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| 20090256125 | Winch - The present invention relates to a winch for elevating plant, in particular cranes, cable-operated excavators and similar construction machinery, comprising a hoisting drum, an electric motor for the drive of the hoisting drum which is received in the interior of the hoisting drum as well as power electronics and/or control electronics for the electric motor comprising at least one frequency inverter and/or frequency converter. In accordance with the invention, the power electronics and/or control electronics for the electric motor are received at least partly in the interior of the hoisting drum. Not only short cabling distances are hereby achieved; interference emissions with negative effects on the electromagnetic compatibility are avoided; and voltage overshoots impairing the service life of the inverter and the motor are reduced, but also a particularly compact construction of the winch is achieved. | 10-15-2009 |
| 20090267426 | Liquid-cooled electric machine and method for cooling such electric machine - The present invention relates to an electric machine with a machine housing, in which a rotor and a stator winding are accommodated, wherein the stator winding includes winding heads arranged on opposite sides each in a winding head space, and with a cooling device which includes a liquid cooling circuit with a stator jacket cooling and cooling coils as well as a fan connected with the rotor for circulating air in the machine housing. The invention furthermore relates to a method for cooling such electric machine. In accordance with the invention it is provided that the cooling coils extend through the winding head spaces outside the winding heads and the fan includes two fan wheels each associated to a winding head space for generating an air flow circulating inside each winding head space, which by means of air duct and/or guiding means in the respective winding head space is circulatingly passed over the exposed cooling coils and through the winding heads. By cooling down the circulating internal air directly in or at the winding head space, a highly efficient cooling of the winding head space can be achieved, without having to sacrifice a compact construction. | 10-29-2009 |
| 20110248110 | Self-Propelled Surface Milling Machine with Electrical Mill Roll Drive - The present invention relates to a self-propelled surface milling machine, preferably in the form of an asphalt-milling machine, snow-milling machine or Surface Miner, having a mill roll which is drivable about a rotational axis, and a mill roll drive comprising an electrical motor which is accommodated within the mill roll, wherein stator and rotor of the electrical motor are accommodated within a dust and air-tightly sealed motor housing. It will be suggested to associate a cooling device comprising a closed circuit liquid cooling system to the electrical motor located within the milling roll body. Due to the high heat capacity of a suitable coolant, such as oil or mixed water and glycol small volume flows and hence small conduit cross sections will be sufficient. On the other hand, any incorporation of dust into the mill-roll drive as well as any formation of dust by discharge air can be avoided by the closed form of the circuit liquid cooling system. | 10-13-2011 |
| 20110248654 | Self-Propelled Working Machine with Electrical Drive System and Processes for Operating the Same - The present invention relates to a self-propelled working machine, especially in the form of a surface milling machine, such as asphalt-milling machine or snow-milling machine comprising a main operating unit and/or a drive unit, which is operable in a steady-state or near steady-state operating status and is drivable by a drive device comprising at least an electrical motor, the electrical motor being associated with a start-up including a frequency converter for the limitation of starting current. The invention also relates to a process for operating such a self-propelled working machine. According to the invention an operating circuit for steady-state operation is provided, comprising a jumper for bridging the frequency converter following starting or reaching steady-state operational status. Optionally, the jumper is switchable to activate or inactivate the frequency converter of the start-up circuit, respectively. | 10-13-2011 |
| 20120097462 | Electric Tracklaying Gear and Use Thereof for a Self-Propelled Working Machine - The present invention relates to an electric tracklaying gear and the use thereof for a self-propelled working machine, preferably for a construction or earth-moving machine or a surface mining machine such as Surface Miner, which includes an endlessly circulating track chain which can be driven by a crawler drive that is arranged inside the path of circulation of the track chain. It is proposed to associate a cooling device with a closed fluid cooling circuit to the electric motor of the crawler drive arranged in the interior of the path of circulation of the track chain. Due to the high thermal capacity of a suitable cooling fluid such as oil or water-glycol mixture small volumetric flow rates in the fluid cooling circuit and hence small conduit cross-sections are sufficient. On the other hand, due to the closed formation of the fluid cooling circuit any dust input into the crawler drive and also any generation of dust by exhaust air can be avoided. | 04-26-2012 |
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| 20090197271 | FUNCTIONAL NUCLEIC ACID LIGANDS TO FLUORESCENT PROTEINS - The present invention relates to a nucleic acid aptamer having a first domain that binds to a fluorescent protein. The nucleic acid aptamer forms a molecular complex whereby the aptamer binds a fluorescent protein at the first domain. A constructed DNA molecule, expression systems, and host cells containing the molecular complex are also disclosed. The invention also relates to a system containing a first DNA molecule encoding the nucleic acid aptamer of the present invention and a second DNA molecule encoding a fluorescent protein capable of being bound by the first domain. Methods of detecting a molecular target and determining location of a molecular target using the nucleic acid aptamer of the invention are also disclosed. | 08-06-2009 |
| 20100062946 | GENOME-WIDE METHOD FOR MAPPING OF ENGAGED RNA POLYMERASES QUANTITATIVELY AND AT HIGH RESOLUTION - A method is provided for detecting genome-wide transcriptionally-engaged RNA polymerases. The method can also be used to assess status and regulation of gene promoters. The method comprises permeabilizing a cell of interest or isolating the nucleus from a cell of interest; performing a nuclear run-on (NRO) reaction with the permeabilized cell or isolated nucleus, wherein a purifiable nucleotide analog is added to the NRO reaction; optimizing the number of bases traveled by engaged polymerases for high resolution and low bias for nucleotide content of transcribed sequences by limiting a second nucleotide concentration or duration of the NRO reaction; isolating NRO-RNA from the NRO reaction; hydrolyzing the NRO-RNA isolated from the NRO reaction to optimize resolution of polymerase location; selecting hydrolyzed NRO-RNA with a solid support to obtain an enriched, purified fraction of the hydrolyzed NRO-RNA; enzymatically repairing the hydrolyzed NRO-RNA; and ligating the hydrolyzed NRO-RNA to compatible adapter oligos. | 03-11-2010 |
| 20100099749 | Nucleic Acid Inhibitors Of Glutamate Receptors - The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors. | 04-22-2010 |
| 20120028811 | DEVICE FOR RAPID IDENTIFICATION OF NUCLEIC ACIDS FOR BINDING TO SPECIFIC CHEMICAL TARGETS - The present invention relates to microfluidic chips and their use in SELEX. The microfluidic chip preferably includes a reaction chamber that contains a high surface area material that contains target. One preferred high surface area material is a sol-gel derived material. Methods of making the microfluidic chips are described herein, as are uses of these devices to select aptamers against the target. | 02-02-2012 |
| 20120225929 | Nucleic Acid Inhibitors Of Glutamate Receptors - The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors. | 09-06-2012 |
| 20140371080 | HIGH-THROUGHPUT RNA INTERACTION ASSAY - The present invention is directed to a method for detecting an interaction between a ribonucleic acid (RNA) molecule and a second molecule. This method involves providing a nucleic acid construct that contains a promoter sequence, a nucleotide sequence encoding the RNA molecule, and an RNA polymerase blocking site. The nucleotide sequence encoding the RNA molecule is transcribed in vitro to produce an RNA transcript corresponding to the RNA molecule. Transcription is halted by the RNA polymerase blocking site under conditions effective for the RNA transcript to remain tethered to the nucleic acid construct. The tethered RNA transcript is contacted with the second molecule and any interaction between the tethered RNA transcript and the second molecule is detecting and identified based on said contacting. | 12-18-2014 |
| 20150204859 | MULTIPLEXED MICROCOLUMN DEVICES AND PROCESSES FOR SELECTION OF NUCLEIC ACID APTAMERS - The present invention relates to a microcolumn device for selecting nucleic acid aptamers for single and multiple target molecules, as well as a method for making the microcolumn device. The present invention also relates to a system for selecting nucleic acid aptamers for single and multiple target molecules. The present invention further relates to methods of using the microcolumn device for selecting nucleic acid aptamers for multiple target molecules. Kits that include one or more microcolumn device and/or system of the present invention are also disclosed. | 07-23-2015 |
| 20150291952 | RNA APTAMER ISOLATION VIA DUAL-CYCLE (RAPID) SELECTION - The present invention relates to a method for selecting an aptamer for a target molecule. The method involves providing a random oligonucleotide library comprising a plurality of unique random sequence oligonucleotides; providing a target mixture comprising at least one target molecule; and subjecting the random oligonucleotide library and the target mixture to at least one round of an aptamer isolation protocol to yield at least one aptamer for the target molecule, wherein a round of the aptamer isolation protocol comprises at least one selection cycle followed by an amplification cycle. The present invention also relates to systems and devices for implementing or performing the method of the present invention. The present invention further relates to using the method to isolate aptamers for high-throughput sequencing analysis and other aptamer analysis protocols. | 10-15-2015 |
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| 20080226811 | Textured Pea Proteins - The invention relates to granulated pea protein composition characterised in that the protein content expressed in terms of a dry substance ranges from 70 to 95% by dry weight, preferably from 70 to 90% by dry weight, more preferably from 80 to 85% by dry weight, a mean diameter ranges from 150 to 300 μm, a compressibility value determined by the HOSOKAWA method ranges from 5 to 15%, preferably from 8 to 13% and a tamped density determined by the HOSOKAWA method ranges from 0.450 and 0.650 g/ml, preferably from 0.550 and 0.650 g/ml. The method for producing said granulated pea protein composition, the use thereof in the form of a raw material for producing textured pea proteins and the thus obtainable textured pea proteins are also disclosed. | 09-18-2008 |
| 20090163700 | GRANULATED MALTITOL FOR DIRECT COMPRESSION AND METHOD OF PREPARATION THEREOF - The invention relates to a granulated maltitol of concentration greater than or equal to 97%, preferably between 98 and 99%, characterized in that it has a water content less than 1%, preferably less than 0.5%, more preferably less than or equal to 0.4%, a compressibility greater than or equal to 300 N, preferably between 300 and 500 N, and a hygroscopicity less than or equal to 2.5%, preferably between 0.15 and 2.5%. | 06-25-2009 |
| 20090324794 | GRANULATED SORBITOL AND PROCESS FOR ITS PREPARATION - The present invention relates to a granulated sorbitol of essentially γ crystalline form and having a high sorbitol content, characterized in that it has a specific surface area, determined according to the BET method, of greater than or equal to 2 m | 12-31-2009 |
| 20110027355 | HIGH-FLUIDITY AND NON-CAKING PULVERULENT CRYSTALLINE MALTITOL COMPOSITION - A pulverulent crystalline maltitol composition, is characterized in that it has a laser volume mean diameter between 10 and 150 μm; in that it has a maltitol content between 80 and 99.9% by weight; in that at least 50% by weight of its particles flow through a sieve having a cut-off threshold of 2000 μm according to a test A1; in that at least 35% by weight of its particles flow through a sieve having a cut-off threshold of 2000 μm according to a test A2; and in that it includes from 0.1 to 20% by weight of at least one water-insoluble anti-caking agent, the anti-caking agent having a hygroscopicity, determined according to the test B, between 2.5 and 25%. This composition is not subject to caking, and finds applications in the food and pharmaceutical fields. | 02-03-2011 |
| 20120156496 | MANNITOL CRYSTAL POWDER HAVING A LOW FINE-PARTICLE CONTENT, AND METHOD FOR PRODUCING SAME - Disclosed is a powder composition of mannitol crystals, produced by: (i) the crystallization of mannitol in a solvent; followed by (ii) a step of separating the crystals from the resulting crystal suspension; (iii) a step of drying the crystals; and (iv) a selection step, the composition having a particle size distribution, as determined by laser particle sizing, of 72 to 99.9 vol % of particles having a particle size greater than 75 μm, of 0.1 to 60 vol % of particles larger than 250 μm, and a mean diameter of between 100 and 300 μm. Also described is a method for producing such a composition by a step of crystallizing a mannitol syrup followed by drying the mannitol crystals, a step of selecting particles, and a step of collecting a fraction of the powder composition including 72 to 99.9% of particles having a particle size greater than 75 μm. | 06-21-2012 |
| 20120164266 | PROCESS FOR THE TOTAL OR PARTIAL REPLACEMENT OF TALC IN CHEWING GUM - Disclosed is a method of production of chewing gum including a step of mixing the ingredients, a step of extrusion of the mixture, a step of dusting with a dusting powder, a rolling step and a forming-cutting step, wherein the dusting powder includes a pulverulent composition containing from 28% to 0.1%, preferably from 25% to 1% of particles of diameter below 75 μm and of hygroscopicity between 0.01 and 5%, the pulverulent composition including at least one polyol. Also disclosed is the chewing gum obtained by application of the method. | 06-28-2012 |
| 20120164267 | METHOD FOR OBTAINING CHEWING GUM, IN WHICH TALC IS REPLACED WITH AGGLOMERATES OF CRYSTALS - A chewing gum production method includes a step in which the ingredients are mixed together, a mixture-extrusion step, a dusting step using a dusting powder, a sheeting step and a shaping/cutting step. The dusting powder includes a powder composition of agglomerates of crystals, the powder composition including at least one polyol. The resulting chewing gum is also described. | 06-28-2012 |
| 20140106051 | MICROALGAL FLOUR GRANULES AND PROCESS FOR PREPARATION THEREOF - The present invention relates to microalgal flour granules, and optionally, lipid-rich microalgal flour. | 04-17-2014 |
| 20150272136 | MICROALGAL FLOUR GRANULES AND PROCESS FOR PREPARATION THEREOF - The present invention relates to microalgal flour granules, and optionally, lipid-rich microalgal flour. | 10-01-2015 |
| 20150313255 | METHOD FOR MANUFACTURING A CHEWING GUM WITH IMPROVED HARDNESS BY IMPLEMENTING AN ANTI-CAKING AGENT AND CHEWING GUM THEREBY OBTAINED - A method of using at least one anti-caking agent, preferably one with a specific surface area BET of at least 20 m | 11-05-2015 |
