Patent application number | Description | Published |
20120024399 | Electrospray Interface To A Microfluidic Substrate - A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate. | 02-02-2012 |
20120037724 | Electrospray Interface To A Microfluidic Substrate - An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal. | 02-16-2012 |
20120287746 | MANIFOLD FOR SOLVENT MIXING IN LIQUID CHROMATOGRAPHY SYSTEMS - Low-pressure mixing of fluids includes a pumping system having a pump and a fluidic inlet port through which fluid is introduced to the pump. A fluid proportioning system is in fluidic communication with the fluidic inlet port of the pumping system to deliver thereto a fluid stream comprised of multiple different fluids. The fluid proportioning system includes a manifold having a plurality of inlet ports, an outlet port connected by tubing to the fluidic inlet port of the pumping system, and an outlet conduit providing an internal fluidic passageway to the outlet port. Each inlet port is fluidically coupled to a fluid source to receive one of the different fluids and to the outlet conduit to deliver thereto the received fluid for delivery out of the manifold through the outlet port to the fluidic inlet port of the pumping system. | 11-15-2012 |
20130334117 | SYSTEM AND METHOD OF COOLING A PUMP HEAD USED IN CHROMATOGRAPHY - An actuator has a support plate, a pump head in thermally conductive contact with the support plate, and an actuator body. Cooling means is disposed between the support plate and the actuator body. The cooling means is configured to remove and transfer heat from the pump head to the actuator body. In one embodiment, the cooling means includes two thermally conductive plates (called cold-side and hot-side plates) and a thermoelectric device disposed in thermally conductive contact between the cold-side and hot-side plates. The cold-side plate is in thermal communication with the pump head through the support plate. The hot-side plate is in thermal communication with the actuator body. The thermoelectric device is configured to transfer heat from the cold-side plate, which is in thermal communication with the pump head, to the hot-side plate, which is in thermal communication with the actuator body, thereby removing heat from the pump head. | 12-19-2013 |
20140319042 | ELECTROSPRAY INTERFACE TO A MICROFLUIDIC SUBSTRATE - An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal. | 10-30-2014 |
20150290644 | Electromechanical and Fluidic Interface To A Microfluidic Substrate - A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate. | 10-15-2015 |