Patent application number | Description | Published |
20120108903 | INFRARED ENDOSCOPIC BALLOON PROBES - Balloon probes, adapted for use in endoscopy and other medical procedures, are useful to obtain spectroscopic information reflected or emitted from a tissue of interest in the infrared spectral region. The information collected by the probe is useful in the diagnosis and treatment of disease. The invention also relates to methods utilizing these probes to analyze a surface of interest, in a minimally invasive manner, in connection with the diagnosis and treatment of disease. | 05-03-2012 |
20120215112 | MULTISPECTRAL/HYPERSPECTRAL MEDICAL INSTRUMENT - A medical instrument that comprises: a first-stage optic responsive to a tissue surface of a patient; a spectral separator optically responsive to the first stage optic and having a control input; an imaging sensor optically responsive to the spectral separator and having an image data output; and a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor and a filter control interface having a control output provided to the control input of the spectral separator. | 08-23-2012 |
20130237841 | MULTISPECTRAL/HYPERSPECTRAL MEDICAL INSTRUMENT - A medical instrument that comprises: a first-stage optic responsive to a tissue surface of a patient; a spectral separator optically responsive to the first stage optic and having a control input; an imaging sensor optically responsive to the spectral separator and having an image data output; aid a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor and a filter control interface having a control output provided to the control input of the spectral separator. | 09-12-2013 |
20130345570 | INFRARED ENDOSCOPIC BALLOON PROBES - Balloon probes, adapted for use in endoscopy and other medical procedures, are useful to obtain spectroscopic information reflected or emitted from a tissue of interest in the infrared spectral region. The information collected by the probe is useful in the diagnosis and treatment of disease. The invention also relates to methods utilizing these probes to analyze a surface of interest, in a minimally invasive manner, in connection with the diagnosis and treatment of disease. | 12-26-2013 |
Patent application number | Description | Published |
20100007877 | Narrow-band spectrometric Measurements - Spectrometers and spectrometric measurement methods are disclosed. These employ narrow-band sources positioned in a circular array to perform spectrometric measurements that can employ Hadamard sequences. | 01-14-2010 |
20100097599 | Spectrometric process monitoring - Spectrometric apparatus that include an array of detector elements and exhibits a number of capabilities is disclosed. The elements can be responsive to incident radiation to produce an output signal that includes information from the incident radiation. A spectrally selective element can be located in an optical path between the radiation source and the array, with an analysis module responsive to the output signal operative to analyze spatial distribution of spectral information received by the array. The apparatus can also correct for differences in intensity and spectral variability for spectral image signals and/or compare the spectral image signals with a pattern in spatial-spectral coordinate space. Detector elements can be responsive to scattering, and spatial information in their output can be analyzed. | 04-22-2010 |
20120197541 | PHARMACEUTICAL MIXTURE EVALUATION - A method of obtaining information about a heterogeneous pharmaceutical mixture is disclosed. This method involves applying an image enhancement agent, such as a stain, to the mixture. An image of the mixture can then be obtained, and information about a distribution of components of the mixture in the image can also be obtained based on spatial information derived from the application of the image enhancement agent. | 08-02-2012 |
20130010105 | SPECTROMETRIC INVESTIGATION OF HETEROGENEITY - In one general aspect, a spectroscopic apparatus is disclosed for investigating heterogeneity of a sample area. The apparatus includes an image acquisition system operative to acquire images of a plurality of sub-areas in the sample area and a sub-area selection interface operative to receive a selection designating one of the sub-areas for which an image has been obtained. A spectrometer has a field of view and is operative to acquire a spectrum of at least part of one of the sub-areas in its field of view, and a positioning mechanism is responsive to the sub-area selection interface and operative to position the field of view of the spectrometer relative to the sample area based on a received selection. | 01-10-2013 |
20140002662 | PARTICLE CHARACTERIZATION | 01-02-2014 |
Patent application number | Description | Published |
20080233585 | USE OF DIFFERENTIALLY EXPRESSED NUCLEIC ACID SEQUENCES AS BIOMARKERS FOR CANCER - The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions. | 09-25-2008 |
20090176228 | LUNG CANCER MARKERS, AND USES THEREOF - Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods. | 07-09-2009 |
20120076725 | LUNG CANCER MARKERS, AND USES THEREOF - Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods. | 03-29-2012 |
20150037820 | LUNG CANCER MARKERS AND USES THEREOF - Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness of a treatment or for selecting a treatment using LCM. Methods and compositions are further provided for modulating cell function using LCM. Also provided are compositions that modulate LCM (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate LCM, and agents identified by these screening methods. | 02-05-2015 |
Patent application number | Description | Published |
20080275566 | Femoral hip stem explant system - A femoral hip stem explant system has an alignment body which is attached to two locations of a femoral bone and has several lockable collet type adjustment features to set the shaft of a reamer or end mill exactly in coincidence with the femoral bone cavity axis. The shaft of the end mill or reamer is supported by a sleeve member, which is inserted into a drill guide central aperture. The drill guide aperture is adjusted first and locked to be in line with the femoral bone cavity. Each of the sleeve members has the same mating outer diameter, which fits into the drill guide central aperture. Accordingly, the sleeve members can be interchanged into the drill guide aperture with shafts of differently sized reamers or end mills. | 11-06-2008 |
20090271923 | Patient lifter with intra operative controlled temperature air delivery system - An air mattress has a top chamber and a bottom chamber separated by a barrier. The patient rests on the top surface of the top chamber, which has a plurality of apertures discharging air through apertures that are not blocked by the patient. The top chamber is provided with temperature-controlled heated or cooled air at a regulated pressure. Heated or cooled air from the top chamber is delivered to an area substantially surrounding the patient. The bottom chamber has a bottom surface containing a plurality of apertures that remain closed due to the weight of the mattress and the patient when the pressure-regulated air is beneath a pre-selected value. When the air pressure is increased, the apertures at the bottom surface of the bottom chamber emit air, creating an air cushion underneath the air mattress that facilitates lateral movement of the mattress over a flat or irregular surface, such as from a hospital bed to a stretcher, or from a stretcher to an operating table. | 11-05-2009 |
20100063507 | Low cost modular tapered and spherical hollow reamers for medical applications - An easy-to-assemble modular tapered or spherical reamer for medical applications includes a shaft portion, a disposable tapered or spherical hollow reamer and a guide pin. The shaft proximal end attaches to a drill and the distal end has a tapered body element with a tapered external surface and a central aperture. The disposable tapered or spherical hollow reamer has a central aperture that accepts the guide pin and an interior taper that matches the taper of the tapered body element. The guide pin has attachment means to attach its distal end to the central aperture in the reamer, and the proximal end to the central aperture of the tapered body element of the shaft, assuring reamer/shaft concentricity. Contact between the reamer taper and the taper of the tapered body element aids this concentricity. Torque transmission between the shaft and the reamer is accomplished by torque transmitting tabs or a threaded connection. | 03-11-2010 |
20100069907 | Modular tapered hollow reamer for medical applications - An easy-to-assemble reamer for medical applications includes a shaft portion, a disposable tapered hollow reamer sleeve and a modular pilot. The shaft portion has a proximal end for attachment to a drill, a central cone element with one or more slots and a distal threaded end. The tapered hollow reamer sleeve has integrally attached one or more torque transmitting tabs at the larger end and a collet taper at the smaller end and slides over the shaft distal end engaging tabs with the slots. The modular pilot has a threaded central aperture engaging shaft thread and a collet taper mating with the collet taper of the reamer sleeve substantially coinciding their centerlines. The disposable hollow cutter sleeve has a plurality of cutting elements and apertures that discharge bone and bone cement debris into the space between the reamer and the shaft. With this construction, the reamer transmits reliable, wobble free, reaming torque in a highly efficient manner. | 03-18-2010 |
20100069908 | Modular spherical hollow reamer assembly for medical applications - A low cost disposable spherical hollow reamer for medical applications includes a reusable shaft and a disposable spherical hollow reamer. The hollow reamer is thin sheet metal with 0.125 mm to 0.812 mm thickness and has plurality of cutters and apertures that extend through its thickness. The shaft has a proximal end for attachment to a drill and a distal precision threaded screw end. The spherical hollow reamer has welded first plate in its interior with a precision threaded aperture engaging with the threaded end of the reusable shaft. The spherical hollow reamer has a welded second plate with a central precision aperture that slides over the shaft external surface. The threaded attachment and sliding fit attachment provides wobble free reaming action. The welded second plate in combination with the interior surface of the spherical hollow reamer forms enclosed space for capturing bone fragment and bone cement debris. | 03-18-2010 |
20100152739 | Disposable flexible reamer shaft for medical applications - A low cost disposable flexible reamer shaft has a flexible cylindrical braided tube shaft with an outer diameter in the range of 4 to 14 millimeters and 250 to 400 mm length, and a central aperture for insertion of a flexible polymeric tube. The braided tube shaft is permanently attached to a first end element and a second end element. The threaded end of the first end element attaches to female threads of modular tapered, cylindrical or spherical, hollow or solid reamer assembly. The second end element fits into a chuck of a drive motor. The threaded attachment of the first end provides local centerline matching. A guide pin is inserted in the bone cavity, which enters the reamer. The central aperture of the flexible polymeric tube provides centerline matched, wobble-free reaming. The reaming end point is precisely the guide pin inserted location while the reaming direction is controlled by the surgeon by flexing the flexible reamer shaft. | 06-17-2010 |
20100168749 | Disposable reamer shaft or modular spherical or tapered hollow reamer assembly for medical applications - A low cost disposable reamer shaft is made from a rod or tube stock of stainless steel, Nitinol or fiber reinforced polymer having a precise outer diameter in the range of 4 to 14 millimeter and is cut to a shaft length of 250 to 400 millimeters. An attachment piece with male or female thread matching a spherical hollow or tapered hollow reamer is machined and glued with epoxy on one end of the rod of tube stock using a precision centerline aligning jig. An attachment piece for connecting to a drive power unit is machined and glued with epoxy to the other end of the rod or tube stock thus forming a low cost disposable reamer shaft that aligns the centerline of the shaft with that of the reamer. The shaft contacts the reamer at two attachment locations that are displaced from each other, providing precise centerline alignment. | 07-01-2010 |
20120079656 | Patient lifter with intraoperative controlled temperature air delivery system - A combination patient-transfer and intraoperative heater has top and bottom chambers separated by a barrier. The patient rests on the top chamber, which has plural apertures for discharge of temperature-controlled heated or cooled air at regulated pressure. Heated or cooled air is delivered to the area surrounding the patient, maintaining body temperature during anesthesia. The bottom chamber has plural apertures. When air pressure is low or off, the bottom chamber is flat and un-inflated. When air pressure is increased, air enters the bottom chamber and the apertures emit air, creating an air cushion facilitating lateral movement of the lifter device. The device is light, flexible, easily stored, and preferably disposable, thereby reducing risk of infection and avoiding cleaning costs. The device performs two functions that now require separate devices and air blowers, it saves space and reduces both costs and complexity in the operating room. | 04-05-2012 |
20130150860 | MEDICAL CUTTING TOOL QUALITY CONTROL SYSTEMS AND METHODS - A cutting tool includes a cutting surface on a first side and an attachment member on a second side. The attachment member is configured to be coupled to a powered driving member. The cutting tool includes a limiting device configured to restrict the use of the cutting tool to a predetermined number of uses. The limiting device can be configured to restrict the number of uses of the cutting tool by restricting the number of times that the attachment member can be coupled to the powered driving member. | 06-13-2013 |
20130245628 | MEDICAL REAMERS AND METHODS OF FORMING THE SAME - A cutting tool is provided with a cutting surface on a first side of the cutting tool and an attachment member on a second side of the cutting tool. The cutting surface can have cutting edges with characteristics that vary along the cutting tool. Novel methods of manufacturing such cutting tools are also provided. | 09-19-2013 |
20140025078 | Disposable Reamer Shaft For Modular Spherical Or Tapered Hollow Reamer Assembly For Medical Applications - A low cost disposable reamer shaft is made from a rod or tube stock of stainless steel, Nitinol or fiber reinforced polymer having a precise outer diameter in the range of 4 to 14 millimeter and is cut to a shaft length of 250 to 400 millimeters. An attachment piece with male or female thread matching a spherical hollow or tapered hollow reamer is machined and glued with epoxy on one end of the rod of tube stock using a precision centerline aligning jig. An attachment piece for connecting to a drive power unit is machined and glued with epoxy to the other end of the rod or tube stock thus forming a low cost disposable reamer shaft that aligns the centerline of the shaft with that of the reamer. The shaft contacts the reamer at two attachment locations that are displaced from each other, providing precise centerline alignment. | 01-23-2014 |
20140188116 | MEDICAL REAMERS AND METHODS OF FORMING THE SAME - A cutting tool is provided with a cutting surface on a first side of the cutting tool and an attachment member on a second side of the cutting tool. The cutting surface can have cutting edges with characteristics that vary along the cutting tool. Novel methods of manufacturing such cutting tools are also provided. | 07-03-2014 |