Patent application number | Description | Published |
20090173386 | Water alteration structure applications and methods - A method is generally described which includes environmental alteration. The method includes determining a placement of at least one vessel capable of moving water to lower depths in the water via wave induced downwelling. The method also includes placing the at least one vessel in the determined placement. Further, the method includes generating movement of the water adjacent the surface of the water in response to the placing. | 07-09-2009 |
20090173404 | Water alteration structure and system - A system is described generally for providing a structure or structures for altering water surface temperature. The system includes a holding vessel configured to hold water. The holding vessel has at least one wall coupled to a lowermost portion. The at least one wall extends above the water level and the lowermost portion is configured to be submerged. At least one conduit extends from the lower side of the holding vessel. The at least one conduit has a length extending to a depth at which a property of water at the depth is substantially different from that of the water at the surface. | 07-09-2009 |
20090173801 | Water alteration structure and system having below surface valves or wave reflectors - A system is described generally for providing a structure or structures for altering water surface temperature. The system includes a holding vessel configured to hold water. The holding vessel has at least one wall coupled to a lowermost portion. The at least one wall extends above the water level and the lowermost portion is configured to be submerged. At least one conduit extends from the lower side of the holding vessel. The at least one conduit has a length extending to a depth at which a property of water at the depth is substantially different from that of the water at the surface. The at least one conduit or the holding vessel includes at least one aperture formed in at least one of the holding vessel or the at least one conduit and located at a distance below the mean surface water level and at least one one way valve is coupled to the at least one aperture and allowing flow of water in only one direction. | 07-09-2009 |
20090175685 | Water alteration structure movement method and system - A structure described generally for altering one or more properties within a body of water includes a vessel configured to hold water. The vessel may have at least one wall. The at least one wall extends at least above a mean surface water level. At least one conduit extends downward from the holding vessel. The at least one conduit has a length that extends below the surface of the water. A propulsion system may be coupled to at least one of the vessel or the conduit and may be configured to provide forces to the vessel. | 07-09-2009 |
20090177569 | Water alteration structure risk management or ecological alteration management systems and methods - A method of managing risk includes selling individual insurance policies regarding areas to be protected by storm suppression equipment. The method discussed also includes finding at least one of purchase, operation, or maintenance of the storm suppression equipment at least partially through premiums collected from the selling. | 07-09-2009 |
20100300560 | Water alteration structure and system having heat transfer conduit - A system is described generally for a water capture structure that is configured to capture wave water lapping over at least one wall of the water capture structure. The at least one wall extends at least above a nominal surface water level and at least one conduit extends downward from the water capture structure. The at least one conduit has a length extending to a depth at which at least one property of water at the depth differs substantially from that of water at the surface. The at least one conduit is configured to provide thermal energy to water outside of the at least one conduit. The at least one conduit has at least one conduit wall. | 12-02-2010 |
20120115240 | Treatment of ruminant exhalations - Methane gas in a ruminant exhalation may be oxidized to reduce the amount of methane gas output by the ruminant. | 05-10-2012 |
20130257144 | METHOD AND APPARATUS FOR SUPPLYING AUXILIARY ELECTRICAL POWER TO AN ELECTRIC OR HYBRID VEHICLE - The present invention may include a towable trailer being mechanically couplable to a vehicle, the towable trailer including an auxiliary battery housing unit, a wheel being rotatably connected to the towable trailer, an auxiliary battery disposed within the auxiliary battery housing unit of the towable trailer, the vehicle including a storage battery, the auxiliary battery of the towable trailer being electrically couplable with the storage battery of the vehicle via a bidirectional pathway, and a control system configured to control a transfer of electrical energy between the auxiliary battery of the towable trailer and the storage battery of the vehicle along the bidirectional pathway. | 10-03-2013 |
20130257145 | METHOD AND APPARATUS FOR SUPPLYING AUXILIARY ELECTRICAL POWER TO AN ELECTRIC OR HYBRID VEHICLE - The present invention may include a towable trailer being mechanically couplable to a vehicle, the towable trailer including an auxiliary battery housing unit, a wheel being rotatably connected to the towable trailer, an auxiliary battery disposed within the auxiliary battery housing unit of the towable trailer, the vehicle including a storage battery, the auxiliary battery of the towable trailer being electrically couplable with the storage battery of the vehicle via a bidirectional pathway, and a control system configured to control a transfer of electrical energy between the auxiliary battery of the towable trailer and the storage battery of the vehicle along the bidirectional pathway. | 10-03-2013 |
20140067296 | METHOD AND APPARATUS FOR MEASURING NEGAWATT USAGE OF AN APPLIANCE - The present invention may include measuring energy usage of one or more appliances for a selected usage metric, receiving reference energy usage data indicative of energy usage of one or more reference appliances for the selected usage metric, comparing the measured energy usage of the one or more appliances for the selected usage metric to the one or more received sets of reference energy usage data for the selected usage metric, and reporting an amount of energy savings based on the comparison of measured energy usage of the one or more appliances and the one or more received sets of reference energy data. | 03-06-2014 |
20140170392 | MULTI-LAYER PHONONIC CRYSTAL THERMAL INSULATORS - A thermal insulator includes a plurality of layers. At least some of the layers include phononic crystals having a phononic bandgap, wherein heat transporting phonons within a selected range of frequencies are substantially blocked by each phononic crystal layer. The plurality of layers thermally isolate a first region from a second region, wherein the first region is at one end of the plurality of layers and the second region is at the other end of the plurality of layers. | 06-19-2014 |
20140182200 | ARTICLES AND METHODS FOR ADMINISTERING CO2 INTO PLANTS - Methods and articles are provided for reducing the amount of water consumed by a plant over a period of time, sequestering CO | 07-03-2014 |
20140185338 | BALANCING POWER GRID PARAMETERS USING DISTRIBUTED ENERGY CONTROL - Described embodiments include a system and a method. A system includes an energy storage device configured to store and release energy. The system includes a waveform sensor configured to detect a second harmonic or higher frequency component deviation in a waveform of electric power supplied to the system by an electrical power grid. The system includes a bi-directional switched-mode converter coupled between the energy storage device and the electrical power grid. The switched-mode converter is configured to receive and convert electric power from the electrical power grid into energy stored in the energy storage device and to convert energy released from the energy storage device into electric power and discharge the converted electric power into the electrical power grid. The system includes a waveform correction manager configured to control the bi-directional switched-mode converter in a manner implementing a waveform deviation reduction strategy responsive to the detected deviation in the waveform. | 07-03-2014 |
20140186916 | ARTICLES AND METHODS FOR ADMINISTERING CO2 INTO PLANTS - Methods and articles are provided for reducing the amount of water consumed by a plant over a period of time, sequestering CO | 07-03-2014 |
20140187425 | ARTICLES AND METHODS FOR ADMINISTERING CO2 INTO PLANTS - Methods and articles are provided for reducing the amount of water consumed by a plant over a period of time, sequestering CO | 07-03-2014 |
20140199225 | TREATMENT OF RUMINANT EXHALATIONS - Methane gas in a ruminant exhalation may be oxidized to reduce the amount of methane gas output by the ruminant. | 07-17-2014 |
20150050159 | DUAL ELEMENT TURBINE BLADE - A turbine blade includes a core element having a base portion, a tip portion, and an intermediate portion extending between the base portion and the tip portion. The intermediate portion includes a non-uniform cross-section and is a high-strength fiber material. The turbine blade further includes a shell disposed around the core element, and the volume between the core element and the shell forms a void. | 02-19-2015 |
Patent application number | Description | Published |
20120141484 | METHODS OF PREVENTING INFLAMMATION AND TREATING PAIN USING ANTI-NGF COMPOSITIONS - Monovalent agents, including Fab fragments and monovalent monoclonal antibodies analogous to MetMab, having binding specificity to human Nerve Growth Factor (“NGF”), and methods treating pain in an individual wherein there is no substantial increase in the inflammatory response of the individual following administration of the monovalent agents. | 06-07-2012 |
20120141485 | METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES - Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.) | 06-07-2012 |
20120148490 | ANTI-NGF COMPOSITIONS AND USE THEREOF - The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 06-14-2012 |
20120164067 | METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES THAT SELECTIVELY INHIBIT THE ASSOCIATION OF NGF WITH TRKA, WITHOUT AFFECTING THE ASSOCIATION OF NGF WITH P75 - NGF antagonists including antibodies and antibody fragments thereof having binding specificity to human Nerve Growth Factor (“NGF”), and methods of treating pain. Methods of treating pain or eliciting an analgesic effect in an individual comprising administering an effective amount of an NGF antagonist inhibits the association of NGF with TrkA without inhibiting the association of NGF with p75. The methods may further comprise administering an effective amount of a second anti-human NGF antibody or fragment thereof which inhibits the association of NGF with p75, that may further also inhibit the association of NGF with TrkA. | 06-28-2012 |
20120277408 | HIGH-PURITY PRODUCTION OF MULTI-SUBUNIT PROTEINS SUCH AS ANTIBODIES IN TRANSFORMED MICROBES SUCH AS PICHIA PASTORIS - Methods for producing heterologous multi-subunit proteins in transformed cells are disclosed. In particular, the present disclosure provides improved methods of producing multi-subunit proteins, including antibodies and other multi-subunit proteins, which may or may not be secreted, with a higher yield and decreased production of undesired side-products. In exemplary embodiments, the transformed cells are a yeast, e.g., methylotrophic yeast such as | 11-01-2012 |
20120294797 | ANTI-CGRP COMPOSITIONS AND USE THEREOF - The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 11-22-2012 |
20120294802 | USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO PREVENT OR INHIBIT PHOTOPHOBIA OR LIGHT AVERSION IN SUBJECTS IN NEED THEREOF, ESPECIALLY MIGRAINE SUFFERERS - The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like. | 11-22-2012 |
20120294822 | USE OF ANTI-CGRP ANTIBODIES AND ANTIBODY FRAGMENTS TO TREAT DIARRHEA IN SUBJECTS WITH DISEASES OR TREATMENTS THAT RESULT IN ELEVATED CGRP LEVELS - The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof. | 11-22-2012 |
20130028860 | ANTAGONISTS OF IL-6 TO PREVENT OR TREAT CACHEXIA, WEAKNESS, FATIGUE AND/OR FEVER - The present invention is directed to therapeutic methods and compositions, especially subcutaneous and intravenous composition using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved. | 01-31-2013 |
20130034554 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. Additional preferred embodiments of the subject invention relate to therapeutic compositions and methods treating or preventing rheumatoid arthritis, especially subcutaneous and intravenous formulations and dosage regimens using IL-6 antagonists according to the invention, as well as methods for preventing or treating GVHD or leukemia relapse in subjects receiving transplanted cells, tissue or organs, use thereof in the treatment or prevention of mucositis, and use thereof to potentiate the cytotoxic, apoptotic, and anti-metastatic or anti-invasive effects of chemotherapeutics and radiation on cancers, especially cancers that have developed a resistance to radiation or chemotherapy, such as an EGFR inhibitor. | 02-07-2013 |
20130183293 | ANTAGONISTS OF IL-6 TO PREVENT OR TREAT CACHEXIA, WEAKNESS, FATIGUE , AND/OR FEVER - The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved. | 07-18-2013 |
20130224201 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others. | 08-29-2013 |
20130302399 | ANTI-PCSK9 ANTIBODIES AND USE THEREOF - The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 11-14-2013 |
20130316353 | CULTURE METHOD FOR OBTAINING A CLONAL POPULATION OF ANTIGEN-SPECIFIC B CELLS - The present invention relates to methods of isolating antigen-specific cells and producing antibodies therefrom. | 11-28-2013 |
20130336975 | ANTI-NGF COMPOSITIONS AND USE THEREOF - The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 12-19-2013 |
20130344068 | METHODS OF PREVENTING INFLAMMATION AND TREATING PAIN USING ANTI-NGF COMPOSITIONS - This invention pertains to monovalent agents, including Fab fragments and monovalent monoclonal antibodies analogous to MetMab, having binding specificity to human Nerve Growth Factor (“NGF”), and methods of treating pain in an individual wherein there is no substantial increase in the inflammatory response of the individual following administration of the monovalent agents. | 12-26-2013 |
20140004115 | METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES THAT SELECTIVELY INHIBIT THE ASSOCIATION OF NGF WITH TRKA, WITHOUT AFFECTING THE ASSOCIATION OF NGF WITH P75 | 01-02-2014 |
20140004116 | METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES | 01-02-2014 |
20140271459 | ANTIBODIES TO HGF AND COMPOSITIONS CONTAINING - The present invention is directed to antibodies and fragments thereof having binding specificity for HGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 09-18-2014 |
20140271464 | THERAPEUTIC USE OF ANTIBODIES TO HGF - The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for HGF and their use in therapy and diagnosis. These antibodies inhibit or block HGF-associated activities including HGF's effects on cell proliferation, invasion, angiogenesis, metastasis and fibrosis. Particularly the antibodies may be used as a monotherapy or in combination therapies in treating cancer, other proliferative disorders and other conditions wherein inhibition of HGF and/or the HGF/HGF-R (c-met) interaction is desired. | 09-18-2014 |
20140271664 | THERAPEUTIC USE OF ANTIBODIES TO HGF - The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for HGF and their use in therapy and diagnosis. These antibodies inhibit or block HGF-associated activities including HGF's effects on cell proliferation, invasion, angiogenesis, metastasis and fibrosis. Particularly the antibodies may be used as a monotherapy or in combination therapies in treating cancer, other proliferative disorders and other conditions wherein inhibition of HGF and/or the HGF/HGF-R (c-met) interaction is desired. | 09-18-2014 |
20140287952 | PROTOCOL FOR IDENTIFYING AND ISOLATING ANTIGEN-SPECIFIC B CELLS AND PRODUCING ANTIBODIES TO DESIRED ANTIGENS - Methods of identifying antigen-specific antibody-secreting and antibody-forming cells, such as antigen-specific B cells, and methods for cloning the antigen-specific antibody sequences of the antibody produced by these cells are provided. In particular, the methods include enriching B cells for antigen-specific B cells, culturing the antigen-specific B cells to generate clonal B cell populations, detecting clonal B cells that produce a single antigen-specific antibody, optionally screening the clonal B cell populations for functional activity, staining and sorting the cells to isolate the antigen-specific B cells, sequencing the nucleic acids encoding the antigen-specific antibody sequences, expressing the sequences to produce an antibody, isolating the antibody and screening the antibody for antigen recognition. The methods provide improved enrichment and selection of antigen-specific antibody-secreting and antibody-forming cells, which enhances recovery of antigen-specific antibodies. | 09-25-2014 |
20140288272 | ANTIBODY PURIFICATION AND PURITY MONITORING - Processes for producing and purifying recombinant proteins are disclosed. In particular, the present disclosure provides processes of producing and purifying multi-subunit proteins expressed in yeast or filamentous fungal cells. The production and/or purification of such proteins are monitored for impurities, preferably using lectin binding assays, such that one or more process parameters may be adjusted to maximize the amount of desired recombinant protein and minimize the amount of glycosylated impurities. The processes can also be monitored for other undesired product-associated impurities, such as aggregates and nucleic acids. In exemplary embodiments, the recombinant proteins are multi-subunit proteins, such as antibodies, the host cell is a yeast, such as | 09-25-2014 |
20150017166 | REGULATION OF GLUCOSE METABOLISM USING ANTI-CGRP ANTIBODIES - The present disclosure provides methods for the prevention or treatment of metabolic disorders. In exemplary embodiments, methods of administering an anti-CGRP antibody are provided, optionally in combination with a second agent, wherein peripheral and/or hepatic glucose utilization is increased, thereby preventing or treating diseases and disorders associated with insulin resistance. Compositions comprising an anti-CGRP antibody are also provided, optionally in combination with a second agent, which are suitable for administration to increase peripheral and/or hepatic glucose utilization and thereby prevent or treat diseases and disorders associated with insulin resistance. | 01-15-2015 |
20150132224 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 05-14-2015 |
20150132304 | METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES THAT SELECTIVELY INHIBIT THE ASSOCIATION OF NGF WITH TRKA, WITHOUT AFFECTING THE ASSOCIATION OF NGF WITH P75 - NGF antagonists including antibodies and antibody fragments thereof having binding specificity to human Nerve Growth Factor (“NGF”), and methods of treating pain. Methods of treating pain or eliciting an analgesic effect in an individual comprising administering an effective amount of an NGF antagonist inhibits the association of NGF with TrkA without inhibiting the association of NGF with p75. The methods may further comprise administering an effective amount of a second anti-human NGF antibody or fragment thereof which inhibits the association of NGF with p75, that may further also inhibit the association of NGF with TrkA. | 05-14-2015 |
20150273058 | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever - The present invention is directed to therapeutic methods and compositions, especially subcutaneous and intravenous composition using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in a patient in need thereof. In preferred embodiments, the anti-IL-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level. In another preferred embodiment, the patient's survivability or quality of life will preferably be improved. | 10-01-2015 |
20150274823 | ANTIBODIES TO IL-6 AND USE THEREOF - The present invention is directed to antibodies and fragments thereof and humanized versions thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V | 10-01-2015 |
20150322145 | THERAPEUTIC USE OF ANTIBODIES TO HGF - The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for HGF and their use in therapy and diagnosis. These antibodies inhibit or block HGF-associated activities including HGF's effects on cell proliferation, invasion, angiogenesis, metastasis and fibrosis. Particularly the antibodies may be used as a monotherapy or in combination therapies in treating cancer, other proliferative disorders and other conditions wherein inhibition of HGF and/or the HGF/HGF-R (c-met) interaction is desired. | 11-12-2015 |
Patent application number | Description | Published |
20100130723 | POLYPEPTIDE SYNTHESIS FOR DRUG DELIVERY - The present invention provides improved methods for the synthesis of polypeptide or peptide-linked compounds via a NCA-based polymerization reaction that produces high product yields in much less time. Such improved methods are achieved by application of a higher temperature and/or reduced pressure to the reaction such that an NCA-containing monomer melts. | 05-27-2010 |
20100137639 | PREPARATION OF ORGANIC COMPOUNDS FOR ENHANCED REACTIVITY - The present invention provides an improved method for preparing, purifying, precipitating, etc., a subject compound for use in a subsequent reaction carried out in suspension. The present invention relies on a precipitating solvent being added to an aqueous solution comprising the subject compound to form a precipitate of the subject compound, which may be further dried and/or purified. Compositions made according to present methods have improved characteristics and properties, such as increased surface and/or reduced density, resulting in a higher reactivity in a subsequent reaction carried out in suspension. | 06-03-2010 |
20130017163 | HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY - The present invention provides compositions and methods of their administration for the protection of cells and tissues from damage caused by FROS in the body of an individual. Compositions comprising halogenated phenol compounds are provided that scavenge or consume FROS in the body. These FROS scavenging compounds may not only protect cells and tissues from damage, but also treat disease and/or alleviate the symptoms of disease associated with high FROS levels. Sunscreen compositions comprising FROS-scavenging compounds of the present invention are further provided to reduce the damaging effects of sunlight on the skin of an individual. | 01-17-2013 |
20130018026 | HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY - The present invention provides compositions and methods for the targeted delivery, release and/or formation of a drug compound at a target site(s) within the body of an individual, such as a diseased and/or inflamed tissue in the body of the individual. These compositions may comprise a halogenated phenol ring cleavably linked to a core structure of a drug compound. Due to the variety of substituents that may be utilized in forming the different types of linkages, numerous examples of drug compounds linked to a halogenated phenol ring are proposed. The present invention further provides compositions comprising halogenated phenol starting compounds that do not undergo cleavage during a dehalogenation reaction to form a drug compound in a targeted tissue when administered to an individual. Methods of administering these non-cleaving compounds are further provided. | 01-17-2013 |
20130022549 | HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY - The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable product may include a halide or a benzenetriol-based or benzenetetrol-based product of a dehalogenation reaction in the presence of FROS. In many embodiments, an indigo-like product formed from an indigogenic compound of the present invention may also be a detectable product for diagnostic purposes. This indigo-like product may have a higher residence time in tissues where it is formed, thus providing a detectable product localized to sites of high FROS. An indigogenic compound containing one or more radioactive isotopes is further provided for therapeutic purposes. | 01-24-2013 |
20130157992 | SUSTAINED DRUG RELEASE AND IMPROVED PRODUCT STABILITY USING NON-COVALENT PARTICLE COATING METHODS - The present invention relates to improved methods of making compositions and compositions made by these methods having improved stability and/or extended release of an active agent or drug upon administration. These compositions may generally comprise an active agent or drug non-covalently immobilized or bound to an excipient substrate. The active agent or drug may include a wide variety of drugs. Binding of the active agent or drug to the substrate may be achieved by evaporating a solvent containing the active agent dissolved therein or by triggering co-precipitation by addition of a precipitating solvent. Additional steps of vacuum removal of surrounding atmosphere and replacement with inert gas may provide additional stability. Present methods and compositions also facilitate manufacturing of drug products and may make these processes safer in some cases. The present invention further provides improved methods of treatment or administration, which may take advantage of improvements with present compositions. | 06-20-2013 |
20130261332 | PREPARATION OF ORGANIC COMPOUNDS FOR ENHANCED REACTIVITY - The present invention provides an improved method for preparing, purifying, precipitating, etc., a subject compound for use in a subsequent reaction carried out in suspension. The present invention relies on a precipitating solvent being added to an aqueous solution comprising the subject compound to form a precipitate of the subject compound, which may be further dried and/or purified. Compositions made according to present methods have improved characteristics and properties, such as increased surface and/or reduced density, resulting in a higher reactivity in a subsequent reaction carried out in suspension. | 10-03-2013 |
Patent application number | Description | Published |
20090016424 | SYSTEMS AND METHODS FOR DIGITAL CONTROL UTILIZING OVERSAMPLING - Methods and systems for digital control utilizing oversampling. | 01-15-2009 |
20100090669 | BUCK DC-TO-DC CONVERTER AND METHOD - A method and apparatus for converting a DC voltage to a lower DC voltage, provides for conducting current from an input terminal, through an inductor to charge a capacitor connected to the inductor at an output terminal and to provide a varying range of load current from the output terminal, alternately switching the input terminal between a supply voltage and a ground potential to produce a desired voltage at the output terminal that is lower than the supply voltage, while providing the varying range of load current, and disconnecting the input terminal from both the supply voltage and the ground potential to reduce an increase in voltage at the output terminal caused by a substantial reduction in the load current, while current through the inductor adjusts in response to the reduced load current. | 04-15-2010 |
20100109630 | NON-LINEAR PWM CONTROLLER FOR DC-TO-DC CONVERTERS - A nonlinear PWM controller for switching power supplies | 05-06-2010 |
20110193537 | NON-LINEAR PWM CONTROLLER FOR DC-TO-DC CONVERTERS - A controller for switching power supplies includes a nonlinear controller component capable of providing a duty cycle to a pulse width modulator. The duty cycle corresponds to at least one predetermining switching power supply state variable. A nonlinear controller component receives as inputs at least one predetermined switching power supply state variable. A relationship between duty cycle and at least one predetermined switching power supply state variable is obtained by a predetermined method. The nonlinear controller component comprises memory for access by an application component. The memory includes a data structure stored in memory and a plurality of duty cycles. Each of the plurality of duty cycles has a corresponding at least one predetermined switching power supply state variable. Each duty cycle, when provided to the pulse width modulator of the switching power supply, provides a predetermined switching power supply output. | 08-11-2011 |
20120035779 | METHODS AND SYSTEMS FOR ADAPTIVE CONTROL - A switching power supply includes a circuit that provides an output voltage, a switching component that switches the circuit between a first output voltage state and a second output voltage state, and a driver component that receives an input control signal and that drives the switching component to cause the circuit to switch between the first output voltage state and the second output voltage state. An adaptive plant estimator receives the output voltage from the circuit and an input to the switching power supply and provides a model of the switching power supply that reflects changes in an output voltage state of the switching power supply. A compensator design component receives the model and provides compensator parameters that reflect changes in the output voltage state of the switching power supply. An adaptive compensator receives the compensator parameters and provides the input control signal to the driver component. | 02-09-2012 |
20120039376 | Systems And Methods For Digital Control Utilizing Oversampling - Methods and systems for digital control utilizing oversampling. | 02-16-2012 |
20120046932 | METHODS AND SYSTEMS FOR ADAPTIVE CONTROL - A system includes a power supply model component and a disturbance estimating component. The power supply model component receives an estimated disturbance. The disturbance estimating component provides said estimated disturbance from a difference between a sensed output of a power supply and an estimated output from said power supply model component. | 02-23-2012 |
20120217940 | DELAY COMPENSATION SYSTEMS AND METHODS FOR DC TO DC CONVERTERS - A control system for a DC to DC converter includes a predicted state generator module, a voltage estimation module, an error module, and a pulse width modulation (PWM) module. During a prior sampling period, the predicted state generator module generates a predicted capacitor voltage and a predicted capacitor current for a current sampling period. The voltage estimation module generates an estimated value of an output voltage of the DC to DC converter during the current sampling period based on the predicted capacitor current, the predicted capacitor voltage, a delay value, and a duty cycle value for the prior sampling period. The error module generates a voltage error value based on difference between a measured value of the output voltage and the estimated value. The PWM module controls the duty cycle of the DC to DC converter based on the voltage error value. | 08-30-2012 |
20120217945 | SYSTEMS AND METHODS FOR FEED-FORWARD CONTROL OF LOAD CURRENT IN DC TO DC BUCK CONVERTERS - A feed-forward control system for load current in a direct current (DC) to DC converter includes a current normalization module, a feed-forward generation module, and a duty cycle generation module. The current normalization module generates a normalized load current by matching a gain of a measured load current to a gain of an inductor current. The feed-forward generation module that generates a load current feed-forward (LCFF) signal based on the normalized load current. The duty cycle generation module generates a duty cycle for the DC to DC converter based on a commanded output voltage and the LCFF signal. | 08-30-2012 |
20140247032 | SYSTEMS AND METHODS FOR FEED-FORWARD CONTROL OF LOAD CURRENT IN DC TO DC BUCK CONVERTERS - A system for controlling load current in a voltage converter includes a current normalization module that receives a first measurement corresponding to the load current, receives a second measurement corresponding to an inductor current, and matches a first gain of the first measurement corresponding to the load current to a second gain of the second measurement corresponding to the inductor current to generate a normalized load current. A feed-forward generation module receives the normalized load current from the current normalization module and generates a load current feed-forward (LCFF) signal based on the normalized load current. A duty cycle generation module generates a duty cycle used to control the voltage converter based on a commanded output voltage of the voltage converter and the LCFF signal. | 09-04-2014 |
Patent application number | Description | Published |
20090306690 | ABRASIVE NOSE CONE WITH EXPANDABLE CUTTING AND SANDING REGION FOR ROTATIONAL ATHERECTOMY DEVICE - An rotational atherectomy apparatus for abrading tissue, comprising: a flexible, elongated, rotatable drive shaft having a proximal end and a distal end opposite the proximal end; a nose cone operatively attached proximate the distal end of the drive shaft comprising a distal tapered section and a plurality of elongate, flexible members adjacent to the distal tapered section of the drive shaft, each member in the plurality being fixed at both a proximal end and a distal end opposite the proximal end; a proximal mount rotatable with the drive shaft and fixedly connected to the proximal ends of all the flexible members in the plurality; and a distal mount axially separated from the proximal mount and fixedly connected to the distal ends of all the flexible members in the plurality. When the axial separation of the proximal and distal mounts is reduced by pulling the distal tapered section proximally, each member in the plurality bows outward from the drive shaft and expands radially in an at least partially elliptical profile. | 12-10-2009 |
20090306691 | CUTTING AND CORING ATHERECTOMY DEVICE AND METHOD - The invention provides a rotational and/or axially translatable atherectomy system, device and method comprising a flexible, elongated drive shaft or catheter comprising an expandable and collapsible conical coil with a cutting edge on the coil's large diameter proximal end. When retracted, the coil's sections are collapsed around each other, held together in the retracted position by a sheath that, when distally retracted, allows the coil to automatically expand. The coil is expanded at a point distal to the occlusion, then pulled proximally to cut the occluding material near the lumen wall. The proximal pulling force may be combined with low-speed rotation and/or translation and/or axial vibration at low to ultrasonic frequency. | 12-10-2009 |
20110315641 | CONTROLLER FOR AN ACOUSTIC STANDING WAVE GENERATION DEVICE IN ORDER TO PREVENT CLOGGING OF A FILTER - The invention relates to a method and apparatus to continuously monitor and control acoustic energy and vacuum pressure to maintain a net unidirectional flow of multi-phase heterogeneous fluids through a porous filter or membrane. The heterogenous fluid may come form a variety of sources including biological sources such as, blood, bone marrow aspirate (BMA), adipose tissue (lipoaspirate), urine, saliva, etc. | 12-29-2011 |
20130205545 | Cable Lacing Tie Devices and Methods of Using the Same - Cable lacing tie devices and methods of using the same are disclosed. The cable lacing tie devices include a head assembly and a cable lacing tape. The head assembly being configured to retain a first portion of the cable lacing tape within the head assembly and having a length of the cable lacing tape extending from the head assembly. The head assembly further adapted to retain a second portion of the cable lacing tape extending from the head assembly. The methods of using the cable lacing tie devices to hold together a plurality of objects with a cable lacing tie device include retaining a first portion of a cable lacing tape in a head assembly, looping the cable lacing tape around the plurality of objects and retaining a second portion of the cable lacing tape within the head assembly. | 08-15-2013 |
20140338931 | Liquid Wet Chemical Fire Extinguishing Spray - An aerosol fire extinguisher for dispensing a liquid wet chemical fire extinguishing agent, and a composition for the liquid wet chemical fire extinguishing agent, where the liquid wet chemical fire extinguishing agent is rated for class A, B, C and K fires. The fire extinguisher includes a container and a valve assembly affixed to the container. A hag is positioned within the container, where the bag includes an output tube connected in fluid communication to the valve assembly. An actuator is connected in fluid communication to the valve assembly opposite the output tube, where. the actuator has an elongated output orifice. A liquid wet chemical fire extinguishing agent is disposed within the bag and a propellant is disposed within the container, wherein the bag isolates the liquid wet chemical fire extinguishing agent from the propellant. The: configuration of the elongated output orifice expels the liquid wet chemical fire extinguishing agent in a substantially planar pattern onto the fire. | 11-20-2014 |
20140373883 | CONNECTOR FOR A DISHWASHER MIDDLE SPRAY ARM - A docking system includes basket and wall conduit systems. The basket conduit system includes a conduit and first and second nozzles mounted to opposite ends of the conduit. The second nozzle has a first funnel shape with a first circumference that decreases from an open end of the second nozzle towards the conduit. The wall conduit system includes front and back housings, a sliding plate, and a third nozzle. A sliding aperture is formed through a front plate of the front housing. A nozzle aperture is formed through a back plate of the back housing. The sliding plate slides within a space formed by the front housing and the back housing. The third nozzle is sized and shaped to slide within the sliding aperture and includes a generally cylindrical shape and a second funnel shape with a second circumference that decreases from the sliding plate towards the generally cylindrical shape. | 12-25-2014 |
20150174511 | CONTROLLER FOR AN ACOUSTIC STANDING WAVE GENERATION DEVICE IN ORDER TO PREVENT CLOGGING OF A FILTER - The invention relates to a method and apparatus to continuously monitor and control acoustic energy and vacuum pressure to maintain a net unidirectional flow of multi-phase heterogeneous fluids through a porous filter or membrane. The heterogeneous fluid may come form a variety of sources including biological sources such as, blood, bone marrow aspirate (BMA), adipose tissue (lipoaspirate), urine, saliva, etc. | 06-25-2015 |
Patent application number | Description | Published |
20080235997 | TOOTHED TRENCHER TRACK AND ELEMENTS THEREFOR - An endless chain for cutting and removing spoil from a trench includes a plurality of links pivotally coupled together. A plurality of flight plates are secured to the plurality of links. A pattern of openings extends through each flight plate between the under surface and the outer surface. A plurality of wear plates is positioned over the outer surface of the plurality of flight plates. A plurality of fasteners pass from the under surface of the flight plate through at least some of the pattern of openings in the flight plate and into the wear plate to secure the wear plate to the flight plate. The fasteners securing the wear plates to the flight plates can have outer ends that terminate short of the outer surface of the wear plates in openings in the under surface of the wear plate. Sockets, which include bores receiving cutting elements, can be fixed to the wear plates with a bottom surface of the socket either angled with respect to or flush with the wear plate outer surface. | 10-02-2008 |
20100148568 | CUTTER BIT INSERT REMOVAL SYSTEM AND METHOD - A system and method to remove quickly an insert, especially an insert with a damaged gripping portion, from a base portion of a mining and/or milling drum are provided. The insert can have a threaded portion engageable with the base portion opening. The insert can define an interior bore configured to receive a cutter bit, and an opening configured to receive an apparatus engageable with the insert opening to facilitate the removal of the insert from the base portion. The insert opening may be polygonal or may include at least one planar surface and/or a rounded corner. An apparatus can engage with the polygonal opening and/or a fastener can engage with the shafted fastener. In both cases, the apparatus and/or fastener is rotated with a force to disengage the threaded portion of the insert from the opening of the base portion. | 06-17-2010 |
20100181820 | WEAR INSERT AND RETAINER - The present invention provides an apparatus for use on a milling or mining drum that is durable and robust, yet easily serviceable. The apparatus can include a base portion adapted to be mounted to the mining drum and a wear insert removably attachable within an opening of the base portion. The opening of the base portion preferably has a first seat at an upper end and a second seat at a lower end. The wear insert includes a surface configured to engage with the first seat and a bore for receiving a cutter bit. A retainer is provided having a threaded portion to threadably engage with the threaded portion of either the wear insert or the cutter bit. The retainer can have a flange dimension to engage with the second seat. The cutter bit preferably includes a hardened tip. | 07-22-2010 |
20120080930 | CUTTER WITH DIAMOND BIT TIP - Apparatus for use on a milling or mining drum having a base portion mounted to the drum and a wear insert removably attachable within an opening of the base portion. The opening of the base portion can have a first seat at an upper end and a second seat at a lower end. The wear insert includes a surface configured to engage with the first seat and a bore for receiving a cutter bit at a fixed position relative to the wear insert. A retainer is provided having a threaded portion to engage with the threaded portion of either the wear insert or the cutter bit. The retainer can have a flange dimension to engage with the second seat. The cutter bit can include working end having a pointed geometry having a hardness similar to diamond. | 04-05-2012 |
20120104833 | WEAR INSERT AND RETAINER - An apparatus can include a base mounted to a mining drum. The base can include an opening including a seat. The apparatus also can include an insert including a bore and an exterior surface. The apparatus also can include a cutter bit including a cutting tip and a shank extending from the cutting tip. The shank can include a threaded portion and a transition positioned between the cutting tip and the threaded portion. The apparatus also can include a retainer including a threaded portion. A portion of the exterior surface of the insert facing the base can be dimensioned to engage the seat of the base. A region of the bore of the insert can be dimensioned to engage the transition of the cutter bit. The threaded portion of the retainer can be configured to engage the threaded portion of the cutter bit. | 05-03-2012 |
20120119562 | MINE SAFETY SYSTEM - A mine safety system having at least a substantial portion of a mine conduit buried within a trench that is formed in the mine floor is provided. The mine safety system can be sturdy and durable in construction and in operation because a substantial pressure from a mine collapse is transferred to the surrounding earth or soil when the mine conduit is partially or fully buried in the mine floor. The mine safety system can be simply and inexpensively installed in newly constructed mines or retrofitted in existing mines. The mine conduit can be made of a lightweight plastic which can make handling of the conduit easier. Moreover, installation of the trench and the mine safety system is quicker and easier with use of a cutter drum that can form a curved trench bottom when the conduit is circular. | 05-17-2012 |
20120121330 | ROAD SURFACE PLANAR - A road surface planner having a coupling mechanism coupled between a working tool attachment and a transporter to permit independent movement (i.e., rotation and/or pivoting) between the transporter and the attachment is provided. The attachment can have a rotary driven element such as a grinding element for modifying an irregular surface of existing pavement. The rotary element can be supported by a rear frame with a rear wheel assembly, a boom at the front of the grinding element, and a front wheel assembly coupled to the boom. The coupling mechanism can include a first member pivotably coupled to the transporter, and a second member fixed to the rear frame. The first member has a central opening defined by an inner edge for slidably contacting along a hub that extends from the second member for rotation there along. | 05-17-2012 |
20150054332 | TOOTH AND RETAINER - A milling drum adapted to be rotated in a cutting direction about an axis defined by the cylindrical surface of the drum. A plurality of pairs of overlapping recesses in the cylindrical surface of the drum. A tooth or cutting bit with a base configuration matching a first of the pair of the overlapping recesses, and a lower portion of a side surface including a retainer engagement feature. A retainer has a base configuration matching a second of the pair of overlapping recesses, and a side surface including a tooth engagement feature. A fastener secures the retainer in the second of the overlapping recesses so that the tooth engagement feature of the retainer engages the retainer engagement feature of the tooth or cutting bit to hold the tooth or cutting bit in the first of the overlapping recesses. | 02-26-2015 |
20150176408 | WEAR RESISTANT INSERT FOR DIAMOND ABRASIVE CUTTER - A cutter bit includes a wear resistant element replaceably mounted to a front surface immediately below the cutting surface of the cutter bit. The body of the cutter bit is generally formed of a hardened steel, the cutting surface can be a diamond composition fixed in a step in the upper end of the cutter bit and the wear resistant element is preferably formed of a carbide composition or a sintered diamond composition. The wear resistant element can be coupled to a front end of a stem passing through an opening in the cutter bit immediately below the cutting surface. | 06-25-2015 |
20150176409 | WEAR RESISTANT INSERT FOR DIAMOND ABRASIVE CUTTER - A cutter bit includes a wear resistant element replaceably mounted to a front surface immediately below the cutting surface of the cutter bit. The body of the cutter bit is generally formed of a hardened steel, the cutting surface can be a diamond composition fixed in a step in the upper end of the cutter bit including side edges that taper laterally outwardly toward a lower edge of the cutting surface situated adjacent to the wear resistant element and the wear resistant element is preferably formed of a carbide composition or a sintered diamond composition. The wear resistant element can have an upper edge that closely conforms to the shape of an adjacent lower edge of the cutting surface, and can be coupled to a front end of a stem passing through an opening in the cutter bit immediately below the cutting surface, the opening being perpendicular to at least a portion of the back surface of the cutter bit. | 06-25-2015 |