Mária
Mária Gyökérné Wittmann, Budapest HU
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20100189631 | PERMEATION METHOD AND APPARATUS FOR PREPARING FLUIDS CONTAINING HIGH PURITY CHLORINE DIOXIDE - Method to prepare fluids (liquids and gases) containing pure chlorine dioxide which is not contaminated by the starting materials or the byproducts of the chlorine dioxide synthesis or to deliver pure chlorine dioxide into any medium capable of dissolving chlorine dioxide, wherein the chlorine dioxide generated in the process is transported across a pore free polymeric membrane via selective permeation into the target medium. Apparatus to realize the said method, wherein the generation of chlorine dioxide is carried out in such a reactor where some or all walls comprising the reactor, or the walls of a permeator unit attached to the reactor, are made of the said pore free polymer, characteristically some kind of silicone rubber, which is highly permeable to chlorine dioxide, but which is practically impermeable for the acidic and corrosive reagents used for the chlorine dioxide synthesis, its permeability being at least 3 orders of magnitude lower for these contaminating components compared to that of chlorine dioxide. The invention can be realized both by batch and by continuous reactors. | 07-29-2010 |
Mária Gyökérné Wittmann, Budapest HU
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20100189631 | PERMEATION METHOD AND APPARATUS FOR PREPARING FLUIDS CONTAINING HIGH PURITY CHLORINE DIOXIDE - Method to prepare fluids (liquids and gases) containing pure chlorine dioxide which is not contaminated by the starting materials or the byproducts of the chlorine dioxide synthesis or to deliver pure chlorine dioxide into any medium capable of dissolving chlorine dioxide, wherein the chlorine dioxide generated in the process is transported across a pore free polymeric membrane via selective permeation into the target medium. Apparatus to realize the said method, wherein the generation of chlorine dioxide is carried out in such a reactor where some or all walls comprising the reactor, or the walls of a permeator unit attached to the reactor, are made of the said pore free polymer, characteristically some kind of silicone rubber, which is highly permeable to chlorine dioxide, but which is practically impermeable for the acidic and corrosive reagents used for the chlorine dioxide synthesis, its permeability being at least 3 orders of magnitude lower for these contaminating components compared to that of chlorine dioxide. The invention can be realized both by batch and by continuous reactors. | 07-29-2010 |
Mária KÖmÜves-Mars, Budapest HU
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20150291503 | PROCESS FOR THE PREPARATION OF TRAVOPROST - The subject of the invention is process the preparation of travoprost of formula (I) characterized by that the free acid of formula (II) is a.) activated with 2-chloro-1,3-dimethyl-imidazolinium chloride (DMC) and the resulting activated carboxylic acid intermediate is reacted with isopropyl alcohol, or b.) reacted with alkyl haloformate and the resulting mixed anhydride is reacted with isopropyl alcohol, or c.) activated with a straight or branched C1-8 dialkyl dicarbonate and reacted with isopropanol in the presence of water-free magnesium salt. | 10-15-2015 |
Mária Kürthy, Budapest HU
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20100267711 | METHOD OF ENHANCING CELLULAR PRODUCTION OF MOLECULAR CHAPERONE, HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE CHAPERONE PRODUCTION AND THE PREPARATION THEREOF - A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). | 10-21-2010 |
Mária Kürthy, Budapest HU
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20100267711 | METHOD OF ENHANCING CELLULAR PRODUCTION OF MOLECULAR CHAPERONE, HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE CHAPERONE PRODUCTION AND THE PREPARATION THEREOF - A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). | 10-21-2010 |
Mária Péter, Eindhoven NL
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20120281192 | LITHOGRAPHIC APPARATUS AND METHOD - A method of obtaining information indicative of the topography of a surface of a flexible substrate, the method including directing a beam of radiation at the surface of the flexible substrate; and detecting changes in intensity distribution, or angle of reflection, of the beam of radiation after the beam of radiation has been reflected from the surface of the substrate to obtain information indicative of the topography of the surface of the flexible substrate. | 11-08-2012 |
Mária Sefferné Szalai, Pécsvárad HU
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20140303105 | Primycin and components thereof for use in the treatment or prevention of infections caused by specific pathogens - The invention refers to primycin or a primycin component or a combination of primycin components, for use in the treatment or prevention of infections caused by Gram-positive bacteria resistant to methicillin and/or vancomycin and/or mupirocin or by penicillin-resistant streptococci. The invention also covers antibiotic compositions containing these active agents. | 10-09-2014 |
Mária Vajjon, Budapest HU
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20100274020 | PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATES - The invention relates to a process for the preparation of cyclopropyl benzyl ketone compounds of formula (II) wherein R | 10-28-2010 |
20110040093 | PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATE - The invention relates to a process for the preparation of compounds of general formula (III), wherein R represents fluorine or chlorine atom and X represents chlorine or bromine atom, by halogenation of cyclopropyl benzyl ketone of general formula (II), wherein R represents fluorine or chlorine atom and the halogenation is carried out in the mixture of aqueous hydrogen halide and aqueous hydrogen peroxide in the presence of a water miscible solvent or in the presence of a phase transfer catalyst; or the halogenation is carried out in the mixture of sulfuric acid and an alkali metal salt of aqueous hydrogen halide. The process can be applied preferably on industrial scale. | 02-17-2011 |
Mária Vajjon, Budapest HU
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20110040093 | PROCESS FOR THE PREPARATION OF PHARMACEUTICAL INTERMEDIATE - The invention relates to a process for the preparation of compounds of general formula (III), wherein R represents fluorine or chlorine atom and X represents chlorine or bromine atom, by halogenation of cyclopropyl benzyl ketone of general formula (II), wherein R represents fluorine or chlorine atom and the halogenation is carried out in the mixture of aqueous hydrogen halide and aqueous hydrogen peroxide in the presence of a water miscible solvent or in the presence of a phase transfer catalyst; or the halogenation is carried out in the mixture of sulfuric acid and an alkali metal salt of aqueous hydrogen halide. The process can be applied preferably on industrial scale. | 02-17-2011 |
Mária Virágh, Budapest HU
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20090297599 | PHARMACEUTICAL COMPOSITIONS CONTAINING ROSUVASTATIN CALCIUM - A pharmaceutical composition is disclosed containing amorphous rosuvastatin calcium and at least one of the following stabilizing agents: magnesium hydroxide, calcium acetate, calcium gluconate, calcium glycerophosphate, or aluminum hydroxide, together with at least one pharmaceutically acceptable excipient. | 12-03-2009 |
Mária Virágh, Budapest HU
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20090297599 | PHARMACEUTICAL COMPOSITIONS CONTAINING ROSUVASTATIN CALCIUM - A pharmaceutical composition is disclosed containing amorphous rosuvastatin calcium and at least one of the following stabilizing agents: magnesium hydroxide, calcium acetate, calcium gluconate, calcium glycerophosphate, or aluminum hydroxide, together with at least one pharmaceutically acceptable excipient. | 12-03-2009 |
Mária Virágh-Hadas, Budapest HU
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20100273746 | PHARMACEUTICAL FORMULATIONS CONTAINING TOLPERISONE - The present invention relates to pharmaceutical formulation containing tolperisone or its pharmaceutically acceptable salts or tolperisone combined with a non-steroidal anti-inflammatory drug or their salts, gel forming macromolecule, solvent, and if required thickening agent, penetration enhancer and pH adjuvant or the mixture thereof. The invention also relates to the manufacturing process of the above mentioned pharmaceutical compositions, further the use of these formulations and the containers suitable for the dosage, which are dual compartment containers consisting of two separated chambers. | 10-28-2010 |
Mária Virágh-Hadas, Budapest HU
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20100273746 | PHARMACEUTICAL FORMULATIONS CONTAINING TOLPERISONE - The present invention relates to pharmaceutical formulation containing tolperisone or its pharmaceutically acceptable salts or tolperisone combined with a non-steroidal anti-inflammatory drug or their salts, gel forming macromolecule, solvent, and if required thickening agent, penetration enhancer and pH adjuvant or the mixture thereof. The invention also relates to the manufacturing process of the above mentioned pharmaceutical compositions, further the use of these formulations and the containers suitable for the dosage, which are dual compartment containers consisting of two separated chambers. | 10-28-2010 |
María Aguirregabiria Izaguirre, Guipuzcoa ES
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20100304306 | FLEXIBLE MICRO/NANOFLUIDIC DEVICES - The present invention relates to a method for manufacturing micro/nanofluidic devices that incorporate overhanging micromechanical and metal components monolithically integrated with the fluidic circuitry. | 12-02-2010 |
María Aguirregabiria Izaguirre, Guipuzcoa ES
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20100304306 | FLEXIBLE MICRO/NANOFLUIDIC DEVICES - The present invention relates to a method for manufacturing micro/nanofluidic devices that incorporate overhanging micromechanical and metal components monolithically integrated with the fluidic circuitry. | 12-02-2010 |
María De La Sierra Flores, Madrid ES
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20150042502 | ELECTROMAGNETIC RADIATION ATTENUATOR - The invention relates to a material configured such as to include a plurality of layers, some layers being made of a composite material and some layers being made of a dielectric material. The layers of composite material include a mixture of host dielectric material and inclusions, such that said inclusions are embedded in the structure of the host dielectric material. Said inclusions preferably include highly conductive fibres, specifically metal microwires. Thus, the structure of the material according to the invention includes a plurality of layers, some layers being made of a composite material, which includes a host dielectric material with inclusions, and some layers being made of a dielectric material. The structure of the material according to the invention is designed so that the surface on which said material is applied is capable of absorbing a portion of the incident electromagnetic radiation, thus substantially reducing the electromagnetic radiation reflected by same curved. | 02-12-2015 |
María De Los Remedios Berenguer Martínez, Orihuela ES
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20150258225 | Apparatus For Instantaneous Expansion With Vacuum And Ultrasound Waves - This invention is based on forming an apparatus in which the technologies of flash vacuum expansion and simultaneous treatment with ultrasounds are combined for various applications in the food, pharmaceutical and cosmetics industries | 09-17-2015 |
María Garranzo García-Ibarrola, Madrid ES
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20090186938 | ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS - Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus | 07-23-2009 |
20100048690 | ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS - Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus | 02-25-2010 |
20100280108 | Antitumoral Compounds - A compound of general formula (I) | 11-04-2010 |
20110034549 | Antitumoral Compounds - A compound of general formula (I) | 02-10-2011 |
20120041063 | ANTITUMORAL COMPOUNDS - A compound of general formula (I) | 02-16-2012 |
María Garranzo García-Ibarrola, Madrid ES
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20110034549 | Antitumoral Compounds - A compound of general formula (I) | 02-10-2011 |
20120190870 | ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS - Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus | 07-26-2012 |
María Iñiguez Martínez, Pamplona ES
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20130130225 | COMPOSITION FOR THE COLD STORAGE OF ORGANS - The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods. | 05-23-2013 |
María Iñiguez Martínez, Pamplona ES
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20130130225 | COMPOSITION FOR THE COLD STORAGE OF ORGANS - The present invention relates to a cold organ preservation composition for transplantation comprising a cold organ preservation solution and cardiotrophin-1 or a functionally equivalent variant thereof. The invention also relates to methods and kits for the preparation of said composition, the uses thereof for the cold organ protection and/or preservation for transplantation (particularly for kidney, lung and heart) and also to the cold preservation methods and cold-preserved isolated organs by these methods. | 05-23-2013 |
María Jordá Beneyto, Paterna ES
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20130143988 | MODIFIED PHYLLOSILICATE - Polymer nanocomposites including: a) a polylactic polymer; and b) a modified phyllosilicate composition including a modifying agent which includes hexadecyl trimethyl ammonium cations which are intercalated between the layers of the phyllosilicate, and preparation processes therefor, as well as the modified phyllosilicate composition. The polymer nanocomposites are particularly useful for packaging, particularly food and drink packaging. | 06-06-2013 |
20130177723 | POLYMER NANOCOMPOSITE COMPRISING POLYLACTIC ACID REINFORCED WITH THE MODIFIED PHYLLOSILICATE - Polymer nanocomposite having: a) a polylactic polymer; and b) a modified phyllosilicate composition having a modifying agent which includes hexadecyl trimethyl ammonium cations which are intercalated between the layers of the phyllosilicate; and preparation process of such a polymer nanocomposite. The polymer nanocomposite is particularly useful for packaging, particularly food and drink packaging. | 07-11-2013 |
María Jordá Beneyto, Paterna ES
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20130143988 | MODIFIED PHYLLOSILICATE - Polymer nanocomposites including: a) a polylactic polymer; and b) a modified phyllosilicate composition including a modifying agent which includes hexadecyl trimethyl ammonium cations which are intercalated between the layers of the phyllosilicate, and preparation processes therefor, as well as the modified phyllosilicate composition. The polymer nanocomposites are particularly useful for packaging, particularly food and drink packaging. | 06-06-2013 |
20130177723 | POLYMER NANOCOMPOSITE COMPRISING POLYLACTIC ACID REINFORCED WITH THE MODIFIED PHYLLOSILICATE - Polymer nanocomposite having: a) a polylactic polymer; and b) a modified phyllosilicate composition having a modifying agent which includes hexadecyl trimethyl ammonium cations which are intercalated between the layers of the phyllosilicate; and preparation process of such a polymer nanocomposite. The polymer nanocomposite is particularly useful for packaging, particularly food and drink packaging. | 07-11-2013 |
20160060453 | COMPOSITION FOR THE PREPARATION OF A NANOSTRUCTURED BIODEGRADABLE POLYMERIC MATERIAL, THE MATERIAL OBTAINED AND ITS APPLICATIONS - The composition comprises a mixture of: i) poly(L-, D-lactide) homopolymer and, optionally, poly(ε-caprolactone) homopolymer, and ii) poly(L-lactide) and poly(ε-caprolactone) diblock copolymer, where said copolymer has a molar mass of the L-lactide block of 20,000 g/mol to 200,000 g/mol and a molar mass of the ε-caprolactone block of 10,000 g/mol to 100,000 g/mol, with the molar ratio between the L-lactide block and the ε-caprolactone block of 2:1. The invention also refers to the nanostructured material obtained from this composition that is characterised by a nanostructure of two mutually self-assembled phases, one phase being formed by a polymeric matrix of poly(L-, D-lactide) units and the other phase by poly(ε-caprolactone) units self-assembled with the matrix and also its use for the manufacture of a plastic article in the form of a transparent film or thin sheet. | 03-03-2016 |
María Lavilla Martin, Erandio ES
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20140093612 | METHOD FOR OBTAINING A FERMENTED DAIRY PRODUCT - The invention defines a method for obtaining a fermented dairy product characterized by a heat treatment step followed or preceded by a high pressure homogenization step at a pressure above 100 MPa and up to 350 MPa of a dairy starting material, wherein the total fat composition of the dairy starting material lies between 0.05% and 10% by weight, wherein the total quantity of protein lies between 3 and 10% by weight, and wherein the fat and protein come exclusively from the dairy starting material. This method allows obtaining fermented dairy products with improved rheological properties avoiding the use of additives such as thickeners or stabilizers. Also, it allows obtaining fermented dairy products with improved mouth-feel. | 04-03-2014 |
María Llamedo, Caracas VE
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20150112105 | ASSESSMENT METHOD FOR HYDRATE INHIBITORS AND FORMULATION OF GAS HYDRATE INHIBITORS - A gas hydrate inhibitor composition including an aqueous solution of anthraquinones. Methods of making and using the inhibitor are also provided, as well as a method of evaluating effectiveness of an inhibitor using THF. | 04-23-2015 |
María Luz Martín-Martín, Toledo ES
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20130245043 | SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS - In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 09-19-2013 |
María Martinez Hansen, Zaragoza ES
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20140265184 | SHOPPING CART - The present invention relates to a shopping cart of the types used by shoppers in supermarkets and/or self-service stores or shops and of the types stored by being horizontally fitted into one another, which has several improved maneuverability and handling features and which basically comprises a basket ( | 09-18-2014 |
María Morales Areizaga, Madrid ES
María Morales Areizaga, Madrid ES
María Nieto Soler, Barcelona ES
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20160024112 | CHEMICAL ENTITIES - Provided are chemical entities selected from compounds of formula (I), wherein R | 01-28-2016 |
María Ortega Muñoz, Toledo ES
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20120252688 | NOVEL BIOMARKERS OF DISEASE HISTOPATHOLOGY - Use of FGF-2 and Anosmin-1 proteins to predict the histopathology of the lesions of a subject with a demyelinating disease of the central nervous system (CNS) by detecting the amount of such proteins in a sample of isolated biological fluid. Furthermore, the present invention relates to a method for the understanding of the histopathological features of the lesions of a subject with a CNS demyelinating disease a kit to carry out this method. Preferably, the CNS demyelinating disease is multiple sclerosis, and the biological fluid is cerebrospinal fluid (CSF). | 10-04-2012 |
María Pedrero Muñoz, Madrid ES
María Pedrero Muñoz, Madrid ES
María Prat Quiñones, Barcelona ES
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20120122826 | NOVEL QUINUCLIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME - The invention provides 3-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide in combination with a steroid, and methods of using it for treatment of respiratory disorders. | 05-17-2012 |
María SatuÉ SahÚn, Palma De Mallorca ES
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20160082147 | IMPLANTS FOR INDUCING SOFT AND HARD TISSUE INTEGRATION - The present invention provides a biocompatible implant comprising one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, wherein an antioxidant compound selected from the group of flavonoids or methoxytryptophols, an ester thereof, a pharmaceutically acceptable salt thereof or a combination thereof, is/are coated to at least a part of a metal, metal alloy or metal oxide surface of said biocompatible implant. This implant is useful for replace bone tissue in vertebrate animals, and furthermore restore the normal function of said tissue, mainly due to its ability of induce osseointegration and soft tissue attachment. | 03-24-2016 |
María Tamaoyo Novas, Madrid ES
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20140206573 | METHOD FOR EVALUATING BACTERIAL CELL WALL INTEGRITY - The present invention relates to a method for evaluating the integrity of the cell wall of the bacteria present in a culture in the presence of an antibiotic acting on the bacterial cell wall which, from a practical point of view, allows quickly determining if a bacterium is sensitive or resistant to an antibiotic acting on the bacterial cell wall. Likewise, the present invention also relates to a lysis solution applicable in the preceding method, specifically affecting bacteria having the cell wall damaged by the action of an antibiotic acting on the bacterial cell wall, which allows distinguishing bacteria sensitive to said antibiotic from those resistant to said antibiotic. | 07-24-2014 |
María Tijero Serna, Mondragon ES
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20100327211 | METHOD FOR THE PRODUCTION OF MICRO/NANOFLUIDIC DEVICES FOR FLOW CONTROL AND RESULTING DEVICE - The present invention refers to a procedure for the manufacture of micro-nanofluidic devices for flow control such as microvalves, micropumps and flow regulators, using a photodefinable polymer and an elastomer as structural materials and to the micro-nanofluidic devices for flow control obtained by said procedure. | 12-30-2010 |
María Tijero Serna, Mondragon ES
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20100327211 | METHOD FOR THE PRODUCTION OF MICRO/NANOFLUIDIC DEVICES FOR FLOW CONTROL AND RESULTING DEVICE - The present invention refers to a procedure for the manufacture of micro-nanofluidic devices for flow control such as microvalves, micropumps and flow regulators, using a photodefinable polymer and an elastomer as structural materials and to the micro-nanofluidic devices for flow control obtained by said procedure. | 12-30-2010 |