Madden, MA
Brian Madden, Plymouth, MA US
Patent application number | Description | Published |
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20090319408 | PROVISON APPLICATION SYSTEM AND METHOD - A system, computer-implemented method, and a computer program product for defining one or more payment distribution priorities associated with one or more rental properties. Rental property performance data is received from a rental property datastore. The one or more payment distribution priorities are applied to the rental property performance data to generate payment distribution data. A payment distribution report is generated. | 12-24-2009 |
20090327350 | INTERACTIVE REVIEW SYSTEM AND METHOD - A system, computer-implemented method, and a computer program product for defining rental property data associated with one or more rental properties within a review datastore. One or more user-definable rules are applied to the rental property data to generate suspect data. At least a portion of an interactive review form is populated with at least a portion of the suspect data. A user is enabled to provide user input associated with the suspect data via one or more data-entry fields included within the interactive review form. The user input is stored within the review datastore. | 12-31-2009 |
20100005100 | DATA MANAGEMENT SYSTEM AND METHOD - A system, computer-implemented method, and a computer program product for defining a plurality of rental properties within a reporting datastore. A report template is defined and data is extracted from the reporting datastore. At least a portion of the report template is populated with at least a portion of the data extracted from the reporting datastore. | 01-07-2010 |
David T. Madden, Boston, MA US
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20090037880 | SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR CONFIGURING A GOAL - A system, method, and computer program product are provided for configuring a goal. Information associated with different aspects of a goal is received utilizing a plurality of graphical user interfaces. In use, a previous one of the graphical user interfaces progresses to a subsequent one of the graphical user interfaces only after receiving the information associated with the aspect associated with the previous one of the graphical user interfaces. To this end, the goal is configured utilizing such information. | 02-05-2009 |
Dulcie Madden, Boston, MA US
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20150068720 | Method and Apparatus for an Infant-milk Warmer - A method and system for controlling the storage and preparation of a container of milk for feeding is disclosed. The system employs collected information associated with the infant or the caregiver to initiate controls of the temperature of the milk without the user's interaction. | 03-12-2015 |
Erin Madden, Lynnfield, MA US
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20150279626 | MICROWAVE PLASMA APPLICATOR WITH IMPROVED POWER UNIFORMITY - An apparatus for generating plasma includes a plasma discharge tube and a conductive coil helically wound around an outer surface of the plasma discharge tube. A waveguide is coupled to a microwave cavity surrounding the plasma discharge tube to guide the microwave energy into the plasma discharge tube such that the plasma is generated in the plasma discharge tube. The waveguide is positioned such that an electric field of the microwave energy is oriented at a predetermined angle with respect to the longitudinal axis of the plasma discharge tube. A resulting induced electric current in the conductive coil affects power absorption in the plasma discharge tube, the predetermined angle being selectable such that power absorption in the plasma discharge tube is according to a predetermined profile with respect to the longitudinal axis of the plasma discharge tube. | 10-01-2015 |
Erin M. Madden, Lynnfield, MA US
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20080292432 | AIRFLOW MANAGEMENT FOR PARTICLE ABATEMENT IN SEMICONDUCTOR MANUFACTURING EQUIPMENT - An airflow management system and/or method used in particle abatement in semiconductor manufacturing equipment. In particular, the apparatus disclosed is capable of creating and managing a carefully controlled particle free environment for the handling of semiconductor wafers or similar articles. The apparatus is particularly suited to be used as an interface between an equipment front end module (EFEM) and a vacuum loadlock chamber or other such article of process equipment. The apparatus also enables relative motion between enclosures while maintaining a particle free environment utilizing a moving air diffuser mounted to an interface panel. | 11-27-2008 |
Karen Madden, Sudbury, MA US
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20140336505 | IMAGING VOLUMES WITH ARBITRARY GEOMETRIES IN NON-CONTACT TOMOGRAPHY - A method for tomographic imaging of diffuse medium includes directing waves into a diffusive medium, solving a surface-bounded inversion problem by forward field calculations through decomposition of contributions from the multiple reflections from an arbitrary surface within the diffusive medium or outside the diffusive medium into a sum of different orders of reflection up to an arbitrary order, and using contact or non-contact measurements of waves outside said diffusive medium to generate a tomographic image. | 11-13-2014 |
Karen N. Madden, Sudbury, MA US
Patent application number | Description | Published |
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20100292567 | Imaging Volumes with Arbitrary Geometries in Contact and Non-Contact Tomography - A method for tomographic imaging of diffuse medium includes directing waves into a diffusive medium, solving a surface-bounded inversion problem by forward field calculations through decomposition of contributions from the multiple reflections from an arbitrary surface within the diffusive medium or outside the diffusive medium into a sum of different orders of reflection up to an arbitrary order, and using contact or non-contact measurements of waves outside said diffusive medium to generate a tomographic image. | 11-18-2010 |
20110171136 | OPTICAL IMAGING PROBES - This invention relates to optical imaging probes and the use of such probes for diagnosing and monitoring disease, and disease treatment. The optical imaging probes of the current invention can be used to identify and characterize normal and diseased tissues with regards to altered metabolic activity. | 07-14-2011 |
20130114069 | IMAGING VOLUMES WITH ARBITRARY GEOMETRIES IN CONTACT AND NON-CONTACT TOMOGRAPHY - A method for tomographic imaging of diffuse medium includes directing waves into a diffusive medium, solving a surface-bounded inversion problem by forward field calculations through decomposition of contributions from the multiple reflections from an arbitrary surface within the diffusive medium or outside the diffusive medium into a sum of different orders of reflection up to an arbitrary order, and using contact or non-contact measurements of waves outside said diffusive medium to generate a tomographic image. | 05-09-2013 |
Karen N. Madden, Bedford, MA US
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20100074847 | Chromophore Probes for Optical Imaging - Chromophore probes that are capable of being taken up by, retained by or bound to a biocompatible molecule to form an imaging construct are provided. Various activation strategies of the resulting imaging construct are also provided. | 03-25-2010 |
Kevin Madden, Charlestown, MA US
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20090075327 | Methods for improving secondary metabolite production in fungi - The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production. | 03-19-2009 |
Kevin T. Madden, Arlington, MA US
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20090324800 | PRODUCTION OF QUINONE DERIVED COMPOUNDS IN OLEAGINOUS YEAST AND FUNGI - The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds. | 12-31-2009 |
20100305341 | PRODUCTION OF STEROLS IN OLEAGINOUS YEAST AND FUNGI - The present invention provides methods for production of one or more sterol compounds. Further provided are methods and systems for producing engineered oleaginous yeast or fungi that are capable of production of one or more sterol compounds, and compositions which utilize the produced sterol compound(s). | 12-02-2010 |
20110014669 | Production of 1,4 Butanediol in a Microorganism - A biological method for the conversion of L-glutamate to 1,4-butanediol that involves a decarboxylation step and avoids production of 4-hydroxybutyrate as an intermediate is described. The method includes: (a) conversion of L-glutamate to L-glutamate 5-phosphate; (b) conversion of L-glutamate 5-phosphate to L-glutamate 5-semialdehyde; (c) conversion of L-glutamate 5-semialdehyde to 5-hydroxy-L-norvaline; (d) conversion of 5-hydroxy-L-norvaline to 5-hydroxy-2-oxopentanoate; (e) conversion of 5-hydroxy-2-oxopentanoate to 4-hydroxybutanal; and (f) the conversion of 4-hydroxybutanal to 1,4-butanediol. | 01-20-2011 |
20110021843 | PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI - The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids | 01-27-2011 |
20110039299 | PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI - The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids. | 02-17-2011 |
20110039327 | ORGANIC ACID PRODUCTION BY FUNGAL CELLS - Improved systems for the biological production of organic acids are described. | 02-17-2011 |
20110045559 | MALIC ACID PRODUCTION IN RECOMBINANT YEAST - The present disclosure relates to modified yeast, wherein the yeast has reduced pyruvate decarboxylase polypeptide (PDC) activity and methods of using such yeast to produce malic and/or succinic acid. | 02-24-2011 |
20120149886 | PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI - The present disclosure provides systems for producing engineered oleaginous yeast or fungi that express carotenoids. | 06-14-2012 |
20130045504 | PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI - The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids | 02-21-2013 |
20140234928 | PRODUCTION OF CAROTENOIDS IN OLEAGINOUS YEAST AND FUNGI - The present invention provides systems for producing engineered oleaginous yeast or fungi that express retinolic compounds. | 08-21-2014 |
20140315279 | PRODUCTION OF QUINONE DERIVED COMPOUNDS IN OLEAGINOUS YEAST AND FUNGI - The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds. | 10-23-2014 |
20150104543 | ORGANIC ACID PRODUCTION BY FUNGAL CELLS - Improved systems for the biological production of organic acids are described. | 04-16-2015 |
Michael Madden, Princeton, MA US
Patent application number | Description | Published |
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20090259150 | Device and Method for Detecting and Treating Lesions - A device for treating tissue comprises an enlongate probe and a light delivery unit illuminating a target area with light within a first wavelength band selected to enhance identification of target tissue in combination with an ultrasound crystal mounted at a distal end of the probe, the crystal being stimulated to treat target tissue identified using the light delivery unit. | 10-15-2009 |
20100121345 | DILATOR WITH EXPANDABLE MEMBER - The invention relates to a dilator having an expandable member and relates to a dilator and access sheath assembly including a first conduit which includes a wall defining a lumen therethrough and which is sufficiently rigid to dilate tissue in a body vessel; a member coaxially surrounding a first section of the first conduit, where the member is capable of expanding; and a second conduit coaxially surrounding a second section of the first conduit. | 05-13-2010 |
20120224165 | SYSTEMS AND METHODS FOR SIGNAL PROCESSING IN OPTICAL IMAGING SYSTEMS - Systems, devices and methods of producing an image are provided. A electro-magnetic radiation source provides electro-magnetic radiation to a sample and a reference. A detector/interferogram unit produces at least one interferogram that is supplied to a signal processing unit. The signal processing unit extracts phase, magnitude, and/or polarization data from the supplied signals, and produces an image based on at least the extracted data. | 09-06-2012 |
20120308629 | INJECTABLE BULKING COMPOSITIONS - According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable. | 12-06-2012 |
20130116498 | SURGICAL SLINGS - The invention relates generally to surgical implants, and in various embodiments to surgical implants configured for promoting growth of well-organized collagenous tissue at an anatomical site. | 05-09-2013 |
20130204126 | IMAGING SYSTEM PRODUCING MULTIPLE REGISTERED IMAGES OF A BODY LUMEN - Systems, devices and methods for producing registered images of a body lumen are provided. The system includes a first imaging device having an imager positioned at a distal end thereof, said first imaging device configured to produce a first image of a body cavity; and an imaging system, including a second imaging device having an imager positioned at a distal end thereof and configured to be positioned approximate to said imager of said first imaging device within said body cavity and configured to produce a second image; an elongated member configured to contain said second imaging device; and at least one marker configured to produce registration information in the first image and the second image. | 08-08-2013 |
20140031610 | SURGICAL SLINGS - The invention relates generally to surgical implants, and in various embodiments to surgical implants configured for promoting growth of collagenous tissue at an anatomical site. | 01-30-2014 |
20140255458 | INJECTABLE BULKING COMPOSITIONS - According to an aspect of the invention, injectable bulking compositions are provided which contain the following: (a) fibers that are configured to prevent migration to locations in the body remote from the injection site, for example, because they have a minimum length that is sufficiently large to prevent migration of the fibers and/or because they have surface features that stimulate host tissue response to lock the fibers in position and (b) a carrier in an amount effective to render the composition injectable. | 09-11-2014 |
20140343409 | INFLATION APPARATUS WITH PRESSURE RELIEF, RELATED SYSTEMS, METHODS AND KITS - An inflation system is provided including a housing having an interior portion including an opening. A connector is positioned within the interior portion. The connector includes a first portion defining a first passageway and a second portion defining a second passageway. The second portion includes a pressure relief valve. A shaft defines a third passageway. The shaft extends through the first passageway. An inflatable member defines a fourth passageway. The inflatable member includes a first end coupled to the connector and a second end positioned external to the interior portion defining a chamber that is in communication with the fourth passageway. Methods and kits are also disclosed. | 11-20-2014 |
Mike Madden, Princeton, MA US
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20110064774 | BULKING AGENT - The invention relates to bulking agents and apparatus and methods for using the disclosed bulking agents. The bulking agents can be used to treat such conditions as urinary and fecal incontinence, gastro-esophageal reflux, aneurismal blockages, and cosmetic deformities. The invention also relates to an injection method that reduces the injection pressure required to place the bulking agents. | 03-17-2011 |
20120160408 | Composite ePTFE- Silicone Covering for Stent - A medical device consists of a stent having a first surface and a second surface parallel to the first surface; a single expanded polytetrafluoroethylene (ePTFE) layer contacting the first surface of the stent; and an elastomeric layer applied to at least one surface of the stent. In at least one embodiment, the elastomeric layer is silicone. In at least one embodiment, the medical device is manufactured by positioning the ePTFE layer such that a first surface of the ePTFE layer contacts a first surface of the stent to form a stent-ePTFE assembly; and applying an elastomeric solution to the first surface of the ePTFE layer and at least one surface of the stent. | 06-28-2012 |
Mike Madden, Cambridge, MA US
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20130190720 | BULKING AGENTS - The invention relates to bulking agents and apparatus and methods for using the disclosed bulking agents. The bulking agents can be used to treat such conditions as urinary and fecal incontinence, gastro-esophageal reflux, aneurismal blockages, and cosmetic deformities. The invention also relates to an injection method that reduces the injection pressure required to place the bulking agents. | 07-25-2013 |
Peter G. Madden, Burlington, MA US
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20140255615 | Apparatus and Process for Depositing a Thin Layer of Resist on a Substrate - The present inventions relate to the formation of a thin polymer film on a substrate. Apparatus is described for transforming a solid polymer resist into an aerosol of small particles, electrostatically charging and depositing the particles onto a substrate, and flowing the particles into a continuous layer. Apparatus is further described for transforming solid resist into an aerosol of small particles by heating the resist to form a low viscosity liquid such as is compatible with nebulization and applying the techniques of jet or impact nebulization and aerosol particle sizing to form the aerosol. A method is further described of using ionized gas to confer charge onto the aerosol particles and using a progression of charging devices establish an electric field directing the flow of charged particles to the substrate. The progression of charging devices and associated apparatus results in high collection efficiency for the aerosol particles. | 09-11-2014 |
Peter G. Madden, Somerville, MA US
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20110028676 | Molecular Actuators, and Methods of Use Thereof - The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π-π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators. | 02-03-2011 |
Samuel Madden, Cambridge, MA US
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20100023300 | SENSOR BASED MONITORING OF SOCIAL NETWORKS - A method and system for detecting and monitoring discrete interactions within a physical social network is provided. The system and method detects attributes associated with human communication activities and distinguishes them from other concurrently detected activities in order to identify discrete interactions that are in turn transmitted across a network having a limited data rate. Generally, in its simplest form a plurality of wireless sensors are deployed across a cross-section of people of interest. Once deployed, the wireless sensors establish an ad-hoc network that transmits a small amount of data relating to the each of the discrete individuals bearing a sensor. The collected data is analyzed through the application of rules set forth in a Bayesian belief network to make a determination regarding the probability that an actual interaction between two individuals bearing sensors in fact occurred. | 01-28-2010 |
Samuel Ross Madden, Newton, MA US
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20140278206 | INFERENCE OF VEHICULAR TRAJECTORY CHARACTERISTICS WITH PERSONAL MOBILE DEVICES - Accurate longitudinal acceleration, lateral acceleration (perpendicular to the principal direction of motion, and velocity, is inferred by processing raw data from a commodity three-axis accelerometer that may be oriented arbitrarily in a moving vehicle (or carried by a moving user), and whose orientation and position may change arbitrarily during the motion. The approach is applicable to a range of applications, including insurance telematics, driver behavior and risk assessment, and road surface quality assessment. | 09-18-2014 |
Sean P. Madden, Arlington, MA US
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20130053698 | DETECTION OF LIPID CORE PLAQUE CAP THICKNESS - Described are methods, systems, and apparatus, including computer program products for examining a blood vessel wall. The blood vessel wall is illuminated with near-infrared light. Reflected near-infrared light from the blood vessel wall is received. A reflectance spectrum based on the reflected near-infrared light from the blood vessel wall is determined. Whether the reflectance spectrum is indicative of a presence of a lipid core plaque (LCP) by applying an LCP classifier to the reflectance spectrum is determined. A thickness of an LCP cap is determined by applying an LCP cap thickness classifier to the reflectance spectrum if the reflectance spectrum is indicative of the presence of the LCP. Indicia of the thickness of the LCP cap are displayed. | 02-28-2013 |
20150150461 | Detection of Lipid Core Plaque Cap Thickness - Described are methods, systems, and apparatus, including computer program products for examining a blood vessel wall. The blood vessel wall is illuminated with near-infrared light. Reflected near-infrared light from the blood vessel wall is received. A reflectance spectrum based on the reflected near-infrared light from the blood vessel wall is determined. Whether the reflectance spectrum is indicative of a presence of a lipid core plaque (LCP) by applying an LCP classifier to the reflectance spectrum is determined. A thickness of an LCP cap is determined by applying an LCP cap thickness classifier to the reflectance spectrum if the reflectance spectrum is indicative of the presence of the LCP. Indicia of the thickness of the LCP cap are displayed. | 06-04-2015 |
Stephen Madden, Sudbury, MA US
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20090270265 | Molecular Characteristics of Non-Small Cell Lung Cancer - We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung cancers (NSCLC). Separation of normal and tumor samples, as well as histopathological subtypes, was evident using the 3,921 most abundant transcript tags. This distinction remained when just 115 highly differentially expressed transcript tags were used. Furthermore, these 115 transcript tags clustered into groups that were suggestive of the unique biological and pathological features of the different tissues examined. Adenocarcinomas were characterized by high-level expression of small airway-associated or immunologically related proteins, while squamous cell carcinomas overexpressed genes involved in cellular detoxification or antioxidation. The messages of two p53-regulated genes, p21 | 10-29-2009 |
20120308479 | Brain Endothelial Cell Expression Patterns - To gain a better understanding of brain tumor angiogenesis, new techniques for isolating brain endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from brain ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed genes that were specifically elevated in tumor-associated brain endothelium. These results confirm that neoplastic and normal endothelium in human brains are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future. | 12-06-2012 |
Stephen I. Madden, Sudbury, MA US
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20100062002 | Brain Endothelial Cell Expression Patterns - To gain a better understanding of brain tumor angiogenesis, new techniques for isolating brain endothelial cells (ECs) and evaluating gene expression patterns were developed. When transcripts from brain ECS derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, genes predominantly expressed in the endothelium were identified. Comparison between normal- and tumor-derived endothelium revealed genes that were specifically elevated in tumor-associated brain endothelium. These results confirm that neoplastic and normal endothelium in human brains are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future. | 03-11-2010 |
Stephen L. Madden, Sudbury, MA US
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20090117038 | Breast Endothelial Cell Expression Patterns - To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future. | 05-07-2009 |
20100062443 | Methods for the Diagnosis and Treatment of Lung Cancer - The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition. | 03-11-2010 |
20110091892 | Methods for the Diagnosis and Treatment of Lung Cancer - The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition. | 04-21-2011 |
20110262350 | BREAST ENDOTHELIAL CELL EXPRESSION PATTERNS - To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future. | 10-27-2011 |
20140056911 | Breast Endothelial Cell Expression Patterns - To gain a better understanding of breast tumor angiogenesis, breast endothelial cells (ECs) were isolated and evaluated for gene expression patterns. When transcripts from breast ECs derived from normal and malignant breast tissues were compared, genes that were specifically elevated in tumor-associated breast endothelium were revealed. These results confirm that neoplastic and normal endothelium in human breast are distinct at the molecular level, and have significant implications for the development of anti-angiogenic therapies in the future. | 02-27-2014 |