Li, New York
Cheng-Hong Li, New York, NY US
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20120290283 | Workload Partitioning Procedure For Null Message-Based PDES - An embodiment of the invention includes applying a first partition to a plurality of LPs, wherein a particular LP is assigned to a first set of LPs. A second partition is applied to the LPs, wherein the particular LP is assigned to an LP set different from the first set. For both the first and second partitions, lookahead values and transit times are determined for each of the LPs and related links. For the first partition, a first system progression rate is computed using a specified function with the lookahead values and transit times determined for the first partition. For the second partition, a second system progression rate is computed using the specified function with the lookahead values and transit times determined for the second partition. The first and second system progression rates are compared to determine which is the lowest. | 11-15-2012 |
Dangsheng Li, New York, NY US
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20090286252 | NRIF3, NOVEL CO-ACTIVATOR FOR NUCLEAR HORMONE RECEPTORS - Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is useful in development/implementation of high throughput screens to identify novel thyroid hormone receptor (TR) and retinoid X receptor (RXR) agonists and antagonists. Methods are also provided for identifying compounds that directly interfere with the interaction of NRIF3 and TR or RXR. Finally, therapies based on modulation of NRIF3 activity are disclosed. | 11-19-2009 |
Fubin Li, New York, NY US
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20140010812 | MODULATING AGONISTIC TNFR ANTIBODIES - The instant invention relates to agents (e.g., agonistic antibodies) able to stimulate the immune system of a mammalian animal and activate target-cell specific T lymphocyte responses. Such agents may be identified based on the ability to engage a receptor from the TNFR Superfamily and thereby mimic the natural ligand for the receptor from the TNFR Superfamily. Modified antibodies of this class display enhanced immunostimulatory activity and may be formulated and administered for the treatment of a disease or disorder. | 01-09-2014 |
Grace Li, New York, NY US
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20130077767 | SYSTEM AND METHOD FOR OPTIMIZING CALL FLOWS OF A SPOKEN DIALOG SYSTEM - A dialog manager for a spoken dialog system. A decision module selects a path from a plurality of alternative paths for a given call, wherein each path implements one of a plurality of strategies for a call flow. A weighting module weights the path selection decision and is connected to a probability estimator for estimating the probability value that a given one of the plurality of paths is the best-performing path. | 03-28-2013 |
Guannan Li, New York, NY US
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20140144250 | CORIOLIS MASS FLOW METER WITH MICRO-BEND TUBES - A new type of coriolis mass flow meter is disclosed. In one embodiment, the coriolis mass flow meter comprises two or more flow splitters, each flow splitter being connected to two or more flow tubes; and one or more supporting pipes connecting the flow splitters. The one or more of the flow splitters have a smooth round corner with a 65° turning angle. The distance between the centers of the two or more splitter tubes is about 1.1 to 1.2 times dT, where dT is the inner diameter of each splitter tube. The splitting turning radius RT is about 1 to 2.5 times DN; where DN is inner diameter of the flange portion of the flow splitter. The inner diameter of each splitter tube is about 0.8 to 0.85 times DN/√2. | 05-29-2014 |
Henry C. Li, New York, NY US
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20140007238 | Collective Threat Intelligence Gathering System | 01-02-2014 |
Jianfeng Li, New York, NY US
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20140221420 | CCR5 ANTAGONISTS FOR TREATING HIV - Compounds that modulate the CCR5 chemokine receptor, pharmaceutical compositions containing them, and uses therefor in the treatment of HIV and related diseases are described. | 08-07-2014 |
Jiaojiao Li, New York, NY US
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20140188746 | SYSTEMS, METHODS, AND DEVICES FOR DETERMINING ALIGNMENT OF EDUCATION CONTENT TO ONE OR MORE EDUCATION STANDARDS - Systems, methods, and devices are disclosed for aligning Education Content to Education Standards and determining the degree of such alignment for educators and adaptive learning systems to effectively determine and deliver the most aligned Education Content to address each student's specific learning needs according to the set of Education Standards. | 07-03-2014 |
Jingxia Li, New York, NY US
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20150361062 | HETEROCYCLO COMPOUNDS AS APOPTOTIC INDUCERS AND USES THEREOF - Disclosed are heterocyclo compounds that have a formula represented by the following: and wherein X, R | 12-17-2015 |
Jinyang Li, New York, NY US
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20150256377 | SYSTEM AND METHOD FOR PROVIDING CHANNEL EQUALIZATION IN ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING (OFDM) WIRELESS SYSTEMS - The present disclosure relates to a computer-implemented method for estimating a communication channel response, comprising procedures such as: receiving, via the channel, a signal comprising a plurality of symbols, each comprising a plurality of sub-carriers; determining a pilot sub-carrier response and a pilot sub-carrier metric for one or more pilot sub-carriers; and for one or more non-pilot sub-carriers: i) determining a non-pilot sub-carrier metric; ii) if the non-pilot sub-carrier metric satisfies a criterion, determining a particular component (e.g., real or imaginary) of a non-pilot sub-carrier response as a function of different components of one or more pilot sub-carrier responses; and iii) if the non-pilot sub-carrier metric does not satisfy the criterion, determine the particular component of the non-pilot sub-carrier response as a function of the particular component of one or more pilot sub-carrier responses. Other embodiments include a communication apparatus and a computer-readable medium configurable to perform such procedures. | 09-10-2015 |
Kevin Li, New York, NY US
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20150123949 | Gesture Detection - A supplemental surface area allows gesture recognition on outer surfaces of mobile devices. Inputs may be made without visual observance of display devices. Gesture control on outer surfaces permits socially acceptable, inconspicuous interactions without overt manipulation. | 05-07-2015 |
20150130743 | Gesture Detection - Methods, systems, and products sense contactless gestures. A capacitive sensor measures capacitance during performance of a gesture. The capacitive sensor generates an output signal that is compared to a database. The database stores different output signals that are associated to different commands. The corresponding command is executed in response to the performance of the gesture. | 05-14-2015 |
Kevin A. Li, New York, NY US
Patent application number | Description | Published |
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20140099594 | Methods, Systems, and Products for Monitoring Health - Methods, systems, and products monitor a person's regimen for medicinal and dietary restrictions. When the person's regimen requires a liquid medication or supplement, an oral instrument is commanded to dispense a dosage of fluid. The oral instrument stores a reservoir of the fluid. If the oral instrument is a spoon, for example, the spoon may automatically dispense cough syrup or other medicine. A toothbrush, likewise, may automatically dispense mouthwash. A sensor may confirm presence of the oral instrument in the person's mouth, thus ensuring the dosage of fluid is ingested. | 04-10-2014 |
20140101084 | Methods, Systems, and Products for Interfacing with Neurological and Biological Networks - Methods, systems, and products provide interfaces between intrahost networks and interhost networks within biological hosts. Neuroregional translations are performed to route communications to and from the biological hosts. Bioregional translations may also be performed to route communications to and from the biological hosts. | 04-10-2014 |
20140101296 | Methods, Systems, and Products for Prediction of Mood - Methods, systems, and products predict emotional moods. Predicted moods may then be used to configure devices and machinery. A communications device may be configured to a mood of a user. A car may adjust to the mood of an operator. Even assembly lines may be configured, based on the mood of operators. Machinery and equipment may thus adopt performance and safety precautions that account for varying moods. | 04-10-2014 |
20140101740 | Methods, Systems, and Products for Authentication of Users - Methods, systems, and products authenticate users for access to devices, applications, and services. Skills of a user are learned over time, such that an electronic model of random subject matter may be generated. The user is prompted to interpret the random subject matter, such as with a drawing, physical arrangement, or performance. The user's interpretation is then compared to the electronic model of the random subject matter. If the user is truly who they purport to be, their interpretation will match the electronic model, thus authenticating the user. If interpretation fails to match the electronic model, authentication may be denied. | 04-10-2014 |
20140145873 | Electromagnetic Reflection Profiles - Methods, systems, and products determine electromagnetic reflective characteristics of ambient environments. A wireless communications device sends a cellular impulse and receives reflections of the cellular impulse. The cellular impulse and the reflections of the cellular impulse may be compared to determine the electromagnetic reflective characteristics of an ambient environment. | 05-29-2014 |
20140156697 | Methods, Systems, and Products for Recalling and Retrieving Documentary Evidence - Methods, systems, and products help users recall memories and search for content of those memories. When a user cannot recall a memory, the user is prompted with questions to help recall the memory. As the user answers the questions, a virtual recollection of the memory is synthesized from the answers to the questions. When the user is satisfied with the virtual recollection of the memory, a database of content may be searched for the virtual recollection of the memory. Video data, for example, may be retrieved that matches the virtual recollection of the memory. The video data is thus historical data documenting past events. | 06-05-2014 |
20140192391 | Methods, Systems, and Products for Illuminating Displays - Methods, systems, and products illuminate display devices. Light in a waveguide is frustrated to illuminate an array of picture elements. | 07-10-2014 |
20140237577 | Methods, Systems, and Products for Authentication of Users - Methods, systems, and products authenticate users for access to devices, applications, and services. Skills of a user are learned over time, such that an electronic model of random subject matter may be generated. The user is prompted to interpret the random subject matter, such as with a drawing, physical arrangement, or performance. The user's interpretation is then compared to the electronic model of the random subject matter. If the user is truly who they purport to be, their interpretation will match the electronic model, thus authenticating the user. If interpretation fails to match the electronic model, authentication may be denied. | 08-21-2014 |
20150036977 | Methods, Systems, and Products for Image Displays - Methods, systems, and products illuminate display devices. An image is injected into a waveguide. The image propagates at total internal reflectance within the waveguide. A frustrator withdraws a frustrated image from the waveguide, and the frustrated image may be displayed to a viewer. | 02-05-2015 |
20150220830 | Routing Policies for Biological Hosts - Methods, systems, and products provide interfaces between intrahost networks and interhost networks within biological hosts. Neuroregional translations are performed to route communications to and from the biological hosts. Bioregional translations may also be performed to route communications to and from the biological hosts. | 08-06-2015 |
20150281209 | Methods, Systems, and Products for Authentication of Users - Methods, systems, and products authenticate users for access to devices, applications, and services. Skills of a user are learned over time, such that an electronic model of random subject matter may be generated. The user is prompted to interpret the random subject matter, such as with an electronic drawing. The user's interpretation is then compared to the electronic model of the random subject matter. If the user's interpretation matches the electronic model, the user may be authenticated. | 10-01-2015 |
20150317333 | Methods, Systems, and Products for Recalling and Retrieving Documentary Evidence - Methods, systems, and products help users recall memories and search for content of those memories. When a user cannot recall a memory, the user is prompted with questions to help recall the memory. As the user answers the questions, a virtual recollection of the memory is synthesized from the answers to the questions. When the user is satisfied with the virtual recollection of the memory, a database of content may be searched for the virtual recollection of the memory. Video data, for example, may be retrieved that matches the virtual recollection of the memory. The video data is thus historical data documenting past events. | 11-05-2015 |
20160041261 | Electromagnetic Reflection Profiles - Methods, systems, and products determine electromagnetic reflective characteristics of ambient environments. A wireless communications device sends a cellular impulse and receives reflections of the cellular impulse. The cellular impulse and the reflections of the cellular impulse may be compared to determine the electromagnetic reflective characteristics of an ambient environment. | 02-11-2016 |
Kevin Ansia Li, New York, NY US
Patent application number | Description | Published |
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20150123991 | System and Method for Enabling Mirror Video Chat Using a Wearable Display Device - A method of exchanging audio-visual communication information between users includes detecting using an image capturing device associated with a wearable communication device, a mirror or image reflecting surface disposed in an environment of a first user, detecting a boundary of the mirror or image reflecting surface in response to the mirror being detected in the environment of the first user, selecting a portion of a first image displayed on the mirror or image reflecting surface within the boundary of the mirror or image reflecting surface, and displaying the portion of the first image as an overlay on a second image to a second user. A corresponding system and computer-readable device are also disclosed. | 05-07-2015 |
Ming Li, New York, NY US
Patent application number | Description | Published |
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20160066041 | MOBILITY ENHANCED ADVERTISING ON INTERNET PROTOCOL TELEVISION - Enhanced personalized advertisements may be provided through media such as IPTV, for example, by analyzing data such as subscribers' mobility data (calling and movement data), television (TV) watching history, online browsing data (e.g., Internet, web site browsing), and subscribers' historical purchasing transactions. With the analysis, subscribers' contexts, any information that reflects subscribers' interests and activities, and intents, tendency to buy certain products, items, services, and/or travel to some locations may be inferred. | 03-03-2016 |
Peiwen Li, New York, NY US
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20130111483 | AUTHORING AND USING PERSONALIZED WORKFLOWS | 05-02-2013 |
Ronald Li, New York, NY US
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20150353894 | ENGINEERED PHYSICAL ALIGNMENT OF STEM CELL-DERIVED CARDIOMYOCYTES - Provided are devices and methods of preparing a population of cardiomyocytes by aligning undifferentiated pluripotent cells on a nanosacale textured surface. | 12-10-2015 |
Ronald A. Li, New York, NY US
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20130040335 | MULTI-SCALE WRINKLES FOR FUNCTIONAL ALIGNMENT OF STEM CELLS AND CARDIAC DERIVATIVES - Provided are methods of preparing a biocompatible textured surface on a thermoplastic material comprising treating the material with a plasma and subsequently shrinking the substrate to induce formation of textures. The textured surfaces are useful in one aspect, to align cells such as stem cells. | 02-14-2013 |
Sixin Li, New York, NY US
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20160062555 | SYSTEM FOR PROVIDING DYNAMIC LINKED PANELS IN USER INTERFACE - A computer system may be configured to: execute a first query associated with a first panel; display the first panel in a user interface based on first display settings of the first panel, the first panel displaying at least a portion of the result of the first query, the result of the first query associated with a variable; execute a second query associated with a second panel, wherein the second query refers to the variable associated with the first query; display the second panel in the user interface based on second display settings of the second panel, the second panel displaying at least a portion of the result of the second query; and in response to user input changing the displayed result in the first panel: re-execute the second query; and update the display of the second panel in the user interface based on results of the re-executed second query. | 03-03-2016 |
Wanhe Li, New York, NY US
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20140113952 | TRANSPOSABLE ELEMENTS, TDP-43, AND NEURODEGENERATIVE DISORDERS - A method that includes measuring the expression level of at least one transposon in a biological sample from a subject; and determining whether the measured transposon expression exceeds a predetermined level, and if so, administering to the subject a transposon inhibitor in an amount effective to reduce the expression level of a transposon. | 04-24-2014 |
20140377758 | TRANSPOSON ACTIVATION DURING AGING AND NEURONAL DECLINE - The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such mobilization, along with cells and transgenic animals containing such systems; methods of monitoring neuronal function during normal aging; methods of determining the risk of age-related neuronal decline and age-related mortality; and the use of transposon inhibitors and apoptosis inhibitors to delay age-related neuronal decline and age-related mortality. | 12-25-2014 |
Xiaoguang Li, New York, NY US
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20080255355 | Chiral Diphosphonites as Ligands in the Ruthenium-Catalyzed Enantioselective Reduction of Ketones, B-Ketoesters and Ketimines - Chiral ruthenium complexes are disclosed, obtained by reaction of a ruthenium salt with a chiral diphosphonite. Chiral diols with the general structure given in scheme | 10-16-2008 |
Xiaoxu Li, New York, NY US
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20100092952 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS - This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides. | 04-15-2010 |
20110177508 | UNIVERSAL METHYLATION PROFILING METHODS - This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. This invention also provides neobases and methods of sequencing for methylation patterns using neobases. | 07-21-2011 |
20120021408 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS - This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides. | 01-26-2012 |
20130280700 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS - This invention provides a process for sequencing single-stranded DNA employing modified nucleotides. | 10-24-2013 |
20140315191 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS - This invention provides a process for sequencing single-stranded DNA employing modified nucleotides. | 10-23-2014 |
20150148240 | UNIVERSAL METHYLATION PROFILING METHODS - This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns. | 05-28-2015 |
Xi Ming Li, New York, NY US
Patent application number | Description | Published |
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20100116443 | THROUGH SHADE SYSTEM AND METHOD - A trough shade system and method of use provide improved support for a roller tube and shade material. The roller tube and wound shade material are located within a support cradle to minimize unwanted deflection by the roller tube and associated wrinkling and deformation of the shade material. Various mechanisms allow the roller tube a limited range of movement within the support cradle. The system is suitable for shading larger areas than other shading systems which rely on roller tubes with fixed supports at the ends. | 05-13-2010 |
20110290432 | TROUGH SHADE SYSTEM AND METHOD - A trough shade system and method of use provide improved support for a roller tube and shade material. The roller tube and wound shade material are located within a support cradle to minimize unwanted deflection by the roller tube and associated wrinkling and deformation of the shade material. Various mechanisms allow the roller tube a limited range of movement within the support cradle. The system is suitable for shading larger areas than other shading systems which rely on roller tubes with fixed supports at the ends. | 12-01-2011 |
Xiu-Min Li, New York, NY US
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20100322923 | Medical Uses of Glucans - The invention relates to a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto for use in the treatment of asthma and related diseases of abnormal pulmonary function in an animal. Also described is a method of treating asthma and related diseases of abnormal pulmonary function in an animal comprising administering to said animal an effective amount of a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto. | 12-23-2010 |
20120295868 | Medical Uses of Glucans - The invention relates to a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto for use in the treatment of asthma and related diseases of abnormal pulmonary function in an animal. Also described is a method of treating asthma and related diseases of abnormal pulmonary function in an animal comprising administering to said animal an effective amount of a glucan having a beta-(1,3)-backbone with one or more beta-(1,3)-side chains linked thereto. | 11-22-2012 |
Xuesong Li, New York, NY US
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20140238873 | MODIFIED BUBBLING TRANSFER METHOD FOR GRAPHENE DELAMINATION - In the BB transfer, or so called electrochemical delamination process, a transfer film is firstly spray-coated on a stack formed by two graphene sandwiching a metal (Cu or Cr) foil as a protection layer. Then, direct current (dc) voltage is applied to the first stack as a cathode and an anode (from be a platinum wire, a carbon rod, or others) in an electrolyte aqueous solution. With application of the electrolysis potential, hydrogen bubbles appear at the graphene/metal foil interfaces, while oxygen bubble appear at the anode due to the reduction of water. These H | 08-28-2014 |
Yihong Li, New York, NY US
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20090305252 | Methods and species-specific primers for detection and quantification of Streptococcus mutans and Streptococcus sanguinis in mixed bacterial samples - Dental caries is a polymicrobial infectious disease. Of the hundreds of bacteria present in the biofilms coating teeth, the | 12-10-2009 |
Yilei Li, New York, NY US
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20150369735 | Chemical Sensors Based on Plasmon Resonance in Graphene - Techniques for forming nanoribbon or bulk graphene-based SPR sensors are provided. In one aspect, a method of forming a graphene-based SPR sensor is provided which includes the steps of: depositing graphene onto a substrate, wherein the substrate comprises a dielectric layer on a conductive layer, and wherein the graphene is deposited onto the dielectric layer; and patterning the graphene into multiple, evenly spaced graphene strips, wherein each of the graphene strips has a width of from about 50 nanometers to about 5 micrometers, and ranges therebetween, and wherein the graphene strips are separated from one another by a distance of from about 5 nanometers to about 50 micrometers, and ranges therebetween. Alternatively, bulk graphene may be employed and the dielectric layer is used to form periodic regions of differing permittivity. A testing apparatus and method of analyzing a sample using the present SPR sensors are also provided. | 12-24-2015 |
Yinghao Li, New York, NY US
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20130332532 | Systems and Methods of Classifying Content Items - A method of classifying content items utilizes user-generated playlists. A content item is included in respective playlists from a plurality of respective distinct users. The method receives respective user-generated information corresponding to the content item from each of the respective distinct users. For some users, the respective user-generated information is the respective playlist title. For other users, the user-generated information is the text of social network posting that identifies a respective playlist. In each case, the respective user-generated information specifies a first content item attribute that characterizes the content item. Accordingly, the method assigns the first content item attribute to the content item. Subsequently, a request is received from a first user for a content item having the first content item attribute. In response, the method selects the content item according to the first content item attribute and delivers the first content item to the first user. | 12-12-2013 |
20130332842 | Systems and Methods of Selecting Content Items - A method of selecting content items is performed by an electronic device having one or more processors and memory. The memory stores one or more programs for execution by the one or more processors. The method includes providing a first content item to a first user. The first content item is selected from a plurality of available content items, such as audio tracks or videos. The first user provides feedback relating to the first content item, and the feedback is used to adjust content item selection criteria for a second user distinct from the first user. The method includes receiving a request for a content item from the second user and selecting a content item from the plurality of available content items for the second user according to the adjusted content item selection criteria. The selected content item is then provided to the second user. | 12-12-2013 |
Yuan-Min Li, New York, NY US
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20090145472 | PHOTOVOLTAIC DEVICES HAVING CONDUCTIVE PATHS FORMED THROUGH THE ACTIVE PHOTO ABSORBER - A solar PV module comprises an array of serially interconnected spaced PV solar cells on a common substrate, each cell comprising a 1 | 06-11-2009 |
Yueming Li, New York, NY US
Patent application number | Description | Published |
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20080254442 | Crystal structures of human peptide deformylase - The present invention provides the three-dimensional structure of human mitochondrial | 10-16-2008 |
20100285988 | Gamma-Secretase Substrates And Methods Of Use - Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase. | 11-11-2010 |
20110143954 | GAMMA-SECRETASE SUBSTRATE AND METHODS OF USE - Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase. | 06-16-2011 |
20110257027 | GAMMA-SECRETASE SUBSTRATE AND METHODS OF USE - Polypeptide substrates based on modifications or fragments of the various APP isoforms, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. This disclosure further identifies small polypeptides based on a subsequence motif of Aβ that are shown herein to be potent inhibitors of the activity of γ-secretase. | 10-20-2011 |
20110306605 | COUMARIN-BASED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND CANCER - Compounds including those of the Formula I | 12-15-2011 |
20130158017 | METHODS FOR TREATING OR PREVENTING CANCER AND NEURODEGENERATIVE DISEASES - Provided are methods of treating or preventing a neurodegenerative disease comprising administering to a subject having a neurodegenerative disease an effective amount of a compound of Formula I: | 06-20-2013 |
20150133493 | COUMARIN-BASED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND CANCER - Compounds including those of the Formula I | 05-14-2015 |
20150272962 | METHODS FOR TREATING OR PREVENTING CANCER AND NEURODEGENERATIVE DISEASES - Provided are methods of treating or preventing a neurodegenerative disease comprising administering to a subject having a neurodegenerative disease an effective amount of a compound of Formula I: | 10-01-2015 |
Yue-Ming Li, New York, NY US
Patent application number | Description | Published |
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20140031247 | METHODS AND COMPOSITIONS FOR GAMMA-SECRETASE ASSAY - Presented herein are polypeptide substrates based on Notch polypeptides, assay methods based on the use of these substrates, and screening methods directed toward identifying inhibitors of γ-secretase activity. The assay methods and the screening methods are adapted for use in high throughput multi-well plate assay apparatuses. In many embodiments the substrate polypeptides are labeled for ease of detection, and/or may bind specific ligands that themselves are labeled. Generally the labels promote high specificity as well as high sensitivity of detection. These features render the assay and screening methods that employ the labeled substrates especially suited for use in high throughput assay formats. | 01-30-2014 |
Zengmin Li, New York, NY US
Patent application number | Description | Published |
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20080199868 | Massive parallel method for decoding DNA and RNA - This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose. | 08-21-2008 |
20080319179 | Massive parallel method for decoding DNA and RNA - This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose. | 12-25-2008 |
20100317012 | Massive parallel method for decoding DNA and RNA - This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose. | 12-16-2010 |
20110014611 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCES BY SYNTHESIS - This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto. | 01-20-2011 |
20110039259 | DNA SEQUENCE WITH NON-FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS AND CLEAVABLE LABEL MODIFIED NUCLEOTIDE TERMINATORS - This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached to a base thereof. | 02-17-2011 |
20120142006 | MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA - This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose. | 06-07-2012 |
20130096015 | Massive Parallel Method For Decoding DNA And RNA - This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose. | 04-18-2013 |
20140093869 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS - This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto. | 04-03-2014 |
20140206553 | MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA - This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose. | 07-24-2014 |
20160090621 | DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS - This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto. | 03-31-2016 |
Zhenguo Li, New York, NY US
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20130073221 | SYSTEMS AND METHODS FOR IDENTIFICATION OF FLUID AND SUBSTRATE COMPOSITION OR PHYSICO-CHEMICAL PROPERTIES - Techniques for identifying a composition of a target fluid using a set of vectors representing known residue patterns for a two or more fluids including said target fluid is provided. An exemplary method includes storing one or more digital measurements of residue for the target fluid, extracting one or more descriptive features from the measurements; and processing descriptive features to identify the composition of the target fluid. The processing includes using a machine learning algorithm trained with data linking residue morphology to fluid composition. A distance between a vector representing said one or more descriptive features and said set of vectors representing known residue patterns is determined, and a residue is assigned to one or more of the known residue patterns. | 03-21-2013 |
Zongdong Li, New York, NY US
Patent application number | Description | Published |
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20110045008 | THERAPEUTIC AGENTS FOR INDUCING PLATELET FRAGMENTATION AND TREATING THROMBOEMBOLIC DISORDERS - The present invention is directed to a therapeutic agent comprising a GPIIIa(49-66) specific targeting agent and a thrombi-specific homing agent. Also disclosed is the use of the therapeutic agent in carrying out a method of treating thromboembolic disorders and a method of inducing platelet fragmentation. | 02-24-2011 |