| Patent application number | Description | Published |
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| 20080296234 | Controlled release of microbiocides - A container for releasing a microbiocide component into a liquid composition susceptible to unwanted microbial growth (LCMG) includes a LCMG-impermeable casing separate and apart from an internal combustion engine housing, and having a hollow interior and at least one opening. A microbiocide component, for example, at least one LCMG-soluble microbiocide, is located in the hollow interior. At least one LCMG-permeable element is provided at or near an opening in the casing and is effective to provide for release of microbiocide component into the LCMG. Methods of releasing microbiocide component into LCMGs are also provided. | 12-04-2008 |
| 20090294345 | Controlled release of microbiocides - A container for releasing a microbiocide component into a liquid composition susceptible to unwanted microbial growth (LCMG) includes a LCMG impermeable casing separate and apart from an internal combustion engine filter housing, and having a hollow interior and at least one opening. A microbiocide component, for example, at least one LCMG-soluble microbiocide, as the only active material located in the hollow interior. At least one liquid permeable element, for example, a membrane member, is provided at or near an opening in the casing and is effective to provide for release of microbiocide component into the LCMG. Methods of releasing microbiocide component into LCMGs are also provided. | 12-03-2009 |
| 20090294379 | Controlled release of additive compositions - A container for releasing an additive composition into a liquid composition includes a liquid impermeable casing separate and apart from an internal combustion engine filter housing, and having a hollow interior, and at least one opening and a further opening into the hollow interior. The container further includes a structure operatively coupled to the further opening and operable to allow air to pass out of the hollow interior through the further opening and to substantially prevent a liquid composition from passing out of the hollow interior through the further opening. An additive composition is located in the hollow interior. At least one liquid permeable element, for example, a membrane member, is provided at or near the least one opening in the casing and is effective to provide for release of additive composition into the liquid composition. Methods of releasing additive compositions into liquid compositions are also provided. | 12-03-2009 |
| 20090294725 | Controlled release cooling additive compositions - A controlled release additive composition for use in aqueous coolant systems is disclosed and comprises a core containing at least one additive component and a polymeric coating including one or more defined polymers substantially surrounding the core. The controlled released additive composition slowly releases the additive component into the aqueous coolant of an open, circulating cooling water system, thereby delivering an effective concentration level of the additive component over an extended period. | 12-03-2009 |
| 20090301968 | Devices and methods for controlled release of additive compositions - Containers for controlled release of an additive composition into a liquid composition include a liquid impermeable casing having a hollow interior, at least one opening and a membrane component secured to the casing. Methods of releasing additive compositions into liquid compositions are also provided. | 12-10-2009 |
| 20090304868 | Controlled release cooling additive composition - Controlled release potability additive compositions for use in potable water systems include a core containing at least one potability additive component and a polymeric coating. Controlled release systems for releasing potability additive components into potable water systems are also provided. Methods of using such compositions and systems to benefit potability of water in potable water systems, for example, drinking water systems, are disclosed. | 12-10-2009 |
| 20120291869 | Systems and Methods for Releasing Additive Compositions - Systems and methods for releasing additive components into liquid media are provided. The systems include a plurality of coated items and a container holding the coated items. The container includes an insoluble material and a plurality of through holes through the material. The material covers an area of the container greater than the combined area of the through holes. | 11-22-2012 |
| 20130255951 | Compositions, Systems and Methods for Releasing Additive Components - Compositions, systems and methods for the controlled and/or delayed release of chemical additive components into an aqueous fluid used in hydraulic fracturing of oil and/or gas wells. The chemical additive components may include a viscosity-reducing composition, an oxidizer composition, a pH modulating composition, a lubricant composition, a cross-linking composition, an anti-corrosion composition, an biocide composition, a crosslink-enhancing composition, and/or a combination of two or more of these compositions. Further embodiments include additives and methods of delivering a particle comprising an additive component to a desired site in an aqueous medium prior to release of the additive component into the aqueous medium. The coating is permeable, but insoluble in an aqueous medium, whereupon the additive components are released into the medium. | 10-03-2013 |
| 20140027384 | Apparatus and Methods for Controlled Release of Additive Compositions - Containers for controlled release of an additive composition into a liquid composition include a liquid impermeable casing having a hollow interior, at least one first opening, at least one second opening and at least one third opening, a liquid valve operable to allow a liquid composition to pass into the hollow interior across the liquid valve, an air valve operable to allow air to pass out of the hollow interior across the air valve and a membrane component secured to the casing. Methods of releasing additive compositions into liquid compositions are also provided. | 01-30-2014 |
| 20140271756 | Controlled Release of Microbiocides - A container for releasing a microbiocide component into a liquid composition susceptible to unwanted microbial growth (LCMG) includes a LCMG impermeable casing separate and apart from an internal combustion engine filter housing, and having a hollow interior and at least one opening. A microbiocide component, for example, at least one LCMG-soluble microbiocide, as the only active material located in the hollow interior. At least one liquid permeable element, for example, a membrane member, is provided at or near an opening in the casing and is effective to provide for release of microbiocide component into the LCMG. Methods of releasing microbiocide component into LCMGs are also provided. | 09-18-2014 |
| Patent application number | Description | Published |
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| 20090295532 | ELECTRICAL SWITCHING APPARATUS AND HEATER ASSEMBLY THEREFOR - A heater assembly is provided for an electrical switching apparatus. The heater assembly includes a heater element and an elongated bimetal. The heater element includes first and second ends, an intermediate portion disposed therebetween and an aperture disposed proximate the first end. The elongated bimetal includes opposing first and second ends, and is movable between first and second positions corresponding respectively to the separable contacts of the electrical switching apparatus being closeable, and to the first end of the elongated bimetal cooperating with a trip bar to cause an operating mechanism to open the separable contacts. The second end of the elongated bimetal is coupled to the intermediate portion of the heater element. When the elongated bimetal is disposed in the first position, the first end of the elongated bimetal extends beyond the upper surface of the first end of the heater element into the aperture of the heater element. | 12-03-2009 |
| 20110192822 | LIMITER INCLUDING A NUMBER OF GAS CHANNELS AND ELECTRICAL SWITCHING APPARATUS EMPLOYING THE SAME - A limiter includes a housing having a number of gas ports, a number of gas vents and a number of gas channels. Each of the number of gas channels is between a corresponding one of the number of gas ports and a corresponding one of the number of gas vents. The limiter also includes a number of first terminals, a number of second terminals, and a number of limiter devices. Each of the number of limiter devices is electrically connected between a corresponding one of the number of first terminals and a corresponding one of the number of second terminals. Each of the number of gas ports is structured to receive a corresponding ionized gas flow for passage through a corresponding one of the number of gas channels to the corresponding one of the number of gas vents. | 08-11-2011 |
| 20140263188 | ARC CHAMBER FOR BI-DIRECTIONAL DC - A circuit breaker including a pair of separable contacts and an arc chamber is provided. The separable contacts include a fixed contact having an upper surface. The arc chamber includes magnetic members disposed on either side of the separable contacts. The magnetic members have a lower surface below the fixed contact upper surface. | 09-18-2014 |
| Patent application number | Description | Published |
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| 20090136553 | TRIGGERABLY DISSOLVABLE HOLLOW FIBERS FOR CONTROLLED DELIVERY - Provided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded within a cell growth scaffold. The tubular structures are useful in growing 3-dimensional tissue structures because nutrients, cytokines or other cell growth and/or differentiation compounds, as well as drugs, such as antibiotics and steroids, can be administered over time, and the tubular structures can be dissolved non-invasively. | 05-28-2009 |
| 20120148676 | ARTIFICIAL CELL CONSTRUCTS FOR CELLULAR MANIPULATION - The present invention contemplates induction of immunological tolerance thereby providing permanent allogcaft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is thought to be mediated by regulatory T lymphocytes (T | 06-14-2012 |
| 20120172456 | ENGINEERED MICROPARTICLES FOR MACROMOLECULE DELIVERY - A method for making a modified release composition, comprising:
| 07-05-2012 |
| 20120214001 | METHODS TO PREPARE PATCHY MICROPARTICLES - A method for making microparticles having an exterior surface that includes preparing a self-assembled arrangement of microparticles; contacting the self-assembled microparticles with a patch-forming agent resulting in a microparticle/patch-forming agent assembly having proximal regions between adjacent microparticles and/or proximal regions between a microparticle and another substrate, wherein the patch-forming agent is present in the proximal region; and condensing the patch-forming agent such that a pattern of a plurality of discrete patches of patch-forming agent are formed on the exterior surfaces of the microparticles at the proximal regions. A synthetic microsphere having an exterior spherical surface, wherein the exterior spherical surface comprises a first material and a plurality of discrete, uniformly-dimensioned, patches of a second bioactive material arranged in an orderly array over more than one hemisphere of the microsphere. | 08-23-2012 |
| 20140142039 | Vasoactive lntestinal Peptide Release From Microparticles - Controlled release of VIP from PLGA microparticles was accomplished and varied through use of different polymer molecular sizes, addition of solutes to the inner aqueous phase, and use of our computer model. Released VIP from microparticles appeared to be bioactive and caused DCs to produce more CCL22 than DCs treated with blank particles at 7 and 24 hours. Additionally, DCs treated with VIP microparticle releasates recruited higher percentages of FoxP3+ T-cells in in vitro chemotaxis studies. Testing in a mouse model in vivo indicated that VIP microparticles have significant therapeutic potential to treat periodontal disease by reducing the bone loss in infected mice relative to the blank group. | 05-22-2014 |
| 20140356445 | Artificial Cell Constructs For Cellular Manipulation - The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is thought to be mediated by regulatory T lymphocytes (T | 12-04-2014 |
| 20150079026 | Controlled Release Formulations for the Induction and Proliferation of Blood Cells - The absence of regulatory T cells (Treg) may underlie disorders including but not limited to autoimmunity, dermatitis, periodontitis and even transplant rejection. Enhancing local numbers of Treg through in situ Treg expansion or induction is contemplated herein as a treatment option for these disorders. Current methods for in vivo Treg expansion are not Treg specific and are associated with many adverse side-effects. The data presented herein provides in vitro testing of a Treg-inducing microparticle providing a predictable controlled release for combinations of cytokines and drugs (e.g., IL-2, TGF-β, and/or rapamycin) resulting in targeted Treg migration. These controlled release microparticles are also capable of inducing FoxP3+ Treg in human cells in vitro suggesting that these compositions be developed into an in vivo Treg induction and expansion therapy. | 03-19-2015 |
| 20150265677 | RECRUITMENT OF MENSENCHYMAL CELLS USING CONTROLLED RELEASE SYSTEMS - The present invention provides microparticles that deliver in vivo predictable release profiles of at least one chemokine to create a biomimetic chemokine concentration gradient that induces the migration of multipotent stem cells to the anatomical site of the microparticles. Various release profiles are demonstrated that depend upon the relative concentration of alginate in the chemokine-loaded microparticle. Local administration and/or intraarticular injection of the microparticles are useful in conditions such as osteoarthritis. Targeted systemic delivery of the alginate chemokine microparticles to distant anatomical sites subjected to autoimmune disease symptomology can be performed by encapsulation within liposomes having targeting ligands. Consequently, upon the creation of the appropriate chemokine gradient, multipotent stem cells will migrate to the distant anatomical site where the liposomes are attached. | 09-24-2015 |
| 20150374633 | THERMORESPONSIVE HYDROGEL CONTAINING POLYMER MICROPARTICLES FOR NONINVASIVE OCULAR DRUG DELIVERY - A method for sustained delivery of an agent to an ocular organ in a subject, comprising topically delivering to the ocular surface a liquid thermoresponsive hydrogel comprising agent-loaded polymer microparticles, wherein the agent is sustainably released for a period of at least five days. | 12-31-2015 |
