Patent application number | Description | Published |
20090025189 | Cleat Holding Device - The present invention is a holding device for a rope, cable, wire and the like hereafter referred to as rope and more particularly a sliding cam rope cleat comprised of a holding device, a slideable cam member controlled by a sliding handle and two passageways therethrough for the rope member. While the sliding handle is engaged in the open position, the cam member will not be resident in the first passageway and a rope member may be freely inserted and drawn. However once the sliding handle is engaged in the clamping position, the cam member will partially obstruct the first passageway and the tapered serrated bottom of the cam member will engagingly grip and secure the inserted rope member. Subsequently, the holding device provides for a quick release of the secured rope member by returning the sliding member to its first open position thereby disengaging the tapered serrated cam member for the inserted rope member. In addition, the holding device offers a second passageway which serves as a storage receptacle for any slack in the rope member. | 01-29-2009 |
20100102079 | FLUID NOZZLE - This invention relates to a hand pump adapted for discharging fluid from a portable container, and particularly relates to a hand pump having a first and second valve means for discharging fluid from a portable container. The invention also relates to a method of discharging fluid from a portable container by use of a hand pump. | 04-29-2010 |
20110232069 | AUTOMATIC RIVET DIE - A device to rivet two pieces together each having aligned holes comprising a rivet holder body having a cylindrical hole there through, an upper punch and a lower punch coaxially disposed along an axis of a cylindrical hole presented in the rivet holder body; structure for guiding a rivet to the rivet holder body in a selected orientation as well as structure for catching the falling rivet in the cylindrical hole when the upper and lower punches are in a first separated position and to withdraw from the cylindrical hole as the upper punch moves relative to the lower punch to a second riveting position. | 09-29-2011 |
Patent application number | Description | Published |
20090176849 | Process for the preparation of 2-alkyl-1-((2'-substituted-biphenyl-4-yl) Methyl)-imidazole, dihydroimidazole or benzimidazloe derivatives - The invention relates to a new process for the preparation of sartans 2-butyl-3-[[2′-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one is disclosed, which proceeds via novel intermediate, 4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]phenylboronic acid (Formula (II)) or its analogs. Compound (II) reacts with 5-(2-bromophenyl)-1-(triphenylmethyl)-1H-tetrazole (III) in the presence of catalyst, using conditions of Suzuki reaction, to give trityl irbesartan (I), whereas analogs to compound (II) may give candesartan, valsartan, telmisartan, losartan and olmesartan. | 07-09-2009 |
20090234139 | Novel Process - A novel process for the preparation of 1′-hydroxy-2′-substituted cyclohexyl azetidin-2-one compound of formula 2, which is important intermediate in the synthesis of trinems, is described by epoxide ring opening of (3S,4R)-3-[(1R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-[(1′R,2′S,3′R)-1′,2′-epoxycyclohexan-3′-yl]azetidin-2-one of formula 1 with the nucleophile compound of formula RYH, where nucleophile may act as solvent itself if the nucleophile is in the liquid form, in a suitable solvent and in the presence of a suitable catalyst from the group of salt of trifluoromethane sulfonic acid, preferably ytterbium (III) trifluoromethanesulfonate, stannous (II) trifluoromethanesulfonate or dysprosium (III) trifluoromethanesulfonate, under a) ultrasonic irradiation or b) under microwave irradiation of the reaction mixture following by isolation and purification of the desired compound. A variant of the novel process describes ring epoxide opening of the starting compound of formula 1 with the compound of formula NH | 09-17-2009 |
20090240060 | PROCESS FOR THE PREPARATION OF PURE IRBESARTAN - A process for the manufacturing of a pure irbesartan comprising converting irbesartan or a protected derivative thereof into an isolated hydrohalide acid addition salt, whereupon said hydrohalide acid addition salt is converted into the irbesartan is described. | 09-24-2009 |
20110263666 | PROCESS FOR THE PREPARATION OR PURIFICATION OF OLMESARTAN MEDOXOMIL - The present invention relates to a process for the preparation and purification of olmesartan medoxomil hydrohalide salts and optionally converting them to olmesartan medoxomil. The invention also relates to products obtainable by the process of the invention, to pharmaceutical compositions comprising the products and to their use in medicine, particularly to treat hypertension. | 10-27-2011 |
Patent application number | Description | Published |
20110130378 | EZETIMIBE PROCESS AND COMPOSITION - The present invention describes a process for producing ezetimibe (EZT) from a protected compound, including a step of deprotecting the 4-(p-hydroxyphenyl) protection group by catalytic hydrogenation, wherein the catalyst is used in an amount of 0.7 wt.-% or lower, relative to the weight of the compound used for the deprotection reaction. After carrying out a step of deprotection reaction, the process preferably comprises: (a) the reaction product is dissolved or extracted in ethyl acetate, and (b) the ethyl acetate solution is washed with an aqueous salt solution. The invention further describes a process for obtaining pure EZT, wherein raw EZT is dissolved in a solvent at a concentration of lower than 0.1 g/ml, and a crystallization step is carried out from this solution. These measures, respectively alone and particularly in combination contribute to attain ezetimibe (EZT) free of critical impurities described herein, and thus to use exceptionally pure ezetimibe (EZT) to be formulated into a pharmaceutical composition together with a pharmaceutically acceptable carrier or excipient. | 06-02-2011 |
20110263671 | NOVEL SALTS OF SUNITINIB - Pharmaceutically acceptable salts of sunitinib, processes of making sunitinib salts, as well as related pharmaceuticals and methods of treating are described. | 10-27-2011 |
20110275690 | NEW CRYSTAL FORM OF SUNITINIB MALATE - A process for the preparation of a new crystal form of sunitinib malate, along with pharmaceuticals comprising the same are described. | 11-10-2011 |
20120077760 | NOVEL SALTS OF SITAGLIPTIN - The present invention relates to novel pharmaceutically acceptable salts of sitagliptin, to processes for their preparation and to pharmaceutical compositions containing them. | 03-29-2012 |