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| 20090297582 | VASCULAR OCCLUSION DEVICES AND METHODS - A device for in situ treatment of vascular or cerebral aneurysms comprises an occlusion device having a flexible, longitudinally extending elastomeric matrix member that assumes a non-linear shape to conformally fill a targeted site. The occlusion device comprises a flexible, longitudinally extending elastomeric matrix member, wherein the device assumes a non-linear shape capable of fully, substantially, or partially conformally filling a targeted vascular site. In one embodiment the vascular occlusion device comprises a first longitudinally extending structural element having a longitudinally extending lumen and an outer surface; a second longitudinally extending structural element extending through the lumen; and an elastomeric matrix member surrounding the outer surface, wherein the second structural member does not engage or attach to the first structural element or the elastomeric matrix. | 12-03-2009 |
| 20100318108 | COMPOSITE MESH DEVICES AND METHODS FOR SOFT TISSUE REPAIR - A composite implantable device for promoting tissue ingrowth therein comprising a biodurable reticulated elastomeric matrix having a three-dimensional porous structure having a continueous network of interconnected and intercommunicating open pores and a support structure is disclosed. The support structure may be a polymeric surgical mesh comprising a plurality of intersecting one-dimensional reinforcement elements, wherein said mesh is affixed to a face of said first matrix. Methods of making and using the implantable device are also provided. | 12-16-2010 |
| 20110184530 | High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair - This invention relates to reticulated elastomeric matrices, their manufacture, their post-processing, such as their reinforcement, compressive molding or annealing, and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for surgical devices, tissue augmentation, tissue repair, therapeutic, nutritional, or other useful purposes. | 07-28-2011 |
| 20120239161 | AT LEAST PARTIALLY RESORBABLE RETICULATED ELASTOMERIC MATRIX ELEMENTS AND METHODS OF MAKING SAME - The present disclosure relates to reticulated elastomeric matrices, and more particularly to at least partially degradable elastomeric elements that are compressible and exhibit resilience in their recovery and that can be employed in diverse applications including, without limitation, biological implantation, especially in humans. | 09-20-2012 |
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| 20120152788 | CONTAINER - A display container is provided herein which includes a box portion having a base portion, spaced-apart upstanding first and second end panels, and spaced-apart upstanding first and second edge panels extending from the base portion. The first and second edge panels are located between the first and second end panels, and the first edge panel extends a lesser distance from the base portion than the first end panel and the second end panel. The display container also includes a reinforcing layer having a first panel disposed to overlap at least portions of the base portion, a second panel disposed adjacent to the first end panel in face-to-face engagement, and a third panel disposed adjacent to the second end panel in face-to-face engagement. The reinforcing layer is formed of a material stronger in shear than the material of the box portion. Advantageously, with the subject invention, a display container may be formed which has greater strength both for product containment and stacking as compared to the prior art. | 06-21-2012 |
| 20130139734 | RISER PLATFORM - An environmentally friendly, lightweight, sturdy, water-resistant riser platform having columns of multiple heights is disclosed. The riser platform can be provided with a top cover suitable for the display of promotional materials. The riser platform can also be provided with internal dowels for increased load-bearing capacity. The riser platform can be utilized in and for any variety of industries or needs, including residential, commercial, retail, food service, and industrial uses. | 06-06-2013 |
| 20140076762 | STACKABLE DISPLAY CONTAINER WITH BOX PORTION AND REINFORCING LAYER - A display container is provided herein which includes a box portion having a base portion, spaced-apart upstanding first and second end panels, and spaced-apart upstanding first and second edge panels extending from the base portion. The first and second edge panels are located between the first and second end panels, and the first edge panel extends a lesser distance from the base portion than the first end panel and the second end panel. The display container also includes a reinforcing layer which may be formed of a material stronger in shear than the material of the box portion. Advantageously, with the subject invention, a display container may be formed which has greater strength both for product containment and stacking as compared to the prior art. | 03-20-2014 |
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| 20110127208 | METHODS, COMPOSITIONS AND DEVICES UTILIZING STRUCTURALLY STABLE CYANURIC ACID HYDROLASE - The present invention relates to stable cyanuric acid hydrolase enzymes, compositions, and devices for use in the treatment of a liquid, such as water. The present invention also relates to methods of using these enzymes, compositions and devices for the treatment of a liquid, such as water. | 06-02-2011 |
| 20120015414 | Production of organic compounds - The present invention provides methods for the production of hydrocarbons, particularly alkanes and alkenes, using biosynthetic routes, as well as genes and enzymes involved therein. | 01-19-2012 |
| 20130112608 | METHODS, COMPOSITIONS AND DEVICES UTILIZING STRUCTURALLY STABLE CYANURIC ACID HYDROLASE - The present invention relates to stable cyanuric acid hydrolase enzymes, compositions, and devices for use in the treatment of a liquid, such as water. The present invention also relates to methods of using these enzymes, compositions and devices for the treatment of a liquid, such as water. | 05-09-2013 |
| 20140051144 | SILICA ENCAPSULATED BIOMATERIALS - The present invention relates to compositions for encapsulation of biomaterials in a silica-matrix. The present invention includes a composition for formation of a silica-matrix encapsulated biomaterial. The composition includes a reactive silicon compound and a biomaterial with a catalytic activity. When encapsulated in the silica-matrix, the biomaterial at least partially retains its catalytic activity. The present invention also relates to methods of making silica-matrix encapsulated biomaterials, and to methods of using silica-matrix encapsulated biomaterials, including methods of treating water or gas using the silica-matrix encapsulated biomaterials. | 02-20-2014 |
| 20140335148 | BIOACTIVE SUBSTANCE-CONTAINING NANOFIBERS AND USES THEREOF - An ultrafine fiber comprises a ceramic-based fibrous body and a biologically active substance encapsulated in the body, substantially encapsulated in the body, or surface-attached to the body. In an example, an ultrafine fiber comprises a core comprising a biologically active substance and a ceramic-based shell surrounding or substantially surrounding the core. | 11-13-2014 |
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| 20100173878 | ORGANIC COMPOUNDS - 2-benzyl-3-(optionally hetero)arylamino-[2H]-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-diones, in free, salt or prodrug form, are useful as pharmaceuticals, particularly as phosphodiesterase 1 inhibitors. | 07-08-2010 |
| 20100323997 | NOVEL USES - The present invention relates to a new use for compounds that inhibit phosphodiesterase 1 (PDE1), e.g., that inhibit PDE1-mediated suppression of the dopamine D1 receptor and/or progesterone signaling pathways, including, e.g., methods of treatment or prophylaxis for conditions which may be ameliorated by enhancing the progesterone signaling response, particularly female sexual dysfunction. | 12-23-2010 |
| 20110112105 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SOLID - The present invention relates to toluenesulfonic acid addition salt crystals of specific substituted heterocycle fused gamma-carbolines, the method of making and using such crystals. | 05-12-2011 |
| 20110281832 | ORGANIC COMPOUNDS - Optionally substituted (5- or 7-amino)-3,4-dihydro-(optionally 4-oxo, 4-thioxo or 4-imino)-1H-pyrrolo[3,4-d]pyrimidin-2(6H)-ones, Compounds of Formula I, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. | 11-17-2011 |
| 20120136013 | ORGANIC COMPOUNDS - Optionally substituted (5- or 7-amino)-3,4-dihydro-(optionally 4-oxo, 4-thioxo or 4-imino)-1H-pyrrolo[3,4-d]pyrimidin-2(6H)-ones, Compounds of Formula I, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. | 05-31-2012 |
| 20120201754 | PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS - Tracers targeting phosphodiesterase 1 for use in gamma radiation detection-based diagnostic techniques, particulaly gamma-emitter labeled tracers for SPECT and positron emitter-labeled compositions for PET are disclosed. Radio-labeled multiple novel scaffolds as PDE1 inhibitors such as substituted pyrazolo-pyrimidin-4-one derivatives, biomarkers for phosphodiesterase 1 [PDE1) in vivo, methods for developing novel therapies for PDE1-implicated conditions such as pulmonary arterial hypertension (PAH), Central Nervous System (CNS) and Cardiovascular (CV) disorders, and methods of detection and treatment are also disclosed. | 08-09-2012 |
| 20130085123 | ORGANIC COMPOUNDS - Optionally substituted 4,5,7,8-tetrahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-(1H or 2H)-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidine or 4,5,7,8,9-pentahydro-(optionally 4-oxo, 4-thioxo or 4-imino)-(1H or 2H)-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidine compounds, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. | 04-04-2013 |
| 20130149309 | NOVEL REGULATORY PROTEINS AND INHIBITORS - The invention provides a previously uncharacterized protein (gamma secretase activating protein or gSAP) that activates γ-secretase to produce β-amyloid protein (Aβ). Deposition of Aβ has been associated with Alzheimer's disease and other pathologies. The invention thus additionally provides, e.g., screening methods and novel research tools, inhibitors of this novel protein, and methods of diagnosis, treatment and control of Alzheimer's disease and other neurodegenerative conditions associated with deposition of Aβ. | 06-13-2013 |
| 20130202692 | ORGANIC COMPOUNDS - The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT | 08-08-2013 |
| 20140005155 | ORGANIC COMPOUNDS | 01-02-2014 |
| 20140050783 | METHODS AND COMPOSITIONS FOR SLEEP DISORDERS AND OTHER DISORDERS - Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-HT2A, SERT and/or dopamine D2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or Parkinson's disease or any combinations. | 02-20-2014 |
| 20140194396 | ORGANIC COMPOUNDS - The present invention relates to PDEI inhibitory compounds of Formula I as described herein, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. | 07-10-2014 |
| 20140205595 | COMPOUNDS AND METHODS OF PROPHYLAXIS AND TREATMENT REGARDING NICOTINIC RECEPTOR ANTAGONISTS - It is an object of the present invention that the novel nicotinic receptor antagonists disclosed herein may be used in a broad array of clinical or medicinal facets. For example, it is a contemplated use of the present invention that the novel nicotinic receptor antagonists be used to inhibit the growth cycle of non-small cell lung cancer cells. Without being bound by theory, it is an object of the present invention that the nicotinic receptor antagonists disclosed herein are believed to possess reversible binding properties. Moreover, the compounds of the present invention are selective for 0.7 nAChR. For example, the compounds of the present invention are not believed to bind to 0.4 (32 nAChR neuromuscular receptors. It is also contemplated that the nicotinic receptor antagonists of the present invention will be used as a counter measure to treat exposure, or potential exposure, to a wide array of potential neurotoxins. | 07-24-2014 |
| 20140205596 | ORGANIC COMPOUNDS - The invention relates to compounds and methods of treatment relating to nicotinic receptor antagonists. For example, the compounds and methods of treatment function block the activity of certain acetylcholine receptors and subtypes therein, and are useful treating diseases and conditions mediated by nicotinic receptor stimulation, e.g., small cell lung cancer. | 07-24-2014 |
| 20140275131 | ORGANIC COMPOUNDS - Provided are PDE1 inhibitors of Formula I, processes for their production, their use as pharmaceuticals, and pharmaceutical compositions comprising them. | 09-18-2014 |
| 20140323491 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SOLID - The present invention relates to toluenesulfonic acid addition salt crystals of specific substituted heterocycle fused gamma-carbolines, the method of making and using such crystals. | 10-30-2014 |
| 20140364609 | SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SYNTHESIS - The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines. | 12-11-2014 |
| 20150038474 | ORGANIC COMPOUNDS - Optionally substituted 3-(thio, sulfinyl or sulfonyl)-7,8-dihydro-(1H or 2H)-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one or a substituted 3-(thio, sulfinyl or sulfonyl)-7,8,9-trihydro-(1H or 2H)-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5H)-one compounds or Compounds of Formula (I), processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. | 02-05-2015 |
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| 20090000146 | Evaporator Core Drying System - An evaporator core drying system in which air that is blown by a blower is concentrated into a narrow cross-sectional air stream of high speed purge air which passes progressively across the area of the evaporator core, per an appropriate blow algorithm, so as to effectively and efficiently dry the evaporator core. Preferably, the configurable barrier is composed of at least one roller door located between the blower and the evaporator core. | 01-01-2009 |
| 20090107172 | Receiver/Dryer-Accumulator-Internal Heat Exchanger for Vehicle Air Conditioning System - An integrated receiver/dryer-accumulator-internal heat exchanger for use in a vehicle HVAC system and a method of operation are disclosed. The integrated receiver/dryer-accumulator-internal heat exchanger may comprise an accumulator portion having an accumulator inlet configured to be in fluid communication with an evaporator, and an accumulator outlet configured to be in fluid communication with a compressor; and a receiver/dryer portion mounted within the accumulator portion and having receiver/dryer inlet configured to be in fluid communication with a first portion of a condenser and a receiver/dryer outlet configured to be in fluid communication with a sub-cooler portion of the condenser. The integrated receiver/dryer-accumulator-internal heat exchanger allows for exchanging heat between the refrigerant in the accumulator portion and refrigerant in the receiver/dryer portion. | 04-30-2009 |
| 20090236089 | Controlling Temperature of Vehicle Devices Using a Variable Speed Fan - A method for controlling a fan in a vehicle includes comparing the current temperature of at least a first device and a second device to multiple temperature ranges for each of said devices and determining on the basis of said comparisons whether fan speed should be changed, increasing fan speed to a maximum fan speed if at least one of the comparisons indicates that the maximum fan speed is desired, increasing fan speed to a reference fan speed if at least one of the comparisons indicates that an increase in fan speed less than the maximum fan speed is desired, and decreasing fan speed to a reference fan speed if the comparisons indicate that a decrease in fan speed is desired. | 09-24-2009 |
| 20100011789 | VEHICLE HVAC CONTROL - A method of controlling a HVAC system for a hybrid vehicle having a refrigerant compressor driven by an engine is disclosed. The method may comprise: determining a requested air conditioning operating point for a passenger compartment; estimating a time to reach the requested operating point; based on the previous steps, estimating a maximum allowed compressor off time; determining if the allowed compressor off time is greater than a minimum engine off time; if the allowed compressor off time is greater than the engine off time, determining if the vehicle is entering an allowable engine off mode; if so, commencing engine shut-off mode; if engine shut-off is anticipated, prior to commencing the shut-off mode, adjusting the HVAC system to maximize cooling of the passenger compartment with minimum energy usage; and if the engine shut-off is commenced, monitoring the HVAC system to determine when engine restart is needed to maintain comfort. | 01-21-2010 |
| 20100064700 | Refrigerant System Oil Accumulation Removal - A method and system for removing oil accumulation from refrigerant lines of a vehicle HVAC system having multiple refrigerant loops each having an evaporator is disclosed. The method for operating the system may comprise the steps of: monitoring a flow rate through at least one of the refrigerant loops; determining if the flow rate through any of the at least one refrigerant loops being monitored is below a predetermined flow rate for greater than a predetermined time limit; monitoring for an indication of imminent vehicle operation; and if the indication of imminent vehicle operation is detected and the flow rate through any of the at least one refrigerant loops being monitored is below the predetermined flow rate for greater than the predetermined time limit, opening a valve to allow for maximum flow through the at least one refrigerant loop. | 03-18-2010 |
| 20100230505 | Auxiliary Heater Pump Control - A method of auxiliary heater pump control in a vehicle including a heater core and an auxiliary pump in a heater core branch of a vehicle coolant system is disclosed. The method comprises the steps of: determining if a power plant is on, the power plant being connected to the coolant system; calculating an estimated heating power required to meet HVAC system heating requirements that is a function of mass air flow, specific heat, and a change in temperature in a passenger compartment; determining if the calculated estimated heating power required is greater than a minimum required heating power that will be able to maintain thermal comfort in the passenger compartment of the vehicle; and if the calculated estimated heating power required is greater than the minimum required heating power and the power plant is not on, activating the auxiliary pump to pump a coolant through the heater core. | 09-16-2010 |
| 20120082871 | Thermal Management Controls for a Vehicle Having a Rechargeable Energy Storage System - A method of operating a RESS thermal system in a vehicle having a coolant loop for directing a coolant through a RESS and a refrigerant loop configured to selectively cool the coolant flowing through a chiller in the coolant loop, including: determining a current target temperature range for the RESS based on a current vehicle operating mode and ambient temperature; determining a temperature of the RESS; determining if the temperature of the RESS needs to increase or decrease to be within the current target temperature range; if the determination is made that the temperature of the RESS needs to increase, determining if an active heating or a passive heating of the coolant will be employed, the active heating using a greater amount of energy over a shorter time period than the passive heating; and activating the determined active heating or passive heating of the coolant. | 04-05-2012 |
| 20140174707 | METHOD AND SYSTEM FOR THERMAL STORAGE IN A VEHICLE - A method for charging a thermal storage device of a thermal storage heat pump system in a vehicle is provided. The method includes comparing an actual temperature of the thermal storage device to a target temperature, and an actual charge time to an available charge time, where the comparing is performed by a controller. The target temperature may be based upon ambient air temperature and ambient air humidity. The actual charge time is the time it takes to charge the thermal storage device to the target temperature. The available charge time is the difference between the current time and an intended departure time. When the target temperature is greater than the actual temperature, and the available charge time is equal to or greater than the actual charge time, the controller may charge the thermal storage device until the actual temperature is equal to the target temperature. | 06-26-2014 |
| 20140196485 | METHOD FOR CONTROLLING A THERMAL STORAGE HEAT PUMP SYSTEM - A thermal storage heat pump system transfers heat to a passenger compartment of a vehicle from at least one of a thermal storage device and ambient air. Heat from the thermal storage device is absorbed by a first coolant flowing through it, and is transferred to a refrigerant via a first heat exchanger. The heat is then transferred from the refrigerant to a second coolant via a second heat exchanger, and then from the second coolant to air flowing into the passenger compartment via a heater core. Heat from ambient air is absorbed by the refrigerant via a third heat exchanger. The heat source is determined by at least one of the thermal storage device temperature, ambient air temperature, and ambient air humidity. At start-up of the vehicle, heat transfer to the refrigerant and to the second coolant is controlled based on low-side and high-side pressure measurements of the refrigerant. | 07-17-2014 |
| 20140208789 | VEHICLE HEAT PUMP SYSTEM AND METHOD UTILIZING THERMAL STORAGE - A heat pump system for use in a vehicle having a passenger compartment, and a thermal storage medium is provided. A method for providing heat to a vehicle passenger compartment is also provided. The vehicle may have an electric only vehicle mode wherein the vehicle may occupy one of an active electric drive state and an inactive state. The heat pump system may include a thermal storage medium configured to store heat produced during the inactive state. The thermal storage medium may be a device which has a thermal capacity exchangeable with a fluid medium such as an Rechargeable Energy Storage System (RESS) or a phase change material. The heat stored by the thermal storage medium during the vehicle charge event may be transmitted from the thermal storage medium to the passenger compartment via the heat pump system during the active electric drive state. | 07-31-2014 |
| 20140216689 | VEHICULAR THERMAL MANAGEMENT SYSTEM AND METHOD THEREOF - A thermal management system having a first heating device, such as a rechargeable energy storage system (RESS), and a second heating device, such as an internal combustion engine (ICE), for a vehicle is provided. The system may allow waste heat within an ICE to be stored in a RESS, and may cool the RESS by depositing heat in the ICE. The RESS and the ICE are located in a first coolant circuit and a second coolant circuit, respectively. The system also includes a third coolant circuit interconnected with the first coolant circuit, and in thermal communication with the second coolant circuit via a first heat exchanger. The first and third coolant circuits are configured to circulate a first coolant, and the second coolant circuit is configured to circulate a second coolant. The RESS and the ICE are each configured to selectively operate as a heat source or a heat sink. | 08-07-2014 |
| 20140230463 | METHOD FOR CONTROLLING A COMPRESSOR OF A THERMAL STORAGE HEAT PUMP SYSTEM - A method of controlling a compressor of a thermal storage heat pump system of a vehicle is provided. The system may operate in one of a heating mode and a cooling mode, as determined by at least one system controller based on at least one parameter. The at least one parameter may be ambient air temperature. The compressor has a compressor motor and a motor controller configured to selectively operate the compressor in an unmodified state or a modified state based on the operating mode of the system. The compressor motor is operated in the unmodified state when the system is in the cooling mode, and in the modified state when the system is in the heating mode. Operating the compressor motor in the modified state may include decreasing its coefficient of performance (COP). | 08-21-2014 |
| 20140277878 | METHOD FOR OPERATING HYBRID VEHICLE - A method and system used to identify an optimal hybrid vehicle operating mode based on a variety of potential factors, and then recommend the optimal operating mode to the driver so that they can make an informed decision regarding their operating mode selection. In one embodiment, the method uses geographic-, vehicle- and/or environmental-related factors to establish one or more operating zones, monitors the location of the hybrid vehicle and determines when it is within one of the operating zones, and then determines an operating mode that is optimal for that particular operating zone. | 09-18-2014 |
