Lengauer
Christopher Lengauer, Baltimore, MD US
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20110059434 | P13k pathway mutations in cancer - Given the important role of protein kinases in pathways affecting cellular growth and invasion, we have analyzed 340 serine/threonine kinases for genetic mutations in colorectal cancers. Mutations in eight genes were identified, including three members of the phosphatidylinositol-3-kinase (PI3K) pathway; the alterations in the latter genes each occurred in different tumors and did not overlap with mutations in PIK3CA or other non-serine-threonine kinase (STK) members of the PI3K pathway, suggesting that mutations in any of these genes had equivalent tumorigenic effects. These data demonstrate that the PI3K pathway is a major target for mutational activation in colorectal cancers and provide new opportunities for therapeutic intervention. | 03-10-2011 |
Gerhard Lengauer, Bad Zell AT
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20110003113 | PROCESS FOR PRODUCING SHAPED COMPONENTS FROM HIGH-STRENGTH AND ULTRA HIGH-STRENGTH STEELS - This invention pertains to a process for producing shaped components from high-strength and ultra high-strength steels with tensile strengths >780 MPa, wherein a steel sheet-metal strip is fed to a roll-forming installation and in the roll-forming installation is passed through roll stands and deformed by means of deformation rollers acting on the steel sheet, and wherein to avoid hydrogen embrittlement in plastically deformed regions of the deformed steel sheet-metal strip compressive stresses are introduced by stamping and/or upset-forging and/or overbending and bending-back or by machining the strip edges. | 01-06-2011 |
20110011499 | METHOD AND DEVICE FOR HARDENING PROFILES - The invention relates to a method for producing hardened profiles, in particular hardened open profiles, wherein the component is at least partly heated to above the austenitizing temperature of the base material and after heating the component is cooled at a rate above the critical hardening rate, the energy necessary for the heating being introduced at least partly by induction, wherein free edges are provided in the component to adjust a temperature or hardness gradient over the cross section of the component, the size, type and extension of the edges being set for a desired degree of hardness and/or hardness gradient. | 01-20-2011 |
Gunter Lengauer, Gallneukirchen AT
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20160054282 | LANCE AND METHOD FOR DETERMINING REACTION DATA OF THE COURSE OF A REACTION - A lance and a method determine reaction data of the course of a reaction, in which a reaction gas is top-blown by at least one lance onto a metallic melt in a metallurgical vessel and measured data are determined in this way, reaction data for the course of the reaction are determined as a function of these, where the lance for determining measured data blows out a gas which is conveyed separately from the reaction gas through at least one outlet opening of at least one measuring conduit. The lance for determining measured data blows out the gas which is conveyed separately from the reaction gas laterally through at least one outlet opening of at least one measuring conduit and the internal pressure of at least one gas bubble of this gas formed at this outlet opening of the respective measuring conduit is measured. | 02-25-2016 |
Hannes Lengauer, Kundl AT
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20100204470 | METHOD FOR SALT PREPARATION - The present invention provides a new method for preparation and crystallization of hydrochlorides, hydrobromides or hydroiodides of pharmaceutical compounds or their intermediates in which the base or its acid addition salt is reacted in a solvent with a Trialkylsilylhalogenide. | 08-12-2010 |
20150274732 | PREPARATION OF ERTAPENEM INTERMEDIATES - The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics, preferably carbapenem antibiotics, more preferably ertapenem, and salts thereof. | 10-01-2015 |
Thomas Lengauer, Linz AT
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20150196941 | METHOD AND DEVICE FOR A COMBINED CONTINUOUS CASTING AND ROLLING SYSTEM - A method and device for producing hot-rolled products in a combined continuous casting and rolling system ( | 07-16-2015 |
Walter Lengauer, Leobendorf AT
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20110150692 | Submicron Cemented Carbide with Mixed Carbides - A cemented carbide body is 1-30% by mass of binder consisting of Co, Co/Ni, Co/Fe, Co/Ni/Fe or Ni/Fe and a hard material having a hexagonal WC phase and having a face-centered cubic phase of the form (M | 06-23-2011 |