Patent application number | Description | Published |
20100248213 | COLLECTION/EXTRACTION CONTAINER FOR BIOLOGICAL MATERIAL IN FORENSIC SAMPLES - Relates to a collection/extraction container ( | 09-30-2010 |
20110290647 | SYSTEM AND INSTRUMENT FOR PROCESSING BIOLOGICAL SAMPLES AND MANIPULATING LIQUIDS HAVING BIOLOGICAL SAMPLES - A biological sample processing system comprises a container for large volume processing, a flat polymer film having a lower surface and a hydrophobic upper surface, which is kept at a distance d to the base side of the container by the protrusions. The distance d defines at least one gap when the container is positioned on the film. A liquid droplet manipulation instrument comprises at least one electrode array for inducing liquid droplet movements; a substrate supporting the at least one electrode array; and a control unit is characterized in that the container and the film are reversibly attached to the liquid droplet manipulation instrument. The system thus enables displacement of at least one liquid droplet from the at least one well through the channel of the container onto the hydrophobic upper surface of the flat polymer film and above the at least one electrode array; wherein the liquid droplet manipulation instrument controls a guided movement of the liquid droplet on the hydrophobic upper surface of the flat polymer film by electrowetting and to process there the biological sample. | 12-01-2011 |
20130020202 | Cartridge and System for Manipulating Samples in Liquid Droplets - A cartridge ( | 01-24-2013 |
20130118900 | CARTRIDGE AND SYSTEM FOR MANIPULATING SAMPLES IN LIQUID DROPLETS - A cartridge manipulates samples in liquid droplets with an electrode array when a working film is placed on the array. The cartridge has a body with lower surface and wells to hold samples, each with a bottom opening to release liquid. A piercable bottom structure seals the bottom openings. A working film below the body has a hydrophobic upper surface. A peripheral spacer connects the working film to the body and forms a gap is between the body and surface. A top piercing system located in at least one of the wells has a piston and a piercing element, the piston being movable in the well and the piercing element piercing the piercable bottom structure for releasing a sample from a well into the gap. | 05-16-2013 |
20130175169 | MANIPULATING THE SIZE OF LIQUID DROPLETS IN DIGITAL MICROFLUIDICS - Liquid droplet manipulation instrument has electrode array for inducing movement of a droplet by electrowetting, substrate supporting the array and control with electrode selector connected to a voltage control. The selector selects each electrode and provides each with a controlled voltage. The control includes central processing unit for providing the selected electrode with an individual voltage pulse which is a drive voltage or a ground voltage or a stop voltage. The control defines a path for movement of a liquid portion of a larger volume that covers more than one electrode by the simultaneous selection of a group of two or more subsequent drive electrodes and to provide each selected drive electrode with a drive voltage pulse along the path. The control simultaneously provides a group of two or more electrodes adjacent to or identical with the pulsed drive electrodes, with a ground or stop voltage pulse. | 07-11-2013 |
20130183666 | PARTIAL GENOTYPING BY DIFFERENTIAL HYBRIDIZATION - In a method of detecting the number of repeat units in a selected short tandem repeat (STR) in a genomic sample, the genomic sample is amplified by PCR and a single stranded target DNA is selected and separated for use in differential hybridization experiments. Subsequent partial genotyping comprises the steps of admixing to the target DNA at least one fluorescent labeled STR probe oligonucleotide and one different fluorescent labeled reference probe oligonucleotide allowing hybridization to the single stranded target DNA in a hybridization experiment. Measurement of the fluorescence intensities of the probes that are bound to the repeat units of the selected STR and normalizing the fluorescence intensity of the STR probes on the base of the reference probe intensity reveals a relative fluorescence signal representing the result of the differential hybridization experiment. Also disclosed are kits for carrying out partial genotyping by differential hybridization. | 07-18-2013 |
20130270114 | Digital MicroFluidics System with Swappable PCB's - Digital microfluidics system manipulates samples in liquid droplets within disposable cartridges that have bottom layer, top layer, and gap between the bottom and top layers. The system has a base unit with cartridge accommodation sites and a central control unit for controlling selection of individual electrodes of electrode arrays and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the cartridges by electrowetting. The system further has board accommodation sites located at the cartridge accommodation sites that each can take up a swappable electrode board having an electrode array and electrical board contact elements individually connected to electrodes of the electrode array. Each board accommodation site has electrical base unit contact elements that are connected to the central control unit and that are configured to engage with the electrical board contact elements of a swappable electrode board that is placed at the board accommodation site. | 10-17-2013 |
20150096890 | MANIPULATING THE SIZE OF LIQUID DROPLETS IN DIGITAL MICROFLUIDICS - A biological sample processing system ( | 04-09-2015 |
20150144489 | DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS - A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting. | 05-28-2015 |
Patent application number | Description | Published |
20120165685 | PLASMAPHERESIS DONOR DISPLAY AND METHOD OF USE - Certain examples provide a blood collection system including an operator user interface to allow an operator to configure the system for a blood collection procedure from a donor. The system also includes a donor display, separate from the operator user interface, arranged in the system to be within view of the donor who is to donate via the system. The donor display is to display information and instruction to the donor. The information and instruction include a first indicator regarding a progress of the blood collection procedure for the donor and a second indicator including a visual instruction to the donor regarding the blood collection procedure. The system includes a processor and a memory. The processor is to execute instructions stored in the memory to process input from and provide output to the operator user interface and the donor display. | 06-28-2012 |
20120220915 | SYSTEMS AND METHODS FOR SINGLE NEEDLE CONTINUOUS PLASMA PROCESSING - Certain examples describe systems and methods for increasing plasma extracted from donor blood. An example method includes receiving blood extracted from a donor connected to a blood collection machine. The example method includes filtering the blood using a filtration device to remove at least a portion of plasma included in the blood to separate the plasma removed from remaining blood. The example method includes routing the plasma removed for collection. The example method includes re-filtering the remaining blood using a or the filtration device to remove additional plasma from the remaining blood. The example method includes routing the additional plasma removed for collection. | 08-30-2012 |
20120273416 | SYSTEMS AND METHODS OF CONTROLLING FOULING DURING A FILTRATION PROCEDURE - Systems and methods of controlling fouling during a filtration procedure are described. A plasmapheresis method includes accepting a selection of a plasma flow rate and predicting an estimated procedure end time based at least partially on a plasma collection target volume. The method also includes flowing blood past a membrane and changing a plasma flow rate until the selected plasma flow rate through the membrane is achieved. The method also includes determining an acceptable rate of pressure change with time for respective times to the estimated procedure end time, the acceptable fouling rate limit being associated with a system pressure and adjusting the plasma flow rate based on the determined acceptable rate of pressure change with time. | 11-01-2012 |
20130284653 | SYSTEMS AND METHODS FOR SINGLE NEEDLE CONTINUOUS PLASMA PROCESSING - Certain examples describe systems and methods for increasing plasma extracted from donor blood. An example method includes receiving blood extracted from a donor connected to a blood collection machine. The example method includes filtering the blood using a filtration device to remove at least a portion of plasma included in the blood to separate the plasma removed from remaining blood. The example method includes routing the plasma removed for collection. The example method includes re-filtering the remaining blood using a or the filtration device to remove additional plasma from the remaining blood. The example method includes routing the additional plasma removed for collection. | 10-31-2013 |
20140066281 | BLOOD BAG SYSTEMS FOR SEPARATION OF WHOLE BLOOD AND METHODS OF USE THEREOF - The present disclosure relates generally to systems for processing a unit of whole blood into its components while the unit is still in the centrifuge. The system comprises a container holding whole blood and one or more satellite bags or containers that are installed into a holder, which is then inserted into a bucket of the centrifuge. Tubes interconnect the containers, one or more of which are preferably installed into clamping mechanisms resident in the holder. The holder further preferably includes sensing means, such as optical sensors, to sense the location of the interfaces between the separated layers of the whole blood that result from rotation of the centrifuge. | 03-06-2014 |