Patent application number | Description | Published |
20080260769 | Polypeptides for Oligomeric Assembly of Antigens - A system for expressing antigenic polypeptides in oligomeric form fuses the antigenic polypeptide to an oligomerisation polypeptide such that the oligomerisation polypeptide can interact with other oligomerisation polypeptides and bring multiple copies of the antigenic polypeptide into close proximity in the form of an oligomer. Expressing the polypeptides in oligomeric form in this way can improve their immunogenicity compared to a monomeric form. | 10-23-2008 |
20090162392 | MUTANT FORMS OF STREPTOLYSIN O - Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against | 06-25-2009 |
20090232820 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 09-17-2009 |
20090285845 | Domains And Epitopes Of Meningococcal Protein NMB1870 - ‘NMB1870’ is a known surface protein in | 11-19-2009 |
20100047267 | Staphylococcus aureus proteins and nucleic acids - The invention provides proteins from | 02-25-2010 |
20100055130 | STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS - The invention provides proteins from | 03-04-2010 |
20100105875 | Antibodies against neisserial factor H binding protein - Monoclonal antibody MAb502 binds to an epitope of meningococcal fHbp protein including Arg-204. Related antibodies are provided. | 04-29-2010 |
20100158935 | MUTANT FORMS OF STREPTOLYSIN O - Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against | 06-24-2010 |
20100183653 | Fusion Proteins Comprising CD4 Minimal Modules and Methods of Use Thereof - Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided. | 07-22-2010 |
20100183674 | COMPOSITIONS COMPRISING YERSINIA PESTIS ANTIGENS - Disclosed are several | 07-22-2010 |
20100189737 | Meningococcal vaccines including hemoglobin receptor - The meningococcal haemoglobin receptor, HmbR, is used as a vaccine antigen in combination with one or more further antigens e.g. in combination with a meningococcal outer membrane vesicle, with another purified meningococcal antigen (e.g. fHBP, 287, NadA, NspA, NhhA, App, Omp85, LOS), with a conjugated meningococcal capsular saccharide, etc. | 07-29-2010 |
20110008279 | Methods and Compositions Relating to Adhesins as Adjuvants - This invention is in the field of immunology and relates to the discovery that adhesins are potent activators of dendritic cells. | 01-13-2011 |
20110020390 | MENINGOCOCCAL FHBP POLYPEPTIDES - fHBP is a protein in | 01-27-2011 |
20110076300 | Hybrid Polypeptides Including Meningococcal fHBP Sequences - fHBP is a protein in | 03-31-2011 |
20110166323 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 - NMB1870 is a protein in | 07-07-2011 |
20120003258 | MUTANT FORMS OF STREPTOLYSIN O - Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against | 01-05-2012 |
20120020890 | STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS - The invention provides proteins from | 01-26-2012 |
20120027801 | POLYPEPTIDES FROM NEISSERIA MENINGITIDIS - Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis. | 02-02-2012 |
20120058143 | STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS - The invention provides proteins from | 03-08-2012 |
20120070457 | Polypeptides from neisseria meningitidis - Polypeptides comprising | 03-22-2012 |
20120093850 | COMPOSITIONS FOR IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS - Hla polypeptides having various deletions, insertions, and/or mutations which are useful for immunisation are provided herein. Also provided herein are Hla heptamers which are non-haemolytic. Additionally, an effective | 04-19-2012 |
20120107322 | IMMUNOGENIC AND THERAPEUTIC COMPOSITIONS FOR STREPTOCOCCUS PYOGENES - Compositions for preventing and/or treating | 05-03-2012 |
20120107340 | COMPOSITIONS FOR IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS - An effective | 05-03-2012 |
20120135024 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 05-31-2012 |
20120148616 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 06-14-2012 |
20120156236 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 06-21-2012 |
20120164166 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 06-28-2012 |
20120219578 | NEISSERIAL ANTIGENIC PEPTIDES - This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria | 08-30-2012 |
20120276129 | NEISSERIAL ANTIGENIC PEPTIDES - This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria | 11-01-2012 |
20120283413 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 - NMB1870 is a protein in Neisseria meningitidis. Three families of NMB1870 are known. To increase the ability of a NMB1870 protein to elicit antibodies that are cross-reactive between the families, NMB1870 is engineered. Sequences can be substituted from one NMB1870 family into the corresponding position in another family. Proteins of NMB1870 sequences from different families can be joined to each other. | 11-08-2012 |
20130022633 | MENINGOCOCCAL fHBP POLYPEPTIDES - The factor H binding activity of meningococcal fHBP can be uncoupled from its bactericidal sensitivity. NMR studies have identified various amino acid residues involved in the fHBP/fH interaction and one or more of these residues is modified in a fHBP to reduce or eliminate its ability to bind to fH. | 01-24-2013 |
20130115238 | MENINGOCOCCAL FHBP POLYPEPTIDES - fHBP is a protein in | 05-09-2013 |
20130129740 | NUCLEIC ACIDS AND PROTEINS FROM STREPTOCOCCUS GROUPS A AND B - The invention provides proteins from group B | 05-23-2013 |
20130189295 | COMBINATIONS OF MENINGOCOCCAL FACTOR H BINDING PROTEINS - The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. | 07-25-2013 |
20130217859 | CHIMERIC, HYBRID AND TANDEM POLYPEPTIDES OF MENINGOCOCCAL NMB1870 - NMB 1870 is a protein in | 08-22-2013 |
20140127250 | STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS - The invention provides proteins from | 05-08-2014 |
20140178425 | COMPOSITIONS FOR IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS - An effective | 06-26-2014 |
20140242106 | STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS - The invention provides proteins from | 08-28-2014 |
20140348869 | MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES - The factor H binding activity of meningococcal fHBP can be uncoupled from its bactericidal sensitivity. NMR studies have identified various amino acid residues involved in the fHBP/fH interaction and one or more of these residues is modified in a fHBP to reduce or eliminate its ability to bind to fH. | 11-27-2014 |
20150079124 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 03-19-2015 |
20150086582 | NEISSERIA MENINGITIDIS ANTIGENS AND COMPOSITIONS - The invention provides proteins from | 03-26-2015 |