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| 20120229619 | PROTOCOL-BASED INSPECTION SYSTEM - One form of the present application provides a system comprising an illumination source capable of providing an electromagnetic illumination of an engine component, an imaging system structured to capture illumination of the engine component, a component manipulation system structured to position the engine component in a variety of orientations relative to one of the illumination source and the imaging system, a computer based user interface capable of identifying an inspection protocol defined to acquire an image of the engine component at the variety of positions using the illumination system, the imaging system and the component manipulation system, and a processor configured to process the inspection protocol for the purposes of analyzing the acquired image in response to the inspection protocol. | 09-13-2012 |
| 20120230807 | AUTOMATED OBJECT MANIPULATION SYSTEM - An apparatus of an automated object manipulation system includes a support base; a finger assembly mechanically coupled to the support base; a first drive unit operable to rotate the finger assembly about a first axis; a second drive unit operable to rotate the finger assembly about a second axis; a third drive unit operable to rotate the finger assembly about a third axis, and a processor capable of conducting a profile assessment; determining a manipulation program in response to the profile assessment; and controlling the finger assembly in response to the manipulation program where the finger assembly has a support bracket with a set of parallel jaws and the support bracket is mechanically coupled to the first drive unit, a linking bracket mechanically coupled to the second drive unit and a circular frame mechanically coupled to the finger assembly and the third drive unit. | 09-13-2012 |
| 20120232841 | INTELLIGENT AIRFOIL COMPONENT GRAIN DEFECT INSPECTION - A system including a positioning system with a component manipulator structured to position a component in response to a positioning algorithm; a scanning system capable of producing a set of light waves directed at a surface of the component, detecting a set of reflected light waves from the surface of the component, and producing a reflectivity data set in response to the set of reflected light waves; and a microprocessor structured to apply a fuzzy logic algorithm to the reflectivity signal to determine a solution set and produce a grain structure characterization in response to the solution set. | 09-13-2012 |
| 20120233111 | INTELLIGENT AIRFOIL COMPONENT SURFACE INSPECTION - An apparatus includes a positioning system; a surface indicator system to collect an indication data set from a surface of a component utilizing a fluorescent penetration process; an indication data processing system to create an output data set in response to the indication data set utilizing a fuzzy logic algorithm; and a microprocessor to provide at least one surface variance in response to the indication data set and the output data set. A method including conducting a surface indication technique for a component; utilizing a positioning algorithm to manipulate positioning equipment in response to the component; directing an indication source to a surface of the component; collecting an indication data set in response to directing the indication source; applying a fuzzy logic analysis in response to the indication data set to provide an output data set; and providing at least one surface variance in response to the output data set. | 09-13-2012 |
| 20120236557 | ILLUMINATION SYSTEM WITH ILLUMINATION SHIELD - An apparatus for an illumination system including a concentric light source providing a quantity of light; a diffusion shield to diffuse the light and produce a diffused illumination where the diffused illumination is provided to a component positioned in an interior portion of the diffusion shield; a support structure where the diffusion shield is mechanically coupled with the support structure at a first base portion of the diffusion shield and where the concentric light sources are mechanically coupled with the support structure and positioned radially outward from the first base portion of the diffusion shield; and a harvesting shield where the harvesting shield is mechanically coupled with the support structure and positioned radially outward from the concentric light sources and where the harvesting shield redirects at least a portion of the quantity of light from the concentric light sources towards the diffusion shield. | 09-20-2012 |
| 20140259589 | REPAIR OF GAS TURBINE ENGINE COMPONENTS - In some examples, a technique includes delivering, using a material delivery device, material adjacent to a repair surface of a component and delivering, using a gas delivery device, a gas adjacent to the repair surface. The technique also may include delivering, from an energy source, energy to the material adjacent the repair surface to fuse the material to the repair surface; and receiving, by a computing device, at least one parameter indicative of at least one of a temperature or a geometry of the component. The technique may further include, responsive to the at least one parameter indicative of the at least one of the temperature or the geometry of the component, controlling, by the computing device, at least one processing parameter to control the temperature of the component. | 09-18-2014 |
| 20150160143 | THERMOGRAPHIC INSPECTION TECHNIQUES - A system may include a fluid source fluidically coupled to a plenum; a thermal camera; at least one flow meter; and a computing device communicatively connected to the at least one flow meter and the thermal camera. The computing device may be configured to receive flow rate values from the at least one flow meter relating to flow testing of a first component fluidically coupled to the plenum; receive thermographic image data captured by the thermal camera during flowing thermographic testing of a second component fluidically coupled to the plenum; and associate the flow rate values with the thermographic image data to produce quantitative flowing thermographic image data. | 06-11-2015 |
| 20150161777 | THERMOGRAPHIC INSPECTION TECHNIQUES - A system may include a thermal camera and a computing device configured to receive master image data representative of a geometry and thermal response of at least one of a theoretical component, a fabricated gold standard component, or an average of a plurality of components; receive, from the thermal camera, thermographic image data representative of a thermal response of a tested component; morph the thermographic image data to substantially align with the three-dimensional image data and produce morphed thermographic image data; and output a representation based on the morphed thermographic image data for display. | 06-11-2015 |
| 20150161778 | THERMOGRAPHIC INSPECTION TECHNIQUES - A system may include a source of dry ice, a thermal camera, and a computing device. The computing device may be configured to control the source of dry ice to cause dry ice to be introduced into an internal passage of a tested component. The tested component may include debris within the internal passage, and the dry ice may remove at least some of the debris from the internal passage. The computing device also may be configured to receive, from the thermal camera, thermographic image data representative of the thermal response of the tested component and output a representation based on the thermographic image data. | 06-11-2015 |
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| 20110209615 | APPARATUS AND METHOD FOR TREATING EXHAUST GAS - Presented is a method and apparatus for treating an exhaust gas. A series of filters and conditioning units are used to separate and extract various substances from the exhaust gas, typically originating from an industrial process. In an exemplary embodiment, a cyclone filter, a ceramic filter, a baghouse filter, and a pair of gas conditioners are used to initially separate and extract iron-rich dust from an exhaust gas and then extract zinc from the gas. | 09-01-2011 |
| 20130160646 | APPARATUS AND METHOD FOR TREATING EXHAUST GAS - Presented is a method and apparatus for treating an exhaust gas. A series of filters and conditioning units are used to separate and extract various substances from the exhaust gas, typically originating from an industrial process. In an exemplary embodiment, a cyclone filter, a ceramic filter, a baghouse filter, and a pair of gas conditioners are used to initially separate and extract iron-rich dust from an exhaust gas and then extract zinc from the gas. | 06-27-2013 |
| 20140174299 | APPARATUS AND METHOD FOR TREATING EXHAUST GAS - Presented is a method and apparatus for treating an exhaust gas. A series of filters and conditioning units are used to separate and extract various substances from the exhaust gas, typically originating from an industrial process. In an exemplary embodiment, a cyclone filter, a ceramic filter, a baghouse filter, and a pair of gas conditioners are used to initially separate and extract iron-rich dust from an exhaust gas and then extract zinc from the gas. | 06-26-2014 |
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| 20090143275 | ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE - Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed. | 06-04-2009 |
| 20110301089 | ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE - Methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using C-terminal fragments of adiponectin receptor R1. Methods of causing the secretion of insulin in healthy and diabetic patients using C-terminal fragments of adiponectin receptor R1 are also disclosed. In addition, methods are disclosed of increasing the insulin levels in healthy patients using C-terminal fragments of adiponectin receptor R1. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed. | 12-08-2011 |
| 20120135916 | MONOMERIC AND DIMERIC FORMS OF ADIPONECTIN RECEPTOR FRAGMENTS AND METHODS OF USE - Methods are disclosed for determining progression of a condition, onset of a condition, or efficacy of treatment of a condition characterized by an adipocyte imbalance in a patient. In addition, methods are disclosed of treating diabetes, abnormal adipocyte activity, and insulin resistance using monomeric, homodimeric, and heterodimeric forms of certain C-terminal fragments of adiponectin receptor. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, inhibiting a protease, treating a condition associated with TNF-alpha, and treating a condition associated with HER2-neu are disclosed. Compositions, dosage forms, and kits are also disclosed. | 05-31-2012 |
| 20150038426 | Monomeric and Dimeric Forms of Adiponectin Receptor Fragments and Methods of Use - Methods are disclosed for determining progression of a condition, onset of a condition, or efficacy of treatment of a condition characterized by an adipocyte imbalance in a patient. In addition, disclosed herein are methods of treating diabetes, abnormal adipocyte activity, and insulin resistance using monomeric, homodimeric, and heterodimeric forms of certain C-terminal fragments of adiponectin receptor. In addition, methods of treating abnormal adipocyte activity, treating metabolic syndrome, causing insulin secretion, increasing insulin levels, inhibiting insulin degradation enzyme, treating Alzheimer's disease, treating cardiovascular disease associated with adiponectin levels, inhibiting ADAM-17 enzyme, inhibiting a protease, treating a condition associated with TNF-alpha, and treating a condition associated with HER | 02-05-2015 |
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| 20120172295 | GIP RECEPTOR-ACTIVE GLUCAGON COMPOUNDS - Glucagon peptides with increased GIP activity are provided, optionally with GLP-I and/or glucagon activity. In some embodiments, C-terminally extended glucagon peptides comprising an amino acid sequence substantially similar to native glucagon are provided herein. | 07-05-2012 |
| 20120322725 | GLUCAGON ANTAGONIST-GIP AGONIST CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS AND OBESITY - Provided herein are peptide combinations comprising a GIP agonist peptide and a glucagon antagonist peptide. In some embodiments, the peptide combination is provided as a composition, e.g., a pharmaceutical composition, while in other embodiments, the peptide combination is provided as a kit. In yet other embodiments, the peptide combination is provided as a conjugate, e.g., a fusion peptide, a heterodimer. In specific aspects, the GIP agonist peptide is an analog of native human glucagon. In specific aspects, the glucagon antagonist peptide is an analog of native human glucagon. In some embodiments, the GIP agonist peptide is covalently attached to the glucagon antagonist peptide via a linker. Methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the peptide compositions described herein are further provided. | 12-20-2012 |
| 20140107021 | GLUCAGON ANTAGONIST-GIP AGONIST CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLIC DISORDERS AND OBESITY - Provided herein are peptide combinations comprising a GIP agonist peptide and a glucagon antagonist peptide. In some embodiments, the peptide combination is provided as a composition, e.g., a pharmaceutical composition, while in other embodiments, the peptide combination is provided as a kit. In yet other embodiments, the peptide combination is provided as a conjugate, e.g., a fusion peptide, a heterodimer. In specific aspects, the GIP agonist peptide is an analog of native human glucagon. In specific aspects, the glucagon antagonist peptide is an analog of native human glucagon. In some embodiments, the GIP agonist peptide is covalently attached to the glucagon antagonist peptide via a linker. Method of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the peptide compositions described herein are further provided. | 04-17-2014 |
| 20150322130 | GIP-BASED MIXED AGONISTS FOR TREATMENT OF METABOLIC DISORDERS AND OBESITY - Glucagon peptides that exhibit GIP agonist activity in addition to glucagon and/or GLP-1 activity are provided. Pharmaceutical compositions comprising such glucagon peptides and therapeutic methods of using such peptides are also provided. | 11-12-2015 |
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| 20080200552 | Vitamin D Receptor Modulators - The present invention relates to novel, non-secosteroidal, hydroxyl substituted, carbon-linked diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1?,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis. | 08-21-2008 |
| 20080306125 | Compounds and Methods for Modulating Fx-Receptors - Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases. | 12-11-2008 |
| 20090018058 | Vitamin D Receptor Modulators - The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating and psoriasis. | 01-15-2009 |
| 20090093524 | COMPOUNDS AND METHODS FOR MODULATING FXR - Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases. | 04-09-2009 |
| 20090270460 | FXR AGONISTS - Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases. | 10-29-2009 |
| 20100099725 | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS - The present invention is directed to compounds of the structural Formula: wherein: R | 04-22-2010 |
