Patent application number | Description | Published |
20100093644 | TEMPLATE-FIXED PEPTIDOMIMETICS - Template-fixed β-hairpin peptidomimetics of the general formula (I) wherein Z is a template-fixed chain of 4 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to agonize or to antagonize GPCR receptors such as CXCR3, urotensin and CCR10. They can be used as medicaments to treat or prevent diseases such as cardiovascular disorders, dermatological disorders, endocrine system and hormone disorders, metabolic diseases, inflammatory diseases, neurological diseases, respiratory diseases, haematological diseases and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy. | 04-15-2010 |
20110230426 | TEMPLATE-FIXED PEPTIDOMIMETICS - Template-fixed β-hairpin peptidomimetics of the general formula | 09-22-2011 |
20110312879 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY - Template-fixed peptidomimetics formula (Ia) formula (Ib) wherein Z is a template-fixed chain of 14 α-amino and/or α-hydroxy acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Pro, Gly, a glycolic acid residue or of certain types which, as the remaining symbols in the above formulae, are defined in the description and the claims, and salts thereof, have CXCR4 antagonizing properties and can be used for preventing HIV infections in non-infected individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immuno suppression; or during apheresis collections of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These depsipeptides can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy. | 12-22-2011 |
20120135942 | BETA-HAIRPIN PEPTIDOMIMETICS - β-Hairpin peptidomimetics of the general formula Cyclo(-Xaa | 05-31-2012 |
20120283168 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY - Novel template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to antagonize the receptor CCR10. They can be used as medicaments to treat or prevent diseases or conditions in the area of dermatological and cutaneous disorders, inflammation, allergic disorders, respiratory diseases, diseases of the gastro-intestinal tract, ophthalmic diseases, haematology and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy. | 11-08-2012 |
20120283196 | BETA-HAIRPIN PEPTIDOMIMETICS - β-Hairpin peptidomimetics of the general formula Cyclo(-Xaa | 11-08-2012 |
20130023483 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY - Specific template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected from the carbonyl (C═O) point of attachment to the nitrogen (N) of the next element in clockwise direction and wherein said elements, depending on their positions in the chain, are defined in the description and the claims have the property to act on the receptor CXCR7. Thus, these β-hairpin peptidomimetics can be useful in the treatment or prevention of diseases or conditions in the area of dermatological disorders, metabolic diseases, inflammatory diseases, fibrotic diseases, infectious diseases, neurological diseases, cardiovascular diseases, respiratory diseases, gastro-intestinal tract disorders, urological diseases, ophthalmic diseases, stomatological diseases, haematological diseases and cancer; or the mobilisation of stem cells. | 01-24-2013 |
20130225506 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY - Novel template-fixed β-hairpin peptidomimetics of the general formula (I), wherein the single elements T or P are α-amino acid residues connected from the carbonyl (C═O) point of attachment to the nitrogen (N) of the next element in clockwise direction and wherein said elements, depending on their positions in the chain, are defined in the description and the claims have the property to act on the receptor CXCR7. Thus, these β-hairpin peptidomimetics can be useful in the treatment or prevention of diseases or conditions in the area of dermatological disorders, metabolic diseases, inflammatory diseases, fibrotic diseases, infectious diseases, neurological diseases, cardiovascular diseases, respiratory diseases, gastro-intestinal tract disorders, urological diseases, ophthalmic diseases, stomatological diseases, haematological diseases and cancer; or the mobilisation of stem cells. | 08-29-2013 |
20140107031 | TEMPLATE-FIXED PEPTIDOMIMETICS - Template-fixed β-hairpin peptidomimetics of the general formula | 04-17-2014 |
20140364583 | BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY - β-Hairpin peptidomimetics of the general formula Cyclo(—Xaa | 12-11-2014 |
20150218219 | BETA-HAIRPIN PEPTIDOMIMETICS - β-Hairpin peptidomimetics of the general formula cyclo(-Tyr | 08-06-2015 |
20150307556 | TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY - Novel template-fixed β-hairpin peptidomimetics of the general formula (I) | 10-29-2015 |
Patent application number | Description | Published |
20100286310 | LOW-STICKY ADDITIVE PACKAGE FOR AUTOMOTIVE INTERIOR APPLICATIONS - Composition comprising polypropylene and (a) at least one phenolic antioxidant (A) (b) at least one hindered amine light stabilizer (B) (c) at least one slip agent (C) being a fatty acid amide, (d) a bisphenol A epoxy resin with an average molecular weight (Mw) below 2000 g/mol (D), and (e) talc (E). | 11-11-2010 |
20120115995 | AUTOMOTIVE INTERIOR ARTICLE WITH REDUCED SMELL - Automotive interior article comprising a polypropylene composition having a melt flow rate MFR2 (230° C.) of 2.0 to 80.0 g/10 min, said polypropylene composition comprises (a) at least 25 wt.-% of a heterophasic polypropylene (H-PP1), (b) 10,000 to 550,000 ppm inosilicate, (c) 1000 to 5,000 ppm of phenolic antioxidants, and further wherein said heterophasic polypropylene (i) comprises a polypropylene matrix and an elastomeric copolymer, said elastomeric copolymer comprises units from .propylene and .ethylene and/or C4 to C20 α-olefin (ii) has comonomer content of 8 to 30 wt.-% based on said heterophasic polypropylene, said comonomer is ethylene and/or at least one C4 to C20 α-olefin, and (iii) has a xylene cold soluble (XCS) content measured according to ISO 6427 of 15.0 to 40.0 wt.-% based on the heterophasic polypropylene. | 05-10-2012 |
20120123033 | POLYPROPYLENE MINERAL COMPOUND WITH REDUCED VOLATILES - Use of an inosilicate in a polymer composition to accomplish a headspace emission of all volatiles together of said polymer composition of equal or below 120 μgC/g. | 05-17-2012 |
20130123413 | Automotive Interior Compound - Composition having a melt flow rate MFR | 05-16-2013 |
20140303301 | COMPOSITION WITH IMPROVED LONG TERM SCRATCH RESISTANCE AND REDUCED SURFACE TACK - Automotive interior article comprising a composition comprising a heterophasic propylene copolymer (HECO), and a fatty acid amide derivative of formula (I) wherein R | 10-09-2014 |
20140306484 | EXTERIOR AUTOMOTIVE ARTICLE WITH REDUCED PAINTABILITY FAILURE - Exterior automotive article comprising a composition comprising a polypropylene, an elastomeric copolymer, and a mineral filler, wherein said polypropylene (PP) has a comonomer content of equal or below 1.0 wt.-%, the comonomers are ethylene and/or at least one C | 10-16-2014 |
20150322251 | AUTOMOTIVE COMPOUNDS WITH IMPROVED ODOR - The present invention relates to a polymer composition comprising a heterophasic propylene copolymer, a mineral filler and a light stabilizer comprising a fatty acid derivative and a benzoate derivative. The polymer composition according to the present invention is applicable for automotive articles whereupon the undesired effect of the final odor is reduced significantly compared to automotive articles comprising conventional light stabilizers. | 11-12-2015 |