Lisanti
Michael P. Lisanti, Philadelphia, PA US
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20090068258 | Caveolin-mimetic peptide for prevention and treatment of pulmonary hypertension and right ventricular hypertrophy - Methods are provided for preventing and treating pulmonary hypertension and right ventricular hypertrophy involving administering to a patient a caveolin peptide coupled to a cell permeating compound such as a cell permeating peptide. | 03-12-2009 |
20120039805 | Therapeutics And Methods For Treating Neoplastic Diseases Comprising Determining The Level Of Caveolin-1 And/Or Caveolin-2 In A Stromal Cell Sample - The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial; lymphomas, sarcomas, melanomas, and the like, comprising determining the level of caveolin-1 and/or caveolin-2 in stromal cells adjacent to a neoplasm. | 02-16-2012 |
20120190565 | Method Of Diagnosis Or Prognosis Of A Neoplasm Comprising Determining The Level Of Expression Of A Protein In Stromal Cells Adjacent To The Neoplasm - The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, EF-I-delta, or M2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm. | 07-26-2012 |
20130172430 | PROGNOSIS AND TREATMENT OF BREAST CANCER - Methods of prognosis and monitoring of breast cancer include determining the level of one or more of the markers comprising asymmetric dimethyl arginine (ADMA), beta-hydroxybutyrate (BHB) and microRNA-31 (miR-31) in patient samples. An increased level is correlated with poor prognosis. Breast cancer is treated by administration of one or more inhibitors of ADMA and/or BHB. | 07-04-2013 |
Michael P. Lisanti, Withington GB
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20140026234 | BIOMARKERS AND THEIR USES IN CANCER DETECTION AND THERAPY - Presented herein are novel protein biomarkers related to cancers with stromal components. These newly identified biomarkers create the basis for multiple (single) assays using traditional bioassay technologies and when used in combination yield exceptional clinical sensitivity and specificity in the determination of diagnosis and/or prognosis of cancer. A new genetic model able to identify potential genetic suppressors and/or potential therapeutic agents for treating stromal cancers is also described. Means and methods for evaluating data generated using multiple biomarkers in order to validate findings and further the use of the biomarkers and the genetic model system in clinical, diagnostic and therapeutic uses is also included. | 01-23-2014 |
20140221496 | Method of Diagnosis or Prognosis of a Neoplasm Comprising Determining the Level of Expression of a Protein in Stromal Cells Adjacent to the Neoplasm - The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, EF-I-delta, or M2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm. | 08-07-2014 |
20140322705 | Cancer diagnostic and cancer therapeutic - This invention relates to methods and kits for making a prognosis of disease course in a neoplastic disease patient by determining the level, expression and/or activity of a biomarker. | 10-30-2014 |
Michael P. Lisanti, Manchester GB
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20140378477 | MCT PROTEIN INHIBITOR-RELATED PROGNOSTIC AND THERAPEUTIC METHODS - This invention provides a method of identifying one or more subgroups of cancer patients that are likely to benefit from treatment with a monocarboxylate transporter (MCT) protein inhibitor comprising: (a) obtaining a sample of a cancer/tumor tissue from each of said cancer patients; (b) determining the expression level of stromal MCT4 protein in each of said samples of cancer/tumor tissue to obtain a first dataset; and (c) using the expression level of the stromal MCT4 protein from said first dataset to classify each of said sets of one or more cancer patients as stromal MCT4-positive or stromal MCT4-negative, wherein the cancer patients classified as stromal MCT4-positive are patients that are more likely to benefit from treatment with said MCT protein inhibitor. This invention also provides related methods for treating a cancer/tumor whose stromal component expresses the MCT4 protein in a patient. | 12-25-2014 |
20150240240 | MSF REPROGRAMS MYOFIBROBLASTS TOWARD LACTATE PRODUCTION AND FUEL ANAERBOIC TUMOR GROWTH - Presented herein is a method for treating a subject afflicted with a tumor comprising administering to the subject a therapeutically effective amount of an agent that inhibits the MSF/Cdc42/NFkB cascade in the subject's tumor-associated fibroblasts. | 08-27-2015 |
Michael P. Lisanti US
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20150240240 | MSF REPROGRAMS MYOFIBROBLASTS TOWARD LACTATE PRODUCTION AND FUEL ANAERBOIC TUMOR GROWTH - Presented herein is a method for treating a subject afflicted with a tumor comprising administering to the subject a therapeutically effective amount of an agent that inhibits the MSF/Cdc42/NFkB cascade in the subject's tumor-associated fibroblasts. | 08-27-2015 |
Michael P. Lisanti, Withington, Ot GB
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20160074389 | CAVEOLIN-1 RELATED METHODS FOR TREATING GLIOBLASTOMA WITH TEMOZOLOMIDE - This invention provides a method for treating a subject afflicted with glioblastoma multiforme comprising administering a therapeutically effective regimen of temoxolomide to be glioblastoma multiforme-afflicted subject, wherein the subject's glioblastoma multiforme cells are known to be caveolin-1-positive. This invention also provides a method for determining whether a subject afflicted with glioblastoma multiforme is likely to progress therapeutically in response to a therapeutically effective regimen of temoxolomide comprising determining whether the subject's glioblastoma multiforme cells are caveolin-1-positive, whereby if the subject's glioblastoma multiforme cells are caveolin-1-positive, the subject is likely to progress therapeutically in response to a therapeutically effective regimen of temozolomide. | 03-17-2016 |
Michele Lisanti, Pisa IT
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20140358152 | DRILLING MASK FOR IMPLANTING A TRANSPEDICULAR SCREW - A drilling mask for implanting a transpedicular screw on a spine section includes a guide body with a distal surface and a proximal surface, opposite to the distal surface and facing towards the spine section. The guide body includes a reference element obtained on the proximal surface and arranged to contact the spinous process, a guide channel that extends starting from the distal surface, which is arranged to work as drilling guide for drilling the pedicle and implanting the transpedicular screw, and a plurality of support elements made on the proximal surface, associated with the reference element, arranged to contact side parts of the spine section. The guide body also includes at least one reference portion. | 12-04-2014 |
Paolo Lisanti, Lallio IT
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20150336473 | System For Controlling The Machine Torque Of A Vehicle Having Two Drive Wheels Actuated By Distinct Motors - A system for the control of the machine torque of a vehicle ( | 11-26-2015 |
Paolo Lisanti, Lallio (bg) IT
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20150019062 | Pedal Assisted Bicycle And Method Of Controlling The Pedal Assisted Bicycle - A pedal assisted bicycle a first and a second wheel; a pedaling assembly mechanically decoupled from the first and second wheels by which an user can supply a pedaling power; an electric motor mechanically coupled to at least one of the wheels capable of taking a motor power; a generator device adapted to generate a generator device electric power from the pedaling power, arranged in an energy exchange relationship with the pedaling assembly and the electric motor; an energy storage device arranged in an energy exchange relationship with the electric motor and with the generator device; a control system including a module for controlling the power required to the generator device to be supplied to the electric motor and/or to the storage device; a heartbeat sensor adapted to generate a signal representing heartbeat. | 01-15-2015 |