Patent application number | Description | Published |
20120099398 | REMOTE FLOODED MEMBER DETECTION - Utilizing a sonar system to determine if a structural member of an underwater support structure that is supposed to be filled with air is instead flooded with water. The determination that a supposedly air filled structural member is instead flooded with water provides an indication that the structural member is cracked or damaged, making it easier to find damaged members and effect suitable repair. The sonar system is located a distance from the structural member so that it is spaced from the structural member. | 04-26-2012 |
20120099399 | SONAR DATA COLLECTION SYSTEM - A system that can be used for inspecting underwater structures. The system allows a user to gain a better understanding of the condition of an underwater structure. The system is a self-contained, modular system that can be operated by divers, coupled to an AUV, ROV or other host platform vehicle deployment platform, towed by a ship, pole mounted, or hull mounted. All of the components necessary to achieve the desired scanning functions are incorporated onto the self-contained, modular system. The system can include and fully utilize a 3D sonar system and an inertial navigation system. This combination of features permits the system to be used to, for example, generate 3D models of underwater structures, detect changes in underwater structures by comparing the generated 3D model against an a priori 3D model, and provide navigational updates to the host platform based on the observed features of an underwater structure. | 04-26-2012 |
Patent application number | Description | Published |
20080254140 | Combination Methods and Therapies for Treating Opthalmic Conditions with 13-Cis-Retinyl Derivatives - Described herein are combination methods, compositions and therapies for treating ophthalmic conditions or diseases arising from, associated with or leading to the overproduction of waste products in the visual cycle. Agents included within these combinations are 13-cis-retinyl derivatives; other agents included within these combinations are selected from vitamins, antioxidants, minerals, inducers of nitric oxide production, anti-inflammatory agents, and negatively-charged phospholipids. Such combination methods may be used as single or multiple administration therapies, or in combination with other agents or therapies. | 10-16-2008 |
20110294891 | METHODS AND COMPOSITIONS FOR TREATING OPTHALMIC CONDITIONS WITH RETINOL DERIVATIVES - Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies. | 12-01-2011 |
20120202885 | METHODS, ASSAYS AND COMPOSITIONS FOR TREATING RETINOL-RELATED DISEASES - Described herein are methods and compositions for treating certain retinol-related diseases and conditions by modulation of transthyretin (TTR) and retinol binding protein (RBP) availability in the subject. For example, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-related macular degeneration and/or dystrophies, metabolic disorders, idiopathic intracranial hypertension, hyperostosis, and protein misfolding and aggregation diseases. The compositions disclosed may be used as single agent therapy or in combination with other agents or therapies. In addition, described herein are methods and assays for selecting appropriate agents that can modulate the TTR and RBP availability in a subject. | 08-09-2012 |
20120288568 | METHODS AND COMPOSITIONS FOR TREATING OPHTHALMIC CONDITIONS VIA SERUM RETINOL, SERUM RETINOL BINDING PROTEIN (RBP), AND/OR SERUM RETINOL-RBP MODULATION - Compounds that reduce serum retinol, serum RBP, and/or serum retinol-RBP levels may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies. | 11-15-2012 |
20120309835 | METHODS, ASSAYS AND COMPOSITIONS FOR TREATING RETINOL-RELATED DISEASES - Described herein are methods and compositions for treating certain retinol-related diseases and conditions by modulation of transthyretin (TTR) and retinol binding protein (RBP) availability in the subject. For example, the methods and compositions provide for therapeutic agents for the treatment and/or prevention of age-related macular degeneration and/or dystrophies, metabolic disorders, idiopathic intracranial hypertension, hyperostosis, and protein misfolding and aggregation diseases. The compositions disclosed may be used as single agent therapy or in combination with other agents or therapies. In addition, described herein are methods and assays for selecting appropriate agents that can modulate the TTR and RBP availability in a subject. | 12-06-2012 |
20130116210 | CONTROLLED RELEASE ANTIMICROBIAL COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS - Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s). | 05-09-2013 |
Patent application number | Description | Published |
20110270437 | PERFORMANCE VENUE WITH DYNAMIC MECHANICAL LOAD MANAGEMENT SYSTEM AND METHOD - A performance venue having a dynamic load management system for use in managing loads. The system uses a dead man circuit as a means for determining the actual or anticipated dynamic load produced by moving loads, and then disables the system by opening the dead man circuit when too many loads are moved or selected to be moved. Preferably, the invention is embodied in a dead man circuit is pure hardware, and is free of software components. The invention also provides a method of controlling movement of loads in a performance venue having a plurality machines. In its basic form, the method comprises selecting at least one of the machines for movement, closing a dead man circuit, and opening the dead man circuit if the current in the dead man circuit falls outside a predetermined range. | 11-03-2011 |
20130015315 | LIFT ASSEMBLY SYSTEMS AND METHODS - A lift assembly comprising an article to be raised and lowered, a cable coupled to the article and defining a longitudinal axis, a power mechanism coupled to the drive element, a drum powered by the power mechanism, a cable keeper biasing the drive element toward the drum, a keeper shaft providing lateral movement of the cable keeper, and an encoder mounted for rotation with the keeper shaft. The encoder provides information regarding the position of the article. The lift assembly can also include a load cell assembly including a load cell housing, a load cell member contacting the drive element and movable relative to the load cell housing, and a load cell sensor coupled to the load cell member and operative to provide an output corresponding with a load on the drive element. The load cell member can be mounted for movement laterally relative to the longitudinal axis. | 01-17-2013 |
Patent application number | Description | Published |
20090203587 | Diagnosis and Therapy of Cell Proliferative Disorders Characterized by Resistance to Trail Induced Apoptosis - Described are methods and compounds for diagnosis and therapy of subsets of cell proliferative disorders which are characterized by resistance to TRAIL induced apoptosis. Examples of such diseases are B-cell chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and prostate cancer. Furthermore, methods for identifying drugs which are suitable for treatment of such diseases are described. | 08-13-2009 |
20130072397 | METHODS FOR THE DIAGNOSIS AND PROGNOSIS OF A TUMOR USING BCAT1 PROTEIN - The present invention relates to methods for the diagnosis of a tumor, in particular a brain tumor, and for the estimation of a prognosis for patients afflicted with such tumor based on the determination of expression of BCAT1 in a patient sample. | 03-21-2013 |
20130310545 | Inhibitors of Branched-Chain-Aminotransferase-1 (BCAT1) for the Treatment of Brain Tumors - Described is a compound capable of reducing or inhibiting (a) the biological activity of branched-chain-aminotranferase-1 (BCAT1) or (b) the expression of the gene encoding BCAT1 for use in a method of treating a neoplasia. A preferred compound is 1-(aminomethyl) cyclohexaneacetic acid (gabapentin). | 11-21-2013 |
20140309292 | Mutations of Histone Proteins Associated with Proliferative Disorders - The present application shows the relationship between variations in the amino acid sequence of histone proteins, more specifically the H3.3 protein, and proliferation-associated disorders. Herewith provided are predictive methods, commercial packages, therapeutic methods and screening methods based on this relationship. | 10-16-2014 |