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Liu, Lexington

Chunming Liu, Lexington, KY US

Patent application numberDescriptionPublished
20120196874STILBENE ANALOGS AND METHODS OF TREATING CANCER - Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.08-02-2012
20140249161STILBENE ANALOGS AND METHODS OF TREATING CANCER - Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.09-04-2014

D. Liu, Lexington, MA US

Patent application numberDescriptionPublished
20090149347Ordered Multi-Step Synthesis by Nucleic Acid-Mediated Chemistry - The present invention provides methods and compositions for performing ordered multi-step syntheses by nucleic acid-mediated chemistry. This approach provides increased yields, and control over the preparation, of products produced via sequential, multi-step syntheses in a single reaction vessel.06-11-2009

Eric Liu, Lexington, MA US

Patent application numberDescriptionPublished
20100043232Colored Razor Blades - Colored razor blades are provided. Methods for manufacturing such blades are also provided, including methods involving depositing an oxide coating prior to heat treatment of the blade material and heat treating under conditions selected to enhance the color of the coating.02-25-2010

Patent applications by Eric Liu, Lexington, MA US

Gui Liu, Lexington, MA US

Patent application numberDescriptionPublished
200903259089-SUBSTITUTED MINOCYCLINE COMPOUNDS - The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.12-31-2009
20100179181PHARMACEUTICAL FORMULATIONS OF BIODEGRADABLE BIOCOMPATIBLE CAMPTOTHECIN-POLYMER CONJUGATES - A camptothecin/polymer dual phase drug release system is described that is stable in both liquid and lyophilized states. The polymer contains acetals and/or ketals.07-15-2010
20100305149Polyal Drug Conjugates Comprising Variable Rate-Releasing Linkers - Polyal-Drug conjugates comprising a variable rate-releasing linker are described along with methods of making such conjugates. Uses for such Polyal-Drug conjugates is also described.12-02-2010
201202832019-SUBSTITUTED MINOCYCLINE COMPOUNDS - The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.11-08-2012
20130189218PHARMACEUTICAL FORMULATIONS FOR FUMAGILLIN DERIVATIVE-PHF CONJUGATES - The invention described herein provides a mixture comprising polymer molecules or salts thereof, wherein a polymer molecule in the mixture comprises covalently bound subunits L, K, and M wherein the average molecular weight of the polymer molecules in the mixture is about 50 kDa to about 200 kDa, wherein the mole percentage of subunit M, K and L, relative to the total amount of subunits in the mixture, is about 90.5 to about 96 mol %, about 2.8 to about 7.3 mol %, and about 1.2 to about 2.2 mol %, respectively.07-25-2013
20140004074Pharmaceutical Formulations of Biodegradable Biocompatible Camptothecin-Polymer Conjugates01-02-2014

Patent applications by Gui Liu, Lexington, MA US

Haibo Liu, Lexington, MA US

Patent application numberDescriptionPublished
20140296233HETEROARYL COMPOUNDS AND USES THEREOF - The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.10-02-2014

Hanlan Liu, Lexington, MA US

Patent application numberDescriptionPublished
20130137743AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE - The hemitartrate salt of a compound represented by the following structural formula: (Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described.05-30-2013

Julie Liu, Lexington, MA US

Patent application numberDescriptionPublished
20090192188TETRAHYDROISOQUINOLINE DERIVATIVES - This invention relates to novel tetrahydroisoquinoline derivatives, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a dual OX-1/OX-2 orexin antagonist.07-30-2009
201102129442-OXO-1-PYRROLIDINE DERIVATIVES - This invention relates to novel 2-oxo-1-pyrrolidines, their derivatives, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound with the ability to act as a synaptic vesicle protein 2A (SV2A) ligand and/or a sodium channel blocker.09-01-2011

Julie Fields Liu, Lexington, MA US

Patent application numberDescriptionPublished
20100093713BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE - This invention provides beta-carboline compounds of formula04-15-2010
20100311715ALPHA CARBOLINES AND USES THEREOF - This invention provides alpha-carboline compounds of formula I:12-09-2010

Patent applications by Julie Fields Liu, Lexington, MA US

Kunlei Liu, Lexington, KY US

Patent application numberDescriptionPublished
20110311429Method for Removing CO2 from Coal-Fired Power Plant Flue Gas Using Ammonia as the Scrubbing Solution, with a Chemical Additive for Reducing NH3 Losses, Coupled with a Membrane for Concentrating the CO2 Stream to the Gas Stripper - A method for removing and capturing carbon dioxide from a fluid stream includes the steps of exposing the fluid stream to an aqueous scrubbing solution that removes and holds carbon dioxide from the fluid stream, passing the aqueous scrubbing solution through a membrane in order to separate excess water from the scrubbing solution and increase the concentration of carbon dioxide in the scrubbing solution, heating the scrubbing solution having an increased concentration of carbon dioxide so as to release carbon dioxide gas and recycling the scrubbing solution. A carbon dioxide capture apparatus includes a carbon dioxide scrubber, a membrane downstream from the scrubber for separating water and concentrating carbon dioxide in a scrubbing solution and a stripper vessel.12-22-2011
20120082604CONTAMINANT-TOLERANT SOLVENT AND STRIPPING CHEMICAL AND PROCESS FOR USING SAME FOR CARBON CAPTURE FROM COMBUSTION GASES - A contaminant-tolerant hybrid scrubbing solvent is provided for post-combustion CO04-05-2012
20130192230FOSSIL-FUEL-FIRED POWER PLANT - A power plant includes a boiler, a stream turbine generator, a post combustion processing system, a feed water regeneration processing system and a heat exchanger. Heat from the heat exchanger is used to regenerate (a) a reagent that absorbs carbon dioxide from flue gas and (b) a water-lean desiccant used to increase plant operating efficiency.08-01-2013
20140208753METHOD FOR ENERGY STORAGE TO UTILIZE INTERMITTENT RENEWABLE ENERGY AND LOW-VALUE ELECTRICITY FOR CO2 CAPTURE AND UTILIZATION - A power plant includes a boiler, a steam turbine, a generator driven by that steam turbine, a condenser, a post combustion processing system and an energy storage system including at least one electrochemical cell to store excess electrical energy generated by the generator during period valley demand and release thermal energy for power plant operations at other times.07-31-2014
20140294704SOLVENT AND METHOD FOR REMOVAL OF AN ACID GAS FROM A FLUID STREAM - A solvent for removal of an acid gas from a fluid stream includes a promoter amine with a pKa of between 6.5 and 10.5 and a tertiary amine with a pKa of between 8.5 and 10.5.10-02-2014
20140294705METHOD OF INCREASING MASS TRANSFER RATE OF ACID GAS SCRUBBING SOLVENTS - A method of increasing the overall mass transfer rate of acid gas scrubbing solids is disclosed. Various catalyst compounds for that purpose are also disclosed.10-02-2014
20140296061CATALYSTS AND METHODS OF INCREASING MASS TRANSFER RATE OF ACID GAS SCRUBBING SOLVENTS - A novel transition metal trimer compound/catalyst is disclosed. A method of increasing the overall mass transfer rate of acid gas scrubbing solvents utilizing that catalyst is also provided.10-02-2014

Patent applications by Kunlei Liu, Lexington, KY US

Qizhi Liu, Lexington, MA US

Patent application numberDescriptionPublished
20120248573TUNABLE SEMICONDUCTOR DEVICE - Embodiments of the invention include a method for forming a tunable semiconductor device and the resulting structure. The invention comprises forming a semiconductor substrate. Next, pattern a first mask over the semiconductor substrate. Dope regions of the semiconductor substrate not protected by the first mask to form a first discontinuous subcollector. Remove the first mask. Pattern a second mask over the semiconductor substrate. Dope regions of the semiconductor substrate not protected by the second mask and on top of the first discontinuous subcollector to form a second discontinuous subcollector. Remove the second mask and form a collector above the second discontinuous subcollector. Breakdown voltage of the device may be tuned by varying the gaps separating doped regions within the first and second discontinuous subcollectors. Doped regions of the first and second discontinuous subcollectors may be formed in a mesh pattern.10-04-2012
20120313146TRANSISTOR AND METHOD OF FORMING THE TRANSISTOR SO AS TO HAVE REDUCED BASE RESISTANCE - Disclosed is a transistor structure, having a completely silicided extrinsic base for reduced base resistance R12-13-2012
20130119434BIPOLAR TRANSISTOR WITH A COLLECTOR HAVING A PROTECTED OUTER EDGE PORTION FOR REDUCED BASED-COLLECTOR JUNCTION CAPACITANCE AND A METHOD OF FORMING THE TRANSISTOR - Disclosed are embodiments of a transistor (e.g., bipolar junction transistor (BJT) or a heterojunction bipolar transistor (HBT)) and a method of forming the transistor with a collector region having a protected upper edge portion for reduced base-collector junction capacitance C05-16-2013
20130119436INTERFACE CONTROL IN A BIPOLAR JUNCTION TRANSISTOR - Methods of fabricating bipolar junction transistors, bipolar junction transistors, and design structures for a bipolar junction transistor. A first portion of the intrinsic base layer is masked while a second portion of an intrinsic base layer is etched. As a consequence of the masking, the second portion of the intrinsic base layer is thinner than the first portion of the intrinsic base layer. An emitter and an extrinsic base layer are formed in respective contacting relationships with the first and second portions of the intrinsic base layer.05-16-2013
20130119442JUNCTION FIELD-EFFECT TRANSISTOR WITH RAISED SOURCE AND DRAIN REGIONS FORMED BY SELECTIVE EPITAXY - Junction field-effect transistors, methods for fabricating junction field-effect transistors, and design structures for a junction field-effect transistor. A source and a drain of the junction field-effect transistor are comprised of a semiconductor material grown by selective epitaxy and in direct contact with a top surface of a semiconductor layer. A gate is formed that is aligned with a channel laterally disposed in the semiconductor layer between the source and the drain. The source, the drain, and the semiconductor layer are each comprised of a second semiconductor material having an opposite conductivity type from a first semiconductor material comprising the gate.05-16-2013
20130119505Schottky Barrier Diodes With a Guard Ring Formed by Selective Epitaxy - Schottky barrier diodes, methods for fabricating Schottky barrier diodes, and design structures for a Schottky barrier diode. A guard ring for a Schottky barrier diode is formed with a selective epitaxial growth process. The guard ring for the Schottky barrier diode and an extrinsic base of a vertical bipolar junction diode on a different device region than the Schottky barrier diode may be concurrently formed using the same selective epitaxial growth process.05-16-2013
20130119508BIPOLAR JUNCTION TRANSISTOR WITH MULTIPLE EMITTER FINGERS - Methods for fabricating bipolar junction transistors, bipolar junction transistors, and design structures for a bipolar junction transistor. The bipolar junction transistor may include a plurality of emitters that are arranged in distinct emitter fingers. A silicide layer is formed that covers an extrinsic base layer of the bipolar junction transistor and that fills the gaps between adjacent emitters. Non-conductive spacers on the emitter sidewalls electrically insulate the emitters from the silicide layer. The emitters extend through the extrinsic base layer and the silicide layer to contact the intrinsic base layer. The emitters may be formed using sacrificial emitter pedestals in a replacement-type process.05-16-2013
20130119516PNP BIPOLAR JUNCTION TRANSISTOR FABRICATION USING SELECTIVE EPITAXY - Lateral PNP bipolar junction transistors, methods for fabricating lateral PNP bipolar junction transistors, and design structures for a lateral PNP bipolar junction transistor. An emitter and a collector of the lateral PNP bipolar junction transistor are comprised of p-type semiconductor material that is formed by a selective epitaxial growth process. The source and drain each directly contact a top surface of a device region used to form the emitter and collector. A base contact may be formed on the top surface and overlies an n-type base defined within the device region. The emitter is laterally separated from the collector by the base contact. Another base contact may be formed in the device region that is separated from the other base contact by the base.05-16-2013
20130126944HETEROJUNCTION BIPOLAR TRANSISTOR WITH EPITAXIAL EMITTER STACK TO IMPROVE VERTICAL SCALING - A heterojunction bipolar transistor (HBT) may include an n-type doped crystalline collector formed in an upper portion of a crystalline silicon substrate layer; a p-type doped crystalline p05-23-2013
20130130462TUNABLE SEMICONDUCTOR DEVICE - Embodiments of the present invention include a method for forming a tunable semiconductor device. In one embodiment, the method comprises: forming a semiconductor substrate; patterning a first mask over the semiconductor substrate; doping regions of the semiconductor substrate not protected by the first mask to form a first discontinuous subcollector; removing the first mask; patterning a second mask over the semiconductor substrate; doping regions of the semiconductor substrate not protected by the second mask and on top of the first discontinuous subcollector to form a second discontinuous subcollector; removing the second mask; and forming a single continuous collector above the second discontinuous subcollector.05-23-2013
20130134483BIPOLAR TRANSISTOR WITH A RAISED COLLECTOR PEDASTAL FOR REDUCED CAPACITANCE AND A METHOD OF FORMING THE TRANSISTOR - Disclosed are a transistor and a method of forming the transistor with a raised collector pedestal in reduced dimension for reduced base-collector junction capacitance. The raised collector pedestal is on the top surface of a substrate, extends vertically through dielectric layer(s), is un-doped or low-doped, is aligned above a sub-collector region contained within the substrate and is narrower than that sub-collector region. An intrinsic base layer is above the raised collector pedestal and the dielectric layer(s). An extrinsic base layer is above the intrinsic base layer. Thus, the space between the extrinsic base layer and the sub-collector region is increased. This increased space is filled by dielectric material and the electrical connection between the intrinsic base layer and the sub-collector region is provided by the relatively narrow, un-doped or low-doped, raised collector pedestal. Consequently, base-collector junction capacitance is reduced and, consequently, the maximum oscillation frequency is increased.05-30-2013
20130146947SELF-ALIGNED EMITTER-BASE IN ADVANCED BiCMOS TECHNOLOGY - A self-aligned bipolar transistor and method of fabricating the same are disclosed. In an embodiment, a substrate and an intrinsic base are provided, followed by a first oxide layer, and an extrinsic base over the first oxide layer. A first opening is formed, exposing a portion of a surface of the extrinsic base. Sidewall spacers are formed in the first opening, and a self-aligned oxide mask is selectively formed on the exposed surface of the extrinsic base. The spacers are removed, and using the self-aligned oxide mask, the exposed extrinsic base and the first oxide layer are etched to expose the intrinsic base layer, forming a first and a second slot. A silicon layer stripe is selectively grown on the exposed intrinsic and/or extrinsic base layers in each of the first and second slots, substantially filling the respective slot.06-13-2013
20130168783MICRO-ELECTRO-MECHANICAL SYSTEM (MEMS) CAPACITIVE OHMIC SWITCH AND DESIGN STRUCTURES - A micro-electro-mechanical system (MEMS), methods of forming the MEMS and design structures are provided. The method comprises forming a coplanar waveguide (CPW) comprising a signal electrode and a pair of electrodes on a substrate. The method comprises forming a first sacrificial material over the CPW, and a wiring layer over the first sacrificial material and above the CPW. The method comprises forming a second sacrificial material layer over the wiring layer, and forming insulator material about the first sacrificial material and the second sacrificial material. The method comprises forming at least one vent hole in the insulator material to expose portions of the second sacrificial material, and removing the first and second sacrificial material through the vent hole to form a cavity structure about the wiring layer and which exposes the signal line and pair of electrodes below the wiring layer. The vent hole is sealed with sealing material.07-04-2013
20130168820POWER SIGE HETEROJUNCTION BIPOLAR TRANSISTOR (HBT) WITH IMPROVED DRIVE CURRENT BY STRAIN COMPENSATION - A power SiGe heterojunction bipolor transistor (HBT) with improved drive current by strain compensation and methods of manufacture are provided. A method includes adding carbon in a continuous steady concentration in layers of a device including a subcollector layer, a collector layer, a base buffer layer, a base layer, and an emitter buffer layer.07-04-2013
20130187198HETEROJUNCTION BIPOLAR TRANSISTOR WITH REDUCED SUB-COLLECTOR LENGTH, METHOD OF MANUFACTURE AND DESIGN STRUCTURE - A heterojunction bipolar transistor (HBT) structure, method of manufacturing the same and design structure thereof are provided. The HBT structure includes a semiconductor substrate having a sub-collector region therein. The HBT structure further includes a collector region overlying a portion of the sub-collector region. The HBT structure further includes an intrinsic base layer overlying at least a portion of the collector region. The HBT structure further includes an extrinsic base layer adjacent to and electrically connected to the intrinsic base layer. The HBT structure further includes an isolation region extending vertically between the extrinsic base layer and the sub-collector region. The HBT structure further includes an emitter overlying a portion of the intrinsic base layer. The HBT structure further includes a collector contact electrically connected to the sub-collector region. The collector contact advantageously extends through at least a portion of the extrinsic base layer.07-25-2013
20130207235SELF-ALIGNED EMITTER-BASE REGION - Aspects of the invention provide a method of forming a bipolar junction transistor. The method includes: providing a semiconductor substrate including a uniform silicon nitride layer over an emitter pedestal, and a base layer below the emitter pedestal; applying a photomask at a first end and a second end of a base region; and performing a silicon nitride etch with the photomask to simultaneously form silicon nitride spacers adjacent to the emitter pedestal and exposing the base region of the bipolar junction transistor. The silicon nitride etch may be an end-pointed etch.08-15-2013
20130214275TRANSISTOR HAVING A NARROW IN-SUBSTRATE COLLECTOR REGION FOR REDUCED BASE-COLLECTOR JUNCTION CAPACITANCE AND A METHOD OF FORMING THE TRANSISTOR - Disclosed are a transistor (e.g., bipolar junction transistor (BJT) or a heterojunction bipolar transistor (HBT)) and a method of forming the transistor with a narrow in-substrate collector region for reduced base-collector junction capacitance. The transistor has, within a substrate, a collector region positioned laterally adjacent to a trench isolation region. A relatively thin seed layer covers the trench isolation region and collector region. This seed layer has a monocrystalline center, which is aligned above and wider than the collector region (e.g., due to a solid phase epitaxy regrowth process), and a polycrystalline outer section. An intrinsic base layer is epitaxially deposited on the seed layer such that it similarly has a monocrystalline center section that is aligned above and wider than the collector region. An extrinsic base layer is the intrinsic base layer and has a monocrystalline extrinsic base-to-intrinsic base link-up region that is offset vertically from the collector region.08-22-2013
20130277804BIPOLAR JUNCTION TRANSISTORS WITH REDUCED BASE-COLLECTOR JUNCTION CAPACITANCE - Methods for fabricating a device structure such as a bipolar junction transistor, device structures for a bipolar junction transistor, and design structures for a bipolar junction transistor. The device structure includes a collector region formed in a substrate, an intrinsic base coextensive with the collector region, an emitter coupled with the intrinsic base, a first isolation region surrounding the collector region, and a second isolation region formed at least partially within the collector region. The first isolation region has a first sidewall and the second isolation region having a second sidewall peripherally inside the first sidewall. A portion of the collector region is disposed between the first sidewall of the first isolation region and the second sidewall of the second isolation region.10-24-2013
20130334664INTERFACE CONTROL IN A BIPOLAR JUNCTION TRANSISTOR - Methods of fabricating bipolar junction transistors, bipolar junction transistors, and design structures for a bipolar junction transistor. A first portion of the intrinsic base layer is masked while a second portion of an intrinsic base layer is etched. As a consequence of the masking, the second portion of the intrinsic base layer is thinner than the first portion of the intrinsic base layer. An emitter and an extrinsic base layer are formed in respective contacting relationships with the first and second portions of the intrinsic base layer.12-19-2013
20140021547INTEGRATED CIRCUIT INCLUDING TRANSISTOR STRUCTURE ON DEPLETED SILICON-ON-INSULATOR, RELATED METHOD AND DESIGN STRUCTURE - An Integrated Circuit (IC) and a method of making the same. In one embodiment, the IC includes: a substrate; a first semiconductor layer disposed on the substrate; a shallow trench isolation (STI) extending through the first semiconductor layer to within a portion of the substrate, the STI substantially separating a first n+ region and a second n+ region; and a gate disposed on a portion of the first semiconductor layer and connected to the STI, the gate including: a buried metal oxide (BOX) layer disposed on the first semiconductor layer and connected to the STI; a cap layer disposed on the BOX layer; and a p-type well component disposed within the first semiconductor layer and the substrate, the p-type well component connected to the second n+ region.01-23-2014
20140021587LOCAL WIRING FOR A BIPOLAR JUNCTION TRANSISTOR INCLUDING A SELF-ALIGNED EMITTER REGION - Aspects of the invention provide for a bipolar transistor of a self-aligned emitter. In one embodiment, the invention provides a method of forming local wiring for a bipolar transistor with a self-aligned sacrificial emitter, including: performing an etch to remove the sacrificial emitter to form an emitter opening between two nitride spacers; depositing an in-situ doped emitter into the emitter opening; performing a recess etch to partially remove a portion of the in-situ doped emitter; depositing a silicon dioxide layer over the recessed in-situ doped emitter; planarizing the silicon dioxide layer via chemical mechanical polishing; etching an emitter trench over the recessed in-situ doped emitter; and depositing tungsten and forming a tungsten wiring within the emitter trench via chemical mechanical polishing.01-23-2014
20140035064SEMICONDUCTOR STRUCTURES AND METHODS OF MANUFACTURE - Semiconductor structures and methods of manufacture are disclosed herein. Specifically, disclosed herein are methods of manufacturing a high-voltage metal-oxide-semiconductor field-effect transistor and respective structures. A method includes forming a field-effect transistor (FET) on a substrate in a FET region, forming a high-voltage FET (HVFET) on a dielectric stack over a over lightly-doped diffusion (LDD) drain in a HVFET region, and forming an NPN on the substrate in an NPN region.02-06-2014
20140084420METHOD TO BRIDGE EXTRINSIC AND INTRINSIC BASE BY SELECTIVE EPITAXY IN BICMOS TECHNOLOGY - A method of forming a heterojunction bipolar transistor. The method includes providing a structure comprising at least an intrinsic base region and an emitter pedestal region. A stack is formed on the intrinsic base region. The stack comprises a polysilicon layer and a top sacrificial oxide layer. A trench is formed in the structure. The trench circumscribes the intrinsic base region and the stack. An extrinsic base is formed at two regions around the stack. The extrinsic base is formed by a selective epitaxial growth process to create a bridge over the trench. The bridge connects the two regions. An opening is provided in the stack. The opening exposes a portion of the intrinsic base region. An emitter is formed in the opening.03-27-2014
20140113426TRANSISTOR AND METHOD OF FORMING THE TRANSISTOR SO AS TO HAVE REDUCED BASE RESISTANCE - Disclosed is a transistor structure, having a completely silicided extrinsic base for reduced base resistance R04-24-2014
20140117493ISOLATION SCHEME FOR BIPOLAR TRANSISTORS IN BICMOS TECHNOLOGY - Methods for fabricating a device structure, as well as device structures and design structures for a bipolar junction transistor. The device structure includes a collector region in a substrate, a plurality of isolation structures extending into the substrate and comprised of an electrical insulator, and an isolation region in the substrate. The isolation structures have a length and are arranged with a pitch transverse to the length such that each adjacent pair of the isolation structures is separated by a respective section of the substrate. The isolation region is laterally separated from at least one of the isolation structures by a first portion of the collector region. The isolation region laterally separates a second portion of the collector region from the first portion of the collector region. The device structure further includes an intrinsic base on the second portion of the collector region and an emitter on the intrinsic base. The emitter has a length transversely oriented relative to the length of the isolation structures.05-01-2014
20140131773SELF-ALIGNED EMITTER-BASE IN ADVANCED BiCMOS TECHNOLOGY - A self-aligned bipolar transistor and method of fabricating the same are disclosed. In an embodiment, a substrate and an intrinsic base are provided, followed by a first oxide layer, and an extrinsic base over the first oxide layer. A first opening is formed, exposing a portion of a surface of the extrinsic base. Sidewall spacers are formed in the first opening, and a self-aligned oxide mask is selectively formed on the exposed surface of the extrinsic base. The spacers are removed, and using the self-aligned oxide mask, the exposed extrinsic base and the first oxide layer are etched to expose the intrinsic base layer, forming a first and a second slot. A silicon layer stripe is selectively grown on the exposed intrinsic and/or extrinsic base layers in each of the first and second slots, filling the respective slot.05-15-2014
20140151852BIPOLAR JUNCTION TRANSISTORS WITH REDUCED BASE-COLLECTOR JUNCTION CAPACITANCE - Fabrication methods, device structures, and design structures for a bipolar junction transistor. The device structure includes a collector region, an intrinsic base formed on the collector region, an emitter coupled with the intrinsic base and separated from the collector by the intrinsic base, and an isolation region extending through the intrinsic base to the collector region. The isolation region is formed with a first section having first sidewalls that extend through the intrinsic base and a second section with second sidewalls that extend into the collector region. The second sidewalls are inclined relative to the first sidewalls. The isolation region is positioned in a trench that is formed with first and second etching process in which the latter etches different crystallographic directions of a single-crystal semiconductor material at different etch rates.06-05-2014
20140217551TRENCH ISOLATION FOR BIPOLAR JUNCTION TRANSISTORS IN BICMOS TECHNOLOGY - Device structures, fabrication methods, and design structures for a bipolar junction transistor. A first isolation structure is formed in a substrate to define a boundary for a device region. A collector is formed in the device region, and a second isolation structure is formed in the device region. The second isolation structure defines a boundary for the collector. The second isolation structure is laterally positioned relative to the first isolation structure to define a section of the device region between the first and second isolation structures.08-07-2014
20140231236MICRO-ELECTRO-MECHANICAL SYSTEM (MEMS) CAPACITIVE OHMIC SWITCH AND DESIGN STRUCTURES - A micro-electro-mechanical system (MEMS), methods of forming the MEMS and design structures are provided. The method includes forming a coplanar waveguide (CPW) comprising a signal electrode and a pair of electrodes on a substrate. The method includes forming a first sacrificial material over the CPW, and a wiring layer over the first sacrificial material and above the CPW. The method includes forming a second sacrificial material layer over the wiring layer, and forming insulator material about the first sacrificial material and the second sacrificial material. The method includes forming at least one vent hole in the insulator material to expose portions of the second sacrificial material, and removing the first and second sacrificial material through the vent hole to form a cavity structure about the wiring layer and which exposes the signal line and pair of electrodes below the wiring layer. The vent hole is sealed with sealing material.08-21-2014
20140231877COLLECTOR-UP BIPOLAR JUNCTION TRANSISTORS IN BICMOS TECHNOLOGY - Fabrication methods, device structures, and design structures for a bipolar junction transistor. An emitter is formed in a device region defined in a substrate. An intrinsic base is formed on the emitter. A collector is formed that is separated from the emitter by the intrinsic base. The collector includes a semiconductor material having an electronic bandgap greater than an electronic bandgap of a semiconductor material of the device region.08-21-2014
20140231878COLLECTOR-UP BIPOLAR JUNCTION TRANSISTORS IN BICMOS TECHNOLOGY - Fabrication methods, device structures, and design structures for a bipolar junction transistor. An emitter is formed in a device region defined in a substrate. An intrinsic base is formed on the emitter. A collector is formed that is separated from the emitter by the intrinsic base. The collector includes a semiconductor material having an electronic bandgap greater than an electronic bandgap of a semiconductor material of the device region.08-21-2014
20140284758SELF-ALIGNED BIPOLAR JUNCTION TRANSISTORS - Device structures, fabrication methods, and design structures for a bipolar junction transistor. An intrinsic base is formed on the substrate, a terminal is formed on the intrinsic base, and an extrinsic base is formed that is arranged in juxtaposition with the intrinsic base on the substrate. The intrinsic base and terminal are respectively comprised of first and second semiconductor materials.09-25-2014
20140312453SCHOTTKY BARRIER DIODES WITH A GUARD RING FORMED BY SELECTIVE EPITAXY - Schottky barrier diodes, methods for fabricating Schottky barrier diodes, and design structures for a Schottky barrier diode. A guard ring for a Schottky barrier diode is formed with a selective epitaxial growth process. The guard ring for the Schottky barrier diode and an extrinsic base of a vertical bipolar junction diode on a different device region than the Schottky barrier diode may be concurrently formed using the same selective epitaxial growth process.10-23-2014
20140327106BIPOLAR JUNCTION TRANSISTORS WITH SELF-ALIGNED TERMINALS - Device structures, fabrication methods, and design structures for a bipolar junction transistor. A semiconductor material layer is formed on a substrate and a mask layer is formed on the semiconductor material layer. The mask layer is patterned to form a plurality of openings to the semiconductor material layer. After the mask layer is formed and patterned, the semiconductor material layer is etched at respective locations of the openings to define a first trench, a second trench separated from the first trench by a first section of the semiconductor material layer defining a terminal of the bipolar junction transistor, and a third trench separated from the first trench by a second section of the semiconductor material layer defining an isolation pedestal. A trench isolation region is formed at a location in the substrate that is determined at least in part using the isolation pedestal as a positional reference.11-06-2014
20140332927SELF-ALIGNED BIPOLAR JUNCTION TRANSISTOR HAVING SELF-PLANARIZING ISOLATION RAISED BASE STRUCTURES - A collector region is formed between insulating shallow trench isolation regions within a substrate. A base material is epitaxially grown on the collector region and the shallow trench isolation regions. The base material forms a base region on the collector region and extrinsic base regions on the shallow trench isolation regions. Further, a sacrificial emitter structure is patterned on the base region and sidewall spacers are formed on the sacrificial emitter structure. Planar raised base structures are epitaxially grown on the base region and the extrinsic base regions, and the upper layer of the raised base structures is oxidized. The sacrificial emitter structure is removed to leave an open space between the sidewall spacers and an emitter is formed within the open space between the sidewall spacers. The upper layer of the raised base structures comprises a planar insulator electrically insulating the emitter from the raised base structures.11-13-2014
20140353725SEMICONDUCTOR DEVICE AND METHOD OF FORMING THE DEVICE BY FORMING MONOCRYSTALLINE SEMICONDUCTOR LAYERS ON A DIELECTRIC LAYER OVER ISOLATION REGIONS - Disclosed are devices and methods of forming the devices wherein pair(s) of first openings are formed through a dielectric layer and a first semiconductor layer into a substrate and, within the substrate, the first openings of each pair are expanded laterally and merged to form a corresponding trench. Dielectric material is deposited, filling the upper portions of the first openings and creating trench isolation region(s). A second semiconductor layer is deposited and second opening(s) are formed through the second semiconductor and dielectric layers, exposing monocrystalline portion(s) of the first semiconductor layer between the each pair of first openings. A third semiconductor layer is epitaxially deposited with a polycrystalline section on the second semiconductor layer and monocrystalline section(s) on the exposed monocrystalline portion(s) of the first semiconductor layer. A crystallization anneal is performed and a device (e.g., a bipolar device) is formed incorporating the resulting monocrystalline second and third semiconductor layers.12-04-2014
20140374802BIPOLAR TRANSISTOR WITH MASKLESS SELF-ALIGNED EMITTER - Embodiments of the present invention include a method for forming a semiconductor emitter and the resulting structure. The invention comprises forming an epitaxial base layer on a semiconductor substrate. A dielectric layer is deposited over the epitaxial base layer. An opening is etched in a portion of the dielectric layer exposing a portion of the epitaxial base layer and a spacer is deposited along the sidewall of the opening. The emitter is grown from the epitaxial base layer to overlap the top surface of the spacer and a portion of the dielectric layer. The single crystal emitter is formed without a mask and without the requirement of subsequent patterning processes.12-25-2014
20150014747METHOD TO BRIDGE EXTRINSIC AND INTRINSIC BASE BY SELECTIVE EPITAXY IN BICMOS TECHNOLOGY - A method of forming a heterojunction bipolar transistor. The method includes providing a structure comprising at least an intrinsic base region and an emitter pedestal region. A stack is formed on the intrinsic base region. The stack comprises a polysilicon layer and a top sacrificial oxide layer. A trench is formed in the structure. The trench circumscribes the intrinsic base region and the stack. An extrinsic base is formed at two regions around the stack. The extrinsic base is formed by a selective epitaxial growth process to create a bridge over the trench. The bridge connects the two regions. An opening is provided in the stack. The opening exposes a portion of the intrinsic base region. An emitter is formed in the opening.01-15-2015
20150041895SEMICONDUCTOR STRUCTURES AND METHODS OF MANUFACTURE - Semiconductor structures and methods of manufacture are disclosed herein. Specifically, disclosed herein are methods of manufacturing a high-voltage metal-oxide-semiconductor field-effect transistor and respective structures. A method includes forming a field-effect transistor (FET) on a substrate in a FET region, forming a high-voltage FET (HVFET) on a dielectric stack over a over lightly-doped diffusion (LDD) drain in a HVFET region, and forming an NPN on the substrate in an NPN region.02-12-2015
20150041956ISOLATION SCHEME FOR BIPOLAR TRANSISTORS IN BICMOS TECHNOLOGY - Device structures and design structures for a bipolar junction transistor. The device structure includes a collector region in a substrate, a plurality of isolation structures extending into the substrate and comprised of an electrical insulator, and an isolation region in the substrate. The isolation structures have a length and are arranged with a pitch transverse to the length such that each adjacent pair of the isolation structures is separated by a respective section of the substrate. The isolation region is laterally separated from at least one of the isolation structures by a first portion of the collector region. The isolation region laterally separates a second portion of the collector region from the first portion of the collector region. The device structure further includes an intrinsic base on the second portion of the collector region and an emitter on the intrinsic base. The emitter has a length transversely oriented relative to the length of the isolation structures.02-12-2015
20150048478TRENCH ISOLATION FOR BIPOLAR JUNCTION TRANSISTORS IN BICMOS TECHNOLOGY - Device structures and design structures for a bipolar junction transistor. A first isolation structure is formed in a substrate to define a boundary for a device region. A collector is formed in the device region, and a second isolation structure is formed in the device region. The second isolation structure defines a boundary for the collector. The second isolation structure is laterally positioned relative to the first isolation structure to define a section of the device region between the first and second isolation structures.02-19-2015
20150054123SELF-ALIGNED EMITTER-BASE REGION - Aspects of the invention provide a method of forming a bipolar junction transistor. The method includes: providing a semiconductor substrate including a uniform silicon nitride layer over an emitter pedestal, and a base layer below the emitter pedestal; applying a photomask at a first end and a second end of a base region; and performing a silicon nitride etch with the photomask to simultaneously form silicon nitride spacers adjacent to the emitter pedestal and exposing the base region of the bipolar junction transistor. The silicon nitride etch may be an end-pointed etch.02-26-2015
20150056777DEVICE ISOLATION WITH IMPROVED THERMAL CONDUCTIVITY - A method of making a semiconductor structure includes forming a trench through a shallow trench isolation (STI) structure and into a substrate, and forming a liner including an electrical insulator material on sidewalls of the trench. The method also includes forming a core including a high thermal conductivity material in the trench and on the liner, and forming a cap in the trench and on the core.02-26-2015
20150069571HEAT DISSIPATION THROUGH DEVICE ISOLATION - According to a structure herein, a silicon substrate has an active device in the silicon substrate. A dielectric film is on the active device. An isolation trench is in the dielectric film surrounding the active device. The trench extends through the dielectric film and at least partially into the silicon substrate. A core is in the isolation trench. The core comprises material having thermal conductivity greater than silicon dioxide and electrical conductivity approximately equal to silicon dioxide.03-12-2015
20150084128SEMICONDUCTOR-ON-INSULATOR (SOI) STRUCTURES WITH LOCAL HEAT DISSIPATER(S) AND METHODS - Disclosed are semiconductor-on-insulator (SOI) structures comprising an SOI device (e.g., an SOI metal oxide semiconductor field effect transistor (MOSFET)) with local heat dissipater(s). Each heat dissipater comprises an opening, which is adjacent an active region of the SOI device, which extends through the insulator layer on which the SOI device sits to the semiconductor substrate below, and which is at least partially filled with a fill material. This fill material is a thermal conductor so as to dissipate heat generated by the SOI device and is also an electrical isolator so as to minimize current leakage. In the case of MOSFET, the local heat dissipater(s) can be aligned below the source/drain extension(s) or the source/drain(s). Alternatively, the local heat dissipater(s) can be aligned below the channel or parallel and adjacent to opposing sides of the channel. Also disclosed herein are methods of forming these SOI structures.03-26-2015

Patent applications by Qizhi Liu, Lexington, MA US

Tongyao Liu, Lexington, MA US

Patent application numberDescriptionPublished
20130017997Factor VIII Compositions and Methods of Making and Using Same - The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.01-17-2013
20140370035METHODS OF REDUCING IMMUNOGENICITY AGAINST FACTOR VIII IN INDIVIDUALS UNDERGOING FACTOR VIII THERAPY - The present disclosure provides methods of administering chimeric and hybrid Factor VIII (FVIII) polypeptides comprising FVIII and Fc to subjects at risk of developing inhibitory FVIII immune responses, including anti-FVIII antibodies and/or cell-mediated immunity. The administration is sufficient to promote coagulation and to induce immune tolerance to FVIII. The chimeric polypeptide can comprise full-length FVIII or a FVIII polypeptide containing a deletion, e.g., a full or partial deletion of the B domain.12-18-2014
20150023959CHIMERIC FACTOR VIII POLYPEPTIDES AND USES THEREOF - The present invention provides a VWF fragment comprising the D′ domain and D3 domain of VWF, a chimeric protein comprising the VWF fragment and a heterologous moiety, or a chimeric protein comprising the VWF fragment and a FVIII protein and methods of using the same. A polypeptide chain comprising a VWF fragment of the invention binds to or is associated with a polypeptide chain comprising a FVIII protein and the polypeptide chain comprising the VWF fragment can prevent or inhibit binding of endogenous VWF to the FVIII protein. By preventing or inhibiting binding of endogenous VWF to the FVIII, which is a half-life limiting factor for FVIII, the VWF fragment can induce extension of half-life of the FVIII protein. The invention also includes nucleotides, vectors, host cells, methods of using the VWF fragment, or the chimeric proteins.01-22-2015
20150038421FACTOR VIII COMPOSITIONS AND METHODS OF MAKING AND USING SAME - The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.02-05-2015

Patent applications by Tongyao Liu, Lexington, MA US

Xiaocheng Jason Liu, Lexington, KY US

Patent application numberDescriptionPublished
20080237197SYSTEM AND METHOD FOR WELDING AND REAL TIME MONITORING OF SEAM WELDED PARTS - A welding system having welder with an electrode for creating a weld. The welding system may include a sensor for monitoring the weld. A method of monitoring a weld is also provided.10-02-2008

Yanming Liu, Lexington, MA US

Patent application numberDescriptionPublished
20090154924PASSIVE OPTICAL NETWORK WITH WAVELENGTH DIVISION MULTIPLEXING - In one embodiment, a passive optical network is provided that includes: an optical line terminal (OLT) configured to transmit a plurality of downstream signals into a corresponding plurality of passive optical networks and to receive a corresponding plurality of upstream signals from the plurality of passive optical networks, wherein each downstream signal is separated in wavelength from the remaining wavelength signals, and wherein each upstream signal is separated in wavelength from the remaining upstream signal; a Mux/Demux configured to multiplex the downstream signals from the OLT into a optical fiber and to demultiplex upstream signals from the optical fibers to the OLT; and a splitter configured to split the downstream signals from the OLT to a plurality of optical network units such that each optical network unit receives the plurality of downstream signals.06-18-2009

Yansheng Liu, Lexington, KY US

Patent application numberDescriptionPublished
20100180914CONDUCTOR CLEANING SYSTEM AND METHOD - A conductor cleaning system for cleaning aluminum strands of all aluminum and steel reinforced conductors, such as ACSS, ACSR, ACAR, and AAA. The conductor cleaning system having a container adapted to receive a portion of a conductor to be cleaned, a housing adapted to receive and support the container, and a cleaning solution contained in the container for cleaning the portion of the conductor. The cleaning solution being adapted to clean the conductor without reacting with or damaging the conductor.07-22-2010
20130255726CONDUCTOR CLEANING SYSTEM AND METHOD - A conductor cleaning system for cleaning aluminum strands of all aluminum and steel reinforced conductors, such as ACSS, ACSR, ACAR, and AAA. The conductor cleaning system having a container adapted to receive a portion of a conductor to be cleaned, a housing adapted to receive and support the container, and a cleaning solution contained in the container for cleaning the portion of the conductor. The cleaning solution being adapted to clean the conductor without reacting with or damaging the conductor.10-03-2013
20130255730CONDUCTOR CLEANING SYSTEM AND METHOD - A conductor cleaning system for cleaning aluminum strands of all aluminum and steel reinforced conductors, such as ACSS, ACSR, ACAR, and AAA. The conductor cleaning system having a container adapted to receive a portion of a conductor to be cleaned, a housing adapted to receive and support the container, and a cleaning solution contained in the container for cleaning the portion of the conductor. The cleaning solution being adapted to clean the conductor without reacting with or damaging the conductor.10-03-2013
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