Lazar, CA
Bereli M. Lazar, San Francisco, CA US
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20090010756 | Combined hydrodynamic - inertial rotoset - selfbooster - The Combined Hydrodynamic-Inertial Rotoset-Selfbooster is a non-fuel power unit which includes: | 01-08-2009 |
20100006133 | Solar irradiance inductive expeller - A Solar Irradiance Inductive Expeller for electro-dynamic radiant energy extracting, comprises an aggregated electro-magnetic structure and a technological method including: | 01-14-2010 |
20100052329 | Air flow dynamo-selfbooster - The Air Flow Dynamo-Self-booster includes a method and means for obtaining energy in direct transfer from ionized, seeded, cyclical, intense operative air flow by electromagnetic induction inside a closed loop tunnel. | 03-04-2010 |
20100271908 | Tectonic discharger - The structure for severe earthquakes prevention includes : | 10-28-2010 |
20110068690 | Plasma jet guard - The system includes a method and means of technological defense against violent atmospheric cyclones: tornadoes, hurricanes, others. The controlled meteorological missiles equipped with rocket servo-motors and magneto-gas-dynamic ionizers are used. | 03-24-2011 |
20120214364 | Ring boost propulsor - The Propulsor includes a tubular oval ring and a duct assembly with their pumps, a nozzle ejector with a thrust impeller, a hydraulic pipe-connector with its valve-adjuster, a spring piston valve unit, and devices of motor vessels' hydraulic infrastructure. | 08-23-2012 |
Daniel Chesnaye Lazar, San Diego, CA US
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20140308669 | METHODS FOR OBTAINING SINGLE CELLS AND APPLICATIONS OF SINGLE CELL OMICS - The present application provides methods for obtaining single cells from a sample. Methods for isolating and analyzing molecular features obtained from a single cell are also disclosed herein. For example, individual circulating tumor cells (CTCs) from a sample such as a patient's blood sample can be identified and obtained using methods disclosed herein, and picked for further analysis. | 10-16-2014 |
David Lazar, Malibu, CA US
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20090310491 | Distributed Flow Analysis - There are disclosed apparatus, methods, and a storage medium for testing a network. A plurality of flows may be received and performance statistics for the flows may be measured and stored. At least a portion of the performance statistics may be analyzed in near real-time using a hierarchical array of processors. | 12-17-2009 |
Gary S. Lazar, Encino, CA US
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20150329621 | ANTI-EMP2 THERAPY REDUCES CANCER STEM CELLS - Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1α, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells. | 11-19-2015 |
Gary Steven Lazar, Encino, CA US
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20130041443 | IN VIVO TREATMENT OF SKIN LESIONS BY ELECTRICAL NANOPULSES - This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 0.01 nanoseconds at the full-width-at-half-maximum. This treatment may at least prevent growth of the lesion. | 02-14-2013 |
Gregory Lazar, Monrovia, CA US
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20150152183 | Fc VARIANTS WITH ALTERED BINDING TO FcRn - The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes. | 06-04-2015 |
Gregory Lazar, Pacifica, CA US
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20150232567 | Fc Variants with Increased Affinity for FcyRIIc - The present invention relates to Fc variants having increased affinity for FcγRIIc, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants. | 08-20-2015 |
Gregory A. Lazar, Pacifica, CA US
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20160068588 | ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS AND IMMUNOFILTERING - The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo. | 03-10-2016 |
Gregory A. Lazar, Arcadia, CA US
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20110054151 | COMPOSITIONS AND METHODS FOR SIMULTANEOUS BIVALENT AND MONOVALENT CO-ENGAGEMENT OF ANTIGENS - Immunoglobulin compositions that simultaneously co-engage antigens, where one of the antigens is bound bivalently and the other antigen is bound monovalently. The novel immunoglobulins described preferably utilize heterodimeric Fc regions. | 03-03-2011 |
20110236375 | ANTIBODY VARIANTS WITH ENHANCED COMPLEMENT ACTIVITY - The present invention relates to novel Fc variants that comprise at least one novel amino acid residue which may provide for enhanced effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more Fc receptor or ligand (e.g., Fc gamma R, C1q). Additionally, the Fc variants have altered complement dependent cytotoxicity (CDC) activity and/or antibody-dependent cell-mediated cytotoxicity (ADCC). The invention further provides methods and protocols for the application of said Fc variants, particularly for therapeutic purposes. | 09-29-2011 |
20110287032 | NOVEL CTLA4-IG IMMUNOADHESINS - The present application relates to CTLA4-Ig immunoadhesins that target CD80 and CD86, and their use, particularly for therapeutic purposes. | 11-24-2011 |
20130089550 | NOVEL CTLA4-IG IMMUNOADHESINS - The present application relates to CTLA4-Ig immunoadhesins that target CD80 and CD86, and their use, particularly for therapeutic purposes. | 04-11-2013 |
20130122001 | ANTIBODY VARIANTS WITH ENHANCED COMPLEMENT ACTIVITY - The present invention relates to novel Fc variants that comprise at least one novel amino acid residue which may provide for enhanced effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more Fc receptor or ligand (e.g., Fc gamma R, C1q). Additionally, the Fc variants have altered complement dependent cytotoxicity (CDC) activity and/or antibody-dependent cell-mediated cytotoxicity (ADCC). The invention further provides methods and protocols for the application of said Fc variants, particularly for therapeutic purposes. | 05-16-2013 |
20140056879 | FC VARIANTS THAT EXTEND ANTIBODY HALF-LIFE - The invention relates generally to compositions and methods for altering the serum half-life in vivo of an antibody. | 02-27-2014 |
20140112924 | NOVEL CTLA4-IG IMMUNOADHESINS - The present application relates to CTLA4-Ig immunoadhesins that target CD80 and CD86, and their use, particularly for therapeutic purposes. | 04-24-2014 |
20140249297 | ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS - The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo. | 09-04-2014 |
Gregory A. Lazar, Los Angeles, CA US
Patent application number | Description | Published |
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20120028304 | ANTIBODIES WITH MODIFIED ISOELECTRIC POINTS - The invention relates generally to compositions and methods for altering the isoelectric point of an antibody, and in some cases, resulting in improved plasma pharmacokinetics, e.g. increased serum half-life in vivo. | 02-02-2012 |
20120128663 | Fc VARIANTS THAT EXTEND ANTIBODY HALF-LIFE - The invention relates generally to compositions and methods for altering the serum half-life in vivo of an antibody. | 05-24-2012 |
20120225058 | NOVEL IMMUNOGLOBULIN INSERTIONS, DELETIONS, AND SUBSTITUTIONS - An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide. | 09-06-2012 |
20120258092 | Optimized Fc Variants - The present invention relates to optimized CD20 antibodies having Fc variants, methods for their generation, and method for their application, such as methods of enhancing macrophage activation, particularly for therapeutic purposes. | 10-11-2012 |
Gregory A. Lazar, South San Francisco, CA US
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20150110791 | ANTI-TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE - The present invention relates to anti-transferrin receptor antibodies and methods of their use. | 04-23-2015 |
James F. Lazar, Moorpark, CA US
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20120299649 | MULTI-TIER POWER SUPPLY FOR AUDIO AMPLIFIERS - Techniques for providing multiple power supplies in electronic devices are disclosed. According to one aspect of the present invention, an appropriate power supply is provided only to accommodate a volume setting. In other words, there are at least two power supplies, one with a low voltage and the other with a high voltage. The high voltage power supply is only applied when there is a need to accommodate a volume setting. Thus the power consumption of the amplifiers is well controlled. As a result, the designs of the device and heat dissipation therein can be simplified and lowered in cost. | 11-29-2012 |
James Frederick Lazar, Moorpark, CA US
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20120176826 | SOURCE AND MULTIPLE LOADS REGULATOR - A circuit that has one or more control units that divide a load into two or more load groups, with each load group comprised of at least one load element. The one or more control units directing power from a power source to one or more of the load groups based on voltage variations in an output of the power source, load grouping, and operational parameters of the load elements. The circuit further includes one or more pass stages that regulate current flow from the power source to the load groups. | 07-12-2012 |
20140375129 | Dynamic Power Management - A circuit that has one or more control units that divide a load into two or more load groups, with each load group comprised of at least one load element. The one or more control units directing power from a power source to one or more of the load groups based on voltage variations in an output of the power source, load grouping, and operational parameters of the load elements. The circuit further includes one or more pass stages that regulate current flow from the power source to the load groups. | 12-25-2014 |
John A. Lazar, Menlo Park, CA US
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20150355264 | Predicting the End of Service Life for a Vacuum Electron Device - The subject matter described herein generally relates to apparatus, systems, methods and associated computer instructions for predicting the end of service life of a space charge limited vacuum electron device. The device produces an electron beam current and has a cathode and a filament powered by an adjustable voltage power supply providing a voltage between a first low voltage and a second higher voltage to heat the cathode to an electron emitting temperature. The process includes periodically, while the device is in operation, adjusting the voltage provided by the power supply while monitoring the beam current, determining a knee-point in the voltage where the beam current begins to decrease as the voltage is decreased, and calculating, based on the determined knee-point and a predetermined voltage vs service life remaining relationship, the amount of service life left in the device. | 12-10-2015 |
Mark Andrew Lazar, Los Altos Hills, CA US
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20140254778 | SYSTEMS AND METHODS FOR IDENTIFYING A CALLER - Systems and methods for authenticating callers are disclosed that may obtain identifying data and a voice print, and compare the voice print to one or more stored voice prints. Further, one or more initial scores may be calculated based on the data and the comparison, and a confidence interval score may also be calculated. The systems and methods may determine whether to authenticate based on the one or more initial scores and the confidence interval score. | 09-11-2014 |
Patrick Lazar, San Jose, CA US
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20140282484 | SYSTEM AND METHOD FOR REMOTELY UPDATING CABLE MODEM SOFTWARE - A telecommunication network device for implementing the DOCSIS standard during a transition from a coaxial cable network to a fiber-optic network is described. The device includes a memory including installed firmware for implementing a telecommunication gateway function in accordance with the DOCSIS telecommunication standard and a processor configured to update the installed firmware by downloading the update from a first TFTP server over a coaxial cable network, wherein the processor is further configured to update the installed firmware by downloading the update from a second TFTP server over a fiber-optic network. | 09-18-2014 |
20150117228 | WIRELESS ACCESS POINT MANAGEMENT SYSTEM AND METHOD - Methods and apparatuses are provided for graphically displaying the noise level on each WLAN channel, along with the arrangement of other (neighboring) wireless host devices on each channel with their respective signal strengths as a distance indicator. As a result, collected information may be gathered and displayed intuitively to allow a user to quickly assess the environment and manually configure the wireless host device. in addition, methods and apparatuses are provided for suggesting to a user or automatically selecting a wireless host device configuration based on the noise level on each WLAN channel and the arrangement of other wireless host devices on each channel with consideration of their respective signal strengths. As a result, an optimal configuration for a deployed wireless host device may be determined and consistently suggested or automatically configured. | 04-30-2015 |
Yuriy B. Lazar, San Francisco, CA US
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20080272628 | Office furniture, fitness combined utilities - A kit of office furniture fitness combined utilities for systematic and periodic working operators' posture changing with and by static body-spirit exercises, comprises ergonomic devices: | 11-06-2008 |