Manucharyan
Karen Manucharyan, Coyoacan MX
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20110065654 | COMPOSITIONS AND METHODS FOR ALZHEIMER'S DISEASE - The present invention concerns methods and compositions of use for treatment of Alzheimer's Disease (AD). In certain embodiments, the methods concern preparation of phage-display single chain antibody libraries and screening against amyloid-beta (Aβ) protein or peptide. Anti-Aβ antibodies are selected and sequenced. In certain embodiments, synthetic Aβ binding peptides are designed and prepared, using portions of the anti-Aβ antibody sequences. The antibodies and peptides are of use for treatment of AD or for treatment of individuals at risk of developing AD. Compositions comprising anti-Aβ antibodies or Aβ binding peptides are also disclosed. | 03-17-2011 |
Karen Manucharyan, Mexico MX
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20090214591 | Immunogens for Vaccines Against Antigenically Variable Pathogens and Diseases - The present invention provides compositions and methods for the therapeutic and/or prophylactic treatment of pathogen infections and/or disease states. The compositions may comprise variable epitope libraries (VELs), containing antigenic epitopes with one or more amino acid substitutions in the native epitope sequence. In preferred embodiments, the substituted amino acid may be replaced with each of the 19 other naturally occurring amino acids. In more preferred embodiments, multiple amino acid residues may be substituted. Such compositions and methods may be of use for production of vaccines against pathogens or diseases that show a high degree of genetic variability. | 08-27-2009 |
Karen Manucharyan, Los Reyes Coyoacan MX
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20090023627 | COMPOSITIONS AND METHODS FOR ALZHEIMER'S DISEASE - The present invention concerns methods and compositions of use for treatment of Alzheimer's Disease (AD). In certain embodiments, the methods concern preparation of phage-display single chain antibody libraries and screening against amyloid-beta (Aβ) protein or peptide. Anti-Aβ antibodies are selected and sequenced. In certain embodiments, synthetic Aβ binding peptides are designed and prepared, using portions of the anti-Aβ antibody sequences. The antibodies and peptides are of use for treatment of AF or for treatment of individuals at risk of developing AD. Compositions comprising anti-Aβ antibodies or Aβ binding peptides are also disclosed. | 01-22-2009 |
Karen Manucharyan, Mexico City MX
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20140302085 | USE OF GK-1 PEPTIDE EXPRESSED ON M13 FILAMENTOUS PHAGE AS PHARMACEUTICAL INGREDIENT TO ENHANCE THE EFFICIENCY OF THE IMMUNE RESPONSE INDUCED BY VACCINE OR PATHOGEN ANTIGENS - The present invention is directed to the use of FGK-1 immunopotentiator, composed by the peptide named GK-1, characterized by the sequence G-Y-Y-Y-P-S-D-P-N-T-F-Y-A-P-P-Y-S-A and linked to the pVIII surface protein of M13 filamentous phage, to prepare pharmaceutical products potentiating the protective immune response of vaccine antigens when used by itself or conjointly with these antigens administered either intranasally, subcutaneously, or intramuscularly, yielding an increase in the level of specific antibodies against vaccine antigens in serum and in bronchoalveolar lavages. | 10-09-2014 |