Manalo, CA
Dante Manalo, Santa Clara, CA US
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20100087062 | HIGH TEMPERATURE BD DEVELOPMENT FOR MEMORY APPLICATIONS - A method and apparatus for depositing organosilicate dielectric layers having good adhesion properties and low dielectric constant. Embodiments are described in which layers are deposited at low temperature and at high temperature. The low temperature layers are generally post-treated, whereas the high temperature layers need no post treating. Adhesion of the layers is promoted by use of an initiation layer. | 04-08-2010 |
Erwin Manalo, West Covina, CA US
Gil David Manalo, San Clemente, CA US
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20130211304 | WRIST BRACE AND METHOD AND COMPONENTS FOR SECURING THE SAME - A universal wrist brace is arranged for both right and left handed use. The wrist brace has a main body panel defining symmetrical first and second sides. Each of the first and second sides has a wing located at a distal end flaring outwardly from longitudinal side portions of the main body panel in a transverse direction of the main body panel and parallel to an upper edge portion. The main body panel defines an opening located between the first and second sides, proximate and adjacent to the upper edge portion. A main securing device is anchored to the first side of the main body panel and detachably attaches to the second side of the main body panel. | 08-15-2013 |
20150088046 | ORTHOPEDIC DEVICE - An orthopedic device includes a base shell having ankle and foot receiving portions. The base shell forms an opening over a dorsal aspect of the base shell. A dorsal shell is contoured to generally correspond to the opening in the base shell. The dorsal shell includes a proximal member connected to distal member via a flexible or resilient connecting portion arranged to accommodate a portion of a user's lower leg or ankle A first flexible edge portion is attached to a distal terminal end of the distal member. The first flexible edge portion is arranged to bend or flex relative to the distal member so as to reduce the likelihood of pressure points on the user's toes from the distal member. | 03-26-2015 |
Jean-Claire L. Manalo, Daly City, CA US
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20110071145 | Raf Modulators And Methods Of Use - The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention. | 03-24-2011 |
Jean-Claire Limun Manalo, Daly City, CA US
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20090156576 | Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases - Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer. | 06-18-2009 |
20090163471 | Tropane compounds - A compound according to Formula I or II: | 06-25-2009 |
20100130488 | Pyrazolo-Pyrimidines as Casein Kinase II (CK2) Modulators - A compound according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R | 05-27-2010 |
20100249096 | Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases - Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer. | 09-30-2010 |
20100298290 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture - The invention is directed to Compounds of Formula I: | 11-25-2010 |
20110263558 | Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases - Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer. | 10-27-2011 |
20120258953 | Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture - The invention is directed to Compounds of Formula (I): the invention provides compounds that inhibit, regulate, and/or modulate P13K and/or mTOR that are useful in the treatment of hyperproliferative diseases, such as cancer, in mammals. This invention also provides methods of making the compound methods of using such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds. For example, cancer in which activity against PI3fC-alph mTOR, or both contributes to its pathology and/or symptomatology include breast cancer mantle cell lymphoma, renal cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, NPM/ALK-transformed anaplastic large cell lymphoma, diffu large B cell lymphoma, rhabdomyosarcoma, ovarian cancer, endometrial cancer, cervic cancer, non small cell lung carcinoma, small cell lung carcinoma, adenocarcinoma, col cancer, rectal cancer, gastric carcinoma, hepatocellular carcinoma, melanoma, pancreat cancer, prostate carcinoma, thyroid carcinoma, anaplastic large cell lymphoma, hemangiom glioblastoma, or head and neck cancer. | 10-11-2012 |
20140275527 | Azetidines as MEK Inhibitors for the Treatment of Proliferative Diseases - Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer. | 09-18-2014 |
Jean-Claire Limun Manalo, Dale City, CA US
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20090215803 | Pyrimidinones as Casein Kinase II (CK2) Modulators - A compound having Formula (I) or a pharmaceutically acceptable salt thereof, wherein X, R | 08-27-2009 |
Nikita R. Manalo, Santa Clara, CA US
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20090087468 | Semi-Rigid Gel Article For Disinfecting A Surface - The present invention relates to a semi-rigid gel article which contains an antibacterial agent and can be used for disinfecting and/or cleaning a surface. More particularly, the article comprises water, a gelling agent, an antibacterial agent and wherein the article is capable of disinfecting a surface by contacting the surface with the article, rupturing the article by application of pressure and spreading the article on the surface to deliver the antimicrobial agent. The article is suitable to disinfect and/or clean an inanimate or animate surface with or without water. | 04-02-2009 |
20090312215 | Semi-Rigid Gel Cleansing Article and Uses Thereof - The present invention relates to semi-rigid gels, methods of manufacture and uses thereof. | 12-17-2009 |