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used independently. In some embodiments, instruments communicate status information to each other, and adjust operating parameters based on the communications. | 10-30-2014 |
20140357957 | SELF CONTAINED ILLUMINATED INFUSION CANNULA SYSTEMS AND METHODS AND DEVICES - A cannula is described having a housing, a first lumen, a second lumen, and a port capable of fluid communication with the first lumen. The second lumen configured to receive fluid from the first lumen and to direct the fluid to a surgical site. A light emitting diode light source is positionable within the housing and configured to direct light through the second lumen to the surgical site. | 12-04-2014 |
20140365235 | PERSONAL SURGICAL CENTER - A personal surgical center embodied as a general purpose computer (e.g. laptop) with wireless technology for monitoring the operation of an independent surgical center and/or handheld instruments. The computer tracks procedures in the operating room and instruments used during those procedures, and accounts for billing, supply management, and payment options. The monitoring of the instruments used during the surgery is conducted by the personal surgical center while actual control of the settings of those instruments is via the independent surgical center or via controls included in the instruments themselves. The monitored information is stored in a log file which is then transmitted to a hospital server for generating reports, inventory control, billing, and the like. Other information generated during the procedure (e.g. doctor notes) is also stored in the log file. The personal surgical center may also access the hospital server or local data storage device for retrieving a surgeon's specific surgery parameters, obtaining patient files, and the like. | 12-11-2014 |
20140378952 | STERILE SURGICAL TRAY - A sterile surgical tray includes structure for receiving a plurality of surgical instruments. The sterile surgical tray also may include electrical input and output connectors attached to tray. | 12-25-2014 |
20150032207 | INSTRUMENTS AND METHODS FOR THE IMPLANTATION OF CELL-SEEDED SUBSTRATES - Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue. | 01-29-2015 |