Patent application number | Description | Published |
20090036419 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 02-05-2009 |
20100130515 | Polymorphs and solvates of a pharmaceutical and method of making - Polymorphic and solvated forms of solid 3-(4-amino-3-methylbenzyl)-7-(furan-2-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine, and methods of making them, are described. | 05-27-2010 |
20100173914 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME - Compounds that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making the compounds, are disclosed. The compounds and compositions can be used in treating or preventing disorders related to purine receptor hyperfunctioning. | 07-08-2010 |
20130065858 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 03-14-2013 |
20150080568 | COMPOUNDS USEFUL AS RAF KINASE INHIBITORS - The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases. | 03-19-2015 |
Patent application number | Description | Published |
20120082338 | ATTITUDE ESTIMATION BY REDUCING NOISE WITH DRAGBACK - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
20120082345 | ATTITUDE ESTIMATION IN COMPRESSED DOMAIN - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
20120082393 | ATTITUDE ESTIMATION WITH COMPRESSIVE SAMPLING OF STARFIELD DATA - In general, in one embodiment, a starfield image as seen by an object is analyzed. Compressive samples are taken of the starfield image and, in the compressed domain, processed to remove noise. Stars in the starfield image are identified and used to determine an attitude of the object. | 04-05-2012 |
20120192622 | GEO-LOCATION SYSTEMS AND METHODS BASED ON ATMOSPHERIC PRESSURE MEASUREMENT - System and method for geo-location of a device (such as a tag) using barometric pressure readings taken in the vicinity of the device and correlated to datasets of barometric pressure that have pressure gradients over time and space. The readings taken in the vicinity of the device may be correlated to the datasets using an iterative Bayesian approach to determine a geo-location of the device with a high degree of confidence. | 08-02-2012 |
20120280108 | SYSTEMS AND METHODS FOR ADDING OR SUBTRACTING PIXELS - A pixel array including circuitry for combining charges accumulated by individual pixels in the array enables addition and/or subtraction of individual pixel values, prior to their digitization, in the pixel array. | 11-08-2012 |
20140267641 | ELECTRON-BOMBARDED ACTIVE PIXEL SENSOR STAR CAMERA - A star camera system that includes an optical system configured to focus radiation from a star to be imaged onto a collector. Specifically, the collector is in the form of an electron bombarded active pixel sensor (EBAPS) configured to provide high gain. The EBAPS comprising a photocathode disposed in a vacuum is configured to release electron into a vacuum when exposed to radiation focused thereon by the optical system. In addition, the EBAPS includes an active pixel sensor anode disposed distant from the photocathode in the vacuum. An electric field is generated by a voltage source to direct electrons from the photocathode to the active pixel sensor anode to thereby generate an image of the star. | 09-18-2014 |
20140267755 | HIGH PERFORMANCE SCANNING MINIATURE STAR CAMERA SYSTEM - A star camera system that includes an optical system configured to focus radiation from a star to be imaged onto a collector that is in the form of an electron bombarded active pixel sensor (EBAPS) configured to provide high gain. The EBAPS comprising a photocathode disposed in a vacuum is configured to release electrons into the vacuum when exposed to radiation focused thereon by the optical system. The EBAPS includes an active pixel sensor anode disposed distant from the photocathode in the vacuum. An electric field is generated by a voltage source to direct the electrons from the photocathode to the active pixel sensor anode. Furthermore, the collector is mounted on a translation device configured to move the collector relative to the optical system by a predetermined amount of less than pixel size in the focal plane of the optical system to increase image resolution of a plurality of images. | 09-18-2014 |
20150268050 | Navigation by Ocean Surface Topography - Methods and apparatus ascertain a geographic position based on topographic contours of ocean surfaces. Observed ocean topographic contours are matched to predicted ocean topography and/or ocean topographic information stored in a database. Such systems and methods do not necessarily require INS, GPS, RF beacons, optical beacons or celestial sightings. These systems and methods may be used as references to correct INS. These systems and methods may be used to ascertain a geographic location of an aircraft, spacecraft, watercraft, landcraft (vehicle), person or the like. Similarly, these systems and methods may be used as part of a guidance system for guiding a craft to a destination. These systems and methods may be used in tandem with, or as backups for, other types of navigation or guidance systems or as one input to a navigation filter. | 09-24-2015 |
Patent application number | Description | Published |
20120184568 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES - Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof. | 07-19-2012 |
20140371450 | PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES - Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof. | 12-18-2014 |
Patent application number | Description | Published |
20080228165 | SYSTEMS AND METHODS FOR INTRODUCING ELEMENTS INTO TISSUE - Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty. | 09-18-2008 |
20080228198 | SUTURE CUTTER AND METHOD OF CUTTING SUTURE - Suture cutters and methods of cutting suture in a surgical procedure. The suture cutter may include an actuator, an intermediate cannula portion and a movable cutting assembly. The cutting assembly may be operatively coupled to the actuator and include a cutting element. An adjustably sized cutting window receives the suture. The adjustably sized cutting window may be bound on at least one side with the cutting element for cutting the suture received inside the cutting window. Actuation moves the cutting assembly to cut the suture. | 09-18-2008 |
20080228265 | TISSUE ANCHORS, SYSTEMS AND METHODS, AND DEVICES - Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty. | 09-18-2008 |
20080228266 | PLICATION ASSISTANCE DEVICES AND METHODS - Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty. | 09-18-2008 |
20130041388 | APPARATUS AND METHOD FOR SUTURING TISSUE - A suturing device of the present invention is in the form a compact, light-weight handheld device that includes a needle and suture assembly, a mechanism for gripping and releasing the needle/suture (a “needle transfer mechanism” or “needle shuttle mechanism”), safely capturing the needle/suture upon exit from the patient's tissue, and returning the needle to a position such that the process of delivering additional sutures to the patient can be repeated. A safety shield mechanism ensures the user is protected from the needle at all times. The device of the present invention accommodates the right or left-handed user, rests comfortably in the user's hand, allows sufficient visualization of the procedure site, and permits the user to either control penetration depth of the needle or default to a device-determined depth. The present device permits the user to utilize a wrist-rotation (pivoting) suture delivery technique. | 02-14-2013 |
20130190863 | METHOD TO REDUCE MITRAL REGURGITATION BY CINCHING THE COMMISSURE OF THE MITRAL VALVE - Methods of repairing the mitral valve and reducing mitral regurgitation. One method includes securing a first tissue anchor to a position on a posterior portion of the annular tissue of the mitral valve and a second tissue anchor to a position on an anterior portion of the annular tissue of the mitral valve. At least one tensile member spans between the first and second tissue anchors and across the orifice of the mitral valve. When tension is applied to the at least one tensile member, the posterior portion of the annular tissue is pulled toward the anterior portion. | 07-25-2013 |
20130245646 | MEANS AND METHODS FOR SUTURING TISSUE - A device for suturing tissue includes a handle that has a proximal end and a distal end. The device also includes a generally hollow suturing needle including a pointed distal end, an opposite proximal end and an inner lumen having an suture exit port through which the suture exits. The device further includes a suture dispensing mechanism disposed within the handle and including an actuator which when manipulated by a user is configured to advance suture material within the handle such that the suture material is guided into the inner lumen of the hollow suturing needle and exits through the suture exit port. The device includes a safety mechanism that shields at least a portion of the needle. | 09-19-2013 |
20130253661 | METHOD AND APPARATUS FOR TREATING BONE FRACTURES, AND/OR FOR FORTIFYING AND/OR AUGMENTING BONE, INCLUDING THE PROVISION AND USE OF COMPOSITE IMPLANTS - A composite implant comprising an injectable matrix material which is flowable and settable, and at least one reinforcing element for integration with the injectable matrix material, the at least one reinforcing element adding sufficient strength to the injectable matrix material such that when the composite implant is disposed in a cavity in a bone, the composite implant supports the bone. | 09-26-2013 |
20140094906 | TISSUE ANCHORS, SYSTEMS AND METHODS, AND DEVICES - Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty. | 04-03-2014 |
20140276989 | MEANS AND METHODS FOR SUTURING TISSUE - A device according to one exemplary embodiment is a compact, light-weight handheld device that includes a needle and suture assembly, a mechanism for gripping and releasing the needle and suture assembly (a “needle transfer mechanism” or “needle shuttle mechanism”), safely capturing the needle assembly upon exit from the patient's tissue, and returning the needle to position such that the process of delivering additional sutures to the patient can be repeated. The device of the present invention accommodates the right or left-handed user, rests comfortably in the user's hand, allows sufficient visualization of the procedure site, and permits the user to either control penetration depth of the needle or default to a device-determined depth. The present device permits the user to utilize a wrist-rotation (pivoting) suture delivery technique that is familiar to a user based on experience with other surgical techniques. | 09-18-2014 |
20140303720 | TISSUE PLICATION DEVICES AND METHODS FOR THEIR USE - A tissue plication device and method of using the same is described. The tissue plication device includes a helical fastener having a distal portion with a first pitch and a proximal portion with a second pitch that is smaller than the first pitch. The method includes introducing the distal tip of the helical fastener into the tissue and advancing the helical fastener to plicate the tissue. Another tissue plication device includes a helical fastener having a first configuration with a first pitch and a second configuration with a second pitch. The helical fastener in the first configuration is advanced into a tissue and then converted to the second configuration by applying a stimulus. | 10-09-2014 |
20150051697 | SYSTEMS AND METHODS FOR INTRODUCING ELEMENTS INTO TISSUE - Systems, devices and methods for securing tissue including the annulus of a mitral valve. The systems, devices and methods may employ catheter based techniques and devices to plicate tissue and perform an annuloplasty. | 02-19-2015 |
20150335326 | SYSTEMS AND METHODS FOR SUTURING TISSUE - A device for suturing tissue includes a handle including a housing and a suturing needle for advancing a suture through the tissue. The device also includes a first needle gripper that is configured to both grasp and release the suturing needle. A second needle gripper is also configured to both grasp and release the suturing needle. An actuator is coupled to the housing and is operatively coupled to: (a) a first linkage that pivots the second gripping gripper between a fully extended position and a retracted position relative to the housing; and (b) a second linkage that is operatively coupled to the first and second needle grippers and configured to alter a state of each of the first and second needle grippers. The second linkage can include a one-way clutch. | 11-26-2015 |
Patent application number | Description | Published |
20130288022 | Chromic Luminescent Compositions and Textiles - A chromic luminescent composition and method for fabricating the composition are disclosed. The chromic luminescent composition comprises at least one or more non-luminescent materials and one or more luminescent materials. The one or more non-luminescent materials having absorption spectra that at least partially overlap with the spectrum of incident electromagnetic radiation. The one or more luminescent materials convert at least a portion of energy of incident electromagnetic radiation to a lower energy wavelength. The one or more non-luminescent materials and the one or more luminescent materials are selected such that, when subsequently exposed to incident electromagnetic radiation, color and brightness are substantially modulated through absorption and emission as a function of incident electromagnetic radiation. Also disclosed are a chromic luminescent textile and a method for fabricating the textile. | 10-31-2013 |
20130288075 | CHROMIC LUMINESCENT OBJECTS - A chromic luminescent object comprising one or more chromic luminescent compositions incorporated into or onto one or more portions of the object, in which the one or more chromic luminescent compositions are selected such that, when subsequently exposed to incident electromagnetic radiation, at least brightness of the one or more portions of the object is substantially modulated through absorption and emission as a function of incident electromagnetic radiation is disclosed. Also disclosed are methods for fabricating the chromic luminescent object. | 10-31-2013 |
20140103258 | CHROMIC LUMINESCENT COMPOSITIONS AND TEXTILES - A chromic luminescent composition and method for fabricating the composition are disclosed. The chromic luminescent composition comprises at least one or more non-luminescent materials and one or more luminescent materials. The one or more non-luminescent materials having absorption spectra that at least partially overlap with the spectrum of incident electromagnetic radiation. The one or more luminescent materials convert at least a portion of energy of incident electromagnetic radiation to a lower energy wavelength. The one or more non-luminescent materials and the one or more luminescent materials are selected such that, when subsequently exposed to incident electromagnetic radiation, color and brightness are substantially modulated through absorption and emission as a function of incident electromagnetic radiation. Also disclosed are a chromic luminescent textile and a method for fabricating the textile. | 04-17-2014 |
Patent application number | Description | Published |
20110285765 | MOBILE PRINTER NETWORKING AND INTERFACING - Provided herein are devices, methods and other means, including those related to printers, as well as computer readable media for storing code to execute instructions for a device, and other systems for providing and supporting mobile printing and other types of devices. The printer, for example, can be coupled with one or more docks and/or other accessory devices, examples of which are also discussed herein. | 11-24-2011 |
20140327927 | MOBILE PRINTER NETWORKING AND INTERFACING - Provided herein are devices, methods and other means, including those related to printers, as well as computer readable media for storing code to execute instructions for a device, and other systems for providing and supporting mobile printing and other types of devices. The printer, for example, can be coupled with one or more docks and/or other accessory devices, examples of which are also discussed herein. | 11-06-2014 |
Patent application number | Description | Published |
20150356138 | DATASTORE MECHANISM FOR MANAGING OUT-OF-MEMORY DATA - According to some embodiments, a method for making input data available for processing by one or more processors comprises storing one or more parameters, wherein the one or more parameters comprise information identifying a location of the input data; and creating a datastore object using the one or more parameters, wherein the datastore object interfaces the input data and includes a read method for reading a chunk, the chunk being a subset of the input data, and having a size that does not exceed a memory size assigned to the one or more processors. According to some embodiments, the one or more parameters further comprise one or more of a type of the input data; a format of the input data; an offset for reading from the input data; a size of the chunk; a condition for determining the chunk; and a query for deriving the input data. | 12-10-2015 |
20150356157 | UNIFIED MAPREDUCE FRAMEWORK FOR LARGE-SCALE DATA PROCESSING - According to some embodiments, a method for processing input data comprises creating a MapReducer object corresponding to a MapReduce environment; and receiving, by a MapReduce interface, a plurality of input parameters comprising the input data; a mapper function; a reducer function; and the MapReducer object; and using the MapReduce interface to process the input data by one or more processors in the MapReduce environment using the mapper function and the reducer function. According to some embodiments, the method further comprises creating a second MapReducer object, wherein the second MapReducer object corresponds to a second MapReduce environment; receiving, by the MapReduce interface, the second MapReducer object in place of the first MapReducer object; and utilizing the MapReduce interface to process the input data by the one or more processors in the second MapReduce environment using the mapper function and the reducer function. | 12-10-2015 |