Manning, MA
Anne Manning, Charlestown, MA US
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20110010183 | SYSTEM AND METHOD FOR PROVIDING MARKET SURVEY ANALYSIS - Provided is a method for conducting a market survey, including identifying a survey topic and administrating the survey to a survey participant. The survey includes requesting the participant to enter text expressing an emotion regarding a topic of the survey. The survey also requests the participant enter a metric indicating the level of emotional intensity in relation to the text expressing an emotion. The survey administrator correlates an emotionally based theme to the emotion expressing text, and assigns a second emotion measuring metric to the emotionally based theme. The administrator may additionally present a set of images to the survey participant and request the participant to select an image to associate with the text expressing an emotion. | 01-13-2011 |
Anthony Manning, Cambridge, MA US
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20160090409 | METHODS FOR THE TREATMENT OF NEURODEGENERATION - The invention encompasses the discovery that Fc-containing polypeptides that include branched glycans and that are sialylated on the branched glycan (e.g., on an α 1,3 and/or α 1,6 arm in the Fc region's N-linked glycosylation site), with, e.g., a NeuAc-α 2,6-Gal or NeuAc-α 2,3-Gal terminal linkage, are useful in treating neurodegeneration, e.g., in the treatment of neurodegenerative diseases such as Alzheimer's Disease. The present disclosure provides, in part, methods for treating neurodegeneration or neurodegenerative diseases by administering compositions containing such Fc-containing polypeptides as well as methods for evaluating, identifying, and/or producing (e.g., manufacturing) such polypeptides for the treatment of neurodegeneration. | 03-31-2016 |
Brendan D. Manning, Boston, MA US
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20100022495 | MODULATING ENDOPLASMIC RETICULUM STRESS IN THE TREATMENT OF TUBEROUS SCLEROSIS - Endoplasmic reticulum stress has been found to be associated with the genetic disease tuberous sclerosis. Tuberous sclerosis is cause by defects in the two genes, TSC1 and TSC2. Agents that modulate ER stress may be used to treat tuberous sclerosis and other hamartomatous diseases. In particular, 4-phenyl butyric acid (PBA) has been shown to reduce ER stress is TSC-deficient cells. Other compounds useful in reducing ER stress are chemical chaperones such as trimethylamine N-oxide arid glycerol may also be useful in treating tuberous sclerosis. The present invention provides methods of treating a subject suffering from tuberous sclerosis using ER stress reducers such as PBA, TUDCA, UDCA, and TMAO. Methods of screening for ER stress reducers by identifying agents that reduce levels of ER stress markers in TSC-deficient cells are also provided. These agents may find use in methods and pharmaceutical compositions for treating tuberous sclerosis. | 01-28-2010 |
20140011761 | Modulating Endoplasmic Reticulum Stress in the Treatment of Tuberous Sclerosis - Endoplasmic reticulum stress has been found to be associated with the genetic disease tuberous sclerosis. Tuberous sclerosis is cause by defects in the two genes, TSC1 and TSC2. Agents that modulate ER stress may be used to treat tuberous sclerosis and other hamartomatous diseases. In particular, 4-phenyl butyric acid (PBA) has been shown to reduce ER stress is TSC-deficient cells. Other compounds useful in reducing ER stress are chemical chaperones such as trimethylamine N-oxide arid glycerol may also be useful in treating tuberous sclerosis. The present invention provides methods of treating a subject suffering from tuberous sclerosis using ER stress reducers such as PBA, TUDCA, UDCA, and TMAO. Methods of screening for ER stress reducers by identifying agents that reduce levels of ER stress markers in TSC-deficient cells are also provided. These agents may find use in methods and pharmaceutical compositions for treating tuberous sclerosis. | 01-09-2014 |
Carey B. Manning, Brighton, MA US
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20140276101 | MEDICAL DEVICE FOR DETECTING A TARGET AND RELATED METHODS OF USE - A medical device may include an elongate member having a proximal end, a distal end, and a lumen extending therebetween, wherein the elongate member may be configured for insertion into a patient. The medical device may also include a detection member configured to detect at least one of a location, geometry, or distance of a target relative to the distal end of the elongate member, the target being at least one of a stone, a foreign object, or a tissue within a body cavity. The detection member may include a transmitting element and a receiving element. | 09-18-2014 |
Christa D. Manning, Scituate, MA US
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20120259674 | SYSTEMS AND METHODS FOR PROVIDING MARKET INSIGHT - The present disclosure includes a system, method, and article for providing market insight. The system may generate a market profile based upon actual purchase data. The market profile may include one or more of the following: a pricing trend, a high price, a low price, an average price, a median price, a mean price, a modal price, a most frequently paid price, an optimal date to make a purchase, an optimal date to redeem a purchase, an optimal merchant from which to purchase, and an optimal location to make a purchase. The system may further transmit the market profile to a client. | 10-11-2012 |
Christopher Manning, North Easton, MA US
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20100208765 | FURNACE DAMPER CONTROL SYSTEM AND METHOD - A furnace damper control system and method thereof including a furnace having at least one opening through which electromagnetic radiation from within the furnace may be sensed, an exhaust duct capable of receiving an exhaust gas stream emerging from the furnace, and a controllable damper capable of adjusting the pressure in the exhaust duct. A sensor is capable of sensing electromagnetic radiation through one or more of the openings of the furnace and generating a sensor signal corresponding to the electromagnetic radiation, and a processor is capable of processing the sensor signal and generating a monitoring signal responsive to a parameter of the electromagnetic radiation indicative of furnace emissions. A controller is capable of controlling the damper responsive to the monitoring signal indicative of the furnace emissions. | 08-19-2010 |
20140016663 | FURNACE DAMPER CONTROL SYSTEM - A furnace damper control system including a furnace having at least one opening through which electromagnetic radiation from within the furnace may be sensed, an exhaust duct capable of receiving an exhaust gas stream emerging from the furnace, and a controllable damper capable of adjusting the pressure in the exhaust duct. A sensor is capable of sensing electromagnetic radiation through one or more of the openings of the furnace and generating a sensor signal corresponding to the electromagnetic radiation, and a processor is capable of processing the sensor signal and generating a monitoring signal responsive to a parameter of the electromagnetic radiation indicative of furnace emissions. A controller is capable of controlling the damper responsive to the monitoring signal indicative of the furnace emissions. | 01-16-2014 |
Christopher P. Manning, North Easton, MA US
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20130230720 | PROCESSED DRI MATERIAL - A processed DRI material having an average surface roughness (Ra) of less than 1.5 μm is disclosed. A method and system for making processed DRI are also disclosed. One embodiment of the method and system may include assembling a rotatable chamber having an internal screen capable of supporting DRI during tumbling, with at least one opening in the chamber to permit fines to exit the chamber during tumbling, and delivering DRI into the chamber to tumble the DRI on the screen to remove fines from the DRI. Another embodiment of the method and system may include assembling a rotatable chamber having a feed end and an exit end, and having a screen therein capable of supporting DRI as the DRI moves through the chamber, and delivering DRI to the chamber and rotating the chamber to tumble the DRI while removing fines. | 09-05-2013 |
James Manning, Braintree, MA US
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20100022170 | COATED ABRASIVE PRODUCTS CONTAINING AGGREGATES - A coated abrasive product includes a particulate material containing green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles and a nanoparticle binder. Free abrasive products, bonded abrasive products, and the particulate material also contain aggregates. | 01-28-2010 |
James J. Manning, Braintree, MA US
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20100159805 | RIGID OR FLEXIBLE, MACRO-POROUS ABRASIVE ARTICLE - A macro-porous abrasive article includes a spun lace substrate having a macro-porous structure and a coating. The coating is made of a resin binder and abrasive aggregates. The abrasive aggregates are formed from a composition of abrasive grit particles and a nanoparticle binder. The coating is at least partially embedded in the substrate. A method for making the macro-porous abrasive article includes combining abrasive aggregates of abrasive grit particles and a nanoparticle binder with a resin binder to form a slurry. The slurry is applied to a macro-porous support structure so that the slurry at least partially penetrates the substrate. The resin is then cured to bond the aggregate grains to the substrate. | 06-24-2010 |
20120192500 | COATED ABRASIVE AGGREGATES AND PRODUCTS CONTAING SAME - A coated abrasive product includes a particulate material containing green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles, a nanoparticle binder, a dual function material, and a cross-linking agent. These green unfired abrasive aggregates can also be used in free abrasive products and bonded abrasive products. | 08-02-2012 |
20130095731 | ABRASIVE PRODUCTS AND METHODS FOR FINISHING HARD SURFACES - A coated abrasive product includes green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles and a nanoparticle binder, wherein the abrasive aggregates are dispersed within a polymer resin coating, and wherein the coated abrasive product is capable of superfinishing a metal surface having an initial Ra in the range of about 1.5 micro inches to about 12.5 micro inches prior to application of the coated abrasive product and after application the surface has an Ra of less than 1.0 micro inch. | 04-18-2013 |
20130189911 | ABRASIVE PRODUCTS AND METHODS FOR FINISHING COATED SURFACES - A coated abrasive product includes green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles, a nanoparticle binder, a sulfosuccinate, and a crosslinking, wherein the abrasive aggregates are dispersed within a polymer resin coating comprising a mixture of copolyester resin. The coated abrasive product is capable of finishing coated surfaces and repairing defects in coated surfaces, including surfaces coated with automotive primers, paints, clear coats, and combinations thereof. | 07-25-2013 |
20130283702 | ABRASIVE PRODUCTS AND METHODS FOR FINE POLISHING OF OPHTHALMIC LENSES - A coated abrasive product including green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles and a nanoparticle binder, wherein the abrasive aggregates are dispersed within a polymer resin coating, and wherein the coated abrasive product is capable of polishing an optical component, including ophthalmic lenses without the need to apply an abrasive slurry. | 10-31-2013 |
20130298471 | ABRASIVE PRODUCTS AND METHODS FOR FINISHING SURFACES - An engineered coated abrasive product having a three dimensional pattern of abrasive structures formed by embossing an abrasive slurry formulation that was first surface coated with a functional powder, wherein the abrasive slurry includes green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles and a nanoparticle binder. The coated abrasive product is capable of finishing and repairing defects in surfaces, including coated surfaces. | 11-14-2013 |
20150352689 | ABRASIVE PRODUCTS AND METHODS FOR FINISHING HARD SURFACES - A coated abrasive product includes green, unfired abrasive aggregates having a generally spheroidal or toroidal shape, the aggregates formed from a composition comprising abrasive grit particles and a nanoparticle binder, wherein the abrasive aggregates are dispersed within a polymer resin coating, and wherein the coated abrasive product is capable of superfinishing a metal surface having an initial Ra in the range of about 1.5 micro inches to about 12.5 micro inches prior to application of the coated abrasive product and after application the surface has an Ra of less than 1.0 micro inch. | 12-10-2015 |
Jeremy J. Manning, Kingston, MA US
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20100044894 | PREPARATION OF CAPSULES - Prior art processes for producing protein-based capsules (for example, capsules for use in electrophoretic media) tend to be wasteful because they produce many capsules outside the desired size range, which is typically about 20 to 50 μm. Capsule size distribution and yields can be improved by either (a) emulsifying a water-immiscible phase in a preformed coacervate of the protein; or (b) using a limited coalescence process with colloidal alumina as the surface-active particulate material. | 02-25-2010 |
Keith William Manning, Arlington, MA US
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20140198704 | JUST IN TIME LINK TRANSMISSION FOR A MULTI-FREQUENCY MULTI-RATE MULTI-TRANSCEIVER COMMUNICATION DEVICE - An apparatus includes a network node configured to communicate with other network nodes via a communication network. The network node includes a plurality of transceivers and a controller. The controller includes a packet management module that identifies a link profile solution set that includes a set of link profiles corresponding to communication links for multicasting the message packet. The link profile solution set maximizes coverage of network target nodes of the multicast message packet. The packet management module places a first message clone of the message packet in a transceiver queue for transmission to one or more of the network target nodes, updates the link profile solution set when the first message clone reaches the end of the transceiver queue, and initiates transmission of the first message clone or drop the first message clone according to the updated link profile solution set. | 07-17-2014 |
Ken Manning, Framingham, MA US
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20110318324 | METHODS AND COMPOSITIONS FOR CNS DELIVERY OF B-GALACTOCEREBROSIDASE - The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an B-Galactocerebrosidase protein, salt, and a polysorbate surfactant for the treatment of GLD Disease. | 12-29-2011 |
20130295071 | METHODS AND COMPOSITIONS FOR CNS DELIVERY OF B-GALACTOCEREBROSIDASE - The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising an B-Galactocerebrosidase protein, salt, and a polysorbate surfactant for the treatment of GLD Disease. | 11-07-2013 |
Robert Francis Manning, Newburyport, MA US
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20090003987 | Airfoil with improved cooling slot arrangement - The present invention relates to airfoils, and in particular turbine blades and vanes, having cooling slots that are angled from a line of reference to effect metering of cooling air through the cooling slots thereof. This metered cooling airflow also creates a more stable film cooling layer about the surface of the airfoil. | 01-01-2009 |
20090155050 | DIVERGENT TURBINE NOZZLE - A turbine nozzle includes a row of vanes extending radially in span between inner and outer bands. The vanes include opposite pressure and suction sidewalls and opposite leading and trailing edges. Each vane includes an inner pattern of inner cooling holes and an outer pattern of outer cooling holes distributed along the leading edge. The inner and outer holes diverge toward the corresponding inner and outer bands to preferentially discharge cooling air. | 06-18-2009 |
20090245999 | HYBRID IMPINGEMENT COOLED AIRFOIL - A turbine nozzle for a gas turbine engine includes: (a) spaced-apart arcuate inner and outer bands; (b) a hollow, airfoil-shaped turbine vane extending between the inner and outer bands, the interior of the vane defining at least a forward cavity and a mid-cavity positioned aft of the forward cavity; (c) a hollow impingement insert received inside the mid-cavity, the impingement insert having walls which are pierced with at least one impingement cooling hole; (d) a passage in the turbine vane at a radially outer end of the forward cavity adapted to be coupled to a source of cooling air; and (e) a passage in the inner band in fluid communication with a radially inner end of the forward cavity and a radially inner end of the impingement insert. | 10-01-2009 |
20090293495 | TURBINE AIRFOIL WITH METERED COOLING CAVITY - A turbine airfoil for a gas turbine engine includes: (a) spaced-apart pressure and suction sidewalls extending between a leading edge and a trailing edge; (b) a first cavity disposed between the pressure and suction sidewalls, the first cavity being adapted to be fed cooling air from a source within the engine, and connected to at least one film cooling hole which communicates with an exterior surface of the airfoil; (c) a second cavity disposed between the pressure and suction sidewalls, the second cavity being adapted to be fed cooling air from a source within the engine, and connected to at least one film cooling hole which communicates solely with the suction sidewall of the airfoil; and (d) a metering structure adapted to substantially restrict air flow into the second cavity. | 12-03-2009 |
20090317234 | CROSSFLOW TURBINE AIRFOIL - A turbine airfoil includes pressure and suction sidewalls extending axially in chord between opposite leading and trailing edges. The sidewalls are spaced transversely apart to define flow channels extending longitudinally and separated chordally by partitions bridging the sidewalls. A perforate partition includes a row of crossover holes extending obliquely therethrough. | 12-24-2009 |
20100024216 | ROTOR BLADE AND METHOD OF FABRICATING THE SAME - A method of fabricating a rotor blade is provided. The method includes forming at least one passageway within the rotor blade, wherein the passageway extends substantially radially from a root of the rotor blade to a tip of the rotor blade, and coupling a shroud to the tip of the rotor blade. The shroud includes at least one substantially radially-outward extending wall that at least partially defines an outer plenum that is radially outward from at least the shroud, wherein the outer plenum is in flow communication with the passageway. | 02-04-2010 |
20100266386 | FLANGE COOLED TURBINE NOZZLE - A turbine nozzle includes outer and inner bands bounding nozzle vanes. The outer band includes an aft flange. An impingement baffle bridges the outer band and aft flange at the root thereof to provide impingement cooling. | 10-21-2010 |
20130104517 | COMPONENT AND METHOD OF FABRICATING THE SAME | 05-02-2013 |
20130108469 | AIRFOIL AND METHOD OF FABRICATING THE SAME | 05-02-2013 |
20140290254 | Cyclonic Dirt Separating Turbine Accelerator - A dirt separator assembly for a gas turbine engine comprises a cyclonic accelerator in flow communication with compressor discharge air, the accelerator having a plurality of passages, each passage having an inlet, an outlet and at least one vent located in the passage, a plurality of turning vanes disposed along each of the passages, the passage turning tangentially between the inlet and the outlet, the accelerator passages decreasing from a first cross-sectional area to a second cross-sectional area and said turning vanes inducing helical swirl of compressed cooling air, and, at least one vent located in the accelerator passages for expelling dust separated from the swirling compressed cooling air. | 10-02-2014 |
20140348636 | AIRFOIL COOLING CIRCUIT - An airfoil cooling circuit includes an impingement cooling circuit and a serpentine cooling circuit. An airfoil for use in a gas turbine engine having a cooling circuit which includes an impingement cooling circuit and a serpentine cooling circuit | 11-27-2014 |
20160045923 | INERTIAL SEPARATOR - An inertial separator for removing particles from a fluid stream includes a body defining a through passage, with at least one separator inlet and at least one separator outlet, a turn provided in the body between the at least one separator inlet and the at least one separator outlet, and a flow splitter having at least one particle outlet fluidly coupled to the outside of the through passage. | 02-18-2016 |
Robert J. Manning, Middleborough, MA US
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20100229596 | Article Of Jewelry With Sealed Visible Enclosed Container - The article of jewelry includes a hollowed out portion in a body of such article into which a sealed transparent container is inserted. The article of jewelry also has an opening through one of its faces to expose the hollowed out portion. The transparent container is sealed after a substance with special significance is inserted into the container. | 09-16-2010 |
Stephen Manning, Arlington, MA US
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20090269783 | B7-H2 molecules, novel members of the B7 family and uses thereof - Novel B7-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also provides B7-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. | 10-29-2009 |
Stephen R. Manning, North Andover, MA US
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20080298865 | Ablation collection system for an image recorder - An apparatus is mounted on a moveable carriage of an external drum platesetter for removing air-borne ablative particles caused when a printing plate mounted on an outside surface of a rotating drum of the platesetter is imaged via a laser source having a window for transmitting a laser beam. The apparatus includes a nozzle, a redirecting surface and a vacuum chamber. The nozzle transmits a line of compressed air towards the redirecting surface which in turn redirects and splits the line of compressed air into two parts. A first part is directed towards the drum and a second part is diverted towards the laser window. The vacuum chamber is connected to a vacuum channel for removing air including the ablative particles. | 12-04-2008 |
Warren Manning, Natick, MA US
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20080221429 | Magnetic resonance imaging of coronary venous structures - A method and system for magnetic resonance imaging comprises applying at least one radiofrequency magnetization transfer (MT) pulse to a coronary venous region of a subject positioned within a magnetic field, and acquiring magnetic resonance imaging data from the coronary venous region to produce an image of a coronary venous structure. This technique can be utilized as part of a 3D free-breathing, ECG-triggered gradient-echo Cartesian acquisition of the coronary region. One or more magnetization transfer (MT) preparation pulses are used to enhance the contrast between venous blood and myocardium. The MT preparation results in myocardial signal suppression without any significant signal loss in the arterial or venous blood so as to maintain venous blood signal-to-noise ratio while improving contrast between myocardium and veins. The coronary venous structure can comprise one or more of a coronary sinus, a lateral vein and a posterior vein. The image of a coronary venous structure can be acquired in connection with an interventional cardiovascular procedure, such as a cardiac resynchronization therapy. | 09-11-2008 |
Warren J. Manning, Natick, MA US
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20140200436 | SYSTEM AND METHOD FOR IMPROVED CARDIAC IMAGING OF SUBJECTS WITH ADVERSE CARDIAC CONDITIONS - A system and method for controlling a magnetic resonance imaging (MRI) system to acquire images of a subject having inconsistencies in a cardiac cycle of the subject. The process includes receiving an identification of a predetermined point in a cardiac cycle of the subject and, thereupon, performing a saturation module configured to dephase magnetization within a region of interest (ROI) from before the predetermined point. The process also includes performing an inversion module configured to invert spins within the ROI and acquiring medical imaging data from the subject. A delay is inserted between the performance of the saturation module and the performance of the inversion module, wherein a duration of the delay is configured, with the saturation module, to control evidence in the medical imaging data of inconsistencies in the cardiac cycle of the subject by controlling a magnetization history of tissue in the ROI. | 07-17-2014 |
20150161789 | SYSTEM AND METHOD FOR ADAPTIVE REGISTRATION OF VARYING CONTRAST-WEIGHTED IMAGES FOR IMPROVED TISSUE CHARACTERIZATION - Systems and methods for adaptively registering images acquired with different contrast-weightings using a magnetic resonance imaging (“MRI”) system. For instance, motion is estimated as global affine motion refined by a local non-rigid motion estimation algorithm that simultaneously estimates the motion field and intensity variations among the images being registered. The images registered with the described systems and methods can be used for improved tissue characterization. | 06-11-2015 |
20150268320 | SYSTEM AND METHOD FOR ASSESSING T2-RELAXATION TIMES WITH IMPROVED ACCURACY - An MRI apparatus includes: a data processor configured to acquire a first set of T | 09-24-2015 |
20150276909 | MRI METHODS AND APPARATUS FOR FLEXIBLE VISUALIZATION OF ANY SUBSET OF AN ENLARGED TEMPORAL WINDOW - A method and apparatus for MRI retrospective reconstruction determines a period of minimal coronary artery motion within the acquired temporal window with a rotation angle optimized for a K-space four-dimensional (4D) volume by a segmented 4D radial stack-of-stars (SOS) acquisition during a temporal acquisition window (taw). Radial stacks of the image of an object are acquired by performing the radial (SOS) acquisition to determine a plurality of k | 10-01-2015 |