Patent application number | Description | Published |
20090146104 | ALIGNMENT FACILITIES FOR OPTICAL DYES - Various non-limiting embodiments disclosed herein provide phase-separating polymer systems including a cured polymeric liquid crystal matrix phase and a guest phase including at least one photoactive material where the guest phase separates from the matrix phase during the curing process. Optical elements, including ophthalmic elements and other articles of manufacture including the phase-separating polymer systems are also disclosed. Methods of forming a liquid crystal phase-separating photoactive polymer system are also described. | 06-11-2009 |
20100014010 | FORMULATIONS COMPRISING MESOGEN CONTAINING COMPOUNDS - Compounds including at least one mesogenic substructure and at least one long flexible segment and methods of synthesizing the same are disclosed. Formulations which include various embodiments of the mesogen containing compounds and their use in articles of manufacture and ophthalmic devices are also disclosed. | 01-21-2010 |
20110128457 | ALIGNMENT FACILITIES FOR OPTICAL DYES - Provided are phase-separating polymer systems including a cured polymeric liquid crystal matrix phase and a guest phase including at least one photoactive material where the guest phase separates from the matrix phase during the curing process. Optical elements, including ophthalmic elements and other articles of manufacture including the phase-separating polymer systems are also disclosed. Methods of forming a liquid crystal phase-separating photoactive polymer system are also described. | 06-02-2011 |
20110279883 | POLARIZING PHOTOCHROMIC ARTICLES - Provided are photochromic articles that include a substrate, a primer layer that includes a first photochromic compound, and a photochromic-dichroic layer over the primer layer that includes a photochromic-dichroic compound. The first photochromic compound and the photochromic-dichroic compound each are selected such that the photochromic-dichroic compound has an absorbance of less than or equal to 0.1 at the wavelength of peak absorbance of the underlying first photochromic compound. The present invention also relates to such photochromic articles that further include a topcoat layer over the photochromic-dichroic layer. The topcoat layer can include a second photochromic compound that has an absorbance of less than 0.1 at the wavelength of peak absorbance of the underlying photochromic-dichroic compound. The photochromic articles provide, for example, a combination of linear polarizing properties, and reduced percent transmittance when in a colored or darkened state, such as when exposed to actinic light. | 11-17-2011 |
20120002141 | MESOGENIC STABILIZERS - The present invention relates to compounds represented by the following Formula Ia, | 01-05-2012 |
20120003401 | MESOGENIC STABILIZERS - The present invention relates to compounds represented by the following Formula I, | 01-05-2012 |
20120021144 | MESOGENIC STABILIZERS - The present invention relates to compounds represented by the following Formula I, | 01-26-2012 |
20120027960 | MESOGENIC STABILIZERS - The present invention relates to compounds represented by the following Formula Ic, | 02-02-2012 |
20120120473 | POLARIZING PHOTOCHROMIC ARTICLES - Provided are photochromic articles including a substrate, a primer layer that includes a first photochromic compound, and a photochromic-dichroic layer over the primer layer that includes a photochromic-dichroic compound. The first photochromic compound and the photochromic-dichroic compound each are selected such that the photochromic-dichroic compound has an unactivated state terminal minimum absorbance wavelength that is less than or equal to the unactivated state terminal minimum absorbance of the underlying first photochromic compound. The present invention also relates to such photochromic articles that further include a topcoat layer over the photochromic-dichroic layer, the topcoat layer including a second photochromic compound that has an unactivated state terminal minimum absorbance wavelength that is less than the unactivated state terminal minimum absorbance wavelength of the underlying photochromic-dichroic compound. | 05-17-2012 |
Patent application number | Description | Published |
20100305230 | HYBRID POLYMER MATERIALS FOR LIQUID CRYSTAL ALIGNMENT LAYERS - The present invention provides novel hybrid polymer useful for alignment layers for inducing alignment of a liquid crystal medium. Hybrid polymers of this invention are prepared from a) at least one component selected from the group consisting of oligomer(s) and polymer(s) within the class of polyimides, poly(amic acids) and esters thereof wherein the at least one component comprises at least one initiator generating moiety, and b) at least one component selected from the group consisting of addition monomer(s) and addition polymer(s), wherein the two components are covalently bonded to form a copolymer. The invention further describes liquid crystal elements such as all liquid crystal display products or modes, liquid crystal devices and liquid crystal optical films comprising the novel hybrid polymer alignment layers. | 12-02-2010 |
20120228157 | PROTECTION AND SURFACE MODIFICATION OF CARBON NANOSTRUCTURES - Nanostructures comprising carbon and metal catalyst that are formed on a substrate, such as a silicon substrate, are contacted with a composition that, among other useful modifications, protects the nano structures and renders them stable in the presence of oxidizing agents in an aqueous environment. The protected nano structures are rendered stable over an extended period of time and thereby remain useful during such period as components of an electrode, for example, for detecting electrochemical species such as free chlorine, total chlorine, or both in water. | 09-13-2012 |
20140291168 | MULTIPLE POTENTIAL BASED CHRONOAMPEROMETRIC FREE CHLORINE SENSORS - A chronoamperometric method and device to determine concentration of an electrochemically active species in a fluid and pH of the fluid. A plurality of sets of calibration relationships may be determined for a sensor in an aqueous solution, the sensor having one or more working electrodes and one or more reference electrodes. A first plurality of potentials may be applied across the working and reference electrodes of the sensor in solution, and a first plurality of currents and current differences obtained as a function of the applied first plurality of potentials. Concentration of an electrochemically active species may then be determined as a function of the obtained first plurality of currents and current differences using the plural sets of calibration relationships, and pH of the solution may be determined as a function of the obtained first plurality of currents and current differences using the plural sets of calibration relationships. | 10-02-2014 |
20140326600 | CARBON NANOSTRUCTURE ELECTROCHEMICAL SENSOR AND METHOD - Carbon nanostructures may be protected and functionalized using a layer-by-layer method whereby functional groups on the carbon nanostructure surface may be further derivatized to incorporate additional functional moieties. Carbon nanostructures functionalized using such a layer-by-layer method may be used to disperse, sort, separate and purify carbon nanostructures and may be used as sensing elements such as voltammetric, amperometric, and potentiometric pH sensors or as biometric sensing elements and electrodes and intracorporeal sensors and electrodes. | 11-06-2014 |
20140330100 | CARBON NANOSTRUCTURE ELECTROCHEMICAL SENSOR AND METHOD - Carbon nanostructures may be protected and functionalized using a layer-by-layer method whereby functional groups on the carbon nanostructure surface may be further derivatized to incorporate additional functional moieties. Exemplary moieties include redox mediator molecules, crown ethers, catalysts, boric acids, carbohydrates, oligonucleotides, DNA or RNA aptamers, peptide aptamers, proteins such as enzymes and antibodies, quantum dots and nanoparticles, cells, cell organelles, or other cellular components. The density of functional groups or functional moieties on carbon nanostructure surfaces may also be controlled as well as the degree of surface hydrophilicity of the nanostructure. Carbon nanostructures functionalized using such a layer-by-layer method may be used to disperse, sort, separate and purify carbon nanostructures and may be used as sensing elements such as voltammetric, amperometric, and potentiometric pH sensors or as biometric sensing elements and electrodes and intracorporeal sensors and electrode. | 11-06-2014 |
Patent application number | Description | Published |
20090254667 | METHOD FOR ELIMINATING REDUNDANT CONNECTIONS - A method and system for eliminating redundant connections, including transmitting a request to merge two connections, terminating a first portion of a first connection, terminating a first portion of a second connection, and merging a second portion of each of the first and second connections, are described. A method and system for merging connections, including receiving a request to merge two connections, terminating a first portion of a first connection, terminating a first portion of a second connection, and merging a second portion of each of the first and second connections. | 10-08-2009 |
20090327842 | RECOVERY FROM BURST PACKET LOSS IN INTERNET PROTOCOL BASED WIRELESS NETWORKS USING STAGGERCASTING AND CROSS-PACKET FORWARD ERROR CORRECTION - A method and system for transmitting data are described including packetizing the data, performing forward error correction (FEC) encoding on the packetized data in order to generate a parity packet, appending FEC information as padding to the end of payload data of the packetized data and transmitting the packetized data and the at least one parity packet. Also described are a method and system for recovering from loss of a packet including receiving a data packet, receiving a parity packet, buffering the received data packet, detecting packet loss, forward error correction decoding the parity packet to recover from packet loss using forward error correction information extracted from the data packet and from the parity packet and forwarding the recovered packet via an internal socket. Also described is a method for staggercasting. | 12-31-2009 |
20100091669 | METHOD TO SELECT ACCESS POINT AND RELAY NODE IN MULTI-HOP WIRELESS NETWORKING - A method and apparatus are described for selecting an access point in a wireless network, including initializing a channel index, recording a received signal power and information contained in one of a beacon message and a probe request response message, calculating an access link metric for each candidate access point, the access link metric being between an end device and each candidate access point on the channel indexed by the channel index responsive to the received signal power and information receiving a path metric between each candidate access point and a gateway, estimating a function using the access link metric and the path metric, selecting one of the candidate access points based on the function and establishing a connection with the selected access point. Also described is a method and apparatus for maintaining a connection with an access point. | 04-15-2010 |
20110013511 | End-to-end pattern classification based congestion detection using SVM - Because packets dropped due to network congestion cannot reach the intended receiver whereas corrupted packets can still be received, the reception status of multiple packets is different for congested and non-congested paths. This difference reflects a spatial variation in the received data stream that is indicative of congestion. Network congestion detection is described that treats the reception status of sequences of multiple packets as patterns and converts the problem of congestion detection into a two-class pattern classification problem. A Support Vector Machine (SVM) classifier is trained to classify the reception status of sequences of packets as being indicative or not of network congestion. If network congestion is detected, congestion control measures can then be taken. Extensive simulations demonstrate high detection accuracy under different network parameters. | 01-20-2011 |
20120023158 | METHOD FOR SECURE TRANSFER OF MULTIPLE SMALL MESSAGES - A method and system for securely transferring a multiplicity of short messages using an unsecure connection begins by loading a secure domain component on a client device using a secure connection and then loading an unsecure domain component on the client device. Encrypted messages are sent from an unsecure server to the unsecure domain component. The client device transfers the received encrypted message from the unsecure domain to the secure domain, where the secure domain component decrypts the received encrypted messages. This method works repeatedly without reloading either the secure domain component or the unsecure domain component and by using the unsecure connection to transfer the encrypted messages. | 01-26-2012 |
20120243459 | PROTOCOL BOOSTER FOR SCTP IN MULTICAST NETWORKS - A traffic optimizer facilitates communication of data packets using a unicast protocol between a server and at least one of a plurality of clients through a multicast network. The traffic optimizer includes a communication processor and a packet processor. The communication processor receives both data including association data and the data packets using the unicast protocol from the server. The association data includes IP addresses of the server and IP addresses of at least one of a plurality of clients available for communication. The packet processor processes the data packets to optimize data transfer in response to an analysis of the data packets, and forwards the processed data packets to at least one of the plurality of clients at respective ones of the received IP addresses through a multicast network using the unicast protocol. | 09-27-2012 |
20140351676 | RECOVERY FROM BURST PACKET LOSS IN INTERNET PROTOCOL BASED WIRELESS NETWORKS USING STAGGERCASTING AND CROSS-PACKET FORWARD ERROR CORRECTION - A method and system for transmitting data are described including packetizing the data, performing forward error correction (FEC) encoding on the packetized data in order to generate at least one parity packet, appending FEC information as padding to the end of payload data of the packetized data and transmitting the packetized data and the at least one parity packet. Also described are a method and system for recovering from loss of a packet including receiving a data packet, receiving at least one parity packet, buffering the received data packet, detecting packet loss, forward error correction decoding the at least one parity packet to recover from packet loss using forward error correction information extracted from the data packet and from the at least one parity packet and forwarding the recovered packet via an internal socket. Also described is a method for staggercasting. | 11-27-2014 |
Patent application number | Description | Published |
20110219515 | MULTI-TOOL COLLAR STAY - A multi-tool collar stay is disclosed. The collar stay may be a non-bendable single piece that includes a first end, a middle section, and a second end. This single piece is shaped to substantially fit within a collar stay pocket, where the first end is tapered to be proximate to a collar tip, and a first tool may be located in the vicinity of the first end. The second end is proximate to a collar stay pocket entrance, and a second tool may be located in the vicinity of the second end. The non-bendable single piece collar stay comprises at least one of: titanium, brass, stainless steel, sterling silver, reinforced polymer, and/or a combination thereof. Examples of the first and second tool include: a bottle opener, a cutting blade, a flat head screw driver, a flat Phillips screw driver, a full Phillips screw driver, a nail file, and a ruler. | 09-15-2011 |
20110231980 | DRESS SHIRT WITH SWITCHABLE BUTTONS - A dress shirt with a modified button placket with switchable buttons is disclosed. The modified button placket provides a wearer with the ability to switch between “work” and “play” buttons for a different fashion look. The modified button placket includes a button-side section including a first button and a second button. The modified button placket also includes a button-hole side inner layer section and a button-hole side outer layer section. In some embodiments, the first button could be a more conservative “work shirt button” while the second button could be a trendier “social outing button.” If the wearer is going to a professional meeting, the wearer of dress shirt could fasten and expose only the work buttons to the outside audience. The play buttons would be left hidden behind both button-hole side inner layer and a button-hole side outer layer. | 09-29-2011 |
20110251926 | METHODS, SYSTEMS, COMPUTER PRODUCTS, AND WEBSITE FOR PROGRESSIVE E-COMMERCE - An e-commerce system where progressive incentives are displayed to entice shoppers to purchase goods is disclosed. The e-commerce system includes a database with a region of memory having data related to a first inventory of physical goods and a second inventory of digital goods. The e-commerce system also includes a website configured to facilitate an event, where the website is coupled to the database for accessing the first inventory in response to the event. The event may be a purchase of one or more physical goods. The e-commerce system further includes a webpage configured to display at least a portion of the first inventory that is available for sale, and to display one or more digital goods, where the webpage presents a locked digital good before the event occurs, and in response to one or more events occurring, the webpage presents an unlocked digital good. | 10-13-2011 |
20130124374 | METHODS, SYSTEMS, COMPUTER PRODUCTS, AND WEBSITE FOR PROGRESSIVE E-COMMERCE - An e-commerce system where progressive incentives are displayed to entice shoppers to purchase goods is disclosed. The e-commerce system includes a database with a region of memory having data related to a first inventory of physical goods and a second inventory of digital goods. The e-commerce system also includes a website configured to facilitate an event, where the website is coupled to the database for accessing the first inventory in response to the event. The event may be a purchase of one or more physical goods. The e-commerce system further includes a webpage configured to display at least a portion of the first inventory that is available for sale, and to display one or more digital goods, where the webpage presents a locked digital good before the event occurs, and in response to one or more events occurring, the webpage presents an unlocked digital good. | 05-16-2013 |
Patent application number | Description | Published |
20090048095 | NOVEL IRON-CONTAINING ALUMINOSILICATE ZEOLITES AND METHODS OF MAKING AND USING SAME - There is disclosed iron-containing aluminosilicate zeolites having both framework iron and iron cations on the ion-exchange sites. There is also disclosed a direct synthesis method of making an iron-containing aluminosilicate zeolite, which does not require the use of an intermediate step, such as ion-exchange or impregnation. In addition, there is disclosed a method of using the iron-containing aluminosilicate zeolite disclosed herein in a selective catalytic reduction reaction, typically in the presence of ammonia, to reduce or remove nitric oxides from exhaust emissions. | 02-19-2009 |
20100092361 | NOVEL MICROPOROUS CRYSTALLINE MATERIAL COMPRISING A MOLECULAR SIEVE OR ZEOLITE HAVING AN 8-RING PORE OPENING STRUCTURE AND METHODS OF MAKING AND USING SAME - There is disclosed a hydrothermally stable microporous crystalline material comprising a molecular sieve or zeolite having an 8-ring pore opening structure, such as SAPO-34 or aluminosilicate zeolite, able to retain a specific percentage of its surface area and micropore volume after treatment with heat and moisture, such as at least 80% of its surface area and micropore volume after exposure to temperatures of up to 900° C. in the presence of up to 10 volume percent water vapor for a time ranging from 1 to 16 hours. Methods of using the disclosed crystalline material, such as in the SCR of NO | 04-15-2010 |
20100092362 | HIGH SILICA CHABAZITE FOR SELECTIVE CATALYTIC REDUCTION, METHODS OF MAKING AND USING SAME - There is disclosed a microporous crystalline material comprising a metal containing chabazite having a crystal size greater than 0.5 microns and a silica-to-alumina ratio (SAR) greater than 15, wherein the metal containing chabazite retains at least 80% of its initial surface area and micropore volume after exposure to temperatures of up to 900° C. in the presence of up to 10 volume percent water vapor for up to 1 hour. Methods of using the disclosed crystalline material, such as in the SCR of NO | 04-15-2010 |
20100143224 | NOVEL IRON-CONTAINING ALUMINOSILICATE ZEOLITES AND METHODS OF MAKING AND USING SAME - There is disclosed iron-containing aluminosilicate zeolites having both framework iron and iron cations on the ion-exchange sites. There is also disclosed a direct synthesis method of making an iron-containing aluminosilicate zeolite, which does not require the use of an intermediate step, such as ion-exchange or impregnation. In addition, there is disclosed a method of using the iron-containing aluminosilicate zeolite disclosed herein in a selective catalytic reduction reaction, typically in the presence of ammonia, to reduce or remove nitric oxides from exhaust emissions. | 06-10-2010 |
20100217057 | ZSM-5, ITS PREPARATION AND USE IN ETHYLBENZENE DEALKYLATION - A new configuration of ZSM-5 is provided whereby the crystals have a higher average silica to alumina ratio at the edges of each crystallite than in the centre as determined from a narrow slit line scan profile obtained from SEM/EDX or TEM/EDX elemental analysis. Such ZSM-5 crystals are obtained by a preparation process using L-tartaric acid. The new configuration ZSM-5 provides significantly reduced xylene losses in ethylbenzene dealkylation, especially when combined with silica as binder, and one or more hydrogenation metals selected from platinum, tin, lead, silver, copper, and nickel. Further advantages are found if used in combination with a small crystal size ZSM-5. | 08-26-2010 |
20110286914 | NOVEL METAL-CONTAINING ZEOLITE BETA FOR NOx REDUCTION AND METHODS OF MAKING THE SAME - There is disclosed an organic-free, metal-containing zeolite Beta with a silica-to-alumina ratio (SAR) ranging from 5 and 20, and a metal content of at least 0.5 wt. %. There is also disclosed a method of making such a zeolite Beta without organic structure directing agent (SDA). The metal, which may comprise Fe or Cu, can be found in amounts ranging from 1-10 wt. %. A method of selective catalytic reduction of nitrogen oxides in exhaust gases using the disclosed zeolite is also disclosed. | 11-24-2011 |
20120251422 | Fe-SAPO-34 CATALYST AND METHODS OF MAKING AND USING THE SAME - There is disclosed a method of making, through direct synthesis, a catalyst comprising an Fe-SAPO-34 molecular sieve. There is also disclosed an Fe-SAPO-34 molecular sieve made according to the disclosed method herein, wherein the molecular sieve contains both framework iron and iron cations at ion-exchange sites. In addition, there is disclosed a method of using the Fe-SAPO-34 disclosed herein in a selective catalytic reduction reaction, typically in the presence of ammonia or urea, to reduce or remove nitric oxides from exhaust emissions. | 10-04-2012 |
20120269719 | LARGE CRYSTAL, ORGANIC-FREE CHABAZITE, METHODS OF MAKING AND USING THE SAME - There is disclosed a method to synthesize microporous crystalline material comprising a metal containing chabazite having a crystal size greater than 0.5 microns and a silica-to-alumina ratio (SAR) between 5 and 15, wherein the method is carried out without the use of an organic structural directing agent and without requiring calcination. There is also disclosed a large crystal organic free chabazite made according to the disclosed method. In addition, there are disclosed methods of using the disclosed crystalline material, such as in the selective catalytic reduction of NO | 10-25-2012 |
20130142727 | STABILIZED MICROPOROUS CRYSTALLINE MATERIAL, THE METHOD OF MAKING THE SAME, AND THE USE FOR SELECTIVE CATALYTIC REDUCTION OF NOX - There is disclosed a microporous crystalline material having pore opening ranging from 3 to 5 Angstroms, where the material comprises a first metal chosen from alkali earth group, rare earth group, alkali group, or mixtures thereof, and a second metal chosen from iron, copper or mixtures thereof; and has a molar silica to alumina ratio (SAR) from 3 to 10. The microporous crystalline material disclosed herein may comprise a crystal structure having building units of double-6-rings (d6r) and pore opening of 8-rings as exemplified with framework types defined by the Structure Commission of the International Zeolite Association having structural codes of CHA, LEV, AEI, AFT, AFX, EAB, ERI, KFI, SAT, TSC, and SAV. There is also disclosed a method of selective catalytic reduction of nitrogen oxides in exhaust gas, comprising at least partially contacting the exhaust gases with an article comprising the disclosed microporous crystalline material. | 06-06-2013 |
20130281757 | ZSM-5, ITS PREPARATION AND USE IN ETHYLBENZENE DEALKYLATION - A new configuration of ZSM-5 is provided whereby the crystals have a higher average silica to alumina ratio at the edges of each crystallite than in the centre as determined from a narrow slit line scan profile obtained from SEM/EDX or TEM/EDX elemental analysis. Such ZSM-5 crystals are obtained by a preparation process using L-tartaric acid. The new configuration ZSM-5 provides significantly reduced xylene losses in ethylbenzene dealkylation, especially when combined with silica as binder, and one or more hydrogenation metals selected from platinum, tin, lead, silver, copper, and nickel. | 10-24-2013 |
20140128248 | SMALL CRYSTAL FERRIERITE AND METHOD OF MAKING THE SAME - There is disclosed a highly crystalline, small crystal, ferrierite zeolite prepared from a gel containing a source of silica, alumina, alkali metal and a combination of two templating agents. The resulting material includes ferrierite crystals having a particle size of about or less than about 200 nm. The desired crystal size can be achieved by using a specific composition of the gel. The purity of the material and the crystal size was determined by using X-ray powder diffraction and scanning electron microscopy. The material has excellent surface area and micropore volume as determined by nitrogen adsorption. | 05-08-2014 |
20140154175 | STABILIZED MICROPOROUS CRYSTALLINE MATERIAL, THE METHOD OF MAKING THE SAME, AND THE USE FOR SELECTIVE CATALYTIC REDUCTION OF NOX - There is disclosed a microporous crystalline material having pore opening ranging from 3 to 5 Angstroms, where the material comprises a first metal chosen from alkali earth group, rare earth group, alkali group, or mixtures thereof, and a second metal chosen from iron, copper or mixtures thereof; and has a molar silica to alumina ratio (SAR) from 3 to 10. The microporous crystalline material disclosed herein may comprise a crystal structure having building units of double-6-rings (d6r) and pore opening of 8-rings as exemplified with framework types defined by the Structure Commission of the International Zeolite Association having structural codes of CHA, LEV, AEI, AFT, AFX, EAB, ERI, KFI, SAT, TSC, and SAV. There is also disclosed a method of selective catalytic reduction of nitrogen oxides in exhaust gas, comprising at least partially contacting the exhaust gases with an article comprising the disclosed microporous crystalline material. | 06-05-2014 |
Patent application number | Description | Published |
20080206337 | METHOD OF MAKING DOSAGE FORMS COMPRISING POLYMERIC COMPOSITIONS - A dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface; and (c) a shell which resides upon at least a portion of the core outer surface, wherein at least a portion of the shell is semipermeable, such that the liquid medium diffuses through the semipermeable shell or shell portion to the core due to osmosis. The shell also provides for delivery of the active ingredient to a liquid medium outside the shell after contacting of the dosage form with the liquid medium. The dosage form delivers one or more active ingredients in a controlled manner upon contacting of the dosage form with a liquid medium. The dosage form may be employed to provide a burst release of the active ingredient, or to provide release of the active ingredient at an ascending release rate over an extended time period upon contacting of the dosage form with a liquid medium. At least a portion of the shell may be comprised of a polymeric composition containing film former, gelling agents, which can be dissolved in a multisolvent system comprised of water and an organic solvent. | 08-28-2008 |
20090155372 | METHOD OF MANUFACTURING MODIFIED RELEASE DOSAGE FORMS - In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches and combinations thereof, and the matrix is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. The dosage form may additionally comprise uncoated particles which may contain at least one active ingredient. In another embodiment, a dosage form comprises at least one active ingredient, a plurality of particles and a molded matrix, wherein at least a portion of the particles are coated. The coated particles, the matrix or both may comprise at least one active ingredient, and the coated particles or the matrix or a combination thereof is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. | 06-18-2009 |
20090186082 | METHOD OF MANUFACTURING MODIFIED RELEASE DOSAGE FORMS - In one embodiment, a dosage form comprises: (a) at least one active ingredient; (b) a molded core which is solid at room temperature; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment of this invention, a dosage form comprises: (a) at least one active ingredient; (b) a molded core comprising a plurality of particles; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium. | 07-23-2009 |
20100112052 | OSMOTIC TABLET WITH A COMPRESSED OUTER COATING - The present invention features a method of manufacturing an osmotic tablet including the steps of (i) compressing a tablet core including a first pharmaceutically active agent and a hydrophilic polymer; (ii) applying an osmotic coating to the outer surface of the tablet core to form a coated tablet, wherein the osmotic coating includes at least one opening exposing the tablet core; and (iii) compressing an immediate release coating onto the surface of the coated tablet, wherein the release coating includes a second pharmaceutically active agent. | 05-06-2010 |
20120074614 | SYSTEMS, METHODS AND APPARATUSES FOR MANUFACTURING DOSAGE FORMS - Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms. | 03-29-2012 |
20140271891 | PHENYLEPHRINE RESINATE PARTICLES AND USE THEREOF IN PHARMACEUTICAL FORMULATIONS - Phenylephrine particles suitable for solid, semi solid or liquid dosage forms are disclosed. | 09-18-2014 |
Patent application number | Description | Published |
20080214731 | Flame retardant thermoplastic molding composition - A thermoplastic molding composition characterized by its flame retardance is disclosed. The composition contains A) aromatic poly(ester) carbonate having a weight-average molecular weight of at least 25,000, B) (co)polyester and C) graft (co)polymer having a core-shell morphology, comprising a grafted shell that contains polymerized alkyl(meth)acrylate and a composite rubber core that contains interpenetrated and inseparable polyorganosiloxane and poly(meth)alkyl acrylate where the weight ratio of polyorganosiloxane/poly(meth)alkylacrylate/grafted shell is 70-90/5-15/5-15, D) phosphorus-containing compound, E) fluorinated polyolefin and F) boron compound having average particle diameter of 2 to 10 microns. | 09-04-2008 |
20090304762 | Antimicrobial thermoplastic molding composition - A thermoplastic composition having antimicrobial and good impact properties is disclosed. The composition comprises (i) (co)polycarbonate, (ii) (co)polyester, (iii) grafted elastomeric (co)polymer and an amount of an antimicrobial agent. The antimicrobial agent that contains zeolite, metal oxide and hydrotalcite is present in an amount sufficient to impart to the composition antimicrobial efficacy. | 12-10-2009 |
20110130517 | Hydrolytic stability of polycarbonate containing rubber modifier - The present invention provides a thermoplastic molding composition containing an aromatic polycarbonate and a core-shell graft copolymer which is coagulated with a salt of a metal element selected from the group consisting of lithium, sodium, potassium, rubidium, cesium, francium, beryllium, magnesium, calcium, strontium, barium and radium. The molding composition may optionally include a polyalkylene terephthalate. The inventive thermoplastic molding composition exhibits improved hydrolytic stability over a comparable thermoplastic molding composition produced with a core shell graft copolymer coagulated with a salt of a metal element not selected from the group consisting of lithium, sodium, potassium, rubidium, cesium, francium, beryllium, magnesium, calcium, strontium, barium and radium. | 06-02-2011 |
20120319031 | THERMALLY CONDUCTIVE THERMOPLASTIC COMPOSITIONS - The present invention provides a composition containing about 90% to about 30% of at least one amorphous thermoplastic or at least one semi crystalline thermoplastic or a mixture thereof and about 10% to about 70% of expanded graphite, wherein about 90% of the particles of the expanded graphite have a particle size of at least about 200 microns. The inventive compositions may find use in LED heat sink applications. | 12-20-2012 |
20140256861 | HALOGEN FREE FLAME RETARDED POLYCARBONATE - The present invention provides a flame-retardant thermoplastic molding composition made from an aromatic polycarbonate, an impact modifier, a bisphenol-A oligophosphate and glass fibers, wherein the ratio of polycarbonate to bisphenol-A oligophosphate is less than about 7.5, wherein the ratio of glass fibers to bisphenol-A oligophosphate is less than about 2.5, wherein the composition is rated V0 at 1.5 mm according to UL-94, and wherein the composition is free from halogenated flame retardants. | 09-11-2014 |
Patent application number | Description | Published |
20090111064 | Burner System And Method Of Operating A Burner For Reduced NOx Emissions - A burner system and method of operating a burner for reduced NOx emissions. The burner system comprises a flame stabilizer, at least one fuel staging lance, an actuated valve, a temperature sensor and a controller. The amount of fuel to the flame stabilizer relative to the amount of fuel to the fuel staging lances is controlled depending on furnace temperature and/or furnace production rate. | 04-30-2009 |
20090136880 | Method Of Operating A Pyrolysis Heater For Reduced NOx - A method of operating a pyrolysis heater for reduced emissions of NOx and carbon monoxide. One or more wall burners, typically premix burners, are operated with more excess oxidant gas than one or more of the floor or hearth burners, which are typically non-premix burners. The invention takes advantage of different NOx emissions characteristics from different types of burners. | 05-28-2009 |
20100077943 | COMBUSTION SYSTEM WITH STEAM OR WATER INJECTION - A combustion system having a furnace arranged and disposed to receive solid fuel and oxygen and combust the solid fuel and oxygen to form a flue gas. The system includes a heat exchanger arrangement arranged and disposed to receive heat from the flue gas, where the heat exchanger arrangement has a predetermined heat exchange capacity. A water injection arrangement is arranged and disposed to provide water to the flue gas to controllably adjust the flue gas mass flow rate and temperature to provide the predetermined heat exchange capacity. | 04-01-2010 |
20100310113 | System And Method For Temperature Data Acquisition - A system and method is disclosed for acquiring temperature data from a plurality of features in a chamber including capturing a first image of an interior area of the chamber, capturing a second image of the interior area of the chamber, identifying a plurality of features within the data for the first image and the data for the second image, generating an interior area representation based on the first image data, the second image data, and the identification of each feature of the plurality of features in the interior area, and correlating the interior area representation to temperature information related to the interior area. | 12-09-2010 |
20100310949 | Steam-Hydrocarbon Reforming with Reduced Carbon Dioxide Emissions - A process for producing a hydrogen-containing product gas with reduced carbon dioxide emissions compared to conventional hydrogen production processes. A hydrocarbon and steam are reformed in a reformer and the resulting reformate stream is shifted in one or more shift reactors. The shifted mixture is scrubbed to remove carbon dioxide to form a carbon dioxide-depleted stream. The carbon dioxide-depleted stream is separated to form a hydrogen-containing product gas and a by-product gas. A portion of the hydrogen containing product gas is used as a fuel in the reformer and a portion of the by-product gas is recycled back into the process. The process may optionally include reforming in a prereformer and/or an oxygen secondary reformer. | 12-09-2010 |
20110113993 | Method of Operating a Furnace - A method of operating a furnace having process tubes and multiple burners where it is desired to conform the temperatures of the process tubes to selected target temperature criterion. The present method provides a systematic and quantitative approach to determine how to adjust burner flow rates to result in desired tube wall temperatures, for example to minimize the temperature deviation between tube wall temperatures at a predetermined elevation in the furnace. | 05-19-2011 |
20110182802 | Reactor, A Structure Packing, and a Method for Improving Oxidation of Hydrogen Sulfide or Polysulfides in Liquid Sulfur - Disclosed is a reactor, a structured packing, and a method for increasing the rate of decomposition of polysulfides and oxidation of polysulfides and hydrogen sulfide in liquid sulfur. The reactor, the structured packing, and the method involve a structured packing for contacting a first stream and a second stream in a reactor including a catalyst. The catalyst increases the rate of decomposition of polysulfides and oxidation of polysulfides and hydrogen sulfide in the liquid sulfur of the first stream with the second stream. The first stream includes liquid sulfur containing polysulfides and dissolved hydrogen sulfide. The second stream includes an oxygen-containing gas. | 07-28-2011 |
20110206601 | System and Method for Sulfur Recovery - A sulfur recovery system for recovering sulfur from a sulfur plant feed stream including a first sulfur removal system and a second sulfur removal system. The system includes a sulfur plant feed inlet to the first sulfur removal system, the sulfur plant feed inlet being capable of providing a sulfur plant feed stream at a first pressure. One or more oxidizing gas inlets are arranged and disposed to combine at least one oxidizing gas stream with the sulfur plant feed stream to form a combustion gas for combustion in the first sulfur removal system at a second pressure. A flow restriction device is operably configured to control an operating pressure in one or both of the first sulfur removal system and the second sulfur removal system. A gas processing plant and method for recovering sulfur from a sulfur plant feed stream are also disclosed. | 08-25-2011 |
20110220847 | Reformer and Method of Operating the Reformer - A method of combustion and a reformer. The method includes combusting a fuel in combustion region of an up-fired or down-fired reformer and forming non-uniform injection properties with a wall-bound burner. The combusting is performed in a combustion region by burners, wherein at least one of the burners is the wall-bound burner forming the non-uniform injection properties. The non-uniform injection properties generate a heat profile providing a first heat density proximal to a wall and a second heat density distal from the wall, the second heat density being greater than the first heat density. The non-uniform injection properties are formed by injection properties selected from an angle of one or more injectors, a flow rate of one or more injectors, an amount and/or location of oxidant injectors, an amount and/or location of fuel injectors, and combinations thereof. | 09-15-2011 |
20120040296 | Combustion of Oil Floating on Water - A method for combusting oil from an oil-containing layer floating on water as from an oil spill or well leak. In the method, an oxygen-containing gas is passed through a conduit, the oxygen-containing gas from the conduit is introduced proximate the oil-containing layer floating on water, and oil from the oil-containing layer is combusted with the oxygen-containing gas in the presence of a flame. The oxygen-containing gas is introduced with an oxygen molar flow rate sufficient to decrease the opacity of a smoke plume from the combusting oil. | 02-16-2012 |
20130263766 | Combustion of Oil From a Marine Oil Spill - Method and apparatus for burning oil from an oil release in a body of water. A mixture of oil and water is collected from the surface of the body of water and separated into an oil-enriched portion and a water-enriched portion. The oil-enriched portion is passed to a burner where the oil-enriched portion is combusted with an oxygen-containing gas having an oxygen concentration of at least 25 volume % oxygen. | 10-10-2013 |
20140037510 | System and Process for Producing a H2-Containing Gas and Purified Water - System and process for producing a H | 02-06-2014 |
20140174288 | Apparatus And Methods To Monitor And Control Cyclic Process Units In A Steady Plant Environment - Apparatus and methods are disclosed that allow for the monitoring and analysis of production process data for a multi-step asynchronous cyclic production process (e.g. pressure swing adsorption) in a steady state plant (such as a steam methane reforming plant). Data collected from cooperating sensors is processed applying a moving window discrete Fourier transform (DFT). The transformed data can be further analyzed in the broader steady-state plant environment to accurately detect any process anomalies and avoid false alarms. | 06-26-2014 |
Patent application number | Description | Published |
20090112003 | SYNTHESIS OF QUATERNARY SALT COMPOUNDS - The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists. | 04-30-2009 |
20100145075 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS - The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders. | 06-10-2010 |
20100298362 | PROCESS FOR THE PREPARATION OF 4-[6-(6-METHANESULFONYL-2-METHYL-PYRIDIN-3-YLAMINO)-5-METHOXY-PYRIMIDIN-4- -YLOXY]-PIPERIDINE-1-CARBOXYLIC ACID ISOPROPYL ESTER - The present invention is directed to a process for the preparation of 4-[6-(6-methanesulfonyl-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester, useful as glucose dependent insulinotropic receptor agonist, for the treatment of metabolic-related disorders and complications thereof, such as, diabetes and obesity. | 11-25-2010 |
20110294780 | SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-a MODULATORS - The present invention relates to compounds of Formula (I), | 12-01-2011 |
20120309986 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS - The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders. | 12-06-2012 |
20130102584 | PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS - Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: | 04-25-2013 |
20130131401 | PROCESS FOR THE PREPARATION OF CHYMASE MODULATORS - The present invention is a process for the preparation of chymase modulators, useful in the treatment of inflammatory and serine protease mediated disorders. | 05-23-2013 |
20130244998 | PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLCEROL LIPASE INHIBITORS - Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: | 09-19-2013 |
20140206858 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT-2 - The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney. | 07-24-2014 |
20140206859 | PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT-2 - The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney. | 07-24-2014 |
Patent application number | Description | Published |
20080228456 | MODELING WOUND HEALING - Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis. | 09-18-2008 |
20120271611 | Modeling Wound Healing - Provided are methods of simulating tissue healing. The methods comprise using a mechanistic computer model of the interrelated effects of inflammation, tissue damage or dysfunction and tissue healing to predict an outcome of healing of damaged tissue in vivo, thereby predicting the outcome of healing of damaged tissue in vivo. Implementations of these methods on a computing device also are provided. Non-limiting examples of diseases and/or conditions that are amenable to simulation according to the methods described herein include: a diabetes, diabetic foot ulcers, necrotizing enterocolitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, restenosis (post-angioplasty or stent implantation), incisional wounding, excisional wounding, surgery, accidental trauma, pressure ulcer, stasis ulcer, tendon rupture, vocal fold phonotrauma, otitis media and pancreatitis. | 10-25-2012 |
Patent application number | Description | Published |
20110249656 | Sending Feedback for Multiple Downlink Carriers - Feedback information for multiple serving cells are transmitted on high speed dedicated physical control channel (HS-DPCCH). A slot format for transmitting feedback information is determined based on the number of configured secondary serving cells and whether multiple input multiple-output (MIMO) is configured in the serving cells. Spreading factor is reduced to 128 when two secondary serving cells are configured and MIMO is configured in at least one of the two configured secondary serving cells, or when three secondary serving cells are configured. The serving cells are grouped into feedback groups, each feedback group having one or more serving cells. Channel coding may be applied to feedback information for the feedback groups. The resulting encoded feedback information for the feedback groups is concatenated to form composite feedback information. | 10-13-2011 |
20110317748 | DEMODULATION REFERENCE SIGNAL BASED CHANNEL STATE INFORMATION FEEDBACK IN OFDM-MIMO SYSTEMS - A method and apparatus for using demodulation reference signal (DM-RS) based channel state information (CSI) feedback in Orthogonal Frequency Division Multiplexing—multiple-input multiple-output (OFDM-MIMO) systems is disclosed. The wireless transmit/receive unit (WTRU) receives one or more resource blocks from a base station, wherein the resource blocks (RBs) include demodulating reference signals (DM-RS) and precoder information. The precoder information is sent unicast or broadcasted over a common control channel. The WTRU estimates an effective channel estimate based on the DM-RS, derives an unprecoded channel based on the effective channel and the precoder information, generates CSI feedback based on the unprecoded channel, and transmits the CSI feedback to the base station. Alternatively, the WTRU estimates an effective channel estimate based on the DM-RS, quantizes the effective channel estimate and transmits the CSI feedback to the base station. | 12-29-2011 |
20120177011 | METHOD AND APPARATUS FOR SIGNALING FOR MULTI-ANTENNA TRANSMISSION WITH PRECODING - A method and apparatus for signaling for multi-antenna transmission with precoding are disclosed. Precoder phase information may be signaled using bit sequences that provide a degree of error tolerance in that precoder phases having large differences are signaled using bit sequences having large Hamming distances. | 07-12-2012 |
20120275530 | OPEN LOOP SPATIAL PROCESSING - Methods and apparatus for multiple-input multiple-output (MIMO) transmissions are disclosed. A base station may precode wireless transmit/receive unit (WTRU)-specific reference signals and data that are transmitted to a WTRU using a randomly selected precoder. The precoder may be selected based on a predefined precoder selection sequence or by the base station. A different precoder may be applied to different resource blocks (RBs). In addition, a large delay cyclic delay diversity (CDD) or discrete Fourier transform (DFT) spreading may be applied on the WTRU-specific reference signals and the data. For heterogeneous deployed antennas, spatial diversity gain is achieved by dynamically scheduling resources between transmission points. A hopping scheme may be applied across the transmission points as the resources are dynamically partitioned between the transmission points. A different randomly selected precoder may be applied to each RB transmitted from a different transmission point. | 11-01-2012 |
20130201841 | UPLINK FEEDBACK FOR MULTI-SITE SCHEDULING - Systems, methods, and instrumentalities are disclosed for a user equipment (UE) to provide feedback in a multi-site scheduling system (e.g., a system where multiple entities may schedule and/or send data to the UE). For example, the UE may receive a first data from a first network entity and a second data from a second network entity. A network entity may include entities that transmit data and/or control information to the UE, e.g., an eNodeB (eNB). The UE may generate feedback relating to received data, such as ACK/NACK information or channel state information (CSI). The UE may send a first feedback relating to the first data in a first subframe and a second feedback relating to the second data in a second subframe. | 08-08-2013 |
20130201912 | METHOD AND APPARATUS FOR COMPRESSING CHANNEL STATE INFORMATION BASED ON PATH LOCATION INFORMATION - Methods and apparatus are described for compressing channel state information (CSI) in time-domain based on path location information for CSI feedback. Downlink (DL) CSI is compressed in the time domain and fed back by not sending the multipath location information, or sending at a very low rate. In one method, a wireless transmit/receive unit (WTRU) selects the strongest multipath components based on channel characteristics. The multipath components are quantized in the time domain via direct or vector based quantization. The base station reconstructs a channel impulse response from the fed back quantized multipath components and applies same to precoding processing. In another method, the WTRU feeds back information associated with a narrowband portion(s) of a system spectrum. The selected narrowband portion(s) have sufficient density over time to allow good precoding per subband or across the system spectrum. Short term feedback may be augmented with long term channel information. | 08-08-2013 |
Patent application number | Description | Published |
20090192171 | 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases. | 07-30-2009 |
20090221574 | 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases. | 09-03-2009 |
20110212946 | Quinolone Neuropeptide S Receptor Antagonists - The present invention is directed to quinolone compounds which are antagonists of neuropeptide S receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which the neuropeptide S receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the neuropeptide S receptor is involved. | 09-01-2011 |
20120196894 | NOVEL TRPA1 ANTAGONISTS - The present invention relates to compositions and methods that modulate at least one TRP family member. Specifically, the present invention relates to novel TRPA1 antagonists and their use in the treatment of pain such as chronic inflammatory and neuropathic pain. Compounds that can modulate one or more TRPA1 functions are useful in many aspects including, but not limited to, maintaining calcium homeostasis; maintaining sodium homeostasis; modulating intracellular calcium levels; modulating membrane polarization (membrane potential); modulating cation levels; and/or treating or preventing diseases, disorders, or conditions associated with calcium homeostasis, sodium homeostasis, calcium or sodium dyshomeostasis, or membrane polarization/hyperpolarization (including hypo and hyperexcitability), and/or treating or preventing diseases, disorders, or conditions associated with regulation or misregulation of TRPA1 expression or function. The present invention further relates to methods and compositions that antagonize both a function of TRPA1 and a function of one or more additional TRP channels. | 08-02-2012 |
20130102636 | 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors - A method for treating a human comprises administering a therapeutically effective amount of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid or a pharmaceutically acceptable salt or a pharmaceutically acceptable N-oxide thereof, to the human in need. | 04-25-2013 |
Patent application number | Description | Published |
20090318405 | 4-PYRAZOLYL-N-ARYLPYRIMIDIN-2-AMINES AND 4-PYRAZOLYL-N-HETEROARYLPYRIMIDIN-2-AMINES AS JANUS KINASE INHIBITORS - The present invention provides substituted bicyclic heteroaryl compounds, including, for example, 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines that modulate the activity of kinases and are useful in the treatment of diseases related to activity of kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases. | 12-24-2009 |
20110015212 | PYRIMIDINONES AS PI3K INHIBITORS - The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases. | 01-20-2011 |
20110059951 | HETEROCYCLIC DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS - The present invention provides heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines, as well as their compositions and methods of use, that modulate the activity of Janus kinases (JAKs) and are useful in the treatment of diseases related to the activity of JAKs including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases. | 03-10-2011 |
20110136781 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS - The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. | 06-09-2011 |
20110183985 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS - The present invention provides fused aryl and heteroaryl derivatives of Formula I: | 07-28-2011 |
20110190319 | SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS - The present invention provides fused derivatives of Formula I: | 08-04-2011 |
20110207754 | CYCLOBUTANE AND METHYLCYCLOBUTANE DERIVATIVES AS JANUS KINASE INHIBITORS - The present invention relates to cyclobutane and methylcyclobutane derivatives, as well as their salts, compositions, and methods of use, which are Janus kinase (JAK) inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer and myeloproliferative disorders. | 08-25-2011 |
20110312979 | FUSED PYRROLE DERIVATIVES AS PI3K INHIBITORS - The present invention provides fused pyrrole derivatives of Formula I: | 12-22-2011 |
20120077798 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS - The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer. | 03-29-2012 |
20120157430 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS - The present invention provides N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines derivatives that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases. | 06-21-2012 |
20130059835 | HETEROCYCLYLAMINES AS PI3K INHIBITORS - The present invention provides heterocyclylamine derivatives of Formula I: | 03-07-2013 |
20130225556 | AZETIDINE AND CYCLOBUTANE DERIVATIVES AS JAK INHIBITORS - The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer. | 08-29-2013 |
20130324515 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS - The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. | 12-05-2013 |
20140057912 | PYRIMIDINE-4,6-DIAMINE DERIVATIVES AS PI3K INHIBITORS - The present invention provides pyrimidine-4,6-diamine derivatives of Formula (I): wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases. | 02-27-2014 |
20140066448 | SUBSTITUTED DIAMINO-PYRIMIDINE AND DIAMINO-PYRIDINE DERIVATIVES AS PI3K INHIBITORS - The present invention provides substituted diamino-pyrimidine and substituted diamino-pyridine derivatives of Formula I; wherein X, Y, R | 03-06-2014 |
20140073657 | 3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL]OCTANE- OR HEPTANE-NITRILE AS JAK INHIBITORS - The present invention relates to the Janus kinase (JAK) inhibitors 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]octanenitrile or 3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]heptanenitrile, as well as its compositions and methods of use, which is useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, skin disorders, cancer, and other diseases. | 03-13-2014 |
20140121198 | TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS - The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases. | 05-01-2014 |
20140121222 | PYRIMIDINONES AS PI3K INHIBITORS - The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases. | 05-01-2014 |
20140200216 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS - The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases. | 07-17-2014 |
20140200227 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS - The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases. | 07-17-2014 |
20140249132 | USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3K-DELTA RELATED DISORDERS - The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I: | 09-04-2014 |
20140275127 | SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS - The present invention provides fused derivatives of Formula I: | 09-18-2014 |
20140343030 | BIPYRAZOLE DERIVATIVES AS JAK INHIBITORS - The present invention provides compounds of Formula I: | 11-20-2014 |
20150025056 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES - The present invention provides compounds of the formula I: | 01-22-2015 |
20150057265 | FURO- AND THIENO-PYRIDINE CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS - The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases. | 02-26-2015 |
20150087662 | CYCLOBUTANE AND METHYLCYCLOBUTANE DERIVATIVES AS JANUS KINASE INHIBITORS - The present invention relates to cyclobutane and methylcyclobutane derivatives, as well as their salts, compositions, and methods of use, which are Janus kinase (JAK) inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer and myeloproliferative disorders. | 03-26-2015 |