Patent application number | Description | Published |
20090232820 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 09-17-2009 |
20090285845 | Domains And Epitopes Of Meningococcal Protein NMB1870 - ‘NMB1870’ is a known surface protein in | 11-19-2009 |
20090298099 | Gonococcal Proteins and Nucleic Acids - The invention provides proteins from gonococcus ( | 12-03-2009 |
20100015151 | POLYPEPTIDES FROM NEISSERIA MENINGITIDIS - Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis. | 01-21-2010 |
20100015212 | IMMUNOGENIC BACTERIAL VESICLES WITH OUTER MEMBRANE PROTEINS - Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody responses with higher bactericidal titres than OMVs prepared by normal production processes. Thus the invention provides a bacterium having a knockout mutation of its mltA gene. The invention also provides a bacterium, wherein the bacterium: (i) has a cell wall that includes peptidoglycan; and (ii) does not express a protein having the lytic transglycosylase activity of MltA protein. The invention also provides compositions comprising vesicles that, during culture of bacteria of the invention, are released into the culture medium. | 01-21-2010 |
20100105875 | Antibodies against neisserial factor H binding protein - Monoclonal antibody MAb502 binds to an epitope of meningococcal fHbp protein including Arg-204. Related antibodies are provided. | 04-29-2010 |
20100143418 | Immunising Against Meningococcal Serogroup Y Using Proteins - The invention uses polypeptide antigens and/or OMVs to immunize against serogroups A, C, W | 06-10-2010 |
20100166788 | IMMUNOGENS FROM UROPATHOGENIC ESCHERICHIA COLI - Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic | 07-01-2010 |
20100233205 | ADJUVANTED ANTIGENIC MENINGOCOCCAL COMPOSITIONS - Compositions comprising a Neisserial antigen and a detoxified ADP-ribosylating toxin are provided. These compositions have been found useful for mucosal immunization, particularly for nasal immunization against | 09-16-2010 |
20100267931 | HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS - Alternative and improved approaches to the heterologous expression of the proteins of | 10-21-2010 |
20100272725 | Neisserial antigens - The invention provides proteins from | 10-28-2010 |
20110008279 | Methods and Compositions Relating to Adhesins as Adjuvants - This invention is in the field of immunology and relates to the discovery that adhesins are potent activators of dendritic cells. | 01-13-2011 |
20110020390 | MENINGOCOCCAL FHBP POLYPEPTIDES - fHBP is a protein in | 01-27-2011 |
20110076300 | Hybrid Polypeptides Including Meningococcal fHBP Sequences - fHBP is a protein in | 03-31-2011 |
20110091492 | ESCHERICHIA COLI IMMUNOGENS WITH IMPROVED SOLUBILITY - Variants of the pathogenic | 04-21-2011 |
20110104193 | COMBINATION NEISSERIAL COMPOSITIONS - Compositions comprising a first biological molecule from a | 05-05-2011 |
20110166323 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 - NMB1870 is a protein in | 07-07-2011 |
20110250223 | HYBRID AND TANDEM EXPRESSION OF NEISSERIAL PROTEINS - Two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain. Hybrid proteins are represented by the formula NH | 10-13-2011 |
20110300171 | FACTOR H BINDING PROTEIN IMMUNOGENS - The invention relates to immunization against pathogenic bacterial strains which express or can express multiple factor H binding proteins. Certain aspects of the invention include vaccine compositions comprising at least two factor H binding proteins derived from a pathogenic bacterial strain which expresses multiple facto H binding proteins. | 12-08-2011 |
20120027801 | POLYPEPTIDES FROM NEISSERIA MENINGITIDIS - Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis. | 02-02-2012 |
20120058146 | IMMUNOGENS FROM UROPATHOGENIC ESCHERICHIA COLI - Disclosed herein are various genes that can be included in immunogenic compositions specific for pathogenic | 03-08-2012 |
20120135024 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 05-31-2012 |
20120135026 | COMBINATION NEISSERIAL COMPOSITIONS - Compositions comprising a first biological molecule from a | 05-31-2012 |
20120148616 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 06-14-2012 |
20120148618 | MULTIPLE VARIANTS OF MENINGOCOCCAL PROTEIN NMB1870 - Meningococcal protein NMB 1870 has been described in the prior art. The inventors have found that NMB 1870 is an effective antigen for eliciting anti-meningococcal antibody responses, and that it is expressed across all meningococcal serogroups. Forty-two different NMB 1870 sequences have been identified, and these group into three variants. Serum raised against a given variant is bactericidal within the same variant group, but is not active against strains which express one of the other two variants i.e. there is intra-variant cross-protection, but not inter-variant cross-protection. For maximum cross-strain efficacy, therefore, the invention uses mixture comprising different variants of NMB 1870. | 06-14-2012 |
20120156236 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 06-21-2012 |
20120164166 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 06-28-2012 |
20120195919 | HYBRID AND TANDEM EXPRESSION OF NEISSERIAL PROTEINS - Two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain. Hybrid proteins are represented by the formula NH | 08-02-2012 |
20120219578 | NEISSERIAL ANTIGENIC PEPTIDES - This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria | 08-30-2012 |
20120276129 | NEISSERIAL ANTIGENIC PEPTIDES - This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria | 11-01-2012 |
20120283413 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 - NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other. | 11-08-2012 |
20120328643 | OUTER MEMBRANE VESICLE (OMV) VACCINE COMPRISING N. MENINGITIDIS SEROGROUP B OUTER MEMBRANE PROTEINS - A composition comprising (a) | 12-27-2012 |
20130004531 | IMMUNOGENS FROM UROPATHOGENIC ESCHERICHIA COLI - Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic | 01-03-2013 |
20130005667 | HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS - Alternative and improved approaches to the heterologous expression of the proteins of Neisseria meningitidis and | 01-03-2013 |
20130022633 | MENINGOCOCCAL fHBP POLYPEPTIDES - The factor H binding activity of meningococcal fHBP can be uncoupled from its bactericidal sensitivity. NMR studies have identified various amino acid residues involved in the fHBP/fH interaction and one or more of these residues is modified in a fHBP to reduce or eliminate its ability to bind to fH. | 01-24-2013 |
20130064846 | NEISSERIAL ANTIGENS - The invention provides proteins from | 03-14-2013 |
20130115238 | MENINGOCOCCAL FHBP POLYPEPTIDES - fHBP is a protein in | 05-09-2013 |
20130189295 | COMBINATIONS OF MENINGOCOCCAL FACTOR H BINDING PROTEINS - The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. | 07-25-2013 |
20130217859 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 - NMB 1870 is a protein in | 08-22-2013 |
20130236489 | DEVELOPMENTS IN MENINGOCOCCAL OUTER MEMBRANE VESICLES - A first aspect of the invention provides meningococcal outer membrane vesicles in which NHBA is over-expressed. A second aspect of the invention provides meningococcal outer membrane vesicles in which NadA is over-expressed. A third aspect of the invention provides a panel of bacterial strains, each member of which is isogenic except for a single gene which in each strain encodes a different variant of an antigen of interest. | 09-12-2013 |
20130323274 | ESCHERICHIA COLI IMMUNOGENS WITH IMPROVED SOLUBILITY - Variants of the pathogenic | 12-05-2013 |
20140037668 | COMBINATION NEISSERIAL COMPOSITIONS - Compositions comprising a first biological molecule from a | 02-06-2014 |
20140212449 | POLYPEPTIDE-VACCINES FOR BROAD PROTECTION AGAINST HYPERVIRULENT MENINGOCOCCAL LINEAGES - A small number of defined antigens can provide broad protection against meningococcal infection, and the invention provides a composition which, after administration to a subject, is able to induce an antibody response in that subject, wherein the antibody response is bactericidal against two or three of hypervirulent lineages A4, ET 5 and lineage 3 of | 07-31-2014 |
20140294885 | HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS - Alternative and improved approaches to the heterologous expression of the proteins of | 10-02-2014 |
20140294886 | ISOLATED PROTEIN AND COMPOSITIONS COMPRISING THE PROTEIN - Two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain. Hybrid proteins are represented by the formula NH | 10-02-2014 |
20140348869 | MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES - The factor H binding activity of meningococcal fHBP can be uncoupled from its bactericidal sensitivity. NMR studies have identified various amino acid residues involved in the fHBP/fH interaction and one or more of these residues is modified in a fHBP to reduce or eliminate its ability to bind to fH. | 11-27-2014 |
20140356389 | PROTEINS AND NUCLEIC ACIDS FROM MENINGITIS/SEPSIS-ASSOCIATED ESCHERICHIA COLI - Disclosed herein are various open reading frames from a strain of | 12-04-2014 |
20140363462 | HETEROLOGOUS EXPRESSION OF NEISSERIAL PROTEINS - Alternative and improved approaches to the heterologous expression of the proteins of | 12-11-2014 |
20150079124 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 03-19-2015 |
20150086582 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 03-26-2015 |