Lauren O. Bakaletz
Lauren O. Bakaletz, Hilliard, OH US
Patent application number | Description | Published |
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20080292634 | Nontypable Haemophilus Infuenzae Virulence Factors - The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of | 11-27-2008 |
20080311110 | Chimeric Vaccine for Haemophilus Influenzae-Induced Disease - The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention. | 12-18-2008 |
20090041774 | Haemophilus influenzae type IV pili - The invention described herein relates to a | 02-12-2009 |
20100166771 | Genes of an Otitis Media Isolate of Nontypeable Haemophilus Influenzae - The invention relates to the polynucleotide sequence of a nontypeable stain of | 07-01-2010 |
20100196382 | Nontypeable Haemophilus Influenzae Virulence Factors - The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of | 08-05-2010 |
20100310569 | Genes of an Otitis Media Isolate of Nontypeable Haemophilus Influenzae - The invention relates to the polynucleotide sequence of a nontypeable stain of | 12-09-2010 |
20110081357 | Chimeric Vaccine for Haemophilus Influenzae-Induced Disease - The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention. | 04-07-2011 |
20110135646 | Genes of an Otitis Media Isolate of Nontypeable Haemophilus influenzae - The invention relates to the polynucleotide sequence of a nontypeable stain of | 06-09-2011 |
20110150889 | HAEMOPHILUS INFLUENZAE TYPE IV PILI - The invention described herein relates to a | 06-23-2011 |
20110223174 | Nontypeable Haemophilus Influenzae Virulence Factors - The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of | 09-15-2011 |
20110293624 | Genes of an Otitis Media Isolate of NonTypeable Haemophilus Influenzae - The invention relates to the polynucleotide sequence of a nontypeable stain of | 12-01-2011 |
20130017204 | Genes of an Otitis Media Isolate of Nontypeable Haemophilus Influenzae - The invention relates to the polynucleotide sequence of a nontypeable stain of | 01-17-2013 |
20130064828 | Chimeric Vaccine for Haemophilus Influenzae-Induced Disease - The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention. | 03-14-2013 |
20130078254 | GENES OF AN OTITIS MEDIA ISOLATE OF NONTYPEABLE HAEMOPHILUS INFLUENZAE - The invention relates to the polynucleotide sequence of a nontypeable stain of | 03-28-2013 |
20130142803 | Haemophilus Influenzae Type IV PILI - The invention described herein relates to a | 06-06-2013 |
20140120107 | GENES OF AN OTITIS MEDIA ISOLATE OF NONTYPEABLE HAEMOPHILUS INFLUENZAE - The invention relates to the polynucleotide sequence of a nontypeable stain of | 05-01-2014 |
20140127221 | Genes of an Otitis Media Isolate of Nontypeable Haemophilus Influenzae - The invention relates to the polynucleotide sequence of a nontypeable strain of | 05-08-2014 |
20140199350 | CHIMERIC TOPICAL VACCINE FOR HAEMOPHILUS INFLUENZAE-INDUCED DISEASE - Provided are delivery systems for topically administering a chimeric protein including the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. Also provided are methods for eliciting a response by administrating the delivery systems to a subject. | 07-17-2014 |
20140314876 | PROTEOMICS BASED DIAGNOSTIC DETECTION METHOD FOR CHRONIC SINUSITIS - The invention provides for a proteomic approach for identification of specific bacterial protein profiles that may be used in the development of methods for the diagnosis of bacterial chronic sinusitis. The invention provides for methods for determining the presence of pathogenic bacteria in the upper respiratory tract of a subject using protein profiles of the pathogenic bacteria. The invention also provides for methods of diagnosing a bacterial infection of the upper respiratory tract of a subject using protein profiles of a pathogenic bacteria. In addition, the invention provides for devices, immunoassays and kits for identifying pathogenic bacteria in the upper respiratory tract. | 10-23-2014 |
Lauren O. Bakaletz, Columbus, OH US
Patent application number | Description | Published |
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20090175912 | Haemophilus Influenza Outer Membrane Protein and Use Thereof in Vaccination - This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeable | 07-09-2009 |
20110236306 | COMPOSITIONS AND METHODS FOR THE REMOVAL OF BIOFILMS - This invention provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a therapeutic for those with an existing infection. The individual's immune system will then naturally generate antibodies which prevent or clear these bacteria from the host by interfering with the construction and or maintenance of a functional protective biofilm. Alternatively, antibodies to the polypeptides can be administered to treat or prevent infection. Bacteria that cannot form functional biofilms are more readily cleared by the remainder of the host's immune system. | 09-29-2011 |
20120128701 | COMPOSITIONS AND METHODS FOR THE REMOVAL OF BIOFILMS - Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more HMG-box domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system. | 05-24-2012 |