Patent application number | Description | Published |
20090191202 | Methods for manipulating phagocytosis mediated by CD47 - Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable. | 07-30-2009 |
20110014119 | Methods for Manipulating Phagocytosis Mediated by CD47 - Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc. | 01-20-2011 |
20110015090 | Markers of Acute Myeloid Leukemia Stem Cells - Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets. | 01-20-2011 |
20120282174 | Synergistic Anti-CD47 Therapy for Hematologic Cancers - Methods are provided for treatment of hematologic cancers, particularly lymphomas and leukemias, including without limitation myelogenous and lymphocytic leukemias. A combination of antibodies specific for CD47; and specific for a cancer associated cell surface marker are administered to the patient, and provide for a synergistic decrease in cancer cell burden. The combination of antibodies may comprise a plurality of monospecific antibodies, or a bispecific or multispecific antibody. Markers of interest include without limitation, CD20, CD22, CD52, CD33; CD96; CD44; CD123; CD97; CD99; PTHR2; and HAVCR2. | 11-08-2012 |
20130142786 | HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES TO CD47 - Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies. | 06-06-2013 |
20130244326 | Markers of Acute Myeloid Leukemia Stem Cells - Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets. | 09-19-2013 |
20140065169 | Methods of Treating Acute Myeloid Leukemia by Blocking CD47 - Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc. | 03-06-2014 |
20140148351 | Prediction of Clinical Outcome in Hematological Malignancies Using a Self-Renewal Expression Signature - Methods, compositions, and kits are provided for providing a diagnosis, a prognosis, or a prediction of responsiveness to a therapy for a patient with a hematological malignancy. In practicing the subject methods, the expression level of at least one leukemia stem cell (LSC) genes in a tissue sample is assayed to obtain an LSC expression representation. The LSC expression representation is then employed to determine if an individual has a hematological malignancy, to provide a prognosis to a patient with a hematological malignancy, and/or to provide a prediction of the responsiveness of a patient with a hematological malignancy to a therapy. Also provided are screening methods for identifying novel therapies for patients with a hematological malignancy, and compositions and kits for use in these screening methods. | 05-29-2014 |
20140161805 | Methods for Manipulating Phagocytosis Mediated by CD47 - Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable. | 06-12-2014 |
20140161825 | Methods of Treating Acute Myeloid Leukemia by Blocking CD47 - Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc. | 06-12-2014 |
20140255431 | Markers of Acute Myeloid Leukemia Stem Cells - Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets. | 09-11-2014 |
20140271683 | Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor - Therapeutic and diagnostic methods are provided, which methods relate to the expression of calreticulin on cancer cells and hematopoietic cells. | 09-18-2014 |
20140369924 | SYNERGISTIC ANTI-CD47 THERAPY FOR HEMATOLOGIC CANCERS - Methods are provided for treatment of hematologic cancers, particularly lymphomas and leukemias, including without limitation myelogenous and lymphocytic leukemias. A combination of antibodies specific for CD47; and specific for a cancer associated cell surface marker are administered to the patient, and provide for a synergistic decrease in cancer cell burden. The combination of antibodies may comprise a plurality of monospecific antibodies, or a bispecific or multispecific antibody. Markers of interest include without limitation, CD20, CD22, CD52, CD33; CD96; CD44; CD123; CD97; CD99; PTHR2; and HAVCR2. | 12-18-2014 |
20150183874 | HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODIES TO CD47 - Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies; and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies. | 07-02-2015 |
Patent application number | Description | Published |
20110274728 | Compositions and Methods for Alleviating Hyposalivation and for Providing Oral Comfort - Various compositions and methods are provided to alleviate one or more symptoms associated with hyposalivation or xerostomia. Preferred compositions and methods employ one or more plant extracts and/or a proanthocyanidin at a concentration effective to reduce or eliminate the symptoms. Especially preferred extracts are isolated from a fruit and/or seed (e.g., grape, cranberry, blue berry, black berry, etc.), and where a second extract is present, such extract is preferably isolated from a citrus fruit (e.g., lemon, orange, lime, grapefruit, tangerine, mandarin orange, ugli fruit, etc.). | 11-10-2011 |
20150252302 | CLEANING, SURFACTANT, AND PERSONAL CARE COMPOSITIONS - A cleaning or personal care composition containing at least one of 1,4-pentanediol and a ketal alcohol of formula (1) wherein R | 09-10-2015 |
Patent application number | Description | Published |
20080229572 | Micro-Electromechanical Capacitive Strain Sensor - A micro-electromechanical capacitive strain sensor. The micro-electromechanical capacitive strain sensor comprises a first bent beam, a second bent beam, and a straight center beam. The first bent beam, second bent beam, and straight center beam are aligned in the X-axis with the straight center beam located between the first and second bent beams. The first bent beam, second bent beam, and straight center beam are disposed between two anchors. The two anchors are aligned in the Y-axis. The first bent beam is bent away from the center beam and the second bent beam is bent towards the center beam to provide a set of differential capacitors with respect to the center beam, wherein the center beam serves as a common reference with respect to the first and second bent beams. | 09-25-2008 |
20090320607 | Micro-Electromechanical Capacitive Strain Sensor - A micro-electromechanical capacitive strain sensor. The micro-electromechanical capacitive strain sensor comprises a first bent beam, a second bent beam, and a straight center beam. The first bent beam, second bent beam, and straight center beam are aligned in the X-axis with the straight center beam located between the first and second bent beams. The first bent beam, second bent beam, and straight center beam are disposed between two anchors. The two anchors are aligned in the Y-axis. The first bent beam is bent away from the center beam and the second bent beam is bent towards the center beam to provide a set of differential capacitors with respect to the center beam, wherein the center beam serves as a common reference with respect to the first and second bent beams. | 12-31-2009 |
Patent application number | Description | Published |
20100020972 | Wireless mobile device that permits toggling of whether to transmit information contained in SMS messages as encrypted or clear text - An exemplary method is implemented by a wireless mobile device that transmits and receives short message system (SMS) text messages. Entered first text to be transmitted as a first SMS text message from the wireless mobile device is accepted and stored by a resident application. A user selectable input is received by the resident application of the wireless mobile device, where the user selectable input controls whether a resident encryption algorithm will be used to convert the first text into an encrypted first text message. A user control input is received by the resident application that causes the transmission of the first SMS text message from the wireless mobile device. The text of the transmitted first SMS text message contains the first text if the resident encryption algorithm is not selected by the user. The text of the transmitted first SMS text message contains encrypted first text if the resident encryption algorithm is selected by the user. | 01-28-2010 |
20100024010 | Mobile device with customizable login screen - An exemplary method controls the display of information on the screen of a mobile device during a request for login information. Independently controlled regions of the screens are used to concurrently convey different information associated with each region to a user of the mobile device during the rendering of a login request that is contained in one of the regions. | 01-28-2010 |
20100024020 | Wireless mobile device with privacy groups that independently control access to resident application programs - An exemplary method implemented by a wireless mobile device controls user access to programs and files defining items that are resident on the mobile device. A first icon associated with a corresponding first program installed on the wireless mobile device is displayed on the screen of the wireless mobile device, where the first icon can be seen by any person using the wireless mobile device and the corresponding first program is available for execution to said person. A privacy gate and a corresponding privacy icon displayed on the screen are created using a privacy interface program installed on the wireless mobile device. A password associated with the privacy gate is entered by a first user so that a subsequent request by a user to traverse the privacy gate will require entry of this password. The first program and the privacy gate are linked so that a user must traverse the privacy gate in order to execute the first program. | 01-28-2010 |
20100024028 | Wireless mobile device with user selectable privacy for groups of resident application programs and files - An exemplary method implemented by a wireless mobile device provides user selectable access to programs and files defining items that are resident on the mobile device. Screen icons associated with a privacy group are visually differentiated from icons associated with a public group. On receiving a user first input to initially access one of the items, where the first input is the first attempt by the user to access any item since a power up activation of the mobile device, determining whether the first input is a request to access an item associated with the privacy group or public group. If the sought access is to one item associated with the privacy group, a request is displayed on the screen requesting the user to enter a predetermined group privacy password and access is inhibited to the item unless the predetermined group privacy password is input to the mobile device by the user. The same predetermined group privacy password is required to initially access any of the items associated with the privacy group. If the sought access is to one item associated with the public group, the first user input is permitted to be conveyed to the associated one item causing the one item associated with the public group to be accessed without requiring an input by the user of the group privacy password. | 01-28-2010 |
20100162387 | Mobile device with separate access to private and public information stored in the device - An exemplary method is implemented by a wireless mobile device that transmits and receives text-based messages. Public records are stored in a public contact database in the mobile device, the public records containing public contact information for persons. Public contact information contained in a public record corresponding to a person selected by a public user is displayed upon the request of any public user of the device. Private records are stored in a private contact database in the mobile device, the private records containing private contact information for persons. Upon a valid password being received by the device from a private user, access to the private contact information is provided to the private user. In response to the receipt of a request from the private user, private contact information for a selected person from a corresponding private record is displayed on the screen of the mobile device. | 06-24-2010 |
20100162388 | Wireless mobile device with automatic segregation of received messages for private and public access - An exemplary method is implemented by a wireless mobile device that transmits and receives text-based messages. Received messages are stored in memory of the wireless mobile device. Based on a privacy criteria stored in the memory, some of the received messages are automatically identified as public and others of the received messages are automatically identified as private. Access is provided to stored received messages that are designated as public to any user of the mobile device. Access is provided to stored received messages that are designated as private only after receipt of a password entered by a user of the wireless mobile device that permits access to the privately identified messages. | 06-24-2010 |