Patent application number | Description | Published |
20100030339 | METHOD AND APPARATUS FOR ADJUSTING HEIGHT AND ANGLE FOR A RADIAL HEAD - A modular prosthesis system for replacement of a head portion of a radius. The prosthesis system includes a head component having a first connection portion that connects to a second connection portion and a collar component having the second connection portion and a third connection portion. The system also includes a stem component including a fourth connection portion that connects with the third connection portion, the stem component having a stem anchoring portion that connects to the radius. The collar component provides the modular geometry to the prosthesis without having to have an increased number of head components and stem components with variable lengths and angles. | 02-04-2010 |
20100262252 | MODULAR PROSTHESIS AND USE THEREOF FOR REPLACING A RADIAL HEAD - A modular prosthesis system for replacement of a head portion of a proximal radius includes a monolithic stem component, a head component, and a locking mechanism formed by the stem and head components. The stem component defines a stem anchoring portion having a longitudinal axis and configured to couple to the proximal radius, and a dovetail-shaped first mounting portion on a first end face that extends in a first direction transverse to the longitudinal axis. The head component has a dovetail-shaped second mounting portion on a second end face opposite the first end face slidably engaged with the first mounting portion along the first direction. One of the first and second mounting portions intersects the longitudinal axis. The locking mechanism is formed at an interface between the stem and head components and is engaged through relative translational movement between the stem and head components. A related method is provided. | 10-14-2010 |
20110125276 | MODULAR PROSTHESIS AND USE THEREOF FOR REPLACING A RADIAL HEAD - A modular prosthesis system for replacement of a head portion of a proximal radius includes a monolithic stem component, a head component, and a locking mechanism formed by the stem and head components. The stem component defines a stem anchoring portion having a longitudinal axis and configured to couple to the proximal radius, and a dovetail-shaped first mounting portion on a first end face that extends in a first direction transverse to the longitudinal axis. The head component has a dovetail-shaped second mounting portion on a second end face opposite the first end face slidably engaged with the first mounting portion along the first direction. One of the first and second mounting portions intersects the longitudinal axis. The locking mechanism is formed at an interface between the stem and head components and is engaged through relative translational movement between the stem and head components. A related method is provided. | 05-26-2011 |
20110144759 | MODULAR PROSTHESIS AND USE THEREOF FOR REPLACING A RADIAL HEAD - A modular prosthesis system for replacement of a head portion of a proximal radius includes a monolithic stem component, a head component, and a locking mechanism formed by the stem and head components. The stem component defines a stem anchoring portion having a longitudinal axis and configured to couple to the proximal radius, and a dovetail-shaped first mounting portion on a first end face that extends in a first direction transverse to the longitudinal axis. The head component has a dovetail-shaped second mounting portion on a second end face opposite the first end face slidably engaged with the first mounting portion along the first direction. One of the first and second mounting portions intersects the longitudinal axis. The locking mechanism is formed at an interface between the stem and head components and is engaged through relative translational movement between the stem and head components. A related method is provided. | 06-16-2011 |
Patent application number | Description | Published |
20080317707 | PEGYLATED INTERLEUKIN-10 - Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10. | 12-25-2008 |
20100297069 | PEGYLATED INTERLEUKIN-10 - Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10. | 11-25-2010 |
20110064690 | Pegylated Interleukin-10 - Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10. | 03-17-2011 |
20110135623 | Conjugates of a Cholinesterase Moiety and a Polymer - Conjugates of a cholinesterase moiety and one or more nonpeptidic, water soluble polymers are provided. Typically, the nonpeptidic, water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient. | 06-09-2011 |
20110305665 | PEGYLATED INTERLEUKIN-10 - Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10. | 12-15-2011 |
20130143909 | Acid Salt Forms of Polymer-Drug Conjugates and Alkoxylation Methods - Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate. | 06-06-2013 |
20130231359 | Salt Form of a Multi-Arm Polymer-Drug Conjugate - Among other aspects, provided herein is a hydrohalide salt of a multi-arm water-soluble polyethylene glycol-drug conjugate, along with related methods of making and using the same. The hydrohalide salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding free base form of the conjugate. | 09-05-2013 |
20150105519 | ACID SALT FORMS OF POLYMER-DRUG CONJUGATES AND ALKOXYLATION METHODS - Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate. | 04-16-2015 |
Patent application number | Description | Published |
20120193463 | CORRUGATED EDGE NIP - A web tensioner, a web slitter, a method of tensioning a web, and a method of slitting a web are provided. A corrugated edge nip is used in the tensioner, the slitter, and the methods of tensioning and slitting. The corrugated edge nip can provide a crossweb tension to a suspended web or film in a web line. The corrugated edge nip can be used in conjunction with, for example, a rotary shear slitter to improve slit edge quality. | 08-02-2012 |
20130248643 | OPEN GAP FILM ROLL CORE - The disclosure generally relates to a film roll core used for winding a polymeric film around, an apparatus for winding the polymeric film on the film roll core, a process of winding the polymeric film on the film roll core, and a rolled film on the film roll core. The disclosure more particularly relates to an open gap film roll core that is capable of reducing defects in wound films. | 09-26-2013 |
20150232294 | CORRUGATED EDGE NIP - A web tensioner, a web slitter, a method of tensioning a web, and a method of slitting a web are provided. A corrugated edge nip is used in the tensioner, the slitter, and the methods of tensioning and slitting. The corrugated edge nip can provide a crossweb tension to a suspended web or film in a web line. The corrugated edge nip can be used in conjunction with, for example, a rotary shear slitter to improve slit edge quality. | 08-20-2015 |
20150274483 | LOOPED PILE FILM ROLL CORE - The disclosure generally relates to a looped pile film roll core used for winding a polymeric film, a method of winding film on the looped pile film roll core, and a roll of film that includes the looped pile film roll core. The disclosure describes an article and a process to reduce the core impressions created by the starting end of a web on the adjacent web layers next to the core. In one particular embodiment, the present disclosure can lead to a reduction in the amount and severity of such core impressions on a wound polymeric film, by reducing the amount of stress in adjacent layers of wound web. | 10-01-2015 |