Limanto
John Limanto, Rahway, NJ US
Patent application number | Description | Published |
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20090131465 | Synthesis and crystalline forms of melanocortin-4 receptor agonist - The present invention relates to a process for producing crystalline N-[1-((3R)-1′-{[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-yl]carbonyl}-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)-1-methylethyl]acetamide, and novel salts, solvates, hydrates and polymorphs thereof. | 05-21-2009 |
20100228036 | PROCESS FOR MAKING GLUCOCORTICOID RECEPTOR LIGANDS - The invention encompasses a process for making 2-[1-phenyl-5-hydroxy-4alpha-methyl-hexahydrocyclopenta[f]indazol-5-yl]ethyl phenyl derivatives, which are glucocorticoid receptor ligands, useful for the treatment of inflammatory and immunological diseases. | 09-09-2010 |
20120190085 | Transaminase Reactions - The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones. | 07-26-2012 |
20130149751 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS - The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates. | 06-13-2013 |
20150259284 | PROCESS FOR PREPARING AMINOCYCLOHEXYL ETHER COMPOUNDS - The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: | 09-17-2015 |
John Limanto, New Brunswick, NJ US
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20090203922 | Process for Synthesizing 2-Phenyl-1H-Phenanthro[9,10-d]Imidazole Derivative - The present invention describes an efficient and economical process for the preparation of a 2,3-disubstituted 2-phenyl-1h-phenantrho[9,10-d]imidazole derivative that is useful for the large scale production of material for preclinical and clinical use. The process of the present invention represents a convergent approach to generate the 2,3-disubstituted 2-phenyl-1h-phenantrho[9,10-d]imidazole derivative in high overall yield. The compound made by the process of the invention is an inhibitor of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and is therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. | 08-13-2009 |
John Limanto, Metuchen, NJ US
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20130164794 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF (1R,2R)-2-(3,4-DIMETHOXYPHENETHOXY)CYCLOHEXAMINE - The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker. | 06-27-2013 |
20150079640 | TRANSAMINASE REACTIONS - The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones. | 03-19-2015 |
John Limanto US
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20150299167 | Regioselective N-2 Arylation of Indazoles - A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: | 10-22-2015 |
John Limanto, Jersey City, NJ US
Patent application number | Description | Published |
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20150299167 | Regioselective N-2 Arylation of Indazoles - A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: | 10-22-2015 |