Patent application number | Description | Published |
20130046519 | METHOD AND SYSTEM FOR MODELING A POWER PLANT - A method of modeling a power plant including a plurality of major components including at least one of a Heat recovery Steam Generator (HRSG), a steam turbomachine, a condenser, and a cooling system includes establishing a desired power plant output criteria, selecting a plurality of major components to form the power plant, running a model module to create thermodynamic model of the major components to form a power plant model, running an equation module to develop a set of equations for the power plant model, running a performance module to solve the set of equations for the power plant model, running a cost module to determine a cost of the power plant model, determining whether the power plant model meets the desired power plant output criteria, and generating a result that indicates the performance and cost of the power plant. | 02-21-2013 |
20140096535 | GAS TURBINE SYSTEM WITH REHEAT SPRAY CONTROL - The present application provides a gas turbine system. The gas turbine system may include a gas turbine engine producing a flow of exhaust gases, a heat recovery steam generator with a reheater and an evaporator in communication with the flow of exhaust gases, and a gas flow control system for diverting a first portion of the flow of exhaust gases away from the reheater and towards the evaporator. | 04-10-2014 |
Patent application number | Description | Published |
20120162394 | DISPLAYS FOR EASY VISUALIZING OF 3D DISPARITY DATA - Embodiments of the present invention provide various displays for easy visualization of disparity data. Some embodiments provide a “snapshot” display having a plurality of markers, each marker representing a disparity statistic of a horizontal or vertical segment of a 3D image under test. Other embodiments provide a “trend” display having a plurality of markers, each marker representing a disparity statistic, or a rate of change of a disparity statistic, calculated over a single frame or field of a 3D video under test on a frame-by-frame basis. The disparity statistic may be maximum disparity, minimum disparity, mean disparity, RMS disparity, or the like. | 06-28-2012 |
20120257010 | SEMI-AUTOMATIC 3D STEREOSCOPIC DISPARITY CURSOR - Embodiments of the present invention provide a “disparity cursor” for easily measuring disparity within a selected region of a 3D image under test. In operation, a user places a window that defines the disparity cursor over a selected region of the 3D image under test using a mouse, keyboard, or other user-interface device. An average disparity value for the image segments contained within the window is then automatically calculated and reported to the user. | 10-11-2012 |
20140056342 | MEASURING CHANNEL SIGNAL TO NOISE METRIC USING CONSTELLATION DATA - Described are systems and methods of estimating a Signal-to-Noise (S/N) ratio of an input channel carrying a QAM signal. A Modulation Error Ratio (MER) is calculated for the input QAM signal, but uses only the centermost error values of a constellation of the input QAM signal in generating this modified MER. The modified MER accurately represents the S/N ratio of the input channel carrying the QAM signal. In this way the S/N ratio may be accurately determined using only the received I and Q components of the modulated QAM input signal itself. | 02-27-2014 |
Patent application number | Description | Published |
20100104561 | TYROSINE-MODIFIED RECOMBINANT rAAV VECTOR COMPOSITIONS AND METHODS FOR USE - Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors. | 04-29-2010 |
20130203841 | Transduction Efficiency, Capsid-Modified rAAV Vectors and Methods of Use - Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors. | 08-08-2013 |
20130216501 | THERAPEUTIC METHODS BASED ON TYROSINE-SUBSTITUTED, CAPSID-MODIFIED RAAV VECTORS - Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors. | 08-22-2013 |
20140050701 | CAPSID-MODIFIED rAAV VECTOR COMPOSITIONS HAVING IMPROVED TRANSDUCTION EFFICIENCIES, AND METHODS OF USE - Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using novel capsid-protein-mutated rAAV vector constructs in a variety of diagnostic and therapeutic applications including, inter alia, as delivery agents for diagnosis, treatment, or amelioration of one or more symptoms of disease or abnormal conditions via in situ and/or ex vivo mammalian gene therapy methods. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications. | 02-20-2014 |
20140341852 | CAPSID-MODIFIED RAAV VECTOR COMPOSITIONS AND METHODS THEREFOR - Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also provided are methods of preparing and using the disclosed capsid-protein-mutated rAAV constructs in a variety of diagnostic and therapeutic modalities, including, inter alia, as mammalian cell-targeting delivery agents, and as human gene therapy vectors. Also disclosed are large-scale production methods for capsid-modified rAAV expression vectors, viral particles, and infectious virions having improved transduction efficiencies over those of the corresponding, un-modified, rAAV vectors, as well as use of the disclosed compositions in the manufacture of medicaments for a variety of in vitro and/or in vivo applications. | 11-20-2014 |
Patent application number | Description | Published |
20100129843 | CHARACTERIZATION OF N-GLYCANS USING EXOGLYCOSIDASES - The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially. | 05-27-2010 |
20100196940 | METHODS RELATED TO CELL SURFACE GLYCOSYLATION - The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins. | 08-05-2010 |
20100279306 | ANALYSIS OF PHOSPHORYLATED GLYCANS, GLYCOPEPTIDES OR GLYCOPROTEINS BY IMAC - The present disclosure provides technologies for enriching, detecting, and/or quantifying phosphorylated glycans and/or glycoconjugates (e.g., glycopeptides, glycolipids, proteoglycans, etc.). Specifically, the present disclosure provides methods that utilize immobilized metal affinity chromatography (IMAC) to isolate and/or to characterize phosphorylated glycans. The present disclosure particularly provides methods for distinguishing sulfated and phosphorylated glycans. | 11-04-2010 |
20110213137 | ISOTOPICALLY-LABELED GLYCANS - The present disclosure provides methods of making isotopically-labeled glycans or a mixture of glycans (e.g., a glycan preparation) via reductive amination. Such methods are useful, for example, in the determination of the relative amounts of a glycan species present in two or more glycoprotein preparations using mass spectroscopy. In one aspect, the present disclosure provides a method of making an isotopically-labeled glycan by a glycan with an amine and an isotopically-labeled reducing agent to provide an isotopically-labeled aminated glycan. In certain embodiments, the amine is an isotopically-labeled amine. | 09-01-2011 |
20120264927 | METHODS FOR LABELING GLYCANS - Methods for labeling glycans that include a step of freeze-drying a labeled glycan preparation. The labeled glycan preparation is maintained in a substantially frozen state for the duration of the freeze-drying process. | 10-18-2012 |
20120277165 | METHODS OF MODULATING FUCOSYLATION OF GLYCOPROTEINS - The present invention provides methods and materials useful for monitoring and regulating the glycosylation of glycoproteins that are recombinantly produced from cells. In particular, methods are provided for monitoring and regulating levels of cellular indicators which affect the level of fucosylation produced by cells. | 11-01-2012 |
20120329709 | PRODUCTION OF GLYCOPROTEINS - The present invention provides methods and materials by which glycosylation of glycoproteins can be regulated. Methods include the monitoring and regulation of parameters such that a glycoprotein having a desired product quality is obtained. | 12-27-2012 |
20130123126 | SELECTION AND USE OF HOST CELLS FOR PRODUCTION OF GLYCOPROTEINS - A method of making a glycoprotein having a selected glycostructure. | 05-16-2013 |
20130184180 | CHARACTERIZATION OF N-GLYCANS USING EXOGLYCOSIDASES - The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some embodiments, N-glycans are digested with multiple exoglycosidases simultaneously. In some embodiments, N-glycans are digested with multiple exoglycosidases sequentially. In some embodiments, methods in accordance with the present disclosure involve comparison of cleavage products of N-glycans that have been digested with multiple exoglycosidases simultaneously to N-glycans that have been digested with multiple exoglycosidases sequentially. | 07-18-2013 |