Patent application number | Description | Published |
20080312441 | Use of Oripavine as a Starting Material For Buprenorphine - There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group. | 12-18-2008 |
20080312442 | Process for Preparing Morphinan-6-One Products with Low Levels of Alpha, Beta-Unsaturated Ketone Compounds - The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of α,β-unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound. (A) | 12-18-2008 |
20100081816 | Processes for synthesis of opiate alkaloid derivatives - The present invention provides processes for the synthesis of opiate alkaloids. In particular, the opiate alkaloids produced by the process of the invention are typically intermediate compounds that may be utilized to produce a variety of biologically active alkaloids including buprenorphine and diprenorphine. | 04-01-2010 |
20100087647 | Processes for the production of buprenorphine with reduced impurity formation - The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities. | 04-08-2010 |
20100120814 | Crystalline and Amorphous Forms of Naltrexone Hydrochloride - The present invention relates to novel crystalline forms of naltrexone hydrochloride including hydrated and solvated forms and a novel amorphous form. The invention also describes methods of preparing the various crystalline forms. The present invention also relates to pharmaceutical compositions containing crystalline and amorphous forms of naltrexone hydrochloride, as well as methods of treating addictive behavior by administering the pharmaceutical compositions. | 05-13-2010 |
20120059167 | PROCESSES FOR PREPARING MORPHINAN-6-ONE PRODUCTS WITH LOW LEVELS OF ALPHA BETA-UNSATURATED COMPOUNDS - The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of α,β-unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound. (A) | 03-08-2012 |
20150148365 | Processes For Preparing Morphinan-6-One Products With Low Levels Of Alpha, Beta-Unsaturated Ketone Compounds - The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound. | 05-28-2015 |
Patent application number | Description | Published |
20090160169 | DYNAMIC AIRBAG VENTING - An example airbag assembly includes an airbag and a duct having an opening for venting gas. The duct moves between a first position where the opening is outside the airbag and a second position where the opening is inside the airbag. Inflating the airbag moves the duct between the first position and the second position. | 06-25-2009 |
20090261564 | EXTERNAL AND INTERNAL AIRBAG TETHER ARRANGEMENT - An example tethered airbag arrangement includes an airbag movable to an expanded position. The airbag includes a contact face. An internal tether constrains expansion of the contact face. An external tether system includes tether portions and at least one bridge portion. The tether portions constrain expansion of the contact face. The bridge portion limits separation between one of the tether portions and an adjacent one of the tether portions as the airbag moves to an expanded position. | 10-22-2009 |
20110025032 | DYNAMIC AIRBAG VENTING - An example airbag assembly includes an airbag and a duct. The duct has a duct opening for venting gas. The duct is moveable between a first position where the duct opening is outside the airbag and a second position where the duct opening is inside the airbag. Inflating the airbag moves the duct between the first position and the second position. The airbag is configured to be inflated by a first stream of gas moving from the duct opening to an interior of the airbag and by a second stream of gas moving from an airbag inflator to the interior of the airbag. The first stream of gas is separate from the second stream of gas. | 02-03-2011 |
20110121549 | DYNAMIC AIRBAG VENTING - An example airbag assembly includes an airbag having an airbag opening and a duct adjacent the airbag opening. A tether is configured to move the duct between a first position and a second position. The duct communicates a first flow from the duct through the airbag opening in the first position. The duct communicates a second flow from the duct through the airbag opening in the second position. The first flow is greater than the second flow. | 05-26-2011 |
20120032429 | DYNAMIC AIRBAG VENTING - An exemplary airbag assembly includes an airbag and a duct having an duct opening for venting gas. The duct has a first position and a second position. The duct is configured to direct less gas out of the airbag when in the second position than when in the first position. A tether kinks about the duct to move the duct from the first position to the second position. The inflating causes the tether to kink about the duct. | 02-09-2012 |
20120235474 | WINDSHIELD EMBEDDED POWER COIL FOR WIRELESS CHARGING - A wireless power charging or supply system provides a wireless charging coil mounted on or in a vehicle windshield. The wireless charging coil is positioned so that an electronic device that is mounted to the vehicle windshield will receive power from the wireless charging coil. | 09-20-2012 |
20120274054 | DYNAMIC AIRBAG VENTING - An example airbag assembly an airbag, a duct having an duct opening for venting gas outside the airbag, and a flap moveable from a first position to a second position. The duct is configured to direct more gas outside the airbag when the flap is in the first position than when the flap is in the second position. A tether is configured to move the flap from the first position to the second position. | 11-01-2012 |
Patent application number | Description | Published |
20080242625 | Nucleotide-Cochleate Compositions And Methods Of Use - The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may be associated with a transfection agent. The present invention also includes methods for making and using the compositions provided herein. | 10-02-2008 |
20090028904 | Novel cochleate formulations - A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca | 01-29-2009 |
20110091523 | Cochleate compositions directed against expression of proteins - Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions. | 04-21-2011 |
20120178793 | NUCLEOTIDE-COCHLEATE COMPOSITIONS AND METHODS OF USE - The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may he associated with a transfection agent. The present invention also includes methods for making and using, the compositions provided herein. | 07-12-2012 |
20120195932 | Geodate delivery vehicles - The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for to later addition of cargo moieties are also contemplated. | 08-02-2012 |
20120282322 | COCHLEATE COMPOSITIONS DIRECTED AGAINST EXPRESSION OF PROTEINS - Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions. | 11-08-2012 |
20120294901 | NOVEL COCHLEATE FORMULATIONS - A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca | 11-22-2012 |
20130224284 | GEODATE DELIVERY VEHICLES - The present invention provides geodate delivery vehicles and methods of manufacture and administration. A vehicle including a lipid monolayer disposed about a hydrophobic domain is disclosed, that can be part of an emulsion or other mixture, or further disposed in a lipid strata. A vehicle including a lipid strata disposed about a hydrophobic domain is also disclosed. The vehicle can be incorporated into a variety of medicinal, food preparations, and personal care products to deliver or stabilize a cargo moiety. Packaged delivery vehicles for later addition of cargo moieties are also contemplated. | 08-29-2013 |
Patent application number | Description | Published |
20120232260 | AMPHIPHILIC NUCLEOTIDE COCHLEATE COMPOSITIONS AND METHODS OF USING THE SAME - The present invention is directed to cochleate compositions that include a nucleotide that is associated with a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein. | 09-13-2012 |
20140186430 | COCHLEATE COMPOSITIONS DIRECTED AGAINST EXPRESSION OF PROTEINS - Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions. | 07-03-2014 |
20140220109 | NOVEL COCHLEATE FORMULATIONS - A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca | 08-07-2014 |
20140242153 | NOVEL ENCOCHLEATION METHODS, COCHLEATES AND METHODS OF USE - Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed. | 08-28-2014 |
Patent application number | Description | Published |
20100019142 | YTTRIA-METAL THERMIONIC FILAMENTS - A thermionic electron source comprises a nonlinear metallic substrate, a coating of yttria deposited on the substrate, and a current source configured to drive current through the metallic substrate. | 01-28-2010 |
20110089333 | ASSEMBLIES FOR ION AND ELECTRON SOURCES AND METHODS OF USE - Certain embodiments described herein are directed to devices that can be used to align the components of a source assembly in a source housing. In some examples, a terminal lens configured to couple to the housing through respective alignment features can be used to retain the source components in a source housing to provide a source assembly. | 04-21-2011 |
20110211992 | FLUID CHROMATOGRAPHY INJECTORS AND INJECTOR INSERTS - Certain embodiments described herein are directed to injector inserts and injector assemblies. In some examples, an injector insert that includes an inlet comprising a substantially inert metal is described. In other examples, an injector that includes a major amount of a substantially inert metal in a fluid flow path is disclosed. Devices and systems using the injectors inserts and injectors are also described. | 09-01-2011 |
20110211993 | JET ASSEMBLY FOR USE IN DETECTORS AND OTHER DEVICES - Certain embodiments described herein are directed to jet assemblies that include a substantially inert fluid flow path. In some examples, a jet assembly includes a fluid flow path comprising a substantially inert metal in a fluid flow path. Devices and systems using the jet assembly are also described. In other embodiments, a brazeless or weldless jet assembly is provided. In some embodiments, the brazeless jet assembly may include an inert material or coating, e.g., a silica coating, in a fluid flow path. | 09-01-2011 |
20130042469 | POSITIONING GUIDES AND ION SOURCES - Certain embodiments described herein are directed to inserts and ion sources. In some examples, an insert can comprise a positioning guide configured to provide for visual positioning of a chromatography column under the positioning guide. In other examples, an ion source configured with an aperture to couple to a carrier tube to render the ion source non-removable from an instrument housing when the carrier tube is coupled to the ion source is described. | 02-21-2013 |
20150221491 | ASSEMBLIES FOR ION AND ELECTRON SOURCES AND METHODS OF USE - Certain embodiments described herein are directed to devices that can be used to align the components of a source assembly in a source housing. In some examples, a terminal lens configured to couple to the housing through respective alignment features can be used to retain the source components in a source housing to provide a source assembly. | 08-06-2015 |
20150285770 | JET ASSEMBLY FOR USE IN DETECTORS AND OTHER DEVICES - Certain embodiments described herein are directed to jet assemblies that include a substantially inert fluid flow path. In some examples, a jet assembly includes a fluid flow path comprising a substantially inert metal in a fluid flow path. Devices and systems using the jet assembly are also described. In other embodiments, a brazeless or weldless jet assembly is provided. In some embodiments, the brazeless jet assembly may include an inert material or coating, e.g., a silica coating, in a fluid flow path. | 10-08-2015 |