Lan, US
Andrew S. Lan, Houston, TX US
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20140272914 | Sparse Factor Analysis for Learning Analytics and Content Analytics - A mechanism for facilitating personalized learning. A computer receives graded response data including grades that have been assigned to answers provided by learners in response to a set of questions. Output data is computed based on the graded response data using a latent factor model. The output data includes at least: an association matrix that defines a set of K concepts implicit in the set of questions, wherein K is smaller than the number of questions, wherein, for each of the K concepts, the association matrix defines the concept by specifying strengths of association between the concept and the questions; and a learner knowledge matrix including, for each learner and each of the K concepts, an extent of the learner's knowledge of the concept. The computer may display a visual representation of the association strengths in the association matrix and/or the extents in the learner knowledge matrix. | 09-18-2014 |
20140279727 | Sparse Factor Analysis for Analysis of User Content Preferences - A mechanism for discerning user preferences for categories of provided content. A computer receives response data including a set of preference values that have been assigned to content items by content users. Output data is computed based on the response data using a latent factor model. The output data includes at least: an association matrix that defines K concepts associated with the content items, wherein K is smaller than the number of the content items, wherein, for each of the K concepts, the association matrix defines the concept by specifying strengths of association between the concept and the content items; and a concept-preference matrix including, for each content user and each of the K concepts, an extent to which the content user prefers the concept. The computer may display a visual representation of the association strengths in the association matrix and/or the extents in the concept-preference matrix. | 09-18-2014 |
Anjian Lan, Piscataway, NJ US
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20120178173 | COMPOSITIONS AND METHODS FOR DETECTION OF EXPLOSIVES - This invention provides polymeric coordination compounds capable of forming three-dimensional microporous metal organic frameworks (MMOFs) that are useful for detection of explosive compounds. The polymeric coordination compounds comprise a repeating unit comprising a transition metal coordinated to at least one binding member of a bidentate binding site on each of two polyfunctional ligands and one binding site of a bis-pyridine exodentate bridging ligand, for example, the repeating unit comprising formula [Zn | 07-12-2012 |
Chun Lan, Maple Grove, MN US
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20150059662 | PORTABLE GENERATOR - A portable engine-generator is described having an engine and a generator coupled to the engine. An engine mount has a mounting plate coupled to the engine and also includes a frame. An outer housing surrounds the engine, generator and frame. At least one handle is coupled to the outer housing. The housing is defined in three sections; a lower section, a middle section and an upper section. The three housing sections are coupled to the frame. | 03-05-2015 |
Chun Lan, Spring, TX US
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20120101732 | Integrated Source-Free Method and Apparatus for Porosity Determination: NMR Calibrated Acoustic Porosity - NMR porosity measurements made in a gas free-formation are used to calibrate acoustic measurements. The calibration parameters are then used in conjunction with estimates of shale content to provide improved estimates of formation porosity in shaly intervals which may include a gas. | 04-26-2012 |
Chun Lan, Katy, TX US
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20160076348 | METHODS OF INCREASING A THERMAL CONDUCTIVITY AND TRANSFERRING HEAT WITHIN A SUBTERRANEAN FORMATION, AND METHODS OF EXTRACTING HYDROCARBONS FROM THE SUBTERRANEAN FORMATION - A method of increasing a thermal conductivity of a subterranean formation and a hydrocarbon-containing material comprises introducing nanoparticles having a high thermal conductivity into the subterranean formation. The nanoparticles adhere to surfaces of the hydrocarbon-containing material and increase the thermal conductivity of the hydrocarbon-containing material. A heating fluid is injected into the subterranean formation and contacts the nanoparticles. Heat is transferred to hydrocarbons of the hydrocarbon-containing material and reduces a viscosity of the hydrocarbons. Methods of transferring heat to a hydrocarbon-containing material, as well as methods of recovering hydrocarbons from a subterranean formation are also disclosed. | 03-17-2016 |
David Lan, Wilmington, DE US
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20090197108 | NON-VINYL FLOORING AND METHOD FOR MAKING SAME - In one embodiment or the present invention, a non-vinyl flooring is described comprising a flooring substrate having a non-vinyl composition comprising a terpolymer comprising ethylene, methyl acrylate and acrylic acid and a copolymer comprising ethylene and methacrylic acid. In one embodiment of the present invention, the non-vinyl flooring comprises a resilient non-vinyl floor tile comprising a non-vinyl composition comprising a terpolymer and a copolymer. In another embodiment of the present invention, the non-vinyl flooring comprises a resilient non-vinyl sheet flooring comprising a non-vinyl composition comprising a terpolymer and a copolymer. Methods for making the non-vinyl tile and non-vinyl sheet flooring are described. | 08-06-2009 |
David Zhiqiang Lan, Memphis, TN US
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20100057098 | Apparatus Used to Perform Image Guided Medical Procedures - An apparatus used to assist image guided medical procedures utilizing a navigation system having a computer processing unit having navigation system function that controls a tip of a medical instrument is disclosed. The apparatus has a control handle; an adaptor coupled to the control handle wherein the adaptor has at least one sensor which detects the physical manipulation of the control handle, wherein the adaptor translates the physical manipulation of the control handle into digital signals; a communication channel between the adaptor and the computer processing unit, wherein the communication channel enables the computer processing unit to receive the digital signals from the adaptor; and computer software which enables the computer processing unit to translate the digital signals from the adaptor into navigation system function used to control the tip of the medical instrument. | 03-04-2010 |
Dongping Lan, Oak Ridge, NJ US
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20090303897 | METHOD AND APPARATUS FOR VOICE-OVER-IP CALL RECORDING AND ANALYSIS - A method and computer-readable medium for obtaining information associated with a VoIP communication session includes tapping the computer network passively to obtain signaling and media information in a first format, separating the signaling and media information, determining transport information from at least one of the signaling and media information, transcoding the media information to a second format, and storing the transcoded media information in the second format. The media information includes data, voice, audio, and/or video information. A system obtain information associated with a VoIP communication session on a computer network includes a tapping device to passively tap the computer network to obtain signaling and media information in a first format, a processing device to transcode the media information from the first format to a second format, separate the signaling information from the media information, and determine transport information from at least one of the signaling and media information, and a storage device to store the transcoded media information in the second format. | 12-10-2009 |
Erica Sui-Ching Lan, Bellevue, WA US
Patent application number | Description | Published |
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20080216006 | SYSTEM AND METHOD TO FACILITATE MANAGEABLE AND AGILE DEPLOYMENT OF SERVICES IN ACCORDANCE WITH VARIOUS TOPOLOGIES - The present invention relates to a system and methodology to facilitate service deployment in a distributed computing and applications environment. A schema is provided that describes various components of a service and various topologies for execution of the services, wherein a deployment engine utilizes the schema in conjunction with user inputs to determine one or more destination locations for the service. The topologies relate to various machine and/or machine types defined for various groups or individuals that employ the service. A user interface can be provided to receive user inputs for topological selections and to facilitate various parametric configurations associated with service deployment and subsequent execution thereof. | 09-04-2008 |
20090292888 | Backing up Data from Backup Target to Backup Facility - Aspects of the subject matter described herein relate to backup up data. In aspects, a backup target determines a degree to which a data set included on the backup target is not backed up on a backup facility. The degree can represent more than just that the data set is completely backed up or is not backed up at all. If the degree satisfies a condition, the backup target utilizes information derived from a backup history of one or more attempted or successfully completed backup sessions between the backup target and the backup facility to determine whether to provide a notification regarding backup state. The backup target also may send the degree and other backup information to a backup facility which may use this information in determining a backup scheme to employ with the backup target. | 11-26-2009 |
Hong Lan, Bridgewater, NJ US
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20080255064 | Methods for modulating cholecystokinin expression - The invention provides a method for upregulating cholecystokinin (CCK) expression in mammalian pancreatic islets by administrating a CCK upregulating agent. The increased CCK expression activates islet cell proliferation triggering an increase in pancreatic β-cell mass and plasma insulin levels. Accordingly, methods to produce a replenishable supply of islet cells and to ameliorate the symptoms associated with diabetes are also disclosed. | 10-16-2008 |
Hongxiang Lan, Portland, OR US
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20120045764 | METHOD OF EXPANDING HUMAN HEPATOCYTES IN VIVO - Described herein is a method of expanding human hepatocytes in vivo using an immunodeficient mouse which is further deficient in fumarylacetoacetate hydrolase (Fah). The method comprises transplanting human hepatocytes into the immunodeficient and Fah-deficient mice, administering an IL-1R antagonist to the mouse and allowing the hepatocytes to expand. Alternatively, the method includes transplanting human hepatocytes into the immunodeficient and Fah-deficient mice, wherein the mouse is further deficient for IL-1R and allowing the hepatocytes to expand. The method also allows serial transplantation of the human hepatocytes into secondary, tertiary, quaternary or additional mice. | 02-23-2012 |
James (hsu-Hsuan) Lan, Dallas, TX US
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20120063202 | 3T DRAM CELL WITH ADDED CAPACITANCE ON STORAGE NODE - A 3T DRAM cell includes a first transistor having a first control element connected as a storage node and a second transistor connected between the first transistor and a read bit line having a second control element connected to a read word line. The 3T DRAM cell also includes a third transistor connected between the storage node and a write bit line having a third control element connected to a write word line. Additionally, the DRAM cell includes a supplemental capacitance connected to the storage node and configured to extend a refresh interval of the 3T DRAM cell. A method of operating an integrated circuit having a 3T DRAM cell includes providing a memory state on a storage node of the 3T DRAM cell and extending a refresh interval of the memory state with a supplemental capacitance added to the storage node. | 03-15-2012 |
Jay M. Lan, Farmington, UT US
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20090078592 | SYSTEMS AND METHODS FOR DELIVERY OF PERITONEAL DIALYSIS (PD) SOLUTIONS - The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments. | 03-26-2009 |
Justin Lan, Bothell, WA US
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20120091270 | AIRCRAFT CONFIGURATION - An aircraft configuration that may reduce the level of roaring jet exhaust noise, infrared radiation, sonic boom, or combination thereof directed towards the ground from an aircraft in flight. The aircraft's nacelles are mounted to the aircraft higher than the wings, with substantially vertical stabilizers outboard of the outermost engine. Noise shifting means are provided such as, for each nacelle, primary chevrons at the core nozzle, secondary chevrons at the fan nozzle, a partial bypass mixer, a long duct full flow mixer, or a combination thereof to provide a shift in spectrum distribution of jet exhaust noise from lower to higher frequency. Variable geometry chevrons may be used with increased immersion to provide such a shift just during noise-restricted portions of an aircraft flight profile. The aircraft aerodynamic structural surfaces serve as noise shielding barriers that more effectively block or redirect the frequency shifted noise up and away from communities. | 04-19-2012 |
20120119023 | METHOD AND APPARATUS FOR REDUCING AIRCRAFT NOISE - An arrangement for an aircraft includes a fuselage, a wing, and a propulsor. The wing may have a wing upper surface, a rear spar and a wing trailing edge. The propulsor may include at least one rotor having a rotor diameter and a rotor axis. The propulsor may be mounted such that the rotor is located longitudinally between the rear spar and the wing trailing edge. The propulsor may also be mounted such that a lowest point of the rotor diameter is located vertically above the wing upper surface. | 05-17-2012 |
Justin H. Lan, Bothell, WA US
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20140077031 | METALLIC SANDWICH STRUCTURE HAVING SMALL BEND RADIUS - An acoustic-attenuating wall panel for a nacelle of a turbine engine may include a radiused portion. The radiused portion may include an airflow surface having a concave configuration and which may be exposed to an airflow passing through the nacelle. The radiused portion may include an acoustic attenuating section. | 03-20-2014 |
Justin Honshune Lan, Bothell, WA US
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20150027629 | Septumization of Honeycomb Sandwiches - An acoustic liner having a honeycomb core is fabricated by forming septa in a sheet of material, and assembling the sheet of material and the core. During the assembly process, the septa are respectively inserted as a group into cells of the core. | 01-29-2015 |
20150030803 | Composite Laminates Having Hole Patterns Produced by Controlled Fiber Placement - A composite laminate has a pattern of holes therein. The holes are formed by laying down plies of unidirectional pre-preg material having varying fiber orientations. The tows are spaced apart and located to form holes through the laminate. | 01-29-2015 |
20160024963 | NOISE ATTENUATING LIPSKIN ASSEMBLY AND METHODS OF ASSEMBLING THE SAME - An acoustic assembly includes a backsheet including a plurality of perforations defined therethrough and an acoustic core coupled to the backsheet. The acoustic core includes a plurality of channels defined therethrough that are configured to be in flow communication with the plurality of perforations. The acoustic assembly also includes a linear facesheet coupled to the acoustic core, wherein the linear facesheet includes a plurality of apertures configured to be in flow communication with the plurality of channels. A lipskin is coupled to the linear facesheet, wherein the lipskin includes a plurality of openings configured to be in flow communication with the plurality of apertures. | 01-28-2016 |
Ke Lan, Upper Darby, PA US
Patent application number | Description | Published |
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20090060881 | Gamma secretase inhibitor for treatment of herpesvirus infection - This invention relates to methods and compositions for the treatment of malignancies associated with gamma-herpesvirus infection. Specifically, the invention relates to the use of gamma-secretase inhibitors to prevent the production of intracellular Notch1 thereby arresting the growth of the infected cells. | 03-05-2009 |
20120183508 | GAMMA SECRETASE INHIBITOR FOR TREATMENT OF HERPESVIRUS INFECTION - This invention relates to methods and compositions for the treatment of malignancies associated with gamma-herpesvirus infection. Specifically, the invention s relates to the use of gamma-secretase inhibitors to prevent the production of intracellular Notch1 thereby arresting the growth of the infected cells. | 07-19-2012 |
Li Lan, Hinsdale, IL US
Patent application number | Description | Published |
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20120189176 | METHOD, SYSTEM, SOFTWARE AND MEDIUM FOR ADVANCED INTELLIGENT IMAGE ANALYSIS AND DISPLAY OF MEDICAL IMAGES AND INFORMATION - Computerized interpretation of medical images for quantitative analysis of multi-modality breast images including analysis of FFDM, 2D/3D ultrasound, MRI, or other breast imaging methods. Real-time characterization of tumors and background tissue, and calculation of image-based biomarkers is provided for breast cancer detection, diagnosis, prognosis, risk assessment, and therapy response. Analysis includes lesion segmentation, and extraction of relevant characteristics (textural/morphological/kinetic features) from lesion-based or voxel-based analyses. Combinations of characteristics in several classification tasks using artificial intelligence is provided. Output in terms of 1D, 2D or 3D distributions in which an unknown case is identified relative to calculations on known or unlabeled cases, which can go through a dimension-reduction technique. Output to 3D shows relationships of the unknown case to a cloud of known or unlabeled cases, in which the cloud demonstrates the structure of the population of patients with and without the disease. | 07-26-2012 |
20140375671 | METHOD, SYSTEM, SOFTWARE AND MEDIUM FOR ADVANCED IMAGE-BASED ARRAYS FOR ANALYSIS AND DISPLAY OF BIOMEDICAL INFORMATION - An image array includes pixels, each representing an image-based feature value of a patient obtained from imaging. The array includes first and second dimensions. Pixels corresponding to a specific patient of a plurality of patients extend in the first dimension and pixels corresponding to a specific feature of a plurality of features extend in the second dimension. Patients represented in the image array are grouped into two or more groups. Each indicates a known condition, such that patients having a first and second conditions are respectively part of a first and a second group and are in a first and a second portion of the array, respectively. The groups are separately organized according to a selected feature. Patients of the first and second groups are respectively arranged in an order of values for the selected feature within the first and second portions. | 12-25-2014 |
20160078624 | METHOD, SYSTEM, SOFTWARE AND MEDIUM FOR ADVANCED INTELLIGENT IMAGE ANALYSIS AND DISPLAY OF MEDICAL IMAGES AND INFORMATION - Computerized interpretation of medical images for quantitative analysis of multi-modality breast images including analysis of FFDM, 2D/3D ultrasound, MRI, or other breast imaging methods. Real-time characterization of tumors and background tissue, and calculation of image-based biomarkers is provided for breast cancer detection, diagnosis, prognosis, risk assessment, and therapy response. Analysis includes lesion segmentation, and extraction of relevant characteristics (textural/morphological/kinetic features) from lesion-based or voxel-based analyses. Combinations of characteristics in several classification tasks using artificial intelligence is provided. Output in terms of 1D, 2D or 3D distributions in which an unknown case is identified relative to calculations on known or unlabeled cases, which can go through a dimension-reduction technique. Output to 3D shows relationships of the unknown case to a cloud of known or unlabeled cases, in which the cloud demonstrates the structure of the population of patients with and without the disease. | 03-17-2016 |
Lin Lan, Loganville, GA US
Patent application number | Description | Published |
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20100031697 | MODULAR CO2 REFRIGERATION SYSTEM - A cascade CO2 refrigeration system includes a medium temperature loop for circulating a medium refrigerant and a low temperature loop for circulating a CO2 refrigerant. The medium temperature loop includes a heat exchanger having a first side and a second side. The first side evaporates the medium temperature refrigerant. The low temperature loop includes a discharge header for circulating the CO2 refrigerant through the second side of the heat exchanger to condense the CO2 refrigerant, a liquid-vapor separator collects liquid CO2 refrigerant and directs vapor CO2 refrigerant to the second side of the heat exchanger. A liquid CO2 supply header receives liquid CO2 refrigerant from the liquid-vapor separator. Medium temperature loads receive liquid CO2 refrigerant from the liquid supply header for use as a liquid coolant at a medium temperature. An expansion device expands liquid CO2 refrigerant from the liquid supply header into a low temperature liquid-vapor mixture for use by the low temperature loads. | 02-11-2010 |
20140102132 | MODULAR CO2 REFRIGERATION SYSTEM - A cascade CO2 refrigeration system includes a medium temperature loop for circulating a medium refrigerant and a low temperature loop for circulating a CO2 refrigerant. The medium temperature loop includes a heat exchanger having a first side and a second side. The first side evaporates the medium temperature refrigerant. The low temperature loop includes a discharge header for circulating the CO2 refrigerant through the second side of the heat exchanger to condense the CO2 refrigerant, a liquid-vapor separator collects liquid CO2 refrigerant and directs vapor CO2 refrigerant to the second side of the heat exchanger. A liquid CO2 supply header receives liquid CO2 refrigerant from the liquid-vapor separator. Medium temperature loads receive liquid CO2 refrigerant from the liquid supply header for use as a liquid coolant at a medium temperature. An expansion device expands liquid CO2 refrigerant from the liquid supply header into a low temperature liquid-vapor mixture for use by the low temperature loads. | 04-17-2014 |
Matan Lan, Orlando, FL US
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20130204638 | Systems and Methods for Managing Eligible Expenses From Specialized Financial Accounts - Disclosed herein are systems and related methods for administering a financial account on behalf of a system member, where payments from the financial account are restricted to only eligible expenses. Such administration of a restricted-use financial account assists members in properly expending funds from their financial account, and thus maintaining compliance with any guidelines or laws regulating the expenditure of funds from their account. In a more specific aspect, the disclosed principles provide a solution for Medicare Set Aside (MSA) account payments by which individuals may self-administer one or more MSA accounts on their own behalf, yet ensure compliance with the guidelines and laws governing such MSA accounts, such as CMS. | 08-08-2013 |
Michael S. Lan, Metairie, LA US
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20120316225 | Modified INSM1-Promoter for Neuroendocrine Tumor Therapy and Diagnostics - A modification of the existing INSM1 promoter region has been discovered that incorporated DNA elements that silence expression of neuronal genes in non-neuronal cells and that has increased the effectiveness and safety of using the INSM1 promoter for tumor treatment. One modification was addition of one or two tandem copies of neuronal restrictive silencer elements (NRSEs) derived either from the mouse nicotinic acetylcholine receptor (nAChR) or the rat superior cervical ganglion 10 (SCG10) promoters. These NRSEs were placed in the expression construct either directly upstream or downstream of the INSM1 promoter sequence. The most effective expression construct was the nAChR NRSE element positioned downstream of the INSM1 promoter. This expression construct increased the tissue specificity of the INSM1 promoter without a significant decrease in its activity. In addition, the modified INSM1 promoter was placed into a viral vector, adenovirus 5. Constructs with an insulator element, the chicken HS4 β-globin insulator element, with the INSM1 promoter was shown to decrease the interference of the viral genome on its expression. Constructs have been made that do not decrease the INSM1 promoter activity but significantly augment the tumor specificity of the promoter. Linking the construct to a reporter gene allowed for detection of the placement of the viral vector, and this detection can be used for diagnosing or locating neuroendocrine tumors. | 12-13-2012 |
Ping Lan US
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20150274672 | SUBSTITUTED SPIROPIPERIDINYL COMPOUNDS USEFUL AS GPR120 AGONISTS - The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included. | 10-01-2015 |
Ping Lan, Dayton, NJ US
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20100081643 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS - Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension. | 04-01-2010 |
20110195964 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS - Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension. | 08-11-2011 |
20110218174 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS - Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension. | 09-08-2011 |
20110263533 | NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS - Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension. | 10-27-2011 |
20130331419 | MINERALOCORTICOID RECEPTOR ANTAGONISTS - Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too. | 12-12-2013 |
20150284376 | MINERALOCORTICOID RECEPTOR ANTAGONISTS - The present invention is directed to compounds of the Formula I | 10-08-2015 |
Ping Lan, Plainsboro, NJ US
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20140336224 | MINERALOCORTICOID RECEPTOR ANTAGONISTS - Compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that may be useful for treating aldosterone-mediated diseases are disclosed. Processes for preparing compounds of the Formula (I), use of the compounds for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and pharmaceutical compositions which comprise compounds of the Formula (I) are disclosed. | 11-13-2014 |
20150274672 | SUBSTITUTED SPIROPIPERIDINYL COMPOUNDS USEFUL AS GPR120 AGONISTS - The present invention relates to a compound represented by formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing diabetes, hyperlipidemia, obesity, inflammation related disorders, and related diseases and conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR120. Pharmaceutical compositions and methods of treatment are also included. | 10-01-2015 |
Que Lan, Madison, WI US
Patent application number | Description | Published |
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20080300300 | Use of alpha-mangostin as a mosquito larvicide - Methods of killing mosquito larvae and controlling an adult mosquito population by using α-mangostin, 3,6,8-yrihydroxy-2-methoxy-1,7-bis(3-methylbut-2-enyl)xanthen-9-one, or a salt, solute, hydrate or solvate thereof. Mosquito larvae are killed by contacting a lethal dose of α-mangostin with mosquito larvae. Adult mosquito populations are controlled by treating a mosquito larvae population with a lethal dose of α-mangostin. | 12-04-2008 |
20120088719 | Mosquitocidal Xenorhabdus, Lipopeptide And Methods - Provided is a bacterial strain which produces a family of mosquitocidal toxins, | 04-12-2012 |
20140274880 | MOSQUITOCIDAL XENORHABDUS, LIPOPEPTIDE AND METHODS - Provided is a bacterial strain which produces a family of mosquitocidal toxins, | 09-18-2014 |
Rongpei Lan, San Antonio, TX US
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20110195489 | System and Method of an In-vitro Wound Healing Model on Cultured Cell Monolayer Employing Stamp Device - A system and method of an in vitro wounding model that employs a wounding device compromising a stamp assembly with a stamp disk engraved with alternating grooves and ridges, to dislodge cells of cultured cell monolayer. Strips or islands of cells are left behind, which can be used for morphological observation in biological research. Further and more importantly, these strips or islands of cells can be designed to be sufficiently narrow or small (˜100 μm) to ensure that all remaining cells become rapidly activated and then migrate, dedifferentiate and proliferate in near synchrony, so that samples can be collected in large amount which is suitable for biochemical studies. | 08-11-2011 |
Shuhuai Lan, Ann Arbor, MI US
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20150375335 | HYBRID FRICTION STIR WELDING FOR DISSIMILAR MATERIALS THROUGH ELECTROPLASTIC EFFECT - A hybrid Friction Stir Welding approach and device for dissimilar materials joining employing Electro-Plastic Effect. The approach and device include an introduction of high density, short period current pulses into traditional friction stir welding process, which therefore can generate a localized softened zone in the workpiece during plastic stirring without significant additional temperature increase. This material softened zone is created by high density current pulses based on Electro-Plastic Effect and will move along with the friction stir welding tool. Smaller downward force, larger processing window and better joint quality for dissimilar materials are expected to be achieved through this hybrid welding technique. | 12-31-2015 |
Tian Lan, Pittsburgh, PA US
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20140143183 | HIERARCHICAL MODEL FOR HUMAN ACTIVITY RECOGNITION - The disclosure provides an approach for recognizing and analyzing activities. In one embodiment, a learning application trains parameters of a hierarchical model which represents human (or object) activity at multiple levels of detail. Higher levels of detail may consider more context, and vice versa. Further, learning may be optimized for a user-preferred type of inference by adjusting a learning criterion. An inference application may use the trained model to answer queries about variable(s) at any level of detail. In one embodiment, the inference application may determine scores for each possible value of the query variable by finding the best hierarchical event representation that maximizes a scoring function while fixing the value of the query variable to its possible values. Here, the inference application may approximately determine the best hierarchical event representation by iteratively optimizing one level-of-detail variable at a time while fixing other level-of-detail variables, until convergence. | 05-22-2014 |
Tian Lan, Princeton, NJ US
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20110183678 | SYSTEM AND METHOD FOR RESOURCE ALLOCATION OF A LTE NETWORK INTEGRATED WITH FEMTOCELLS - A resource scheduling and power allocation technique is provided for a LTE radio network integrated with femtocells. The technique utilizes a tri-phase approach that includes a stochastic geometric model of an exemplary radio network that generates a channel attenuation matrix for each channel at each PRB. A resource scheduling and power allocation procedure determines a near optimal assignment of mobile user to PRBs based on the channel attenuations, potential data rates, and transmit power subject to maximizing the data rates in accordance with a fairness objective. A discrete-event simulation procedure simulates the end-to-end transmission of the data packets in a packet-switch network in accordance with the assignments to analyze the behavior of the overall network. | 07-28-2011 |
Tse Hua Lan, Atlanta, GA US
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20100158126 | Integrated Transcoding - Methods and systems for integrated transcoding on a plurality of data channels to convert one or more data channels from an incoming encoding format to an outgoing encoding format are disclosed. | 06-24-2010 |
Wei-Ming Lan, Morrisville, NC US
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20090325594 | Using Base-Station Location to Assist Mobile-Device system Acquisition - Methods and systems are provided for using base-station location to assist mobile-device system acquisition. A mobile station, which stores a network identifier, selects a carrier frequency. The mobile station receives, from a base station on a first carrier frequency, geographic coordinates of the base station and a base-station network identifier, and determines whether the base-station network identifier matches the mobile-station network identifier. If the base-station network identifier matches the mobile-station network identifier, the mobile station will scan the indicated home frequency bands and will connect to one of the home frequencies, and if the base-station network identifier does not match the mobile-station network identifier, the geographic coordinates of the base station are used to identify a market area and a most-preferred carrier frequency is selected from the identified market area. | 12-31-2009 |
20100329181 | APPARATUS AND METHOD FOR DUAL-MODE WIMAX/CDMA OPERATION - A system, computer-readable medium, and method of operating a dual-mode WiMAX and CDMA communications device capable of operating in a CDMA mode or a WiMAX mode includes receiving a first base station (BS) location message from the BS and storing the received location as a current BS location. The BS location is compared to stored region coordinates for the different regions, and the comparison is used to determine a particular region in which the dual-mode device is currently located. Analysis determines whether a WiMAX market is located within the particular region. If no WiMAX markets are located, the dual-mode device is operated in the CDMA mode. If one or more WiMAX markets are located within the particular region, a determination is made as to whether the BS location is within a WiMAX market and, if so, the dual-mode device is placed in a WiMAX mode of operation. Battery power is conserved by avoiding WiMAX transmission when WiMAX service is not available at the current BS location. | 12-30-2010 |
20120071178 | Mobile Network Presence Service with Load-Based Notification Throttling - Methods and systems are described for providing a presence service that is useful for mobile telecommunications devices. A plurality of outgoing presence updates are sent to a presence client. The system monitors the level of network traffic and determines whether the client is in a region of high network load, and if so, the system throttles the outgoing presence updates during the condition of high network load. The level of throttling may depend at least in part on the amount of time that has elapsed since the presence client began a presence session, and/or the amount of time that has elapsed since an incoming presence update was received from the presence client. In determining the latter amount of elapsed time, the system may consider only the amount of time elapsed since an incoming non-automatic presence update was received from the presence client. | 03-22-2012 |
Wenkui Lan, Livingston, NJ US
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20090265184 | Method for the fractionation and separation of particles by step-wise gradient density extraction - A method for the separation of particles of different densities using a step-wise gradient density extraction method as described herein where a sample is suspended in a liquid volume of an extracting medium of specific density and the particles that have a density less than or equal to that of the extracting medium of specific density can be recovered from a horizonatally rotatable hollow disk or a removable receptacle within a horizontally rotatable hollow disk designed for such purposes while the particles that have a density greater than the extracting medium of specific density form a deposit which can be cycled through the extraction process in an iterative fashion by varying the density of the extracting medium allowing the recovery of discrete particles of differing densities from a test sample. Also disclosed herein is the use of the above method as part of a separate method or system to identify a ratio of biomarkers from different fractions of a sample homogenate or lysate which is useful in the evaluation of potential biomarkers, and for the intraoperative pathological diagnosis of positive margins of cancer and other diseases. | 10-22-2009 |
Xiangyang Lan, Ithaca, NY US
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20080240551 | LOCAL BI-GRAM MODEL FOR OBJECT RECOGNITION - A local bi-gram model object recognition system and method for constructing a local bi-gram model and using the model to recognize objects in a query image. In a learning phase, the local bi-gram model is constructed that represents objects found in a set of training images. The local bi-gram model is a local spatial model that only models the relationship of neighboring features without any knowledge of their global context. Object recognition is performed by finding a set of matching primitives in the query image. A tree structure of matching primitives is generated and a search is performed to find a tree structure of matching primitives that obeys the local bi-gram model. The local bi-gram model can be found using unsupervised learning. The system and method also can be used to recognize objects unsupervised that are undergoing non-rigid transformations for both object instance recognition and category recognition. | 10-02-2008 |
Xinwei Lan, Rolla, MO US
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20140340671 | OPTICAL CARRIER BASED MICROWAVE INTERFEROMETRIC SYSTEM AND METHOD - An optical carrier based microwave interferometry (OCMI) system for measuring a physical, chemical, or biological property broadly comprises an optical carrier signal source, a waveguide, a microwave envelope signal source, a microwave modulator, an optical interferometer, a detector, and an analyzer. An optical carrier signal is modulated with a microwave envelope signal and transmitted through an optical interferometer. The optical signal is interrogated in microwave domain to obtain interference patterns or absorption/emission spectra corresponding to the physical, chemical, or biological property being measured. | 11-20-2014 |
20150036147 | DISTRIBUTED MICROWAVE FABRY-PEROT INTERFEROMETER DEVICE AND METHOD - A device and method include a broadband light source in communication with a waveguide to provide a light signal for interrogating each of a plurality for sensors within the waveguide. An analyzer modulates the light signal with a microwave signal and demodulates and evaluates light signals reflected by the sensors. An amplitude and a phase of each reflected signal from each sensor is distinguished in the time domain and the modulated signal is reconstructed in the frequency domain. | 02-05-2015 |
Xuekui Lan, Champaign, IL US
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20130240069 | Hydraulic Fluid Tank - A tank for a hydraulic fluid has a housing with opposed end walls and side walls defining an interior chamber. A primary baffle is disposed inside the housing and divides the interior chamber into an inlet chamber and an outlet chamber, with a primary gap between the primary baffle and the housing fluidly communicating between the inlet chamber and the outlet chamber. The primary baffle further defines a contact surface facing the inlet chamber and has first and second weirs which extend into the inlet chamber. A first fluid inlet fluidly communicates with the inlet chamber and is oriented along a first inlet axis that intersects the contact surface, while a fluid outlet communicates with the outlet chamber. The tank produces an interior flow that mixes and deaerates the fluid as it travels from the first fluid inlet to the fluid outlet. | 09-19-2013 |
Yongqing Lan, Potsdam, NY US
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20120058641 | AQUEOUS POLISHING AGENT COMPRISING SOLID POLYMER PARTICLES AND TWO COMPLEXING AGENTS AND ITS USE IN A PROCESS FOR POLISHING PATTERNED AND UNSTRUCTURED METAL SURFACES - An aqueous CMP agent, comprising (A) solid polymer particles interacting and forming strong complexes with the metal of the surfaces to be polished; (B) a dissolved organic non-polymeric compound interacting and forming strong, water-soluble complexes with the metal and causing an increase of the material removal rate MRR and the static etch rate SER with increasing concentration of the compound (B); and (C) a dissolved organic non-polymeric compound interacting and forming slightly soluble or insoluble complexes with the metal, which complexes are capable of being adsorbed by the metal surfaces, and causing a lower increase of the MRR than the compound (B) and a lower increase of the SER than the compound (B) or no increase of the SER with increasing concentration of the compound (C); a CMP process comprising selecting the components (A) to (C) and the use of the CMP agent and process for polishing wafers with ICs. | 03-08-2012 |
20120058643 | AQUEOUS METAL POLISHING AGENT COMPRISING A POLYMERIC ABRASIV CONTAINING PENDANT FUNCTIONAL GROUPS AND ITS USE IN A CMP PROCESS - (A) solid polymer particles being finely dispersed in the aqueous phase and containing pendant functional groups (a1) capable of strongly interacting and forming strong complexes with the metal of the surfaces to be polished, and pendant functional groups (a2) capable of interacting less strongly with the metal of the surfaces to be polished than the functional groups (a1); and (B) an organic non-polymeric compound dissolved in the aqueous phase and capable of interacting and forming strong, water-soluble complexes with the metal of the surfaces to be polished and causing an increase of the material removal rate MRR and the static etch rate SER of the metal surfaces to be polished with increasing concentration of the compound (B); a CMP process comprising selecting (A) and (B) and the use of the CMP agent and process for polishing wafers with ICs. | 03-08-2012 |
20120231627 | PROCESS FOR REMOVING A BULK MATERIAL LAYER FROM A SUBSTRATE AND A CHEMICAL MECHANICAL POLISHING AGENT SUITABLE FOR THIS PROCESS - An aqueous chemical mechanical polishing (CMP) agent (A) comprising solid particles (a1) containing (a11) a corrosion inhibitor for metals, and (a12) a solid material, the said solid particles (a1) being finely dispersed in the aqueous phase; and its use in a process for removing a bulk material layer from the surface of a substrate and planarizing the exposed surface by chemical mechanical polishing until all material residuals are removed from the exposed surface, wherein the CMP agent exhibits at the end of the chemical mechanical polishing, without the addition of supplementary materials, —the same or essentially the same static etch rate (SER) as at its start and a lower material removal rate (MRR) than at its start, —a lower SER than at its start and the same or essentially the same MRR as at its start or—a lower SER and a lower MRR than at its start; such that the CMP agent exhibits a soft landing behavior. | 09-13-2012 |
20120235081 | PROCESS FOR REMOVING A BULK MATERIAL LAYER FROM A SUBSTRATE AND A CHEMICAL MECHANICAL POLISHING AGENT SUITABLE FOR THIS PROCESS - A process for removing a bulk material layer from a substrate and planarizing the exposed surface by CMP by (1) providing an CMP agent exhibiting at the end of the chemical mechanical polishing, without the addition of supplementary materials, the same SER as at its start and a lower MRR than at its start,—an SER which is lower than the initial SER and an MRR which is the same or essentially the same as the initial MRR or a lower SER and a lower MRR than at its start; (2) contacting the surface of the bulk material layer with the CMP agent; (3) the CMP of the bulk material layer with the CMP agent; and (4) continuing the CMP until all material residuals are removed from the exposed surface; and a CMP agent and their use for manufacturing electrical and optical devices. | 09-20-2012 |
20140004703 | CHEMICAL MECHANICAL POLISHING (CMP) COMPOSITION COMPRISING A POLYMERIC POLYAMINE | 01-02-2014 |
Yongshen Lan, Houston, TX US
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20090285800 | Aberrant expression of CKS1 and CKS2 and uses thereof - The present invention is drawn to providing a therapeutic strategy for prostate cancer. In this regard, the present invention demonstrates that elevated expression of Cks1 contributes to tumorigenicity of prostate tumor cells by promoting cell growth and elevated expression of Cks2 protects cells from apoptosis. Accordingly, the present invention discloses methods to diagnose and treat prostate cancer by targeting expression of Cks1 and Cks2 proteins. | 11-19-2009 |
Zi-Jian Lan, Lexington, KY US
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20160045533 | COMPOSITIONS OF SELENOORGANIC COMPOUNDS AND METHODS OF USE THEREOF - The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of Formula (I), Formula (II), or Formula (III), and combinations thereof, and methods of using the same for modulating glucose metabolism in a subject. | 02-18-2016 |
20160082033 | COMPOSITIONS OF SELENOORGANIC COMPOUNDS AND METHODS OF USE THEREOF - The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, a compound of Formula (I), and combinations thereof, and methods of using the same for inhibiting β amyloid aggregation, ApoE4 expression, p38 or Tau protein phosphorylation, or increasing Neprilysin and Insulin Degrading Enzyme expression. | 03-24-2016 |