Patent application number | Description | Published |
20100158026 | Transparent Interaction with multi-layer protocols via Selective Bridging and Proxying - The current invention defines a device and a method of logically inserting the device between two other network devices, for example, in a 3GPP Radio Access Network. The device transparently monitors and interacts with one or more control protocol layers in the two neighboring devices. The invention defines methods by which the intercepting node selectively passes through or proxies (selectively modifying portions of the protocols content) in such as way that the neighbor nodes are un-aware of the intercepting device. The proxy operation implies that the intercepting node is capable of terminating some protocol elements, injecting some protocol elements, or modifying protocol elements before forwarding them in such a way that the operation is transparent to neighboring nodes. These selective insertion/modifications facilitate identifying signaling connections for specific mobile clients, and enhancing and modifying service features for dataplane accesses for those client devices, while transparently passing other protocol messages. | 06-24-2010 |
20100195602 | Application, Usage & Radio Link Aware Transport Network Scheduler - A packet scheduling method and apparatus with the knowledge of application behavior, anticipated usage/behavior based on the type of content, and underlying transport conditions during the time of delivery, is disclosed. This type of scheduling is applicable to a content server or a transit network device in wireless (e.g., 3G, WIMAX, LTE, WIFI) or wire-line networks. Methods for identifying or estimating rendering times of multi-media objects, segmenting a large media content, and automatically pausing or delaying delivery are disclosed. The scheduling reduces transit network bandwidth wastage, and facilitates optimal sharing of network resources such as in a wireless network. | 08-05-2010 |
20110136488 | SESSION HANDOVER IN MOBILE-NETWORK CONTENT-DELIVERY DEVICES - An application mobility-management entity (“AME”) in a radio-access network detects movement of a mobile device and routes application data for already-active application streams associated with the mobile device to the device's new location by establishing a connection to a second AME in the radio-access network. The second AME merges forwarded application data from/to the first AME for previously active application streams with the new application streams (e.g., new TCP connections) locally and forwards to/from the mobile device through the radio access network elements. | 06-09-2011 |
20110167170 | Adaptive Chunked and Content-aware Pacing of Multi-Media Delivery over HTTP Transport and Network Controlled Bit Rate Selection - A network device, capable of understanding communications between an end user and the core network on a RAN network is disclosed. In some embodiments, the device is able to decode the control plane and the user plane. As such, it is able to determine when the end user has requested multimedia content. Once this is known, the device can optimize the delivery of that content in several ways. In one embodiment, the device requests the content from the content server (located in the core network) and transmits this content in a just-in-time manner to the end user. In another embodiment, the device automatically changes the encoding and resolution of the content, based on overall monitored network traffic. In another embodiment, the device automatically selects or modifies the format and resolution options based on overall bandwidth limitations, independent of the end user. | 07-07-2011 |
20130235845 | SESSION HANDOVER IN MOBILE-NETWORK CONTENT-DELIVERY DEVICES - An application mobility-management entity (“AME”) in a radio-access network detects movement of a mobile device and routes application data for already-active application streams associated with the mobile device to the device's new location by establishing a connection to a second AME in the radio-access network. The second AME merges forwarded application data from/to the first AME for previously active application streams with the new application streams (e.g., new TCP connections) locally and forwards to/from the mobile device through the radio access network elements. | 09-12-2013 |
Patent application number | Description | Published |
20120106715 | FLUOROSCOPY OPERATOR PROTECTION DEVICE - A radiation protection device attaches to the C-arm of a fluoroscope and shields and collimates the X-ray beam between the X-ray source and the patient and between the patient and the image intensifier. One embodiment has a radiation shield of X-ray opaque material that surrounds the C-arm of the fluoroscopy system, the X-ray source and the image intensifier. A padded slot fits around the patient's body. Another embodiment has conical or cylindrical radiation shields that extend between the X-ray source and the patient and between the patient and the image intensifier. The radiation shields have length adjustments and padded ends to fit the device to the patient. The radiation protection device may be motorized to advance and withdraw the radiation shields. A blanket-like radiation shield covers the patient in the area surrounding where the X-ray beam enters the body. | 05-03-2012 |
20120283626 | PORTABLE TOPICAL OXYGEN THERAPY SYSTEM - The present invention provides a topical oxygen therapy system for treating chronic non-healing wounds. The system is configured to be extremely portable, allowing patients to be completely ambulatory during treatment. The topical oxygen therapy system includes an oxygen source and a wound dressing capsule. The oxygen source includes a miniature compressed oxygen cylinder and a miniature pressure regulator that delivers oxygen through an outlet tube to the interior of the wound dressing capsule. The oxygen source may be attached directly to or integrated into the wound dressing capsule. Alternatively, the oxygen source and wound dressing capsule may be separate modules connected by a flexible tube. | 11-08-2012 |
20130066365 | RAPID CLOSING SURGICAL CLOSURE DEVICE - A surgical or wound closure device utilizes a slide fastener for rapidly closing a surgical incision or wound with precise apposition of the sides of the incision. The surgical closure devices are configured for linear incisions, shaped incisions, such as used for wedge biopsy or excisional biopsy, and long incisions, such as used for laparotomy or surgical removal of redundant skin. The surgical closure device may be adhered to the patient's skin prior to making an incision and is subsequently used for closing the incision. | 03-14-2013 |
20130150832 | APPARATUS AND METHODS FOR HYBRID ENDOSCOPIC AND LAPAROSCOPIC SURGERY - Apparatus and methods are described allow the techniques of endoscopic and laparoscopic surgery to be combined into a minimally invasive hybrid surgical technique called NOTES-assisted laparoscopic surgery. Manual and robotic-controlled versions of a modular laparoscopic tool are described having a small diameter shaft that is delivered laparoscopically to a surgical site. Larger diameter working tips are delivered through a NOTES delivery tube inserted to the surgical site through a natural orifice and joined to the shaft of the modular laparoscopic tool. Larger diameter working tips improve the effectiveness of the modular laparoscopic tools and the number and size of laparoscopic ports used can also be reduced. | 06-13-2013 |
20130150871 | APPARATUS AND METHODS FOR HYBRID ENDOSCOPIC AND LAPAROSCOPIC SURGERY - Apparatus and methods are described allow the techniques of endoscopic and laparoscopic surgery to be combined into a minimally invasive hybrid surgical technique called NOTES-assisted laparoscopic surgery. Manual and robotic-controlled versions of a modular laparoscopic tool are described having a small diameter shaft that is delivered laparoscopically to a surgical site. Larger diameter working tips are delivered through a NOTES delivery tube inserted to the surgical site through a natural orifice and joined to the shaft of the modular laparoscopic tool. Larger diameter working tips improve the effectiveness of the modular laparoscopic tools and the number and size of laparoscopic ports used can also be reduced. | 06-13-2013 |
20140336458 | APPARATUS AND METHODS FOR HYBRID ENDOSCOPIC AND LAPAROSCOPIC SURGERY - Apparatus and methods are described allow the techniques of endoscopic and laparoscopic surgery to be combined into a minimally invasive hybrid surgical technique called NOTES-assisted laparoscopic surgery. Manual and robotic-controlled versions of a modular laparoscopic tool are described having a small diameter shaft that is delivered laparoscopically to a surgical site. Larger diameter working tips are delivered through a NOTES delivery tube inserted to the surgical site through a natural orifice and joined to the shaft of the modular laparoscopic tool. Larger diameter working tips improve the effectiveness of the modular laparoscopic tools and the number and size of laparoscopic ports used can also be reduced. | 11-13-2014 |
20160095597 | RAPID CLOSING SURGICAL CLOSURE DEVICE - A surgical or wound closure device utilizes a slide fastener for rapidly closing a surgical incision or wound with precise apposition of the sides of the incision. The surgical closure devices are configured for linear incisions, shaped incisions, such as used for wedge biopsy or excisional biopsy, and long incisions, such as used for laparotomy or surgical removal of redundant skin. The surgical closure device may be adhered to the patient's skin prior to making an incision and is subsequently used for closing the incision. | 04-07-2016 |
20160106931 | RAPID CLOSING SURGICAL CLOSURE DEVICE - A surgical or wound closure device utilizes a slide fastener for rapidly closing a surgical incision or wound with precise apposition of the sides of the incision. The surgical closure devices are configured for linear incisions, shaped incisions, such as used for wedge biopsy or excisional biopsy, and long incisions, such as used for laparotomy or surgical removal of redundant skin. The surgical closure device may be adhered to the patient's skin prior to making an incision and is subsequently used for closing the incision. | 04-21-2016 |
Patent application number | Description | Published |
20100151284 | METHODS AND CONTROLS FOR HYDROGEN TO CATHODE INLET OF A FUEL CELL SYSTEM - A system and method for quickly heating a fuel cell stack at fuel cell system start-up. The fuel cell system includes a three-way valve positioned in the anode exhaust that selectively directs the anode exhaust gases to the cathode input of the fuel cell stack so that hydrogen in the anode exhaust gas can be used to heat the fuel cell stack. During normal operation when the fuel cell stack is at the desired temperature, the three-way valve in the anode exhaust can be used to bleed nitrogen to the cathode exhaust. | 06-17-2010 |
20100151285 | ANODE REACTIVE BLEED AND INJECTOR SHIFT CONTROL STRATEGY - A system and method for correcting a large fuel cell voltage spread for a split sub-stack fuel cell system. The system includes a hydrogen source that provides hydrogen to each split sub-stack and bleed valves for bleeding the anode side of the sub-stacks. The system also includes a voltage measuring device for measuring the voltage of each cell in the split sub-stacks. The system provides two levels for correcting a large stack voltage spread problem. The first level includes sending fresh hydrogen to the weak sub-stack well before a normal reactive bleed would occur, and the second level includes sending fresh hydrogen to the weak sub-stack and opening the bleed valve of the other sub-stack when the cell voltage spread is close to stack failure. | 06-17-2010 |
20130009082 | ICE BREAKING ANODE VALVE - A valve for a fuel cell system includes a valve housing having a valve seat formed therein. The valve seat includes an orifice formed therein to permit a fluid to flow through the valve housing. A movable member is disposed in the valve housing and is movable between an open position and a closed position. The movable member includes a first end having an elongate portion and a generally conical shaped base. At least a portion of the base is disposed in the orifice of the valve seat when the movable member is in the closed position to militate against a formation of ice across the orifice of the valve seat. | 01-10-2013 |
20140272650 | SLIP STREAM FOR RELIABLE ANODE TO CATHODE FLOW IN FREEZE CONDITIONS - A device and method for ensuring proper fuel cell system warmup or shutdown during freeze conditions. A three-way valve is used in conjunction with a flow-controlling orifice to ensure that the orifice avoids ice blockage during frozen conditions. Dry, warm air is delivered as a slip stream under pressure to a cathode flowpath, where the construction of the orifice is such that it is structurally compliant to promote flexing in response to the pressurized slip stream, thereby helping to break up any small amount of ice that may have formed in or on the orifice. | 09-18-2014 |
Patent application number | Description | Published |
20080280142 | Preparation of organic additive-treated, pyrogenic silica-encapsulated titanium dioxide particles - One aspect of the invention is to provide a composition comprising a titanium dioxide particle having on the surface of said particle a substantially encapsulating layer comprising a pyrogenically-deposited metal oxide; said substantially encapsulating layer having on its surface at least one organic surface treatment material selected from an organo-silane, an organo-siloxane, a fluoro-silane, an organo-phosphonate, an organo-acid phosphate, an organo-pyrophosphate, an organo-polyphosphate, an organo-metaphosphate, an organo-phosphinate, an organo-sulfonic compound, a hydrocarbon-based carboxylic acid, an associated ester of a hydrocarbon-based carboxylic acid, a derivative of a hydrocarbon-based carboxylic acid, a hydrocarbon-based amide, a low molecular weight hydrocarbon wax, a low molecular weight polyolefin, a co-polymer of a low molecular weight polyolefin, a hydrocarbon-based polyol, a derivative of a hydrocarbon-based polyol, an alkanolamine, a derivative of an alkanolamine, an organic dispersing agent, or a mixture thereof. Another aspect of the invention is to provide processes for producing said composition. | 11-13-2008 |
20100324186 | PREPARATION OF ORGANIC ADDITIVE-TREATED, PYROGENIC SILICA-ENCAPSULATED TITANIUM DIOXIDE PARTICLES - One aspect of the invention is to provide a composition comprising a titanium dioxide particle having on the surface of said particle a substantially encapsulating layer comprising a pyrogenically-deposited metal oxide; said substantially encapsulating layer having on its surface at least one organic surface treatment material selected from an organo-silane, an organo-siloxane, a fluoro-silane, an organo-phosphonate, an organo-acid phosphate, an organo-pyrophosphate, an organo-polyphosphate, an organo-metaphosphate, an organo-phosphinate, an organo-sulfonic compound, a hydrocarbon-based carboxylic acid, an associated ester of a hydrocarbon-based carboxylic acid, a derivative of a hydrocarbon-based carboxylic acid, a hydrocarbon-based amide, a low molecular weight hydrocarbon wax, a low molecular weight polyolefin, a co-polymer of a low molecular weight polyolefin, a hydrocarbon-based polyol, a derivative of a hydrocarbon-based polyol, an alkanolamine, a derivative of an alkanolamine, an organic dispersing agent, or a mixture thereof. Another aspect of the invention is to provide processes for producing said composition. | 12-23-2010 |
Patent application number | Description | Published |
20120264698 | METHOD OF USING DOPAMINE REUPTAKE INHIBITORS AND THEIR ANALOGS FOR TREATING AUTOIMMUNE CONDITIONS AND DELAYING OR PREVENTING AUTOIMMUNE RELATED PATHOLOGIC PROGRESSIONS - Dopamine reuptake inhibitors, and their analogs, are disclosed for treating and delaying the progression of autoimmune diseases. | 10-18-2012 |
20130131127 | METHOD OF USING DOPAMINE REUPTAKE INHIBITORS AND THEIR ANALOGS FOR TREATING DIABETES SYMPTOMS AND DELAYING OR PREVENTING DIABETES-ASSOCIATED PATHOLOGIC CONDITIONS - Method of using dopamine reuptake inhibitors, e.g., sydnonimine derivatives, for the management of diabetic symptoms and associated complications or conditions, such as hyperglycemia and diabetic neuropathy. | 05-23-2013 |
20140206625 | METHOD OF USING DOPAMINE REUPTAKE INHIBITORS AND THEIR ANALOGS FOR TREATING AUTOIMMUNE CONDITIONS AND DELAYING OR PREVENTING AUTOIMMUNE RELATED PATHOLOGIC PROGRESSIONS - Dopamine reuptake inhibitors, and their analogs, are disclosed for treating and delaying the progression of autoimmune diseases. | 07-24-2014 |
20150366846 | METHOD OF USING DOPAMINE REUPTAKE INHIBITORS AND THEIR ANALOGS FOR TREATING DIABETES SYMPTOMS AND DELAYING OR PREVENTING DIABETES-ASSOCIATED PATHOLOGIC CONDITIONS - Method of using dopamine reuptake inhibitors, e.g., sydnonimine derivatives, for the management of diabetic symptoms and associated complications or conditions, such as hyperglycemia and diabetic neuropathy. | 12-24-2015 |
20160095839 | METHOD OF USING DOPAMINE REUPTAKE INHIBITORS AND THEIR ANALOGS FOR TREATING AUTOIMMUNE CONDITIONS AND DELAYING OR PREVENTING AUTOIMMUNE RELATED PATHOLOGIC PROGRESSIONS - Dopamine reuptake inhibitors, and their analogs, are disclosed for treating and delaying the progression of autoimmune diseases. | 04-07-2016 |
Patent application number | Description | Published |
20090144797 | Method and Apparatus for Delivering SDV Programming With Multiple Advertisements - A set top terminal is provided that includes a receiver/tuner for receiving (i) switched digital video (SDV) programs over a broadband access network, at least one of the SDV programs including a primary advertisement and (ii) a plurality of alternative advertisements that are each substitutable for the primary advertisement. The set top terminal also includes a processor operationally associated with the receiver/tuner. The processor is configured to selectively cause a first of the alternative advertisements to be rendered instead of the primary advertisement when the first alternative advertisement better matches a prescribed condition than the primary advertisement. | 06-04-2009 |
20110078002 | ALTERNATIVE ADVERTISEMENT PLACEMENT IN RECORDED CONTENT STREAMS - A set top box includes a tuner for receiving a switched digital video (SDV) stream from an SDV source, in which the SDV stream contains content and a default advertisement. The set top box also includes a memory for storing the SDV stream and a controller for generating and outputting an ad catalog to at least one of an ad server and an SDV manager, in which the ad catalog contains information useable by the ad server in identifying one or more alternative advertisements to be played by the set top box during play of the SDV stream in place of the default advertisement, and in which the controller is configured to receive the one or more alternative advertisements and to replace the default advertisement in the SDV stream. | 03-31-2011 |
20120144420 | TARGETED ADVERTISEMENT DISTRIBUTION IN AN SDV ENVIRONMENT - A system and method for distributing targeted advertisements in a switched digital video system. The method monitors a content stream associated with a channel selected by a subscriber, where the content stream includes an advertisement segment having a start time and an end time, and an advertisement replacement opportunity inserted in the content stream. The method detects the advertisement replacement opportunity at a detection time that is prior to the start time of the advertisement segment, and sends a request to select an advertisement replacement for the advertisement segment, thereby broadcasting a service associated with the advertisement replacement prior to the start time for the advertisement segment. The method receives tune data to identify an advertisement replacement stream associated with the advertisement replacement, and tunes to the advertisement replacement at the start time for the advertisement segment. | 06-07-2012 |
20120151532 | SDV QUICK TUNE ALGORITHM - A switched digital video (SDV) system and method that provides a seamless transition when tuning a set-top box from a first SDV service to a second SDV service. The method detects a set up service trigger in a content stream before a tune request time to transition the content stream from the first SDV service to the second SDV service, and sends a request to set up the second SDV service at a time before the tune request time, where a time difference between the time and the tune request time is greater than a service set up time for the second SDV service. The method detects a tune request in the content stream for the second SDV service, sends a service select request to tune to the second SDV service, and receives the second SDV service at the tune request time. | 06-14-2012 |
20130016182 | COMMUNICATING AND PROCESSING 3D VIDEOAANM Booth; Robert C.AACI IvylandAAST PAAACO USAAGP Booth; Robert C. Ivyland PA USAANM Bhat; Dinkar N.AACI PrincetonAAST NJAACO USAAGP Bhat; Dinkar N. Princeton NJ USAANM Leary; Patrick J.AACI HorshamAAST PAAACO USAAGP Leary; Patrick J. Horsham PA US - There is a communicating of 3D video having associated metadata. The communicating may involve devices and includes receiving a first video bitstream with the 3D video encoded in a first format, receiving the associated metadata. The communicating also includes forming a protocol message, utilizing a processor, including the associated metadata. The communicating also includes transmitting a second video bitstream with the 3D video encoded in a second format and transmitting the protocol message separate from the second video bitstream. The protocol message includes data fields holding processing data, based on the associated metadata, describing the rendering of the 3D video. The processing data is operable to be read and utilized to direct a client device to process the 3D video extracted from a video bitstream and present the 3D video on a display. Also, there is a processing of the 3D video. The processing utilizes the protocol message. | 01-17-2013 |
20130174238 | MECHANISM TO DETERMINE SOURCE DEVICE SERVICE TIER BASED ON THE VERSION OF THE HDCP KEY - A source device and method for authenticating a sink device. The source device and method include detecting when the sink device connects to a communication interface and in response to detecting a connected sink device, activating a sink device authentication protocol which authenticates whether the connected sink device is an approved sink device for connecting via the communication interface. The source device determines a level of authentication of the connected sink device from among a first-level authentication and a second-level authentication based on first and second authentication components, respectively derived from different master keys, which affects the type of content provided to the sink device. Responsive to the level of authentication provided through the connected sink device, modifying the content transmitted to the connected sink device, and preventing transfer of any content from the source device to the sink device in response to the sink device not being authenticated. | 07-04-2013 |
20140279047 | ENHANCING TARGETED ADVERTISING IN A HOME NETWORK GATEWAY DEVICE - Advanced set top devices are beginning to merge with home network gateway devices and will soon become the major single entry point into the home. A growing trend and implementation of home gateways is to provide a centralized data entrance point to end user home. Behavioral information may be compiled from each individual device in the home network, and the home network gateway device determines advertisements to insert specifically to each device based on the entirety of the behavioral information compiled from within the home network. The advertisements provided to individual users within the home network may be determined by the home network gateway device, transparent to entities outside the home network. For example, a headend that delivers content to a home network may not know how many devices are connected to a home network gateway device, the type of devices connected, or which devices are receiving content. | 09-18-2014 |
20140282775 | SYSTEM AND METHOD FOR DELIVERING 3DTV CONTENT TO VARIETY OF RECEIVERS - An internet protocol multicast provider is disclosed, which includes a bootstrap code component, a transcoder generator component, a content module and a packetizing module. The bootstrap code component can generate a bootstrap code. The transcoder generator component can generate a transcoder module. The content module can generate content in a first format. The packetizing module can generate internet protocol multicast packets, based on the bootstrap code, the transcoder module and the content. The bootstrap code can determine a second format for which an internet protocol multicast receiver can decode and render the content. The transcoder module can instruct the internet protocol multicast receiver to play the content when the first format is the second format. The transcoder module can instruct the internet protocol multicast receiver to transcode the content from the first format to the second format when the first format is not the second format. | 09-18-2014 |
20160044359 | CHANNEL TUNING WITH SYNTHESIZED KEY CODES - Methods, systems, and computer readable media can be operable to facilitate integrating and coordinating content requests received by a STB from multiple devices. The methods, systems, and apparatuses described in this disclosure enable the integration and coordination of content requests received from different devices by associating a content request with a key code and generating a synthesized key code. The synthesized key code can be customized according to a status of a corresponding STB. | 02-11-2016 |
Patent application number | Description | Published |
20100136560 | Integrated Analyses of Breast and Colorectal Cancers - Genome-wide analysis of copy number changes in breast and colorectal tumors used approaches that can reliably detect homozygous deletions and amplifications. The number of genes altered by major copy number changes—deletion of all copies or amplification of at least twelve copies per cell—averaged thirteen per tumor. These data were integrated with previous mutation analyses of the Reference Sequence genes in these same tumor types to identify genes and cellular pathways affected by both copy number changes and point alterations. Pathways enriched for genetic alterations include those controlling cell adhesion, intracellular signaling, DNA topological change, and cell cycle control. These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that are useful for cancer diagnosis and therapy. | 06-03-2010 |
20110229479 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 09-22-2011 |
20120115735 | Pathways Underlying Pancreatic Tumorigenesis and an Hereditary Pancreatic Cancer Gene - There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehensive analysis of the genes altered in 24 pancreatic tumors. First, we determined the sequences of 23,781 transcripts, representing 20,583 protein-encoding genes, in DNA from these tumors. Second, we searched for homozygous deletions and amplifications using microarrays querying ˜one million single nucleotide polymorphisms in each sample. Third, we analyzed the transcriptomes of the same samples using SAGE and next-generation sequencing-by-synthesis technologies. We found that pancreatic cancers contain an average of 63 genetic alterations, of which 49 are point mutations, 8 are homozygous deletions, and 6 are amplifications. Further analyses revealed a core set of 12 regulatory processes or pathways that were each genetically altered in 70% to 100% of the samples. The data suggest that dysregulation of this core set of pathways is responsible for the major features of pancreatic tumorigenesis. | 05-10-2012 |
20120202207 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 08-09-2012 |
20130035404 | Integrated Analyses of Breast and Colorectal Cancers - Genome-wide analysis of copy number changes in breast and colorectal tumors used approaches that can reliably detect homozygous deletions and amplifications. The number of genes altered by major copy number changes—deletion of all copies or amplification of at least twelve copies per cell—averaged thirteen per tumor. These data were integrated with previous mutation analyses of the Reference Sequence genes in these same tumor types to identify genes and cellular pathways affected by both copy number changes and point alterations. Pathways enriched for genetic alterations include those controlling cell adhesion, intracellular signaling, DNA topological change, and cell cycle control. These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that are useful for cancer diagnosis and therapy. | 02-07-2013 |
20130210645 | PERSONALIZED TUMOR BIOMARKERS - Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients. | 08-15-2013 |
20130296408 | MEDULLOBLASTOMA GENES AS TARGETS FOR DIAGNOSIS AND THERAPEUTICS - Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations, markedly fewer than in common adult cancers. In addition to alterations in the Hedgehog and Wnt pathways, our analysis led to the discovery of genes not previously known to be altered in MBs. Most notably, inactivating mutations of the histone H3K4 trimethylase genes MLL2 or MLL3 were identified in 16% of MB patients. These results demonstrate key differences between the genetic landscapes of adult and childhood cancers, highlight dysregulation of developmental pathways as an important mechanism underlying MBs, and identify a role for a specific type of histone methylation in human tumorigenesis. | 11-07-2013 |
20140187764 | GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA - We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas. | 07-03-2014 |
20150344970 | Personalized Tumor Biomarkers - Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE), which can identify translocations in solid tumors. Analysis of four colorectal and two breast cancers revealed an average of nine rearranged sequences (range 4 to 15) per tumor. Polymerase chain reaction with primers spanning the breakpoints were able to detect mutant DNA molecules present at levels lower than 0.001% and readily identified mutated circulating DNA in patient plasma samples. This approach provides an exquisitely sensitive and broadly applicable approach for the development of personalized biomarkers to enhance the clinical management of cancer patients. | 12-03-2015 |
Patent application number | Description | Published |
20110204198 | METHOD AND APPARATUS FOR INSTALLING A POST MOUNT - In one embodiment, the invention is a method and apparatus for installing a post mount. In one embodiment, a support block for use in securing a post mount includes a body having a first end and a second end and an adjustment mechanism formed integrally with the first end of the body, by which a vertical orientation of a post mount incorporating the support block can be adjusted. | 08-25-2011 |
20110248232 | UNIVERSAL BALUSTER CONNECTOR - In one embodiment, the invention is a universal baluster connector. In one embodiment, a connector for use in securing a baluster to a railing includes a body having a first end and a second end and a stem coupled to the first end of the body, the stem being expandable in a radial direction. Expansion of the stem allows the connector to be used to secure a baluster to a railing of substantially any thickness. | 10-13-2011 |
20120286117 | METHOD AND APPARATUS FOR INSTALLING A RAILING SYSTEM - In one embodiment, the invention is method and apparatus for installing a railing system. In one embodiment, a bracket for mounting a rail to a support surface includes a first surface, a second surface positioned in a substantially parallel orientation relative to the first surface, and a third surface connecting the first surface and the second surface, where at least one of the first surface or the second surface has a perimeter that is at least partially curved. | 11-15-2012 |
20140048663 | METHOD AND APPARATUS FOR INSTALLING A POST MOUNT - In one embodiment, the invention is a method and apparatus for installing a post mount. In one embodiment, a support block for use in securing a post mount includes a body having a first end and a second end and an adjustment mechanism formed integrally with the first end of the body, by which a vertical orientation of a post mount incorporating the support block can be adjusted. | 02-20-2014 |
20150040485 | WINDOW OPENING CONTROL DEVICE - One embodiment of window opening control device that limits the maximum amount by which a window can be opened includes a spool assembly for varying the amount by which the window can be opened and a slider assembly for engaging the spool assembly such that the amount by which the window can be opened does not exceed the maximum amount. | 02-12-2015 |
20150087220 | BARREL-STYLE COIL-ACTUATED VENT - An apparatus for circulating air includes a barrel through which the air is circulated, where the barrel includes a body having a first end and a second end, and a coil positioned near the second end of the barrel for controlling when the air is permitted to circulate through the barrel. In another embodiment, an apparatus for circulating air includes a grating through which the air is circulated and an actuator for controlling when the air is permitted to circulate through the grating, wherein the actuator is activated automatically in response to changes in ambient temperature without requiring a supply of electricity. | 03-26-2015 |
20150216000 | COMBINATION SOLAR/LOW-VOLTAGE LIGHTING APPARATUS - A lighting apparatus includes a housing, a plurality of lighting elements coupled to the housing, wherein a first subset of the plurality of lighting elements is powered by a solar power source and a second subset of the plurality of lighting elements is powered by a low-voltage electrical power source, and a switch for selectively switching between operation of the first subset and the second subset. | 07-30-2015 |
20160069103 | POST MOUNT CABLE RAIL INSTALLATION SYSTEM - Post mount cable rail systems and methods for installation are disclosed. An exemplary post mount system may include a mounting pipe having a plurality of threaded holes for securing at least one hardware item, and a support pipe for fitting over the mounting pipe, where the support pipe includes a plurality of holes that are aligned with the plurality of threaded holes of the mounting pipe. | 03-10-2016 |
Patent application number | Description | Published |
20090068635 | INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME - Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided. | 03-12-2009 |
20100124754 | Cloning, Expression And Purification Of Recombinant Porcine Intrinsic Factor For Use In Diagnostic Assay - The present invention relates to a new method of producing functionally active recombinant porcine Intrinsic Factor as well as the protein (i.e., porcine Intrinsic Factor) produced thereby. In particular, the vector comprising the DNA encoding the protein is introduced into a Chinese Hamster Ovary (CHO) host cell under conditions sufficient for optimal expression of functional protein. The expressed protein may then be subjected to three methods ultimately resulting in a protein having at least 97% purity. | 05-20-2010 |
20100279432 | INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME - Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided. | 11-04-2010 |
20120202295 | MATERIALS AND METHODS FOR ASSAY OF ANTI-HEPATITIS C VIRUS (HCV) ANTIBODIES - A polypeptide comprising the contiguous amino acids 1-198 of SEQ ID NO: 2; a polypeptide, which comprises a contiguous amino acid sequence that is at least about 95% identical to the contiguous amino acids 1-198 of SEQ ID NO: 2, an epitope that is immunoreactive with an antibody that specifically binds to the core protein of hepatitis C virus (HCV), and an epitope that is immunoreactive with an antibody that specifically binds to the NS4 region of HCV; a nucleic acid encoding such a polypeptide; a host cell comprising such a nucleic acid; an immunodiagnostic reagent comprising such a polypeptide; a kit comprising such an immunodiagnostic reagent; and a method of determining the presence, amount, or concentration of anti-HCV antibodies in a test sample. | 08-09-2012 |
20120329176 | INDIRECTLY LABELLED ASSAY CONJUGATES AND METHODS OF PREPARING AND USING SAME - Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by methods that do not include a step of submitting the binding member to denaturing conditions prior to labelling. Processes for the preparation of the indirectly labelled assay conjugates, methods of detecting an analyte comprising the use of the indirectly labelled assay conjugate and kits comprising the indirectly labelled conjugates are also provided. | 12-27-2012 |