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Lam, MA

(david) Ngai Lam, Woburn, MA US

Patent application numberDescriptionPublished
20140317169METHOD, APPARATUS, AND COMPUTER PROGRAM PRODUCT FOR SERVER SIDE DATA MASHUPS SPECIFICATION - A method, apparatus, and computer program product are provided in order to provide for the specification of server-side data mashups. A method is provided comprising receiving a request for data of an object type; retrieving a data model for the object type; interpreting one or more annotations specifying data to be retrieved from one or more sources to be combined with the object data; retrieving data from one or more sources based on the annotations; generating an output payload by merging the object data and the retrieved data; and causing the output payload to be returned to a client application. A corresponding apparatus and a computer program product are also provided.10-23-2014

Derek Lam, Arlington, MA US

Patent application numberDescriptionPublished
20080244372SYSTEM FOR SUMMARIZATION OF THREADS IN ELECTRONIC MAIL - The present invention discloses a pre-processing summarization technique that makes use of knowledge specific to the electronic mail domain to pre-process an electronic mail message so that commercially-available document summarization software can subsequently generate a more useful summary from the message. The summarization technique removes extraneous headers, quoted text, forward information, and electronic signatures, leaving more useful text to be summarized. If an enclosing electronic mail thread exists, the summarization technique uses the electronic mail message's ancestors to provide additional context for summarizing the electronic mail message. The disclosed system can be used with IBM Lotus Notes and Domino infrastructure, along with existing single-document summarizer software, to generate a summary of the discourse activity in an electronic mail thread dynamically. The summary may be further augmented to list any names, dates, and names of companies that are present in the electronic mail message being summarized.10-02-2008

Dylan Lam, Waltham, MA US

Patent application numberDescriptionPublished
20110073344GASKET CONTAINING CARBON NANOTUBES - A composition for forming a gasket comprises a curable elastomer material and 0.1-20 weight % (e.g., 4-10 weight %) carbon nanotubes dispersed throughout the elastomer material. A dispensed bead of elastomer material exhibits a Slump ratio of at least 0.7. The composition provides the correct balance of rheology/dispensing characteristics, seal characteristics, and contamination profile characteristics required in form-in-place gasket applications, while simultaneously providing a conductive form-in-place gasket.03-31-2011

Felix Lam, Cambridge, MA US

Patent application numberDescriptionPublished
20150072391ETHANOL PRODUCTION IN ENGINEERED YEAST - The present disclosure provides, in various aspects, engineered alcohol tolerant yeast and methods of producing high concentrations of ethanol.03-12-2015

Heung Chuan Lam, Newton, MA US

Patent application numberDescriptionPublished
20090020427Plastic microfluidic separation and detection platforms - Plastic electrophoresis separation chips are provided comprising a plurality of microfluidic channels and a detection window, where the detection window comprises a thin plastic; and the detection window comprises a detection region of each microfluidic channel. Such chips can be bonded to a support provided an aperture is provided in the support to allow detection of samples in the electrophoresis chip at the thin plastic detection window. Further, methods for electrophoretically separating and detecting a plurality of samples on the plastic electrophoresis separation chip are described.01-22-2009
20090023603Methods for rapid multiplexed amplification of target nucleic acids - A fast, multiplexed PCR system is described that can rapidly generate amplified nucleic acid products, for example, a full STR profile, from a target nucleic acid. Such systems include, for example, microfluidic biochips and a custom built thermal cycler, which are also described. The resulting STR profiles can satisfy forensic guidelines for signal strength, inter-loci peak height balance, heterozygous peak height ratio, incomplete non-template nucleotide addition, and stutter.01-22-2009
20090059222Integrated nucleic acid analysis - The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.03-05-2009
20090229983Ruggedized apparatus for analysis of nucleic acid and proteins - The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location.09-17-2009
20110312614METHODS FOR RAPID MULTIPLEXED AMPLIFICATION OF TARGET NUCLEIC ACIDS - A fast, multiplexed PCR system is described that can rapidly generate amplified nucleic acid products, for example, a full STR profile, from a target nucleic acid. Such systems include, for example, microfluidic biochips and a custom built thermal cycler, which are also described. The resulting STR profiles can satisfy forensic guidelines for signal strength, inter-loci peak height balance, heterozygous peak height ratio, incomplete non-template nucleotide addition, and stutter.12-22-2011
20120267247Ruggedized Apparatus for Analysis of Nucleic Acid and Proteins - The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location.10-25-2012
20130032483Plastic Microfluidic Separation and Detection Platforms - Plastic electrophoresis separation chips are provided comprising a plurality of microfluidic channels and a detection window, where the detection window comprises a thin plastic; and the detection window comprises a detection region of each microfluidic channel. Such chips can be bonded to a support provided an aperture is provided in the support to allow detection of samples in the electrophoresis chip at the thin plastic detection window. Further, methods for electrophoretically separating and detecting a plurality of samples on the plastic electrophoresis separation chip are described.02-07-2013
20130155403Integrated Nucleic Acid Analysis - The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification, amplification, sequencing, and separation and detection. The present disclosure also provides optical detection systems and methods for separation and detection of biological molecules. In particular, the various aspects of the invention enable the simultaneous separation and detection of a plurality of biological molecules, typically fluorescent dye-labeled nucleic acids, within one or a plurality of microfluidic chambers or channels. The nucleic acids can be labeled with at least 6 dyes, each having a unique peak emission wavelength. The present systems and methods are particularly useful for DNA fragment sizing applications such as human identification by genetic fingerprinting and DNA sequencing applications such as clinical diagnostics.06-20-2013
20130199933Ruggedized Apparatus for Analysis of Nucleic Acid and Proteins - The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location.08-08-2013
20130213810Ruggedized Apparatus for Analysis of Nucleic Acid and Proteins - The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as, for example at a crime scene to collect and analyze forensic data, as well as in semi-controlled environments, such as, for example at a point of care location.08-22-2013

Patent applications by Heung Chuan Lam, Newton, MA US

Jane Lam, Randolph, MA US

Patent application numberDescriptionPublished
20120149117HYDROGEN SULFIDE (H2S) DETECTION USING FUNCTIONALIZED NANOPARTICLES - Methods and related apparatuses and mixtures are described for spectroscopic detection of hydrogen sulfide in a fluid, for example a formation fluid downhole. A reagent mixture is combined with the fluid. The reagent mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and a capping agent that limits growth of the insoluble metal sulfide species by electrosteric or steric stabilization. The particle growth is one of chemical reaction or significant aggregation, and the capping agent further functionalizes the reagent mixture to exhibit properties outside the natural characteristics of the metal sulfide species to allow for spectroscopic detection of the metal sulfide species. The combined mixture and fluid is then spectroscopically interrogated to detect the presence of the metal sulfide thereby indicating the presence of hydrogen sulfide in the fluid. The mixture also includes chelating ligands for sustaining thermal endurance of the mixture under downhole conditions.06-14-2012
20120149604Chemical Scavenger For Downhole Chemical Analysis - A method for analyzing formation fluid in a subterranean formation is disclosed, wherein the method includes the steps of: adding a scavenger compound to an analytical reagent to form a reagent solution; collecting an amount of formation fluid into a formation tester, wherein the formation tester includes at least one fluids analyzer comprising at least one probe, at least one flow line, at least one reagent container, and at least one spectral analyzer, wherein the fluids analyzer is configured such that the collected formation fluid is fed through the at least one flow line to the at least one spectral analyzer; mixing an amount of the collected formation fluid with an amount of the reagent solution to form a mixture; and analyzing the mixture downhole.06-14-2012

Jane T. Lam, Randolph, MA US

Patent application numberDescriptionPublished
20120273203DOWNHOLE MIXING DEVICE FOR MIXING A FIRST FLUID WITH A SECOND FLUID - Methods and devices for mixing a first fluid with a second fluid downhole include a chamber having a first end, a second end and an opening for fluid to flow there through. A top surface of a perforated piston is capable of contacting the second end and a top surface of a piston is capable of contacting a bottom surface of the perforated piston. The perforated piston is located at a first position within the chamber based upon characteristics of a first fluid. A first fluid delivery system supplies the first fluid and a second fluid delivery system supplies a second fluid to the chamber, wherein the second fluid is at a pressure that moves the piston approximate to the first end. An actuating device applies a force against the bottom surface of the piston to inject the fluids through channels of the perforated piston to produce spray droplets.11-01-2012
20120276648ELECTROSTATICALLY STABILIZED METAL SULFIDE NANOPARTICLES FOR COLORIMETRIC MEASUREMENT OF HYDROGEN SULFIDE - Methods and related apparatuses and mixtures are described for spectroscopic detection of hydrogen sulfide in a fluid, for example a formation fluid downhole. A reagent mixture is combined with the fluid. The reagent mixture includes metal ions for reacting with hydrogen sulfide forming a metal sulfide, and a solvent that stabilizes the metal sulfide nanoparticles and assist in preventing precipitation by electrostatic stabilization. The solvent includes a property having a density above 1 kg/l. Further, dissolving the metal ions into the solvent to create the reagent mixture, and mixing the reagent mixture with the hydrogen sulfide sample in a formation. So, the metal ions of the reagent mixture react with the hydrogen sulfide sample to form the metal sulfide nanoparticles, resulting in the metal sulfide nanoparticles having properties with a density from 1 kg/l to about 8 kg/l.11-01-2012
20130075093SYSTEM AND METHOD FOR FLUID PROCESSING WITH VARIABLE DELIVERY FOR DOWNHOLE FLUID ANALYSIS - Described herein are variable-volume reservoir (e.g., syringe pump) based processes and systems usable to characterize samples of reservoir fluids, without having to first transport the fluids to the surface. Variable-volume reservoirs are used, for example, for one or more of storing reactants, controlling mixing ratios and storing used chemicals. The processes and systems can be used in various modes, such as continuous mixing mode, flow injection analysis, and titrations. A fluid interrogator, such as a spectrometer, can be used to detect a change in a physical property of the mixture, which is indicative of an analyte within the mixture. In at least some embodiments, a concentration of the analyte solution can be determined from the detected physical property.03-28-2013

Kapang Lam, Chelmsford, MA US

Patent application numberDescriptionPublished
20150049190System and Method for Video/Audio and Event Dispatch Using Positioning System - A system and method for operating a network security system implementing security cameras, motion sensors, access control systems, security door locks, and mobile panic button devices within a monitored area. Security cameras transmit video to a network video recorder and the video is analyzed by a video analytics system to determine if a security event is occurring. If a security event occurs, a security control system calls a dispatch service, which transmits a notification to only those security guards who are within a given area of the event.02-19-2015

Kelvin Lam, Bedford, MA US

Patent application numberDescriptionPublished
20110099158SYSTEM AND METHOD FOR AUTOMATICALLY DETECTING, REPORTING, AND TRACKING CONFLICTS IN A CHANGE MANAGEMENT SYSTEM - A system and method for automatically detecting, reporting, and tracking conflicts in a change management system is provided. In particular, the system and method described herein may be used to identify potential conflicts associated with resources and schedules involved in a proposed change to an information technology infrastructure. A conflict analysis engine may analyze a change order that includes planned changes to an information technology infrastructure to identify potential conflicts associated with the change order that includes the planned changes to the information technology infrastructure. The potential conflicts may then be added to a conflicts list for the change order and a workflow may be created to manage resolving the potential conflicts. Thus, in response to resolving the potential conflicts, the planned changes may be deployed within the information technology infrastructure.04-28-2011

Kelvin Lam, Arlington, MA US

Patent application numberDescriptionPublished
20110070645COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS - Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.03-24-2011
20120021519EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS - The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-β-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.01-26-2012
20130259842STABLE REPROGRAMMED CELLS - The present invention relates to a stable pluripotent reprogrammed cells, and compositions and methods of isolation and uses thereof, wherein the stable pluripotent reprogrammed cells is derived from a somatic cell and has undergone incomplete remodeling of the epigenome. In some embodiments, the stable reprogrammed cell is a human stable reprogrammed cell. In some embodiments, the stable reprogrammed cell has a statistically significant lower level of expression of one or any combination of Nanog, Dnmt3b, Lefty2 as compared to an induced pluripotent stem cell. In some embodiments, the stable reprogrammed cell has a statistically significant higher level of expression of one or any combination of Tdgf1, Tert or endogenous Sox2 as compared to a somatic cell from which it was derived. In some embodiments, the stable reprogrammed cell has a statistically significant faster rate of doubling as compared to an induced pluripotent stem cell (iPSC) or an embryonic stem (ES) cell. Other aspects of the invention relate to compositions comprising the reprogrammed cell, method of isolation and method of use.10-03-2013
20140335611COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS - Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described.11-13-2014

Patent applications by Kelvin Lam, Arlington, MA US

Lui Lam, Lexington, MA US

Patent application numberDescriptionPublished
20150035605APPARATUS AND METHODS FOR BIASING POWER AMPLIFIERS - Apparatus and methods for biasing power amplifiers are disclosed herein. In certain implementations, a power amplifier system includes a power amplifier and a bias circuit that generates a bias voltage for biasing the power amplifier. The bias circuit includes an amplifier, a current source for generating a reference current, and a reference transistor having a current therethrough that changes in relation to the bias voltage. The amplifier can control the bias voltage based on an error current corresponding to a difference between the reference current and the current through the reference transistor. The amplifier can be used to control the bias voltage such that the reference current and the current through the reference transistor are substantially equal.02-05-2015
20150077187DYNAMIC ERROR VECTOR MAGNITUDE DUTY CYCLE CORRECTION - Aspects of this disclosure relate to dynamic error vector magnitude (DEVM) compensation. In one embodiment, an apparatus includes an amplifier, a low pass filter, and a bias circuit. The amplifier, such as a power amplifier, can amplify an input signal. The low pass filter, such as an integrator, can generate a correction signal based at least partly on an indication of a duty cycle of the amplifier. The indication of the duty cycle of the amplifier can be an enable signal for the amplifier, for example. The bias circuit can generate a bias signal based at least partly on the correction signal and provide the bias signal to the amplifier to bias the amplifier.03-19-2015

Lui Lam, Winchester, MA US

Patent application numberDescriptionPublished
20130099845SYSTEM AND METHOD OF TRANSISTOR SWITCH BIASING IN A HIGH POWER SEMICONDUCTOR SWITCH - A circuit and method are provided for switching in a semiconductor based high power switch. Complementary p-type based transistors are utilized along insertion loss insensitive paths allowing biasing voltages to alternate between supply and ground, allowing for negative voltage supplies and blocking capacitors to be dispensed with, while improving performance.04-25-2013
20130321095LOW-LOSS HIGH-ISOLATION SWITCHING ARCHITECTURE - Disclosed are switching circuits and methods that enable a device to switch between two wireless protocols with antenna sharing. In some implementations, the device may use two different wireless protocols concurrently and with high isolation. In some implementations, the device can be provided with insertion loss matched transmission diversity for one of the wireless protocols. In some embodiments, various signal paths and related switches that allow such functionalities can be implemented on a single die such as a silicon-on-insulator (SOI) die.12-05-2013

Lui (ray) Lam, Winchester, MA US

Patent application numberDescriptionPublished
20120007654SYSTEM AND METHOD OF TRANSISTOR SWITCH BIASING IN A HIGH POWER SEMICONDUCTOR SWITCH - A circuit and method are provided for switching in a semiconductor based high power switch. Complementary p-type based transistors are utilized along insertion loss insensitive paths allowing biasing voltages to alternate between supply and ground, allowing for negative voltage supplies and blocking capacitors to be dispensed with, while improving performance.01-12-2012

Lui (ray) Lam, Woburn, MA US

Patent application numberDescriptionPublished
20110128078System and Method of Prebias for Rapid Power Amplifier Response Correction - A system and method are provided for reducing dynamic EVM of an integrated circuit power amplifier (PA) used for RF communication. In a multistage PA, the largest amplification stage is biased with a high amplitude current pulse upon receipt of a Tx enable, before receipt of the RF signal data burst. The high amplitude current pulse causes a large portion of the total ICQ budget of the multistage PA to pass through the largest amplification stage causing the entire integrated circuit to rapidly approach steady-state operating conditions. A smoothing bias current is applied to the largest amplification stage after the pulse decays to compensate for transient bias current levels while standard bias circuitry is still approaching steady-state temperature.06-02-2011
20130034144SYSTEM AND METHOD OF PREBIAS FOR RAPID POWER AMPLIFIER RESPONSE CORRECTION - A system and method are provided for reducing dynamic EVM of an integrated circuit power amplifier (PA) used for RF communication. In a multistage PA, the largest amplification stage is biased with a high amplitude current pulse upon receipt of a Tx enable, before receipt of the RF signal data burst. The high amplitude current pulse causes a large portion of the total ICQ budget of the multistage PA to pass through the largest amplification stage causing the entire integrated circuit to rapidly approach steady-state operating conditions. A smoothing bias current is applied to the largest amplification stage after the pulse decays to compensate for transient bias current levels while standard bias circuitry is still approaching steady-state temperature.02-07-2013

Peggy Lam, Randolph, MA US

Patent application numberDescriptionPublished
20110030249SYSTEM, COMPONENTS AND METHOD FOR TREATING A FABRIC - A pad system for facilitating treatment of a fabric includes a pad which is placed adjacent to a support surface, and fabric grips which secure the fabric against the pad. The fabric grips may be attachable to the pad. The fabric grips may be used to arrange the fabric on the pad and provide tension to the fabric to facilitate fabric treatments such as steaming, heating and/or pressing.02-10-2011
20110219646FABRIC CARE APPLIANCE - Appliances, methods and systems in which steam can be applied to a fabric and a heated surface can be used to press and/or dry the fabric.09-15-2011
20130276485GARMENT STEAMER - A garment steamer has a housing with a reservoir and a boiler for converting water to steam. The housing includes a normally closed valve in a flow path between the reservoir and the boiler. A removable fill plug in a fill opening or inlet of the reservoir is configured to engage the valve to permit water to be communicated from the reservoir via an outlet to the boiler for conversion into steam. The plug-actuated valve isolates the boiler from the reservoir when the plug is removed, providing safer refilling when the boiler is hot. The garment steamer also includes a steam discharge head coupled by a hose to the housing and configured to direct steam onto a garment or similar item.10-24-2013

Phoebe J. Lam, Falmouth, MA US

Patent application numberDescriptionPublished
20130298702IN SITU MARINE SAMPLE COLLECTION SYSTEM AND METHODS - According to one aspect, the invention relates to a marine sample collection system adapted for in situ use. The system includes a first filter head and a second filter head for filtering material of interest from ambient marine fluid passing therethrough and a respective filter flow meter disposed downstream of each of the filter heads for measuring volumetric flow through each filter head. The system also includes a pump downstream of the filter heads for inducing flow through the filter heads and an outlet flow meter disposed downstream of the pump for measuring volumetric flow through the pump. An optional controller compares a sum of an output of the flow meters associated with the first and second filter heads and an output of the outlet flow meter to determine if there is leakage in the system.11-14-2013

Steven Lam, Boston, MA US

Patent application numberDescriptionPublished
20140263055Ion Sequestration for Scale Prevention in High-Recovery Desalination Systems - Cations that can precipitate from an aqueous composition to produce scaling are sequestered by adding a multi-dentate ligand to the aqueous composition. The multi-dentate ligand bonds with the cation to form a non-scaling ionic complex; and the aqueous solution with the ionic complex is used in a process that produces substantially pure water from the aqueous composition, where the cation, absent formation of the ionic complex, is subject to scaling. The pH of the aqueous composition (or a brine including components of the aqueous composition) is then reduced to release the cation from the multi-dentate ligand; and the multi-dentate ligand, after the cation is released, is then reused in a predominantly closed loop.09-18-2014
20140367871Multi-Stage Bubble Column Humidifier - A feed liquid flows into a second-stage humidifier chamber to form a second-stage humidifier bath. A first remnant of the feed liquid from the second-stage humidifier chamber then flows into a first-stage humidifier chamber to form a first-stage humidifier bath having a temperature lower than that of the second-stage bath. A second remnant of the feed liquid is then removed from the first-stage humidifier. Meanwhile, a carrier gas is injected into and bubbled through the first-stage humidifier bath, collecting a vaporizable component in vapor form from the first remnant of the feed liquid to partially humidify the carrier gas. The partially humidified carrier gas is then bubbled through the second-stage humidifier bath, where the carrier gas collects more of the vaporizable component in vapor form from the feed liquid to further humidify the carrier gas before the humidified carrier gas is removed from the second-stage humidifier chamber.12-18-2014

Steven Lam, Medford, MA US

Patent application numberDescriptionPublished
20150060286WATER TREATMENT SYSTEMS AND ASSOCIATED METHODS - Water treatment systems and associated methods are generally described. Certain of the water treatment systems and methods described herein can be used to pre-treat an aqueous stream that is subsequently transported to a desalination apparatus and/or post-treat an aqueous stream that has been produced by a desalination apparatus.03-05-2015
20150083577DESALINATION SYSTEMS AND ASSOCIATED METHODS - Systems and methods related to the desalination of aqueous solutions containing one or more dissolved salts are generally described.03-26-2015
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